Gene Roco6 (Slime mold)
Roco6
Sequence
Protein domains of Roco6.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| LRR_TYP | Roco6.AA | LRR_TYP | 146-168 | 33 | 0.012954 | 15.32 | SMART | 1-24 (24) | Show / Hide |
Range on Protein: 146-168 Range on HMM: 1-24/24 Sequence Identity: 33% (8 aa) FKLLRKLDVSHNAISSVP-NTFNK ||.|| |.|.....| ..|. LPNLRELDLSNNQLTHLPPGAFQG |
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| LRR_TYP | Roco6.AA | LRR_TYP | 169-192 | 33 | 0.02191 | 13.45 | SMART | 1-24 (24) | Show / Hide |
Range on Protein: 169-192 Range on HMM: 1-24/24 Sequence Identity: 33% (8 aa) FSILEDLNLSNNYISYIHPSLFPE . |. |.|||| .. ..| .| LPNLRELDLSNNQLTHLPPGAFQG |
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| LRR_1 | Roco6.AA | LRR_1 | 101-122 | 33 | 0.032552 | 12.02 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 101-122 Range on HMM: 1-26/26 Sequence Identity: 33% (9 aa) SISILNLND-N--LL-GEIPES-LKQL .. .|.|.. | | |.||.| . .| NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_1 | Roco6.AA | LRR_1 | 148-169 | 25 | 0.038791 | 11.75 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 148-169 Range on HMM: 1-26/26 Sequence Identity: 25% (7 aa) LLRKLDVSH-N--AIS-SVPNT-FNKF |..||.|. | .. ..|. | .. NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_TYP | Roco6.AA | LRR_TYP | 213-236 | 37 | 0.217033 | 5.29 | SMART | 1-24 (24) | Show / Hide |
Range on Protein: 213-236 Range on HMM: 1-24/24 Sequence Identity: 37% (9 aa) FESLLTLDISGNKLKHLGNLPFHL .| .|| |.|.|.|| . |. LPNLRELDLSNNQLTHLPPGAFQG |
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| LRR_TYP | Roco6.AA | LRR_TYP | 122-145 | 20 | 0.421224 | 2.93 | SMART | 1-24 (24) | Show / Hide |
Range on Protein: 122-145 Range on HMM: 1-24/24 Sequence Identity: 20% (5 aa) LTQLISLSIRGNHILEIPLWFPEE |..| .|. .|.. ..| . LPNLRELDLSNNQLTHLPPGAFQG |
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| LRR_1 | Roco6.AA | LRR_1 | 193-216 | 27 | 0.62083 | 7.48 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 193-216 Range on HMM: 1-26/26 Sequence Identity: 27% (8 aa) GIMRLNLSN-N--LF-REVELPPW-FESL . .|.||. | . .. .||. | .| NLQHLDLSGCNCCNLTGH--IPPSCF-NL |
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| LRR_TYP | Roco6.AA | LRR_TYP | 99-121 | 20 | 0.742968 | 0.91 | SMART | 1-24 (24) | Show / Hide |
Range on Protein: 99-121 Range on HMM: 1-24/24 Sequence Identity: 20% (5 aa) FKSISILNLNDNLLGEIPESL-KQ . |.|..| | ..|. . LPNLRELDLSNNQLTHLPPGAFQG |
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| LRR_1 | Roco6.AA | LRR_1 | 124-145 | 25 | 1.235691 | 6.42 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 124-145 Range on HMM: 1-26/26 Sequence Identity: 25% (7 aa) QLISLSIRG-N--HIL-EIPLW-FPEE .| .|...| | .. .|| . | NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_1 | Roco6.AA | LRR_1 | 171-189 | 30 | 1.482084 | 6.14 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 171-189 Range on HMM: 1-26/26 Sequence Identity: 30% (8 aa) ILEDLNLSN-N--YIS-YIHP---SL |. |.||. | .. .|.| .| NLQHLDLSGCNCCNLTGHIPPSCFNL |
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| LRR_1 | Roco6.AA | LRR_1 | 235-257 | 14 | 18.884225 | 2.22 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 235-257 Range on HMM: 1-26/26 Sequence Identity: 14% (4 aa) HLVRVSIDD-N--HLE-SIDHKVILRN .| . .... | .|. .| . . NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_1 | Roco6.AA | LRR_1 | 306-327 | 44 | 1e-05 | 24.45 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 306-327 Range on HMM: 1-26/26 Sequence Identity: 44% (12 aa) HLTHLDLSG-N--CIS-VLPPE-LANL .|.|||||| | ... .||. . || NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_TYP | Roco6.AA | LRR_TYP | 304-326 | 41 | 0.000111 | 22.8 | SMART | 1-24 (24) | Show / Hide |
Range on Protein: 304-326 Range on HMM: 1-24/24 Sequence Identity: 41% (10 aa) LVHLTHLDLSGNCISVLPPEL-AN |..|..||||.| .. |||.. .. LPNLRELDLSNNQLTHLPPGAFQG |
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| LRR_TYP | Roco6.AA | LRR_TYP | 327-350 | 45 | 0.023439 | 13.21 | SMART | 1-24 (24) | Show / Hide |
Range on Protein: 327-350 Range on HMM: 1-24/24 Sequence Identity: 45% (11 aa) LTELVRLDLSFNILTTLPLYIVSY |..| .||||.| ||.|| . . LPNLRELDLSNNQLTHLPPGAFQG |
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| LRR_1 | Roco6.AA | LRR_1 | 329-350 | 33 | 1.02359 | 6.71 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 329-350 Range on HMM: 1-26/26 Sequence Identity: 33% (9 aa) ELVRLDLSF-N--ILT-TLPLY-IVSY | .|||| | || ..| . . NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_1 | Roco6.AA | LRR_1 | 352-360 | 66 | 32.354535 | 1.39 | Pfam | 1-9 (26) | Show / Hide |
Range on Protein: 352-360 Range on HMM: 1-9/26 Sequence Identity: 66% (6 aa) RLEHLDLQG .|.||||.| NLQHLDLSG |
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| ROC | Roco6.AA | ROC | 394-446 | 33 | 1.2e-15 | 49.35 | In-house | 1-56 (215) | Show / Hide |
Range on Protein: 394-446 Range on HMM: 1-56/215 Sequence Identity: 33% (20 aa) SYRVKLMIVGQENVGKTSLVKCLKMKKKF-----SKNSDHLGTNVSTDGID-IDEIKFN ...|||..||..||||||.|.|. |. | .|....|.||. |...... CNEMKLMLCGQGGVGKTSLCKQLMHDKFSDCSCYSC---DKGNHPTTHGIEPIQQWVLD |
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| Miro | Roco6.AA | Miro | 398-414 | 29 | 0.006678 | 12.57 | Pfam | 1-17 (140) | Show / Hide |
Range on Protein: 398-414 Range on HMM: 1-17/140 Sequence Identity: 29% (5 aa) KLMIVGQENVGKTSLVK |....| . .||.|... KVVVCGDKGCGKSSFIH |
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| COR | Roco6.AA | COR | 743-1206 | 16 | 1.6e-59 | 191.63 | In-house | 1-434 (434) | Show / Hide |
Range on Protein: 743-1206
Range on HMM: 1-434/434
Sequence Identity: 16% (91 aa)
LKKTVVELPS-------LKQSLPELYLKLEKLIIKKRSTL----VPPVLTWQSFSQMVLSNLDF---------HDEIHVKVATKALVPLGSISFFD----
. ||. .... ..|..|. ..|... ....| .. |...|..|.|..... . .|| . ... | ||.| .|.
IRKTAKKIKHKQMFEDYMCQPVPQSWWKCKQKLEEMRKWMNRHNEKPWMSWKEFCQICQEHGPPKRLRHQNIIIDEDELHTVAMYLHDLGHIIHFKIWDH
EPGLDQYVFLDPQWLTGVFSSIITTKHKF-----IKDGV-LKKSDLYQIWKPP--------HFIEDEGLHSLLINLLERFELMFPLDSDLVSLSSSNGNN
.|.| ..|.|||||.......|.. |. . |. ....|| .||.|| . . .| .|..|.|.||| .|.|.| .. .
DPMLKDFVVLDPQWFCQMMYHIFNHKESRCFHKLHNKGIFFTHQDLEKIWNPPCRHNPHMNWRRYPDHDHEYLVELMEKFELCYPIDPDWTHFW------
GNSYVNNNNNNNNNSNNNNNGSNKSSPFKTTPSSPSTLRLVDSKSKGSHSSNPILSGNNSSSKNSTSTKRSISGSPLRSRSNSDLDLIGGGGGSPINGSS
----------------------------------------------------------------------------------------------------
IDYSSKSNTLTPGLFNELNQKFIIPSQLPEIRPSFG--LLWPS---LDHSRVEFNRWIQL------SFAPAGLFSRLLIRLLISKEFDMKPIL-------
.... ..||. ||. || . . ||. .|. .. | .. | |||...|.. ||. .| ...
---------------HQETTTYLIPQLLPDDRPQHWEWWQWPQWETNEHDCRYLRRHYHYCMDHHHMFLPAGFWPRFQVRLH---HFIHDMFKCFYERSC
----YWRNGVVVESQSGKSFLSTSTALIEMVPSYANCSSTIKISVRGDRRTGRG-LSAKLLRLIVEIADTLCTSW--YHLE-------TNQVIPCPHCI-
|||||.| . . . . .||..... . |.| |||....... . . ... .|.. . ..| |. .. |||||||
CEWMYWRNGMVLKWEGHNK----NEALVKCDN----HDNKIYITVRGCQDCWIDMCCQLWQIIRQHIQHIHNSWWPWPGLQYQCQHWVCREWIPCPHCIQ
-NKP-NCT--LFSLSDCEAVASSGVWYLLC--GD------------------------RKI-NFET
. . .| ... .|.. ...| .. | | | ....
DHWDTCCDICYYQYDWCIRAEEMGMDSYPCPKCDQYCDAFEMMCCYQHHWHYSHDQNGQWIQRISD
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| ROC | Roco6.AA | ROC | 628-742 | 20 | 1.8e-28 | 92.69 | In-house | 69-215 (215) | Show / Hide |
Range on Protein: 628-742 Range on HMM: 69-215/215 Sequence Identity: 20% (31 aa) VTMSIWDCAGQELYYTSHQMFLTD-SALYVVVWNLCK-----PEV----NSR--VEFWLHSIRSKAEN--------APILLIGTHLDDYLATHSE----- .. ..||..||| |. .||.||| ..|..||.. . . .. .|.|| .|.| . . .|....|||.| . . IKFNVWDFGGQEIYHATHQFFLTNHRSVYLLVWDCRTKCCDGQPEMIVRECNYELEYWLRFIKSRGPQSEHHCMQPSPVIIVGTHWDKVPRQDNKVYQHK SELDEILENIYSKYFRKFRL-------KGISILSCSTG-VGFDNFLDL . . . . .. |. ..... .|. .| || .| |.. . QCC-RMWQKLRNKFPNICHSWMQIEHYQGFFHVDCETGCKGIDKLRHH |
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| Miro | Roco6.AA | Miro | 631-694 | 25 | 2.9e-10 | 38.83 | Pfam | 71-140 (140) | Show / Hide |
Range on Protein: 631-694 Range on HMM: 71-140/140 Sequence Identity: 25% (18 aa) SIWDCAGQELYYTSHQMF--LTDSALYVVVWNLCKPEVNSRV-EF--WLHSIRSKAEN-APILLIGTHLD .||||.|.| . .|. | .... ...| ....| .|| .. || ..|... . |. ..|...| HIWDCGGREYWKFEHMHFACMKWADAICFVYDCTDYESFNRVSNYMAWLPHFRKWGKKAIPVIVVGNKCD |
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| Kinase | Roco6.AA | LRRK | 1356-1625 | 37 | 4.1e-152 | 511.64 | In-house | 1-351 (351) | Show / Hide |
Range on Protein: 1356-1625 Range on HMM: 1-351/351 Sequence Identity: 37% (132 aa) FESPKLIGRGASG-KIYRANLND----------------------------TMVAVKQLEV-------------------------------VGEDAPRI ......||||..| ..|||.... ..||.|.... ..||..|. LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA FSEFRREIHVMSDLKHSNVVNLLGFTLSPFTMVMEYIDCGDLHKFLHSPIGDQL-----NGNWALILKLALDIAKGMEFLHSVTPPLLHRDLKSPNVLL- |.|||.|...||.|.|.|.|.|.||...|..|||||...|||..|||.. |.. . .| |.||.||.||||||.||| .||..||||||||.|| FREFRHEVWIMSHLNHPNIVSLKGFCIHPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILLW SMKDG--------VYTAKVGDFGLSSRMFIQALKHKLRNFPVGNITWVAPEILR---EEEYTVKSDVYAFGLILHELLTRK-HPYREFN----YSMVSLQ |.... ..||..|||.|. || |......... |||..|.||||.| ||||| |.|.|.||.||.|||||. ||..|.. ... ... SSPQNHSPNYPNAHVCAKIADFGISR-MF-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQI EDAIKNGLRPTISPS-YTQTVTGHEYCGLIQDCWDSDIDRRPTFNKIVKRIKQ ||.|..||||||... .......|.|. |||.||. | ..||.|..||||..| EDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ |
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| Kinase | Roco6.AA | TKL | 1362-1623 | 26 | 2.2e-93 | 316.53 | In-house | 1-364 (364) | Show / Hide |
Range on Protein: 1362-1623 Range on HMM: 1-364/364 Sequence Identity: 26% (101 aa) IGRGASGKIYRANLND----------TMVAVKQLEVVG-----------------------EDAPRIFSEFRREIH-VMSDLKHSNVVNLLG-------- ||.|..|..|..... . ||||.. . .. .. | .|..| .|| |.| |.| ..| IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG -FTLSP------FTMVMEYIDCGDLHKFLHSPIGDQLNGNWALILKLALDIAKGMEFLHSVT------PPLLHRDLKSPNVLLS-----------MKDGV . ..| . .||||...|.|. .|| | .....|||||.||..||| . ||..||||||.|.|. . CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD YTAKVGDFGLSSRMF-----------------IQALKHKLRNFPVGNITWVAPEILREE----------------EYTVKSDVYAFGLILHELLTRKHPY ...|..||||| .|. .| . .| .. ..|.. | |||.||.. ||. |.|||.||..| |.|||..|| WCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQ-NNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPY REFNYSMVSLQ-------EDAIKNGLRPTISPSYTQ-------TVTGHEYCGLIQDCWDSDIDRRPTFNKIVKRI ....|... .| . ....||||.| | . . . .... |.|||||.| . ||.|..|.||. YDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL |
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| Kinase | Roco6.AA | TKL-Unique | 1360-1623 | 31 | 1.4e-66 | 227.54 | In-house | 3-290 (290) | Show / Hide |
Range on Protein: 1360-1623 Range on HMM: 3-290/290 Sequence Identity: 31% (93 aa) KLIGRGASGKIYRANLNDTMVAVKQLEVVGEDAPRIFSE-FRREIHVMSDLK-HSNVVNLLGFTL----SPF--TMVMEYIDCGDLHKFLH--SPIG--- ..||.|..|..|.. . . ||.||... || .... |..|. .|. |. | |.| . |.. .| .||||.. | |.. || . NKIGEGGYGQVYKGKWRGYPVAIKQFHP-NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNN -DQLNGNWALILKLALDIAKGMEFLHSVTPPLLHRDLKSPNVLLSMK--DGVYTAKVGDFGLSSRMFIQALKHKLRNF-------PVGNITWVAPEILRE . .. |.....|.|.|||.||..||. || .||||||.|.|.. . . .|. |||| |. . .| .... ..|.. |.|||.|| NNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGL-SKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRM --EEYTVKSDVYAFGLILHELLTRKH------PYREFNYSMVSLQEDAIKNGLRPTISPSYTQTVTGHEYCGLIQDCWDSDIDRRPTFNKIVKRI . |. |||||.|| .| |..||| ||.... . .. . ..||.|... . || |||.||..| . ||.|. |..|. NFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPK-----EYRDLIQQCWHHDPSQRPSFDEIIHRL |
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| Kinase | Roco6.AA | Dicty4 | 1354-1625 | 32 | 4.5e-58 | 192.35 | In-house | 1-277 (277) | Show / Hide |
Range on Protein: 1354-1625 Range on HMM: 1-277/277 Sequence Identity: 32% (96 aa) IEFESPKLIGRGASGKIYRANLNDTMVAVKQLEVVGEDA-PRIFSEFRREIHVMSDLKHSNVVNLLGFTL----SP--FTMVMEYIDCGDLHKFLHS--- | .| ..||.|. |. |... . |||| | ... . .|||.|.| |. . | |.. ..| . | . |.|| |.|.. ||. INIE--QRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPS PIGDQLNGNWALILK---LALDIAKGMEFLHSVTPPLLHRDLKSPNVLLSMKDGVYTAKVGDFGLSSRMFIQALKHKLRNF----PVGNITWVAPEILRE . | ||.. .|.|.|.|| ||. .| .|||||| | | | ...||.||||| .| ||. .. ..| |.|||.... EQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLV---DKNWRVKVCDFGLSQYM----KKHEDHKDNQMTACGTPCWMAPEVMMH EEYTVKSDVYAFGLILHELLTRKHPYR-EFNYSMVSLQEDAIKN-GLRPTISPSYTQTVTGHEYCGLIQDCWDSDIDRRPTFNKIVKR--IKQ ..|. |.||| ||..| |.|||. || .. . . . . |. | .||| |... . . |||.||| | .||.|. |..| QPYNEKADVYSFGIVLWEILTRQEPYQKHHM-PYMQFVR-AVCNKKLRPPIPDW-----CPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH |
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| Kinase | Roco6.AA | MLK | 1356-1623 | 27 | 1.2e-56 | 194.56 | In-house | 1-291 (291) | Show / Hide |
Range on Protein: 1356-1623 Range on HMM: 1-291/291 Sequence Identity: 27% (85 aa) FESPKLIGRGASGKIYRANLNDTM-----VAVKQLEVVGEDAPRI----FSEFRREIHVMSDLKHSN----VVNLLGFTLSP---FTMVMEYIDCGDLHK .. . || |..|| .... . ||||. . . . . .|..|. . |.| | .. ..| |.| | ||||...| |. IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN FLHS-PIGDQ---------LNGNWALILKLALDIAKGMEFLHSVTP-PLLHRDLKSPNVLLSM-----KDGVYTAKVGDFGLSSRMFIQALKHK-LRNFP .||. ... . ..... ||..|.||..||| | |. ||||||.|.|.. ..| |.|. |||.| ... . . ... VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHG--TLKICDFGTS--RDWHQMC-TNMMSNA VGNITWVAPEIL---REEEYTVKSDVYAFGLILHELLTRKHPYR-EFNYSMVSLQEDAIKNGLRPTISPSYTQTVTGHEYCGLIQDCWDSDIDRRPTFNK |. | |||.. |.| |. |.||. .|..| |.|||..||. . . ... . .. |||||.| .. . . |...||..| .||.| -GTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWW--VAYNGLRPPIPST-----CPEHWKKLMKQCWNQDPHKRPSFRQ IVKRI ||. IVQHL |
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| Kinase | Roco6.AA | DRK | 1362-1562 | 39 | 3.2e-52 | 175.18 | In-house | 7-202 (258) | Show / Hide |
Range on Protein: 1362-1562 Range on HMM: 7-202/258 Sequence Identity: 39% (80 aa) IGRGASGKIYRANLNDTMVAVKQLEVVGEDAPRIFSEFRREIHVMSDLKHSNVVNLLGFTLSP--FTMVMEYIDCGDLHKFLHSPIGDQLNGNWALILKL |||| | ..| | |||| | .. . .||.||| .|. | | |.. .| . | .|||. | | . || . . | |.... IGRGNYGEVFRGTWRGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDE---SIEMDWPLMKQM ALDIAKGMEFLHSVTPPLLHRDLKSPNVLLSMKDGVYTAKVGDFGLSSRMFIQALKHKLRNFPVGNITWVAPEILREEEYTVKSDVYAFGLILHELLTRK ..|.|||| .||. .| .|||||| | | | . || ||||| | | . . || ..| |.|||.||.. || | ||| |. .| |..||. MFDCAKGMIYLHCCNPIIIHRDLKSHNLLV---DEHWQVKVADFGLSTR-FKKHKQHKFAMTMCGTPCWTAPEVLRNQRYTEKADVYSFAIVLWECVTRQ HPY || DPY |
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| Kinase | Roco6.AA | TK | 1356-1623 | 16 | 2.4e-49 | 163.13 | In-house | 1-486 (486) | Show / Hide |
Range on Protein: 1356-1623
Range on HMM: 1-486/486
Sequence Identity: 16% (81 aa)
FESPKLIGRGASG---KIYRANLND---------------------------TMVAVKQLEVVGEDAPRIFSE--------------FRREIHVMSD--L
. | .|.|. | ..|.. ... | ||||.| ..... | . . .|. .|. .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG
KHSNVVNLLG-FTLS-------------PFTMVMEYIDCGD----LHKFLHSP-----------------------------------------------
.| |.|.|.| | . |. .|||| ..|| |...|..
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY
-------------IGDQLN------------GNWALILKLALDIAKGMEFLHSVTP----PLLHRDLKSPNVLLSMKDG--------VYTAKVGDFG---
|.|. . . | ...||.|||.||| . |||| |.|.. .. ....|..|||
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR
-----LSSRMFIQALKHKLRNFPVG-NITW-----------------------VAPEILREEE---------YTVKSDVYAFGLILHELLT--RKHPYRE
|. .. .. .. .| .. | ||| |.. . .| ||||..|| ..|..| .. .| .
QGSGVLARDIYSDDDYYRKSSYGTGRPM-WPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGG
FN----------YSMVSLQED----------AIKNGLRPT---ISPS---YTQTVTG-----HEYCGLIQDCWDSDIDRRPTFNKIVKRI
. .. . .. .. ...|. |. | . || |.|.||. | ..|||| .....
MSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRM-H-PPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
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| Kinase | Roco6.AA | TyrKc | 1356-1623 | 28 | 4.9e-49 | 170.13 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 1356-1623 Range on HMM: 1-280/280 Sequence Identity: 28% (87 aa) FESPKLIGRGASGKIYRANLNDTMVAVKQLEVVGEDAPRIFSEFRREIHVMSDL--KHSNVVNLLGFTL---------SPFTMVMEYIDCGDLHKFLHSP . | .|.|| |..|.. .. ..|||| | .|.||. .|. | .| |.|.|.| . | .|||| . |||...|... ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH IGDQLNGNWALILKLALDIAKGMEFLHSVTPPLLHRDLKSPNVLLSMKDGVYTAKVGDFGLSSRMFIQ-------ALKHK----LRN--FPVGNITWVAP .. ... |. ...||.|||.||| .. |||| |.|.. . |.|..||||| ..| .. .| | | || RPK---LCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLP---IRWMAP EILREEEYTVKSDVYAFGLILHELLTR-KHPYRE--FNYSMVSLQE--DAIKNGLRPTISPS-----YTQTVTGHEYCGLIQDCWDSDIDRRPTFNKIVK | ... ..| ||||..|| . |..|. . || . .. |.| || .|.| |. . |. . . . | ....||. | . ||||. |.. ECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ--MMSNQEVIEYVKQGYRMPQPPNDYPMSF-VCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHE RI .. CF |
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| Kinase | Roco6.AA | Dicty4-Unclassified | 1360-1623 | 29 | 9.5e-46 | 154.65 | In-house | 5-263 (263) | Show / Hide |
Range on Protein: 1360-1623 Range on HMM: 5-263/263 Sequence Identity: 29% (82 aa) KLIGRGASGKIYRANLNDTMVAVKQLEVVGEDAPR--IFSEFRREIHVMSDLKHSNVVNLLGFTLSP------FTMVMEYIDCGDLHKFLH---SPIGDQ . ||.|. |... | |||| . . . | . .|..|. .. . | | | . | . | . ||| . | | | | QFIGKGHFSKVHKGNWKGKDVAVKKFN-ENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQP LNGNWALILKLALDIAKGMEFLHSVTPPLLHRDLKSPNVLLSMKDGVYTAKVGDFGLSSRM-FIQALKHKLRNFPVG-NITWVAPEILREEEYTVKSDVY . . ||.| |.|||.|| .||.. . |||.|| |.|. | . .|..|||.| | . . .. | .||.|. | |. ||||| IKLDDTLIIKYAFDIAQGMQHLHTRN--FIHRDIKSSNILM---DKHFNIKIADFGISRVIDFNFNMTT------IAGTPKWESPECLMHESYNQKSDVY AFGLILHELLTRKHPYREFNYSMVSLQEDAIKNGLRPTISPSYTQTVTGHEYCGLIQDCWDSDIDRRPTFNKIVKRI ....| ||.| || | | . . .||| |. . . || .|| | .|||.|.|... SYAMMLYELATGDEPYQEIQ-SIMNAARSVCDKKLRPKIPDNCDNFWK-----KLIKWCWHNDPNKRPTMNQIIQYL |
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| Kinase | Roco6.AA | S_TKc | 1356-1627 | 23 | 3.2e-45 | 157.46 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 1356-1627 Range on HMM: 1-231/231 Sequence Identity: 23% (68 aa) FESPKLIGRGASGKIYRANLND--TMVAVKQLEVVGEDAPRIFSEFRREIHVMSDLKHSNVVNLLGFTL-SPFTMVMEYIDC--GDLHKFLHSPIGDQLN .| ..||.|| || |.. .. ||.|.. .|||| ... .| |.|.|... . . |||||.| |||...... . |. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLR --GNWALILKLALDIAKGMEFLHSVTPPLLHRDLKSPNVLLSMKDGVYTAKVGDFGLSSRMFIQALKHKLRNFPVGNITWVAPEILREEEYTV-KSDVYA . . ... |....|..|| .||||| |.||. . |..||||. .. . .| ..|||.| |. |.|... FPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE-----HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWS FGLILHELLTRKHPYREFNYSMVSLQEDAIKNGLRPTISPSYTQTVTGHEYCGLIQDCWDSDIDRRPTFNKIVK-----RIKQII .| || |.|... |.. |.... . .. .| . .|. |.. | ..||| .. . .. . . CGCILYEMLCGYPPFP---------QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | Roco6.AA | RIPK | 1362-1623 | 26 | 8.6e-45 | 150.56 | In-house | 1-290 (290) | Show / Hide |
Range on Protein: 1362-1623 Range on HMM: 1-290/290 Sequence Identity: 26% (77 aa) IGRGASGKIYRA--NLNDTMVAVKQLEVVGEDAP---RIFSEFRREIHVMSDLKHSNVVNLLGFTLSP--------FTMVMEYIDCGDLHKFLHSPIG-D .|.|..|. ..| ..||.| ... . . .| | |.....| ..||. . . |||| | | .|||. . VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ QLNGNWALILKLALDIAKGMEFLHSVTPPLLHRDLKSPNVLLSMKDGVYTAKVGDFGLSSRMFIQALKHKLR----------NFPVGNITWVAPEILR-- . | | . |. || .||| .||..||||| |.|. |. . .|. ||||.. | .. . .. | . .|| .| HHPDPWPLRCRMIHEISCGMCYLHSMNPPIIHRDLKPENILV---DNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTD EEEY----TVKSDVYAFGLILHELLTRKHPYREFNYSMVSLQEDAIKNGLRPTISPSYTQTVTG---HEYCGLIQDCWDSDIDRRPTFNKIVKRI . | |.||| |. .. |.||.|||| . .|. . .| | || ..| .. . .. |.|.||..| . ||.| . .. NKKPIKVVTPKYDVYSFAIVMWEVLTQKHPYEDRKCMMMIMMC--CKQGHRPCLQPVPEYWPEPPHCEQMIELMQRCWQQDPNDRPCFQECEEWT |
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| Kinase | Roco6.AA | Pkinase | 1356-1623 | 22 | 8.5e-42 | 148.87 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 1356-1623 Range on HMM: 1-293/293 Sequence Identity: 22% (70 aa) FESPKLIGRGASGKIYRANLNDTM--VAVKQLEVVGEDAPRIFSEFRR--EIHVMSDLKHSNVVNLLGFTL---SPFTMVMEYIDCG----DLHKFLH-S .. . ||.|..|. |.. .| ||||..... .. . . || ||..| |.| |.| |... .. ||||| ..| ||. ... . YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIY-MVMEYCEGGLYVMDLFDYISTW PIGDQLNGNWALILKLALDIAKGMEFLHSVTPPLLHRDLKSPNVLLSMKDGV-YTAKVGDFGLSSRMFIQALKHKLRNFPVGNITWVAPEILR-EEEYTV | . . . . . .. |..|.|..|| .|||||. |.|.. .. . . |..||||. . . . ..| . ..|||..| ..|. RHGCFY-FSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGP KSDVYAFGLILHELLTRKHPYREFNY----SMVSLQEDAIKNGLRPTISPSYTQTVTG------------------HEYCGLIQDCWDSDIDRRPTFNKI |.|....|.||.|.|... |.. . . .. .. |.. ..| .. .. .. .. | . .| .|.. | .|||. | KVDMWSCGCILYEMLCGRPPFP--GHCWHDN-HDQMQ-MICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQI VKR--I .. . LQHPWF |
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| Kinase | Roco6.AA | Pkinase_Tyr | 1354-1558 | 31 | 4.4e-41 | 139.77 | Pfam | 93-302 (270) | Show / Hide |
Range on Protein: 1354-1558 Range on HMM: 93-302/270 Sequence Identity: 31% (70 aa) IEFESPKLIGRGASGKIYRANLN------DTMVAVKQLEVVGEDAPRI---FSEFRREIHVMSDL-KHSNVVNLLGFTL---SP--FTMVMEYIDCGDLH |.| | .|.|| |..|.. .. .. |||| | |.| .| ||. .|. | .| |.|.|.| . | .|||| .|||. ITFG--KKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK---EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLL KFLHSP--IGDQLNGNWALILKLALDIAKGMEFLHSVTPPLLHRDLKSPNVLLSMKDGVYTAKVGDFGLSSRMFIQALK-HKLRNFPVGNITWVAPEILR ..|... ...|. . .|. ...||||||.|.| . |||| |.|.. ..|..||||. .. .| . . | | ||| .. DYLRKHREDKQPLTMKD--LLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTE---NNVVKICDFGLARDIYNDDYYYRKRGGGK-LPIKWMAPECIN EEEYTVKSDVYAFGLILHELLTR . ..|.||||..|| . |..|. YGKFTTKSDVWSFGVLMWEIFTY |
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| Kinase | Roco6.AA | TKL-ciliate2 | 1356-1483 | 36 | 7.1e-24 | 76.1 | In-house | 1-126 (273) | Show / Hide |
Range on Protein: 1356-1483
Range on HMM: 1-126/273
Sequence Identity: 36% (48 aa)
FESPKLIGRGASGKIYRANLNDTMVAVKQLEVVGEDAPRIFSEFRREIHVMSDLKHSNVVNLLG-FTLSP-FTMVMEYIDCGDLHKFLHSPIGDQLNGNW
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LEIQNKITEGGYGIIYKAKWREIVVAVKKFKMDHDNQQQIR-DFVNECHAMEALRHPNIVMFLGACTKIPNFCIIMEYCQRGSLWSLLQN---QDVRLTW
ALILKLALDIAKGMEFLHSVTPPLLHRDLK
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EDRRRIALDIARGVHYLHSSNPPIIHRDLK
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| Kinase | Roco6.AA | TKL-ciliate2 | 1523-1624 | 35 | 5e-21 | 66.43 | In-house | 179-273 (273) | Show / Hide |
Range on Protein: 1523-1624 Range on HMM: 179-273/273 Sequence Identity: 35% (36 aa) VGNITWVAPEILREEEYTVKSDVYAFGLILHELLTRKHPYREFNYSMVSLQEDAIKNGLRPTISPSYTQTVTGHEYCGLIQDCWDSDIDRRPTFNKIVKR .| |.|||... || | ||.....|| |. | |||. |. |. ..| ||||| .. |.| ||| . . ||.||.|.| IGTYQWMAPEVIKAFYYTEKADVFSYSIILWEIASREPPYRNKKGDVVA--EKVMCNNLRPTI-----PKNCPPQFADLMQRCWDNNQNLRPSFNEIIKE IK .. LE |
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| Kinase | Roco6.AA | DRK | 1598-1625 | 32 | 1e-06 | 18.53 | In-house | 231-258 (258) | Show / Hide |
Range on Protein: 1598-1625 Range on HMM: 231-258/258 Sequence Identity: 32% (9 aa) YCGLIQDCWDSDIDRRPTFNKIVKRIKQ | |..|||. | ||.. ...|. YIQLMNDCWNEDPQHRPSMQECLERLEA |
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| Kinase | Roco6.AA | Pkinase_Tyr | 1601-1623 | 39 | 1e-05 | 20.07 | Pfam | 248-270 (270) | Show / Hide |
Range on Protein: 1601-1623 Range on HMM: 248-270/270 Sequence Identity: 39% (9 aa) LIQDCWDSDIDRRPTFNKIVKRI |...||. | ..|||| |. .. LMKQCWHYDPEDRPTFSEIHEQL |
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| PH | Roco6.AA | PH | 1822-1923 | 26 | 1.7e-13 | 51.28 | Pfam | 1-92 (92) | Show / Hide |
Range on Protein: 1822-1923 Range on HMM: 1-92/92 Sequence Identity: 26% (27 aa) GTKSDFITKKGRGGSTFGRKSWRLRWFVLSRFDKTLKYYSKQTDKEPSCSLILEGAWLEEISPPGYKVSLHLIHPEKRTMEMEFKSESEKSSWLTAINRV .|. ...||| .||||. ||||| . ..| || . . ..| |. |... ........ . .. ... ..|| . ...|| |. .|..||... VIKEGWLHKKG------KRKSWKKRWFVLFN--NCLYYYKDDK-YRPKGSIPLSDCQVTKVPDNKRPHCFQIRT-DRRTYYFQAESEEEMNDWMQAIQSA IN . CR |
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| PH | Roco6.AA | PH | 1822-1925 | 25 | 2.9e-13 | 51.32 | SMART | 1-82 (82) | Show / Hide |
Range on Protein: 1822-1925 Range on HMM: 1-82/82 Sequence Identity: 25% (26 aa) GTKSDFITKKGRGGSTFGRKSWRLRWFVLSRFDKTLKYYSKQTDKEPSCSLILEGAWLEEISPPGYKVSLHLIHPEKRTMEMEFKSESEKSSWLTAINRV .|. ...||. . .|. ||||| . ..| || . .|. |. |... ..| .. ..| .. |... ..||.|. .|..||... VIKEGWLYKKS-------K-RWKKRWFVLFN--DCLYYYKDK---KPKGSIPLSDCTVRE-P------CFEIHH-DR-TYYFQCESEEEMQEWMQAIQKA INQN |..| IHNN |
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