Gene Roco4 (Slime mold)

Roco4

Species: Slime mold
Alias: DdisK232, Roco4, DDB0191509
External Links: DictyBase Link ,
Annotation:

Classification

Group: TKL
Family: LRRK

Sequence

Name Sequence Type Origin Length Description Download
Roco4.AA Protein None 1726 None Fasta, JSON
Roco4.kin_dom Protein Kinase Domain None 262 None Fasta, JSON

Protein domain

Protein domains of Roco4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LRR_1 Roco4.AA LRR_1 280-301 33 0.000523 18.38 Pfam 1-26 (26) Show / Hide 
Range on Protein: 280-301
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

HLVELDLSD-N--KIT-ELPKD-IQLL
.| .||||. |  ..| ..|.. .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP Roco4.AA LRR_TYP 301-324 33 0.00282 18.13 SMART 1-24 (24) Show / Hide 
Range on Protein: 301-324
Range on HMM: 1-24/24
Sequence Identity: 33% (8 aa)

LKSLRILILRGNLLEDIPLEICYL
| .|| | | .| |. .| ...  
LPNLRELDLSNNQLTHLPPGAFQG
LRR_TYP Roco4.AA LRR_TYP 278-300 45 0.028057 12.57 SMART 1-24 (24) Show / Hide 
Range on Protein: 278-300
Range on HMM: 1-24/24
Sequence Identity: 45% (11 aa)

CTHLVELDLSDNKITELPKDI-QL
 ..| |||||.|..|.|| .. | 
LPNLRELDLSNNQLTHLPPGAFQG
LRR_1 Roco4.AA LRR_1 303-324 33 0.028961 12.2 Pfam 1-26 (26) Show / Hide 
Range on Protein: 303-324
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

SLRILILRG-N--LLE-DIPLE-ICYL
.|..| |.| |   |. .|| . .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 Roco4.AA LRR_1 256-277 25 15.047347 2.57 Pfam 1-26 (26) Show / Hide 
Range on Protein: 256-277
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

KGKRLSLSR-S--NLS-RFPMS-ITQM
. ..|.||.    ||.  .| | . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 Roco4.AA LRR_1 326-347 25 31.322232 1.44 Pfam 1-26 (26) Show / Hide 
Range on Protein: 326-347
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

DLKILELQE-N--PLN-NFPLS-VVQS
 |..| |.  |  .|  ..| |   . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
ROC Roco4.AA ROC 368-536 27 5.6e-46 151.91 In-house 1-215 (215) Show / Hide 
Range on Protein: 368-536
Range on HMM: 1-215/215
Sequence Identity: 27% (59 aa)

WNKVKLMFVGQEGVGKTSLCQALKGSKKKKAELQVT--GDTVSTEGVK-IQNIK-----------NKKVEFHAWDFGGQQVFYPTHQFFLTT-HALYLVV
 | .|||..||.||||||||..|...|..  . ..   |. ..| |.  ||...           .... |. ||||||.....|||||||.  ..||.|
CNEMKLMLCGQGGVGKTSLCKQLMHDKFSDCSCYSCDKGNHPTTHGIEPIQQWVLDCKDMMFRKKEDEIKFNVWDFGGQEIYHATHQFFLTNHRSVYLLV

FKLTD-----PNF----AER--VNYWVRQVKSNSSG-----AVP-AIFLVGTHSDVCTPEQ---LQEAESI--LKANFVKYSRV-KE-------NTINFV
... .      ..     ..  . || | .||....     . |  . .||||.|..  ..   .|   ..   .    |. .. ..       ...  |
WDCRTKCCDGQPEMIVRECNYELEYWLRFIKSRGPQSEHHCMQPSPVIIVGTHWDKVPRQDNKVYQHKQCCRMWQKLRNKFPNICHSWMQIEHYQGFFHV

CCATG-KGIKELKKR
 |.|| |||..|.. 
DCETGCKGIDKLRHH
Miro Roco4.AA Miro 372-490 22 5e-15 55.84 Pfam 1-140 (140) Show / Hide 
Range on Protein: 372-490
Range on HMM: 1-140/140
Sequence Identity: 22% (32 aa)

KLMFVGQEGVGKTSLCQALKGSKKK------------KAELQVTGDTVSTEGVKIQNIK-----NKKVEFHAWDFGGQQVFYPTHQFF--LTTHALYLVV
|.. .| .|.||.|. ... | ..             . | . ..  | |. |... ..      |   || ||.||.  .. .|..|  ...   ...|
KVVVCGDKGCGKSSFIHQYCGEEFPPNIPRVLPDKTMPREMHGHTYYVDTMQVDWDTQSENVDRVKMCYFHIWDCGGREYWKFEHMHFACMKWADAICFV

FKLTDPN-FAERVNY--WVRQVKSNSSGAVPAIFLVGTHSD
. .||.. |.. .||  | .. ..  ..|.| ...||.. |
YDCTDYESFNRVSNYMAWLPHFRKWGKKAIP-VIVVGNKCD
RAB Roco4.AA RAB 371-536 21 0.000188 -87.06 SMART 1-172 (172) Show / Hide 
Range on Protein: 371-536
Range on HMM: 1-172/172
Sequence Identity: 21% (39 aa)

VKLMFVGQEGVGKTSLCQALKGSKKKKAELQVTGDTVSTE-GVKIQNIKNKKVEFHAWDFGGQQVFYP-THQFFLTTHALYLVVFKLTDPNFAERVNYWV
 |.. .|  ||||..| .     ...| ..|    |.  . ..|. ..  |.|    ||  ||  |   |. .    |.  ..|. .|...  |.|  |.
FKIILIGDSGVGKSCLLHRF---TDDKFSEQYK-HTIGVDFKTKTIEVDGKRVKLQIWDTAGQERFRSITSSYYRGAHGC-ILVYDITNRESFENVKNWL

RQVKSNSSG--AVPAIFLVGTHSDVCTPEQLQEAESILK----ANFVKYSRV-----KENTINFVCCATGKGIKELKKR
........     . | |||  .|     |  . |        |   . .       |.||  .| .|  . ......|
KEIRMHANPPPENVVIMLVGNKCDLEHQRQVSTEEAQKFCCDCAEKHGMPFMFETSAKTNT--NVEEAFQCLARKIYQR
COR Roco4.AA COR 594-787 22 1.2e-44 142.54 In-house 43-288 (434) Show / Hide 
Range on Protein: 594-787
Range on HMM: 43-288/434
Sequence Identity: 22% (58 aa)

SQKERYIDYDDYMNECKLSH-----------LQPEEIKGATDFLHNLGIILHFD----TPTLKNLVVLDPQWLADVMSSLITFSHNW-----IKRGI-LN
.... .... .. . |. .            ....|.. ....||.||.|.||.     | ||..|||||||....|.....  .        ..|| ..
HNEKPWMSWKEFCQICQEHGPPKRLRHQNIIIDEDELHTVAMYLHDLGHIIHFKIWDHDPMLKDFVVLDPQWFCQMMYHIFNHKESRCFHKLHNKGIFFT

HSELVAVWGGK-----------YDQSLWPLLLKLLEKFEVSYELPN---------IAKSLIPSLLPEDAEGEISTIKDREWVTLPQAIESG--RCQVFGC
|..|  .| ..           |.... ..|..|.||||..|....            .|||.|||.| ... .      | . ||  |..   |.....
HQDLEKIWNPPCRHNPHMNWRRYPDHDHEYLVELMEKFELCYPIDPDWTHFWHQETTTYLIPQLLPDDRPQHWE------WWQWPQ-WETNEHDCRYLRR

DYNF------DFMPLGFFARLLLRILLISGVEVRT----------YWRNGVLL
 |..      .|.| ||. |.. |.. ..  .. .          |||||..|
HYHYCMDHHHMFLPAGFWPRFQVRLHHFIHDMFKCFYERSCCEWMYWRNGMVL
COR Roco4.AA COR 819-1008 9 2e-10 29.69 In-house 322-434 (434) Show / Hide 
Range on Protein: 819-1008
Range on HMM: 322-434/434
Sequence Identity: 9% (22 aa)

DSSVNNNNNNNNNNNNNNIINSSSSSSLNLTQTSTSTSPSKLSLNNSQINNSNSTLNSQQLINPSVSPLSSTTPRHQALITFIKKKSFESKDKDSYKLNI
|                                                                                                   
D---------------------------------------------------------------------------------------------------

EVRSFNTTIEKDHSASLFFQQILFTIDTLLASSY--VGLE-------ITRMIPCIHCVQKNP--RADPYYFDFSSCISALQDGKPHLFCRNDPS------
             ... ..|.|  .|. ...|..   ||.       .  .||| ||.|...    |..|. . .|| | ..|.  ..| .         
-------------MCCQLWQIIRQHIQHIHNSWWPWPGLQYQCQHWVCREWIPCPHCIQDHWDTCCDICYYQYDWCIRAEEMGMDSYPCPKCDQYCDAFE

-----------------IPV-RIDY
                  .. ||..
MMCCYQHHWHYSHDQNGQWIQRISD
Kinase Roco4.AA LRRK 1026-1291 39 3.5e-157 528.47 In-house 1-351 (351) Show / Hide 
Range on Protein: 1026-1291
Range on HMM: 1-351/351
Sequence Identity: 39% (138 aa)

IEYEKQIGKGGFG-LVHKGRLVK-------------------------DKS-VVAIKSLILG---------DSEG------------------ETEMIEK
...|.|||.|||| .|..... .                         |..  ||||.....         .|..                  .......
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

FQEFQREVFIMSNLNHPNIVKLYGLMHNPPRMVMEFVPCGDLYHRLLDKA-HP-------IKWSVKLRLMLDIALGIEYMQNQNPPIVHRDLRSPNIFLQ
|.||..||.|||.|||||||.|.|....|..||||..|.|||||.| .|. ..       |.|..||...|.|| |.||....||||.||||.||||.|.
FREFRHEVWIMSHLNHPNIVSLKGFCIHPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILLW

SLDEN-------APVCAKVADFGLSQ--QSVHS--VSGLLGNFQWMAPETIGAE-EESYTEKADTYSFAMILYTILTGE-GPFDEYS-YGKIKFINMIRE
|...|       |.||||.||||.|.  |..|.  ..|..||..|||||..... ||.||||.|.|||.|||...||..  ||||.. .........|..
SSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIED

---EGLRPTIPED-CPP-----RLRNVIELCWSGDPKKRPHFSYIVKELSE
   ||||||||.. |||     .. . |..||..|||||||||.||| ||.
KIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase Roco4.AA TKL 1032-1289 28 4.1e-100 338.91 In-house 1-364 (364) Show / Hide 
Range on Protein: 1032-1289
Range on HMM: 1-364/364
Sequence Identity: 28% (105 aa)

IGKGGFGLVHKGRLVKDK--------SVVAIKSLILGDSEGETE-------------------MIEKFQEFQREVF-IMSNLNHPNIVKLYG--------
||.|||| |.||..             .||.| .   ..  .|.                   ....|..| .|.  .||.|.|||||...|        
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-LMHNP------PRMVMEFVPCGDLYHRLLDKAHPIKWSVKLRLMLDIALGIEYMQNQN------PPIVHRDLRSPNIFLQSL---------DENAPVCA
  ...|      . .|||..|.|.|.|.|.       |....|..||||.|..|. ..|      |||.|||| |.||.. .          ..||..|.
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

KVADFGLSQQSVHS----------------------VSGLLGNFQWMAPETIGAE--------------EESYTEKADTYSFAMILYTILTGEGPFDEYS
|..|||||.   .|                       .   |...||||| .  .              ...|.||.| |||...|. |||.. |...| 
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYP

YGKIK-------FINMIREEGLRPTIP------------EDCPPRLRNVIELCWSGDPKKRPHFSYIVKEL
|  ..       .. |. ..||||.||            .||||.... .. ||. ||.||| |. |.|.|
YMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase Roco4.AA TKL-Unique 1030-1289 32 1.8e-67 230.48 In-house 3-290 (290) Show / Hide 
Range on Protein: 1030-1289
Range on HMM: 3-290/290
Sequence Identity: 32% (95 aa)

KQIGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQEFQREVFIMSNLN-HPNIVKLYGLMH----NPP--RMVMEFVPCGDLYHRLL----
. || ||.| | ||   ...  ||||.. .  .. . ||.   ||| .|| .|..|. |||||...|  .     ||   .|||..| | ||  |     
NKIGEGGYGQVYKGKWRGYP--VAIKQFHP-NEDSSNEMM---QEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNN

-----DKAHPIKWSVKLRLMLDIALGIEYMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQSVHS----VS--------GLLGNFQWMAPE
      . ... ....... .|||.| .|  . .||| ||||.|.|. . .    |.. .|..|||||  .  .    ..        . .|.|.|||||
NNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPE

TIGAEEESYTEKADTYSFAMILYTILTGEG------PFDEYSYGKIKFINMIREEGLRPTIPEDCPPRLRNVIELCWSGDPKKRPHFSYIVKEL
 .  ... |.||.| |||...|. |.|..       |.....  ... .   .||..||.||..||...|. |. ||  || .|| |. |...|
VLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase Roco4.AA Dicty4 1026-1291 35 2.3e-65 216.97 In-house 1-277 (277) Show / Hide 
Range on Protein: 1026-1291
Range on HMM: 1-277/277
Sequence Identity: 35% (102 aa)

IEYEKQIGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQEFQREVFIMSNLNHPNIVKLYGLMH----NPPRM--VMEFVPCGDLYHRLLD
|  |. ||||.|| |.||. .. |  ||.| | .     . .|.   .|| .|| ||... ||||....|       .|..|  |.|..| |.||  |.|
INIEQRIGKGSFGEVYKGT-WRGKE-VAVKKLNNHNQNFDENML---NEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHD

------KAHPIKWSVKLR---LMLDIALGIEYMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQ----QSVHSV--SGLLGNFQWMAPETIG
      .  .. |.  .|   ...|.|.|. .  . || |.|||| | |.     |.|  |  ||.||||||     . |.   ..  |   |||||   
KPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLL---VDKNWRV--KVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVM-

AEEESYTEKADTYSFAMILYTILTGEGPFD-EYSYGKIKFINMIREEGLRPTIPEDCPPRLRNVIELCWSGDPKKRPHFSYIVKE--LSE
  ...|.|||| |||...|. |||.. |.  ...    .|.. . ...||| || .|||...  |. ||. ||..|| |. |...  | .
-MHQPYNEKADVYSFGIVLWEILTRQEPYQKHHM-PYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase Roco4.AA MLK 1026-1289 30 3e-64 219.74 In-house 1-291 (291) Show / Hide 
Range on Protein: 1026-1289
Range on HMM: 1-291/291
Sequence Identity: 30% (90 aa)

IEYEKQIGKGGFGLVHKGRLVKDK---SVVAIKSLI---LGDSEGETEMIEKFQEFQREVFIMSNLN-HPNIVKLYGLMHNPPR---MVMEFVPCGDLYH
|. .. ||.|.|| |.|||  .      .||.|        |.  . . ...|... |.. |.| .| ||.|...||  ..||     |||....| ||.
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

RLLDKAH-------------PIKWSVKLRLMLDIALGIEYMQNQNP-PIVHRDLRSPNIFLQSLDENAPVC---AKVADFGLSQQSVHS---VSGLLGNF
 | ..                .. ..... .|..| |..|  .. | ||.|||| |.|| .    .. . .   .|..|||.|    ..     .  |..
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDE-ICH-DMHHGTLKICDFGTSRDWHQMCTNMMSNAGTY

QWMAPETIG-AEEESYTEKADTYSFAMILYTILTGEGPFDEYSYGKIKFINMIREEGLRPTIPEDCPPRLRNVIELCWSGDPKKRPHFSYIVKEL
 ||||| |  ...| |.||.| .|....|. .||.| |..   |  .  . .. ..||||.|| .||... . .. ||. ||.||| |..||..|
AWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYK-QHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase Roco4.AA Pkinase_Tyr 1026-1289 32 5.2e-58 197.09 Pfam 1-270 (270) Show / Hide 
Range on Protein: 1026-1289
Range on HMM: 1-270/270
Sequence Identity: 32% (93 aa)

IEYEKQIGKGGFGLVHKGRLV----KDKSVVAIKSLILGDSEGETEMIEK--FQEFQREVFIMSNL-NHPNIVKLYGLMH---NP--PRMVMEFVPCGDL
|.  |..|.| || |.||..     ..|  ||.|.|       |. | |    ..| ||. ||..| .|||||.|||       |  . .|||..|.|||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-K-----EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDL

YHRLLDK---AHPIKWSVKLRLMLDIALGIEYMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQS-------VHSVSGLLGNFQWMAPETI
.. | ..    .|.. . .|   ..|| | ||  ..|  ..||||.  |. . .     . ..|..||||.          . . .|      ||||| |
LDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTE-----NNVVKICDFGLARDIYNDDYYYRKRGGGK-LPIKWMAPECI

GAEEESYTEKADTYSFAMILYTILT-GEGP-FDEYSYGKIKFINMIREEGLRPTIPEDCPPRLRNVIELCWSGDPKKRPHFSYIVKEL
   .  .|.| | .||   .. |.| || | . .       ....| |.| |  .||.||. . ... .||  ||..|| ||.|. .|
NYGK--FTTKSDVWSFGVLMWEIFTYGEQPTYPGM--SNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase Roco4.AA TK 1026-1289 18 6.8e-56 185.49 In-house 1-486 (486) Show / Hide 
Range on Protein: 1026-1289
Range on HMM: 1-486/486
Sequence Identity: 18% (90 aa)

IEYEKQIGKGGFG---LVHKGRLVKDK-------------------------SVVAIKSLILGDSEGETEMIE----------KFQEFQREVFIMSN--L
|...|..|.| ||    |.||..  ..                           ||.| | .||.. ..|...          .| |. .|  .|..  .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

NHPNIVKLYG--------------LMHNPPRMVMEFVPCGD----LYHRLLDKA----------------------------------------------
.|||||.|||              .   |. .|||..|.||    | . | ..                                               
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-----------------------------HPIKWSVKLRLMLDIALGIEYMQNQNP----PIVHRDLRSPNIFLQSLDE------NAPVCAKVADFGLS-
                             |..    .|  ...|| | ||.  .|      .|||||   |. . . .       . . ..|.|||||| 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

------------------------------------QQSVHSVSGLLGNFQWMAPETIGAEEES-------YTEKADTYSFAMILYTILT-GEGPFDEYS
                                    |. ... ||    . |||||..   ..|       .|.| | .||   .. |.| |..|. .. 
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

YG--------KIKFINMIREE-------------GLRPTIPEDCP--------------PRLRNVIELCWSGDPKKRPHFSYIVKEL
             .....|..             ..|.  |..||              . .  ..  ||. ||..|| || ....|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase Roco4.AA DRK 1026-1291 33 5.9e-47 157.08 In-house 1-258 (258) Show / Hide 
Range on Protein: 1026-1291
Range on HMM: 1-258/258
Sequence Identity: 33% (94 aa)

IEYEKQIGKGGFGLVHKG--RLVKDKSVVAIKSLILGDSEGETEMIEKFQEFQREVFIMSNLNHPNIVKLYGLMHNPPRM--VMEFVPCGDLYHRLLDKA
|     ||.|..| |  |  |     . ||.| | . . . . ...   .||.||. .|..| ||||.   |   |||    .||. | | ||  |.| .
IKIGNRIGRGNYGEVFRGTWR----GTQVAVKMLFN-HNINDENFL---NEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDES

HPIKWSVKLRLMLDIALGIEYMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQ-----QSVHSVSGLLGNFQWMAPETIGAEEESYTEKADT
  . |.  ...|.|.| |. |  . || |.|||| | |      ||.  |  ||||||||      ..        |   | |||     .. |||||| 
IEMDWPLMKQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLL---VDEHWQV--KVADFGLSTRFKKHKQHKFAMTMCGTPCWTAPEVL--RNQRYTEKADV

YSFAMILYTILTGEGPFDEYSYGKIKF--INMIREEGLRPTIPEDCPPRLRNVIELCWSGDPKKRPHFSYIVKELSE
|||| .|  ..| . |.     |.  |  .  .  .|.|| .|. |||     .  ||. ||  || .  ... |  
YSFAIVLWECVTRQDPY----FGMPTFQVVFSVGRHGMRPPMPQWCPPKYIQLMNDCWNEDPQHRPSMQECLERLEA
Kinase Roco4.AA Dicty4-Unclassified 1026-1289 33 8.2e-47 158.34 In-house 1-263 (263) Show / Hide 
Range on Protein: 1026-1289
Range on HMM: 1-263/263
Sequence Identity: 33% (94 aa)

IEYEKQIGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQEFQREVFIMSNLNHPNIVKLYGLMHNP------PRMVMEFVPCGDLYHRLL-
|   . |||| |  ||||   | |  ||.| .  .      |||   |.| .|| |.  . ||| ||.||   ||         |||| . | |      
IQIDQFIGKGHFSKVHKG-NWKGKD-VAVKKFNENKFKFREEMI---QDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHS

---DKAHPIKWSV--KLRLMLDIALGIEYMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQ--QSVHSVSGLLGNFQWMAPETIGAEEESYT
   ..  |||      ..  .||| |. ..   |  ..|||..| ||    .| .    .|.||||.|             |   | .||      |||.
KPSEQQQPIKLDDTLIIKYAFDIAQGMQHLHTRN--FIHRDIKSSNIL---MDKH--FNIKIADFGISRVIDFNFNMTTIAGTPKWESPECL--MHESYN

EKADTYSFAMILYTILTGEGPFDEYSYGKIKFINMIREEGLRPTIPEDCPPRLRNVIELCWSGDPKKRPHFSYIVKEL
 |.| ||.||.||  .||. |. |     .     . . .||| ||. |.. ..  |  ||. ||.||| .  |.. |
QKSDVYSYAMMLYELATGDEPYQEIQ-SIMNAARSVCDKKLRPKIPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL
Kinase Roco4.AA S_TKc 1026-1290 26 5.6e-46 159.98 SMART 1-231 (231) Show / Hide 
Range on Protein: 1026-1290
Range on HMM: 1-231/231
Sequence Identity: 26% (76 aa)

IEYEKQIGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQEFQREVFIMSNLNHPNIVKLYGLMH-NPPRMVMEFVPC--GDLYHRLLDKAH
 |  ..||||.|| |.|.| .|.. .|||| .               . ..||. |... .||||||||. .. .   ||||...   |||.... .. .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGR

P-----IKWSVKLRLMLDIALGIEYMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQSVHSVSGLLGNFQWMAPETIGAEEESYTE-KADT
.     .   .  ..|  |....||. ...  |.||||   ||.| .       . |..||||. |     . . |   .|||| .     .|.  |.| 
HGLRFPFPE-HARFYMYQICCALEYCHSHG--IIHRDLKPENILLDE-------HIKICDFGLARQL----TTFCGTPWYMAPEVL-----GYGKCKCDW

YSFAMILYTILTGEGPFDEYSYGKIKFINMIREEGLRPTIPEDCPPRLRNVIELCWSGDPKKRPHFSYIVK--------ELS
.|.  |||  |.|. ||.       . ...|.            .| ... |. |.  ||.|||    . .        .  
WSCGCILYEMLCGYPPFP----QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Roco4.AA TyrKc 1026-1289 26 1.2e-45 158.91 SMART 1-280 (280) Show / Hide 
Range on Protein: 1026-1289
Range on HMM: 1-280/280
Sequence Identity: 26% (82 aa)

IEYEKQIGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQEFQREVFIMSNL--NHPNIVKLYGLMH---------NPPRMVMEFVPCGDLY
|. .|..| | || |.||..      ||.|.|  .            ..| ||  ||..|  .|||||.|||             |. .|||..| ||| 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLK

HRLLDKAHPIKWSVKLRLMLDIALGIEYMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQSVHS----------VS----GLL--GNFQWM
..| .. . .... .|  ...|| | ||   .  ...||||   |. . .       ..|..|||||    .           ..    |        ||
DYLRKHRPKLCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM

APETIGAEEESYTEKADTYSFAMILYTILTGEGPFDEY---SYGKIKFINMIR--EEGLRPTIPED--------CPPRLRNVIELCWSGDPKKRPHFSYI
|||.|   .  .|.| | .||   .. |.|  ..  .       ... . .|.  ..| |. .|..        ||. . .... ||  ||..|| || |
APECI--NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ--MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI

VKEL
....
HECF
Kinase Roco4.AA Pkinase 1026-1289 26 1.5e-42 151.56 Pfam 1-293 (293) Show / Hide 
Range on Protein: 1026-1289
Range on HMM: 1-293/293
Sequence Identity: 26% (80 aa)

IEYEKQIGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQEFQR--EVFIMSNLNHPNIVKLYGLMHNPPRMV--MEFVPCG----DLYHRL
.. ...||.|.|| | |.. ...  .||.| . .     ..|  .| |.  |  |. || .|||||||.||. .......   ||....|    ||....
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKK-----RHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYI

L-DKAHPI--KWSVKLRLMLDIALGIEYMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLS----QQSVHSVSGLLGNFQWMAPETIGAEEESY
  ..  ..   . .  . |. |. |.||. ..   |.|||| . ||.. . ..... | |..||||.      . .  ... |   .|||| |  . . |
STWRHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHIDA-CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR-GGQYY

TEKADTYSFAMILYTILTGEGPFDEY----SYGKIKFINMIREEGLRPTIPEDCP-------------------PRLRNVIELCWSGDPKKRPHFSYIVK
. |.| .|.  |||  |.|. ||..     .. ... |..|..  |.  .|..|.                   . .. .|. |.  |||||| .  |..
GPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQ

E--L
   .
HPWF
Kinase Roco4.AA CZAK 1026-1289 33 1.5e-38 134.43 In-house 1-279 (279) Show / Hide 
Range on Protein: 1026-1289
Range on HMM: 1-279/279
Sequence Identity: 33% (97 aa)

IEYEKQIGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQEFQREVFIMSNLNHPNIVKLYGL--MHN--PPRMVMEFVPCGDLYHRLLDKA
 . .. ||.| || | |..  . | .|||| . .      .|  |    ||.|| ||| | |||.|   |     .      |||.   | |   | |. 
LKFGQTIGQGFFGEVYKAYW-RGK-DVAIKIIHRNQFRNKDENKE-ENMFQKEVSIMSKLCHPNCVQFLGACSEDGPNHHCIVMEWMGGGSLRRLLTDHY

HPIKW--SVKLRLMLDIALGIEYMQN-QNP-PIVHRDLRSPNIFL-QSLDENAPV-------CAKVADFGLS---QQSVHSVSGLLGNFQWMAPETIGAE
  .|   .... . .||| |  |      | ||.|||| | || | .|..   ||        .|..|||||              |   |||||   . 
FYHKQNPHLQWNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDHSYTPKNPVVSSRQDIICKINDFGLSREMMEQPFEMTQTMGCLCWMAPECFKG-

EESYTEKADTYSFAMILYTILTGEGPFDEYSYGKIKFINMIREEGLRPTIPEDCPPRLR---NVIELCWSGDPKKRPHFSYIVKEL
 |.||||.| |||.|||. |.|.. |  .    |. .      |  || .|   .|       .|| ||   |  || |. |.  |
-ENYTEKVDVYSFGMILWCIITCDQPYQNMQPMKMAHLAAY--ENYRPPMPQPMDPMWKNLGELIEMCWNKNPDERPSFKQILQHL
Kinase Roco4.AA Fer 1026-1155 30 3.9e-21 68.83 In-house 1-137 (283) Show / Hide 
Range on Protein: 1026-1155
Range on HMM: 1-137/283
Sequence Identity: 30% (44 aa)

IEYEKQIGKGGFGLVHKGR-----LVKDKSVV---AIKSLIL-GDSEGETEMIEKFQEFQREVFIMSN-LNHPNIVKLYGL-MHNPPRM-VMEFVPCGDL
.. .|..|.| || |.|||     . . ..||   |.|   . ... .. ...| ..| .    || | ..|||.||.||   .  | | ||||...|.|
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEAR----IMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSL

YHRLLDKAHP-IKWSVKLRLMLDIALGIEYMQNQNPPIVHRDL
  .|  . .  ..   |.|  ...| |.||.  .|  ..|||.
DSYLKKNKNKTVSDNEKIRMCYQAACGMEYLHSKN--CIHRDI
Kinase Roco4.AA Fer 1174-1290 26 9.3e-20 64.05 In-house 154-283 (283) Show / Hide 
Range on Protein: 1174-1290
Range on HMM: 154-283/283
Sequence Identity: 26% (36 aa)

KVADFGLSQQ-SVHSVSGLLG------NFQWMAPETIGAEEESYTEKADTYSFAMILYTILT-GE-----GPFDEYSYGKIKFINM-------IREEGLR
|..|||.| | |.. .. ...      .  |.||||.   .  |..| | .||   .. | | |.     .|  .     .|  |.       |...| .
KISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQTGI--YSPKTDVWSFGVMCWEIFTNGAEPYPGQPH-G-----MKMTNVKKQARKWIIKKGYM

PTIPEDCPPRLRNVIE-LCWSGDPKKRPHFSYIVKELS
...|. .||.......  ||  ||..||... |...| 
MPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
WD40 Roco4.AA WD40 1496-1537 24 0.028124 10.15 SMART 1-46 (46) Show / Hide 
Range on Protein: 1496-1537
Range on HMM: 1-46/46
Sequence Identity: 24% (12 aa)

TMTIVQQLTTPHKGDVCLHFVEYGDN-------NGVWSGGSEGTVCLWD
| . |. ..  |.|    . | . ..       | . ||.  ||...||
T-KCVHTFK-GHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD
WD40 Roco4.AA WD40 1526-1537 50 0.258761 6.4 Pfam 43-54 (39) Show / Hide 
Range on Protein: 1526-1537
Range on HMM: 43-54/39
Sequence Identity: 50% (6 aa)

SGGSEGTVCLWD
||.  ||...||
SGSRDGTIRIWD
WD40 Roco4.AA WD40 1540-1576 16 0.119261 6.19 SMART 1-46 (46) Show / Hide 
Range on Protein: 1540-1576
Range on HMM: 1-46/46
Sequence Identity: 16% (8 aa)

TFEKKHSFS-LES--AITAMSYFGN-------NTLYIASGSH-IVVFK
| .  |.|.  ..  ..|....  .       | |. .|  . | ...
T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD
WD40 Roco4.AA WD40 1541-1571 28 9.860602 1.85 Pfam 1-31 (39) Show / Hide 
Range on Protein: 1541-1571
Range on HMM: 1-31/39
Sequence Identity: 28% (9 aa)

FEKKHSFSLE-SAITAMSYFGNNTLYIASGSH
 . ||.|    ...|....  ..  |.||||.
WKCKHTF-GHTHWVTCCAWHPDMGHYLASGSR
WD40 Roco4.AA WD40 1582-1618 25 0.001902 12.54 Pfam 1-39 (39) Show / Hide 
Range on Protein: 1582-1618
Range on HMM: 1-39/39
Sequence Identity: 25% (10 aa)

MNVNQNWKHSTGSITSILAMKD---EVWSGGSDGRIYIWK
 .. .   . |...|..    |    . ||. || | ||.
WKCKHTF-GHTHWVTCCAWHPDMGHYLASGSRDGTIRIWD
WD40 Roco4.AA WD40 1581-1618 25 0.007265 13.86 SMART 1-46 (46) Show / Hide 
Range on Protein: 1581-1618
Range on HMM: 1-46/46
Sequence Identity: 25% (12 aa)

LMNVNQNWKHSTG--SITSILAMKD--------EVWSGGSDGRIYIWK
  .. . .|  ||  ..|..    |         . ||. || |.||.
T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD
WD40 Roco4.AA WD40 1625-1661 20 0.000461 14.31 Pfam 1-39 (39) Show / Hide 
Range on Protein: 1625-1661
Range on HMM: 1-39/39
Sequence Identity: 20% (8 aa)

LQKVQSLEAHHEKITSLIHLED---NVLSGSTDKCISLFK
 . .... .|  ..|..    |    ..||| |. | ...
WKCKHTF-GHTHWVTCCAWHPDMGHYLASGSRDGTIRIWD
WD40 Roco4.AA WD40 1624-1661 18 0.002019 17.37 SMART 1-46 (46) Show / Hide 
Range on Protein: 1624-1661
Range on HMM: 1-46/46
Sequence Identity: 18% (9 aa)

ELQKVQSLEAHHE--KITSLIHLED--------NVLSGSTDKCISLFK
. . |.....|     .|..    |         ..||| |..| ...
T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD
WD40 Roco4.AA WD40 1665-1705 16 0.191628 4.89 SMART 1-46 (46) Show / Hide 
Range on Protein: 1665-1705
Range on HMM: 1-46/46
Sequence Identity: 16% (8 aa)

PKKPFTTQEHHKQ--GVTSIVKVQS-------HIVWAITSDTTTPLVLWN
. |.  | . |..  .||..   ..       ... .   | |  . .|.
T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGT--IRIWD