Gene Roco9 (Slime mold)

Roco9

Species: Slime mold
Alias: Roco9, DdisK237, DDB0191512
External Links: DictyBase Link ,
Annotation:

Classification

Group: TKL
Family: LRRK

Sequence

Name Sequence Type Origin Length Description Download
Roco9.AA Protein None 3365 None Fasta, JSON
Roco9.kin_dom Protein Kinase Domain None 287 None Fasta, JSON

Protein domain

Protein domains of Roco9.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
RhoGAP Roco9.AA RhoGAP 256-540 12 1.2e-07 17.12 SMART 1-193 (193) Show / Hide 
Range on Protein: 256-540
Range on HMM: 1-193/193
Sequence Identity: 12% (40 aa)

LSIPILLEKSISFLEGHCHVEDLFFRKY-NNEKVKFMRNSFERTGDFN-----------FYYPDPQDPYDVAALLVEFIASLPDQLLNVELYNAIKNHTS
  |||...| |...| |.  .   .||  |. ... .||.|.| .| .           |   . .|..||| .|  .. .||. |.  |||  . .  .
SHIPIIVRKCIEYIEKHGMDTEGIYRKCGNQSRIQELRNAFDRGPD-DLCSTDNYITHEFNDWEEWDVHDVAGVLKQYFRELPEPLITFELYEEFIEAMK

A-------------LNSQYGGYWDIQYLAQKLSVESREFLQRLLFFLKKHVSACLFKQQQQQQQQRESTEVLTLSLSSSTSTLEPEPQPLPLSTSTQRLP
               .. .     .. | ..|. . |. |..|. .|..                                                   
CYQIEQTSRKQWNHSEDEEERIHALHQLISQLPPCHRNTLRYLM-HLNRVA-------------------------------------------------

QQSSDDNSNNDNNNKNDNDNDNDNDNNNDNNNINNDNGEIIPPSIQVTPPTSPQTQPKQQQPPQPPQ-KTLIEKLSELFTPLFVNYKTHSAFYSSTSTLI
                                                               . .. |  .. |.  |.|..   .      . ..  .
--------------------------------------------------------------EHSDVNKMNAHNLAICFGPTLFWPP-----MMDMRHQN

TSCEDIFVHID
. .| . .| |
KCVEFLIEHYD
RhoGAP Roco9.AA RhoGAP 259-379 23 5e-06 21.83 Pfam 1-123 (156) Show / Hide 
Range on Protein: 259-379
Range on HMM: 1-123/156
Sequence Identity: 23% (29 aa)

PILLEKSISFLEGHC-HVEDLFFRKYNNEKVKFMRNSFERTGDFNFYYPDPQDPYDVAALLVEFIASLPDQLLNVELYNAIKNH--TSALNSQYGGYWDI
|. ..| |...| |. ..| .. .  |  ..| .|. |.|  | .   .. .|..||| .| ... .||. |.  |||..         ...       .
PMIVRKCIEYIEQHGLDTEGIYRVSGNKSRIKELREAFDRGPDVDLNDWEWHDVHDVASVLKQYFRELPEPLFTFELYEEFI-EAMAAKIEDEEERIEAM

QYLAQKLSVESREFLQRLLFFLKK
. | .||  . .. |..|...|..
RELIRKLPPPNYDTLRYLMRHLHR
LRR_TYP Roco9.AA LRR_TYP 1549-1572 29 1.8e-05 25.39 SMART 1-24 (24) Show / Hide 
Range on Protein: 1549-1572
Range on HMM: 1-24/24
Sequence Identity: 29% (7 aa)

LSNLTHLWLQDNRIKSIPSSLLKL
|.||..| |..|.....|. ..  
LPNLRELDLSNNQLTHLPPGAFQG
LRR_1 Roco9.AA LRR_1 1551-1572 37 0.00052 18.39 Pfam 1-26 (26) Show / Hide 
Range on Protein: 1551-1572
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

NLTHLWLQD-N--RI-KSIPSS-LLKL
||.|| |.. |  .. ..||.| . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_SD22 Roco9.AA LRR_SD22 1549-1571 47 0.010972 16.17 SMART 1-22 (22) Show / Hide 
Range on Protein: 1549-1571
Range on HMM: 1-22/22
Sequence Identity: 47% (11 aa)

LSNLTHLWLQDNRIKSIPSSLLK
|.||..|||..|.||.| . | .
LTNLEELWLSQNKIKKI-ENLDH
LRR_1 Roco9.AA LRR_1 1528-1549 25 0.212636 9.13 Pfam 1-26 (26) Show / Hide 
Range on Protein: 1528-1549
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

TLTKLNLSR-N--YFN-TFPIE-IILL
.|..|.||. |   .  ..| . .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_SD22 Roco9.AA LRR_SD22 1510-1531 18 1.741215 0.26 SMART 1-22 (22) Show / Hide 
Range on Protein: 1510-1531
Range on HMM: 1-22/22
Sequence Identity: 18% (4 aa)

SQKLTFLSIDRNLLSYFSTLTK
 ..|. |..  |... .. | .
LTNLEELWLSQNKIKKIENLDH
LRR_1 Roco9.AA LRR_1 1578-1599 33 0.008711 14.05 Pfam 1-26 (26) Show / Hide 
Range on Protein: 1578-1599
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

KLQEFDLSH-N--LLE-SLHKS-IYTL
.||. |||. |   |. ....| .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP Roco9.AA LRR_TYP 1578-1599 36 0.113082 7.61 SMART 3-24 (24) Show / Hide 
Range on Protein: 1578-1599
Range on HMM: 3-24/24
Sequence Identity: 36% (8 aa)

KLQEFDLSHNLLESLHKSIYTL
.|.| |||.| |..|.  .   
NLRELDLSNNQLTHLPPGAFQG
LRR_SD22 Roco9.AA LRR_SD22 1576-1594 31 0.904252 2.58 SMART 1-22 (22) Show / Hide 
Range on Protein: 1576-1594
Range on HMM: 1-22/22
Sequence Identity: 31% (7 aa)

KLKLQEFDLSHNLL---ESLHK
  .|.|..||.|..   | |..
LTNLEELWLSQNKIKKIENLDH
LRR_1 Roco9.AA LRR_1 1647-1668 22 0.01503 13.21 Pfam 1-26 (26) Show / Hide 
Range on Protein: 1647-1668
Range on HMM: 1-26/26
Sequence Identity: 22% (6 aa)

GLEELYVQN-N--QI-RELPLG-FFKL
 |..|.... |  .. ...| . | .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP Roco9.AA LRR_TYP 1622-1645 25 0.019746 13.82 SMART 1-24 (24) Show / Hide 
Range on Protein: 1622-1645
Range on HMM: 1-24/24
Sequence Identity: 25% (6 aa)

MKQLKCLSVQNNRLSSFPQALSLC
. .|. |. .||.|.. |. .  .
LPNLRELDLSNNQLTHLPPGAFQG
LRR_1 Roco9.AA LRR_1 1601-1622 29 0.080279 10.63 Pfam 1-26 (26) Show / Hide 
Range on Protein: 1601-1622
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

TLTKLVLDN-N--KLI-IIPES-ISKM
.|..| |.. |  .|   ||.| . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP Roco9.AA LRR_TYP 1668-1692 40 0.09315 8.3 SMART 1-24 (24) Show / Hide 
Range on Protein: 1668-1692
Range on HMM: 1-24/24
Sequence Identity: 40% (10 aa)

LGSLRMLDLRNNQITKFKCHKLDDK
|..|| ||| |||.|    . . . 
LPNLRELDLSNNQLTHLP-PGAFQG
LRR_SD22 Roco9.AA LRR_SD22 1668-1694 25 0.11956 9.74 SMART 1-22 (22) Show / Hide 
Range on Protein: 1668-1694
Range on HMM: 1-22/22
Sequence Identity: 25% (7 aa)

LGSLRMLDLRNNQITKFKCHKLDDKSC
|  |..|.|..|.|     .|... ..
LTNLEELWLSQNKI-----KKIENLDH
LRR_TYP Roco9.AA LRR_TYP 1646-1667 43 0.134984 6.98 SMART 2-24 (24) Show / Hide 
Range on Protein: 1646-1667
Range on HMM: 2-24/24
Sequence Identity: 43% (10 aa)

VGLEELYVQNNQIRELPLG-FFK
. |.||. .|||...|| | |  
PNLRELDLSNNQLTHLPPGAFQG
LRR_1 Roco9.AA LRR_1 1624-1645 18 0.168309 9.49 Pfam 1-26 (26) Show / Hide 
Range on Protein: 1624-1645
Range on HMM: 1-26/26
Sequence Identity: 18% (5 aa)

QLKCLSVQN-N--RLS-SFPQA-LSLC
.|. |.... |  .|. ..|   .  .
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 Roco9.AA LRR_1 1670-1689 26 0.189179 9.31 Pfam 1-26 (26) Show / Hide 
Range on Protein: 1670-1689
Range on HMM: 1-26/26
Sequence Identity: 26% (7 aa)

SLRMLDLRN-N--QIT-KFKCH--KL
.|. |||.. |  ..| .. .   .|
NLQHLDLSGCNCCNLTGHIPPSCFNL
LRR_1 Roco9.AA LRR_1 1746-1767 33 0.00827 14.13 Pfam 1-26 (26) Show / Hide 
Range on Protein: 1746-1767
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

NLEALYLNQ-N--KLS-EISID-FKRL
||. |.|.  |  .|. .|. . |  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP Roco9.AA LRR_TYP 1744-1766 33 0.016084 14.55 SMART 1-24 (24) Show / Hide 
Range on Protein: 1744-1766
Range on HMM: 1-24/24
Sequence Identity: 33% (8 aa)

LVNLEALYLNQNKLSEISID-FKR
|.||. |.|. |.|...  . |  
LPNLRELDLSNNQLTHLPPGAFQG
LRR_1 Roco9.AA LRR_1 1722-1744 37 0.032342 12.03 Pfam 1-26 (26) Show / Hide 
Range on Protein: 1722-1744
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

SLIHLELTGC---SLS-TVPLKLLDNL
.| || | ||   .|. ..|   . ||
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP Roco9.AA LRR_TYP 1720-1743 20 0.091079 8.38 SMART 1-24 (24) Show / Hide 
Range on Protein: 1720-1743
Range on HMM: 1-24/24
Sequence Identity: 20% (5 aa)

MRSLIHLELTGCSLSTVPLKLLDN
...| .| | .  |...|  ....
LPNLRELDLSNNQLTHLPPGAFQG
LRR_TYP Roco9.AA LRR_TYP 1767-1787 52 0.141191 6.82 SMART 1-21 (24) Show / Hide 
Range on Protein: 1767-1787
Range on HMM: 1-21/24
Sequence Identity: 52% (11 aa)

LFKLSVLDLSDNQFTNVPIHA
| .| .||||.||.| .|  |
LPNLRELDLSNNQLTHLPPGA
LRR_1 Roco9.AA LRR_1 1769-1784 40 0.166137 9.51 Pfam 1-20 (26) Show / Hide 
Range on Protein: 1769-1784
Range on HMM: 1-20/26
Sequence Identity: 40% (8 aa)

KLSVLDLSD-N--QFT-NVP
.| .||||. |  ..| ..|
NLQHLDLSGCNCCNLTGHIP
LRR_SD22 Roco9.AA LRR_SD22 1744-1764 50 0.172157 8.45 SMART 1-22 (22) Show / Hide 
Range on Protein: 1744-1764
Range on HMM: 1-22/22
Sequence Identity: 50% (11 aa)

LVNLEALYLNQNKLSEIS-IDF
| ||| |.|.|||.. |. .| 
LTNLEELWLSQNKIKKIENLDH
LRR_TYP Roco9.AA LRR_TYP 1812-1835 41 0.003594 17.78 SMART 1-24 (24) Show / Hide 
Range on Protein: 1812-1835
Range on HMM: 1-24/24
Sequence Identity: 41% (10 aa)

LPLLSELRLDGNKLTYVSPSIGTK
|| | ||.|..|.|| . | .   
LPNLRELDLSNNQLTHLPPGAFQG
LRR_TYP Roco9.AA LRR_TYP 1789-1809 41 0.013512 15.17 SMART 1-24 (24) Show / Hide 
Range on Protein: 1789-1809
Range on HMM: 1-24/24
Sequence Identity: 41% (10 aa)

LPSLKKLYLHNNQLYNIS---FND
||.|..|.|.||||  .    |..
LPNLRELDLSNNQLTHLPPGAFQG
LRR_1 Roco9.AA LRR_1 1838-1860 25 0.020395 12.74 Pfam 1-26 (26) Show / Hide 
Range on Protein: 1838-1860
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

SLTLLNLDR-N-PQIT-TLPHT-LALL
.|. |.|.. | ...| ..|.  .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP Roco9.AA LRR_TYP 1836-1860 36 0.575372 1.82 SMART 1-24 (24) Show / Hide 
Range on Protein: 1836-1860
Range on HMM: 1-24/24
Sequence Identity: 36% (9 aa)

LLSLTLLNLDRNPQITTLPHTLALL
| .|. |.|..| |.|.||. .   
LPNLRELDLSNN-QLTHLPPGAFQG
LRR_1 Roco9.AA LRR_1 1791-1812 29 0.794584 7.1 Pfam 1-26 (26) Show / Hide 
Range on Protein: 1791-1812
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

SLKKLYLHN-N--QLY-NISFN-DFNL
.|..|.| . |  .|  .|. .   ||
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 Roco9.AA LRR_1 1814-1836 37 1.043726 6.68 Pfam 1-26 (26) Show / Hide 
Range on Protein: 1814-1836
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

LLSELRLDG-N--KLT-YVSPSIGTKL
 | .| |.| |  .|| ...||.  .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
COR Roco9.AA COR 2410-2657 12 1.9e-09 26.45 In-house 316-502 (434) Show / Hide 
Range on Protein: 2410-2657
Range on HMM: 316-502/434
Sequence Identity: 12% (37 aa)

IKNVFLNFKP-------FGTKVSSSQKLFEKHIKTL--------QTPFISKKELFSIGEMCK-----------LDKIETKNTCELLTELGLLFWSE---D
| .. ...|         .. |  |  .... .. .          |..|.||.. |  ...           .|. | .    .| .|| ... .   .
IRKTAKKIKHKQMFEDYMCQPVPQSWWKCKQKLEEMRKWMNRHNEKPWMSWKEFCQICQEHGPPKRLRHQNIIIDEDELHTVAMYLHDLGHIIHFKIWDH

----HDWVILDPIWLSNTLNLLLTLKQSSSAPSTPPQIPLNSTNLNNTSIPSQITTTSTNSSSTSTSTSTSTSTSTSTSTSTSTSTPLQTPTSLVSLSNI
    .| |.||| |..  .  ... | | . .                                                                    
DPMLKDFVVLDPQWFCQMMYHIFNHKESRCFHK-------------------------------------------------------------------

SLSTISIPIQPNTSSILLDSSMNDSFNKESSGSNKVANPTIRKRDI-ILMSNLEGIWND------------IPTRLYPYLLTLAKKFNIAYQID
                                        . .. | .  . || |||.             |. ...||. | .||...|.||
----------------------------------------LHNKGIFFTHQDLEKIWNPPCRHNPHMNWRRYPDHDHEYLVELMEKFELCYPID
COR Roco9.AA COR 2819-2863 20 0.000278 9.43 In-house 229-290 (434) Show / Hide 
Range on Protein: 2819-2863
Range on HMM: 229-290/434
Sequence Identity: 20% (13 aa)

EPRSLCRIFQF-----EKKIPSSFFPRLLSQLYMFCSIKH------------CWKNGVILEN
..| |.|....      . .|..|.||..  |. |                 .|.||. |..
DCRYLRRHYHYCMDHHHMFLPAGFWPRFQVRLHHFIHDMFKCFYERSCCEWMYWRNGMVLKW
COR Roco9.AA COR 2895-2976 18 0.002468 6.3 In-house 305-399 (434) Show / Hide 
Range on Protein: 2895-2976
Range on HMM: 305-399/434
Sequence Identity: 18% (18 aa)

ADDLVSIQVLGDTKIEIS-SSKMCRHILQIFESILESY---NQLA-------YTIYISCIHCIETLPK-SEQ-YLFSLNQIEESVIKGKTYQSCP
.| . .|.| |. .  |  .... . | | ...|..|.   ..|        .  .| | |||....  ... . .......... .|...  ||
HDNKIYITVRGCQDCWIDMCCQLWQIIRQHIQHIHNSWWPWPGLQYQCQHWVCREWIPCPHCIQDHWDTCCDICYYQYDWCIRAEEMGMDSYPCP
Kinase Roco9.AA LRRK 3004-3264 30 2.1e-132 446.16 In-house 1-351 (351) Show / Hide 
Range on Protein: 3004-3264
Range on HMM: 1-351/351
Sequence Identity: 30% (108 aa)

FKEVELDPNPIGEGGTA-TVYKGKWRQ----------------------------SDVAIKLLKTD-----------------------------VVGSD
.|. |.    ||.||.. .||..|||.                            ..|||| ...|                             ....|
LKIEEQ----IGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHED

FSKVFAEYRREIFCLSSFIHDNILDLKGFCLEPLAIITEFQSGGNLYDYIHDLK-NP-------LDWQLRIKIAKGIAASLQTLHDSRPSVVHRDLKSPN
....| |.|.|....|.. |.||..|||||..||....|... |.||...|. | ..       ..|.|..|||  ||  .. ||...|...||||||||
CCRAFREFRHEVWIMSHLNHPNIVSLKGFCIHPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPN

ILL-SSK-DS------LTMECHLCDFSLSG----FSTTVANRSVQNPVWLAPEVIN---NELCSDKSDVYAYGVILFELLSRT-RFFSNIT------FMS
||| ||. ..       .. ....||..|.    | ..||...|.||.|.|||...   .| ...|.|.|..|.||.|||.|. ..| ...      .|.
ILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWME

EVEGLITEGVRPSLPSH-NLP-----EYDSLLNICWAQDPTCRPSFIEITKKLEE
..| .|.|| ||..|.| ..|     .|..|.. ||..||..||.|..|.|.|..
QIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase Roco9.AA TKL 3014-3262 25 6e-86 291.85 In-house 1-364 (364) Show / Hide 
Range on Protein: 3014-3262
Range on HMM: 1-364/364
Sequence Identity: 25% (94 aa)

IGEGGTATVYKGKWRQ----------SDVAIKLLKTDVVGS----------------------DFSKVFAEYRREIFCLSSFIHDNILDLKG--------
||.|| ..|||||||.           |||.| .|.. . .                      . |. . . ..|| ..|.. |.||. ..|        
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-FCLEP------LAIITEFQSGGNLYDYIHDLKNPLDWQLRIKIAKGIAASLQTLHDSR------PSVVHRDLKSPNILLSSKDS----------LTMEC
 .|..|      |.|..|. .||.|..|.|       |..|...|..||  .. || ..      | ..||||||.|||. ..             .  |
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

HLCDFSLSGFSTTV----------------------ANRSVQNPVWLAPEVINNE----------------LCSDKSDVYAYGVILFELLSRTRFFSNIT
 .||| || | ..                        .. . .| |.||||....                  | |.|||..|..|.|.|.| | .... 
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYP

FMSEV---------EGLITEGVRPSLP------------SHNLPEYDSLLNICWAQDPTCRPSFIEITKKL
.|...         .. . .| || .|            .. .|.. .|.  ||..||. |||| ||.|.|
YMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase Roco9.AA TKL-Unique 3010-3262 32 7.6e-70 238.36 In-house 1-290 (290) Show / Hide 
Range on Protein: 3010-3262
Range on HMM: 1-290/290
Sequence Identity: 32% (95 aa)

DPNPIGEGGTATVYKGKWRQSDVAIKLLKTDVVGSDFS-KVFAEYRREIFCLSSFI-HDNILDLKGFCL----EPL--AIITEFQSGGNLYDYIH-----
. | ||||| ..|||||||...|||| ..  .  .|.| ..  | ..|.  .. .  |.||. . |.|      |    |..|. .||.|||..|     
FWNKIGEGGYGQVYKGKWRGYPVAIKQFH--P-NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNN

----DLKNPLDWQLRIKIAKGIAASLQTLHDSRPSVVHRDLKSPNILLSSK-DSLTMECHLCDFSLSGFSTTV----ANRS--------VQNPVWLAPEV
      ...|..|.|.|.|. ||  . .|| . | . ||||||.|.|....  .  .   .|||.|| |...     .|..        . .. |.||||
NNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEV

INN--ELCSDKSDVYAYGVILFELLSRTR------FFSNITFMSEVEGLIT--EGVRPSLPSHNLPEYDSLLNICWAQDPTCRPSFIEITKKL
...  .. | |||||..|..| |...|..       ...... .  | . .  |. || .|.|  .||  |.. ||..||. ||||.|| ..|
LRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase Roco9.AA MLK 3002-3262 29 1.9e-47 162.68 In-house 1-291 (291) Show / Hide 
Range on Protein: 3002-3262
Range on HMM: 1-291/291
Sequence Identity: 29% (89 aa)

IDFKEVELDPNPIGEGGTATVYKGKWRQSD-----VAIKLLKTDVVGSDFSKV---FAEYRREIFCLSSFIHDN----ILDLKGFCLEP---LAIITEFQ
|.|.|.      ||.|.   |.||.||  |     ||.|  ...    | |.      . ..|.  |. . | |    |  ..| ||.|   ..|..|. 
IQFHEW------IGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF--DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYC

SGGNLYDYIHDLKN-------------PLDWQLRIKIAKGIAASLQTLHDSRP-SVVHRDLKSPNILLSS--KDSLTMECHLCDFSLSGFSTTV-ANRSV
.|| ||...|. ..               | .. ...|. .|  .. ||   |  ..||||||.|||..   .|   . .  ||| .| . ..  .|.  
EGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMS

Q--NPVWLAPEVI---NNELCSDKSDVYAYGVILFELLSRTRFFS-NITFMSEVEGLITEGVRPSLPSHNLPEYDSLLNICWAQDPTCRPSFIEITKKL
.  .. | |||||    .| .| |.||. .||.| |.|.|   ..  .  |    . . .| || .||   .   .|...|| |||  |||| .| ..|
NAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase Roco9.AA TK 3021-3262 15 5.2e-40 131.31 In-house 17-486 (486) Show / Hide 
Range on Protein: 3021-3262
Range on HMM: 17-486/486
Sequence Identity: 15% (74 aa)

TVYKGKWRQ---------------------------SDVAIKLLK--TDVVGSDFSK-VFAEYR-------REIFCLSSFI-----HDNILDLKGFCL--
.||||.||.                            .||.| ||  ..    .|   .. . |       .|   .. .      |.||. | | |.  
EVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHD-RDGGEDFLEEAEEMKMMCHSLGHHPNIVRLYGVCTQG

------------EPLAIITEFQSGGN----LYDYIHDLKNP-----------------------------------------------------------
            ||. |..|. ..|.    | || .. ...                                                           
EPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTK

----------------LDWQLRIKIAKGIAASLQTLHDSRP----SVVHRDLKSPNILLSSKDSLT-------MECHLCDFSLS--------------GF
                |. . .. ..  ||. .. ||. .      .|||||   |.|.....  .       . | ..|| ||              . 
DLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDD

STTVANRSV--------------------QNPV---WLAPEVINNEL---------CSDKSDVYAYGVILFELLS--RTRFFSNITF--------MSEVE
 ... ....                    .  .   |.|||..|            .. ||||...|| ..|...  .. .  ...         . || 
YYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVM

GLITEG--------------VRPSLPSHNL--------------PEYDSLLNICWAQDPTCRPSFIEITKKL
 ....|               |.  | |                .||. |.  ||. ||  ||.| .. ..|
EYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase Roco9.AA DRK 3012-3264 31 4.6e-39 129.96 In-house 5-258 (258) Show / Hide 
Range on Protein: 3012-3264
Range on HMM: 5-258/258
Sequence Identity: 31% (82 aa)

NPIGEGGTATVYKGKWRQSDVAIKLLKTDVVGSDFSKVFAEYRREIFCLSSFIHDNILDLKGFCLEP--LAIITEFQSGGNLYDYIHDLKNPLDWQLRIK
| || |. . |. | || . ||.| |. . .  .  .   | .|||  ..   | ||    | |..|    |..|. . | ||   || .  .|| |...
NRIGRGNYGEVFRGTWRGTQVAVKMLFNHNI--NDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLMKQ

IAKGIAASLQTLHDSRPSVVHRDLKSPNILLSSKDSLTMECHLCDFSLSG-----FSTTVANRSVQNPVWLAPEVINNELCSDKSDVYAYGVILFELLSR
..  .|  .  || . | ..|||||| | |              || ||       . . |   .  | | ||||  |.    | ||| ....| |.. |
MMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVDEH----WQVKVADFGLSTRFKKHKQHKFAMTMCGTPCWTAPEVLRNQRYTEKADVYSFAIVLWECVTR

TRFFSNITFMSEVEGLITEGVRPSLPSHNLPEYDSLLNICWAQDPTCRPSFIEITKKLEE
   .  .  .  |     .| ||  |    | |  |.| ||  ||. |||. |. . || 
QDPYFGMPTFQVVFSVGRHGMRPPMPQWCPPKYIQLMNDCWNEDPQHRPSMQECLERLEA
Kinase Roco9.AA Dicty4-Unclassified 3007-3262 28 1.7e-37 125.98 In-house 1-263 (263) Show / Hide 
Range on Protein: 3007-3262
Range on HMM: 1-263/263
Sequence Identity: 28% (77 aa)

VELDPNPIGEGGTATVYKGKWRQSDVAIKLLKTDVVGSDFSK--VFAEYRREIFCLSSFIHDNILDLKGFCLEP------LAIITEFQSGGNLYDYIH--
.  |   ||.|  . |.|| |.  |||.| .     ...     .  ....|.  | |  | | . ..| |. |      . |..||   |||   ||  
IQID-QFIGKGHFSKVHKGNWKGKDVAVKKFNE---NKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSK

--DLKNPLDWQL--RIKIAKGIAASLQTLHDSRPSVVHRDLKSPNILLSSKDSLTMECHLCDFSLS-GFSTTVANRSVQ-NPVWLAPEVINNELCSDKSD
  . . |.       ||.|  ||  .| || .|  ..|||.|| |||.             || .|   . .     .   | | .||.   |    |||
PSEQQQPIKLDDTLIIKYAFDIAQGMQHLH-TR-NFIHRDIKSSNILMDKH----FNIKIADFGISRVIDFNFNMTTIAGTPKWESPECLMHESYNQKSD

VYAYGVILFELLSRTRFFSNIT-FMSEVEGLITEGVRPSLPSHNLPEYDSLLNICWAQDPTCRPSFIEITKKL
|| |...|.||.     .  |   |         . || .|.   . . .|   ||  ||  ||.. .|...|
VYSYAMMLYELATGDEPYQEIQSIMNAARSVCDKKLRPKIPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL
Kinase Roco9.AA S_TKc 3008-3268 23 3.6e-34 120.75 SMART 1-231 (231) Show / Hide 
Range on Protein: 3008-3268
Range on HMM: 1-231/231
Sequence Identity: 23% (65 aa)

ELDPNPIGEGGTATVYKGKWRQ--SDVAIKLLKTDVVGSDFSKVFAEYRREIFCLSSFIHDNILDLKGFCL-EPLAIITEFQSG--GNLYDYIHDLKNP-
    ..||.|. ..|||....     |||| .|               |||| .|..  |.||  |....  . | ...|. .|  |.|.|||.. . . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHG

----LDWQLRIKIAKGIAASLQTLHDSRPSVVHRDLKSPNILLSSKDSLTMECHLCDFSLSGFSTTVANRSVQNPVWLAPEVINNELCSD-KSDVYAYGV
    ..     .... |.  |. .|.    ..|||||  ||||..      .  .||| |. .     .  .  | ..||||.     .  |.|... |.
LRFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE------HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGC

ILFELLSRTRFFSNITFMSEVEGLITEGVRPSLPSHNLPEYDSLLNICWAQDPTCRPSFIEITK---KLEEIELI
||.|.|..   |.        . .. . ..        ||  .... |.  ||. ||.  |. .   .    . .
ILYEMLCGYPPFP-------QMQMMFKKIG-------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Roco9.AA Pkinase 3013-3262 21 3.7e-33 118.33 Pfam 6-293 (293) Show / Hide 
Range on Protein: 3013-3262
Range on HMM: 6-293/293
Sequence Identity: 21% (64 aa)

PIGEGGTATVYKGKWRQSD--VAIKLLKTDVVGSDFSKVFAEYRR--EIFCLSSFIHDNILDLKGFCLEP--LAIITEFQSGG----NLYDYIH-DLKNP
.||.|. ..|||.... .   ||.| .| .   .. |..  . ||  ||  . .. |.||. |.... ..  . ...|.  ||     |.|||. . ...
KIGSGSFGCVYKCHHKGTGKIVAVKIIKKR---HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGC

L--DWQLRIKIAKGIAASLQTLHDSRPSVVHRDLKSPNILLSSKDSLTMECHLCDFSLS----GFSTTVANRSVQNPVWLAPEVIN-NELCSDKSDVYAY
.  ...  ..... |.  |. .|. . ...|||||. |||..... .    ..||| |.      . . ..  .  | ..|||||. ..  . |.|....
FYFSEWECKFYMYQILRGLEYCHS-M-GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVILFELLSRTRFFSNI------TFMSEVEGLITEGVRPSLPSHNL-------------------PEYDSLLNICWAQDPTCRPSFIEITKK--L
|.||.|.|..   |..       . |  ..      .. . |  .                    .|  .... |...||..||.. .| .   .
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase Roco9.AA TyrKc 3007-3262 26 3.2e-32 114.29 SMART 1-280 (280) Show / Hide 
Range on Protein: 3007-3262
Range on HMM: 1-280/280
Sequence Identity: 26% (77 aa)

VELDPNPIGEGGTATVYKGKWRQSDVAIKLLKTDVVGSDFSKVFAEYRREIFCLSSF--IHDNILDLKGFCL---------EPLAIITEFQSGGNLYDYI
..|.   .|||   .||||.|.  .||.| || |          .. .||.  ....   |.||. | | |.         ||| |..|. ..|.| ||.
ITLG-KKLGEGAFGEVYKGTWK-IQVAVKMLKEDA--------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

HDLKNPLDWQLRIKIAKGIAASLQTLHDSRPSVVHRDLKSPNILLSSKDSLTMECHLCDFSLSGFSTTV--------ANR-----SVQ--NPV-WLAPEV
.. .. | ..  ....  ||.  . ||.    ..||||   |.|....      .  .|| || . .            |     .     |. |.|||.
RKHRPKLCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPEC

INNELCSDKSDVYAYGVILFELLSRTRFFSNI-----TFMSEVEGLITEGVRPSLPSH--------NLPEYDSLLNICWAQDPTCRPSFIEITKKL
||   .. ||||...|| ..|....               .||  .. .| |.  | .          .|  ..   ||. || .||.| || ...
INYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase Roco9.AA Dicty4 3014-3139 33 7.1e-30 96.96 In-house 7-146 (277) Show / Hide 
Range on Protein: 3014-3139
Range on HMM: 7-146/277
Sequence Identity: 33% (48 aa)

IGEGGTATVYKGKWRQSDVAIKLL---KTDVVGSDFSKVFAEYRREIFCLSSFIHDNILDLKGFCL----EP--LAIITEFQSGGNLYDYIHD------L
||.|. ..||||.||...||.|.|   ....    ...   | |.|.  ...  | ||. ..| |.    .|  . | ||. . ||||  .||       
IGKGSFGEVYKGTWRGKEVAVKKLNNHNQNF----DENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQ

KNPLDWQLRIK---IAKGIAASLQTLHDSRPSVVHRDLKSPNIL
. .||| |...   .|. .|  .. || . | ..|||||| |.|
SIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLL
Kinase Roco9.AA Pkinase_Tyr 3007-3204 26 2e-27 93.5 Pfam 100-309 (270) Show / Hide 
Range on Protein: 3007-3204
Range on HMM: 100-309/270
Sequence Identity: 26% (58 aa)

VELDPNPIGEGGTATVYKGKWR------QSDVAIKLLKTDVVGSDFSKVFAEYRREIFCLSSF-IHDNILDLKGFCL---EP--LAIITEFQSGGNLYDY
....   .|||   .||||.|.      . .||.| || .   ..     ..  ||.  ....  |.||. | | |.   ||  . |..|.  .|.|.||
ITFG-KKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQN--CREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

IHDL---KNPLDWQLRIKIAKGIAASLQTLHDSRPSVVHRDLKSPNILLSSKDSLTMECHLCDFSLSGFS-----T-TVANRSVQNPVWLAPEVINNELC
 ..    |.||. .  ....  ||. .. |.. .   .||||   |.|...    .. .  ||| |.          ...  .     |.|||.||.  .
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTE----NNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKF

SDKSDVYAYGVILFELLSR
. ||||...|| ..|....
TTKSDVWSFGVLMWEIFTY
Kinase Roco9.AA LISK 3013-3155 33 8.2e-26 80.68 In-house 86-234 (296) Show / Hide 
Range on Protein: 3013-3155
Range on HMM: 86-234/296
Sequence Identity: 33% (52 aa)

PIGEGGTATVYKGKWR--QSDVAIKLLKT---DVVGSDFSKVFAEYRREIFCLSSFIHDNILDLKGFCLE---PLAIITEFQSGGNLYDYIHDLKN---P
 ||.|. . |||| .|   ...||| ...   |.   .. | .    ||.  . .. | ||.   | | .    | |.||. .||.| .|..| .    |
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFM---LREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIP

LDWQLRIKIAKGIAASLQTLHDSRPSVVHRDLKSPNILLSSKDSLTMECHLCDF
| |..|.|||..|| ..  ||.    ..|||||| |.|.. .|.   .  .|||
LPWPQRVKIALDIACGMSYLHSM--NIIHRDLKSKNCLVRENDNNQWRIKVCDF
Kinase Roco9.AA Dicty4 3172-3264 35 2.7e-24 78.05 In-house 181-277 (277) Show / Hide 
Range on Protein: 3172-3264
Range on HMM: 181-277/277
Sequence Identity: 35% (34 aa)

PVWLAPEVINNELCSDKSDVYAYGVILFELLSRTRFFS--NITFMSEVEGLITEGVRPSLPSHNLPEYDSLLNICWAQDPTCRPSFIEITKK--LEE
| | ||||  ..    |.||| .| .|.|.| |   ..   . .|  |..   .. ||..|.  .| . .|.. ||  ||. |||| ||...  ||.
PCWMAPEVMMHQPYNEKADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase Roco9.AA TKL-ciliate2 3174-3263 36 2e-20 64.38 In-house 184-273 (273) Show / Hide 
Range on Protein: 3174-3263
Range on HMM: 184-273/273
Sequence Identity: 36% (33 aa)

WLAPEVINNELCSDKSDVYAYGVILFELLSRTRFFSNITFMSEVEGLITEGVRPSLPSHNLPEYDSLLNICWAQDPTCRPSFIEITKKLE
|.|||||   .  .| ||..|..||.|. ||   . |.      |  . . .||..|    |..  |.  || ..   |||| || |.||
WMAPEVIKAFYYTEKADVFSYSIILWEIASREPPYRNKKGDVVAEKVMCNNLRPTIPKNCPPQFADLMQRCWDNNQNLRPSFNEIIKELE
Kinase Roco9.AA TKL-ciliate2 3007-3134 33 1.1e-15 48.33 In-house 1-126 (273) Show / Hide 
Range on Protein: 3007-3134
Range on HMM: 1-126/273
Sequence Identity: 33% (44 aa)

VELDPNPIGEGGTATVYKGKWRQSDVAIKLLKTDVVGSDFSKVFAEYRREIFCLSSFIHDNILDLKGFCLEP--LAIITEFQSGGNLYDYIHDLKNPLDW
.|.. | | |||   .|| |||   ||.|  | |    |  .   ..  |   .    | ||    | | .    .|| |.   | |.  . .   .| |
LEIQ-NKITEGGYGIIYKAKWREIVVAVKKFKMDH---DNQQQIRDFVNECHAMEALRHPNIVMFLGACTKIPNFCIIMEYCQRGSLWSLLQNQDVRLTW

QLRIKIAKGIAASLQTLHDSRPSVVHRDLK
  | .||  ||     || |.| ..|||||
EDRRRIALDIARGVHYLHSSNPPIIHRDLK
Kinase Roco9.AA LISK 3171-3204 32 1.3e-07 20.57 In-house 202-235 (296) Show / Hide 
Range on Protein: 3171-3204
Range on HMM: 202-235/296
Sequence Identity: 32% (11 aa)

NPVWLAPEVINNELCSDKSDVYAYGVILFELLSR
.| | |||... .  ....||. .|..| |.  |
TPYWMAPEMLLGQSYDESCDVFSFGIVLCEIITR
Kinase Roco9.AA LISK 3248-3262 60 6.4e-05 11.71 In-house 282-296 (296) Show / Hide 
Range on Protein: 3248-3262
Range on HMM: 282-296/296
Sequence Identity: 60% (9 aa)

DPTCRPSFIEITKKL
||. |||| ||...|
DPKNRPSFKEIVQWL
Kinase Roco9.AA Pkinase_Tyr 3244-3262 52 0.000462 14.38 Pfam 252-270 (270) Show / Hide 
Range on Protein: 3244-3262
Range on HMM: 252-270/270
Sequence Identity: 52% (10 aa)

CWAQDPTCRPSFIEITKKL
||..||  ||.| ||  .|
CWHYDPEDRPTFSEIHEQL