Gene 14576 (Tetrahymena)

14576

Species: Tetrahymena
Alias: PreTt14576, 14576, 157, TTHERM_00040400, 3825.m02941, 2.m02314
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: AGC
Family: Akt

Sequence

Name Sequence Type Origin Length Description Download
14576.AA Protein None 679 None Fasta, JSON
14576.kin_dom Protein Kinase Domain None 256 None Fasta, JSON
14576.NA RNA None 2040 None Fasta, JSON

Protein domain

Protein domains of 14576.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Ank 14576.AA Ank 130-162 39 4.9e-10 40.47 Pfam 1-33 (33) Show / Hide 
Range on Protein: 130-162
Range on HMM: 1-33/33
Sequence Identity: 39% (13 aa)

DEWTPIHYACNEGHADILQYLISKGADLKAKTS
| .|| |.||  ||......|...|||. |.. 
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank 14576.AA Ank 197-229 33 2e-06 27.47 Pfam 1-33 (33) Show / Hide 
Range on Protein: 197-229
Range on HMM: 1-33/33
Sequence Identity: 33% (11 aa)

EFNTPLHYACKYGFNKIVELLLNYDVDMTIKNH
. .||||.||..|  ..|..||..  |  ... 
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank 14576.AA Ank 163-196 32 0.044305 11.76 Pfam 1-33 (33) Show / Hide 
Range on Protein: 163-196
Range on HMM: 1-33/33
Sequence Identity: 32% (11 aa)

FDYTVLHLGSIRGSHECIKIILENDSSFINEQDK
  .| ||| ...|..|..|  |.     .| ||.
DGFTPLHLACRCGHTEVVKMLLQ-HGADVNAQDD
Kinase 14576.AA Akt 352-607 51 1.2e-186 601.7 In-house 1-264 (264) Show / Hide 
Range on Protein: 352-607
Range on HMM: 1-264/264
Sequence Identity: 51% (135 aa)

FTIVETLGKGAFGQVFLVQKKD-DKLFFAMKVLQKERILGKNILKYALTERNVLSVMQHPFIVSLKYAFQTKNKLYLVMDYCPGGDLDNLLFRKGRIPEP
|.... ||||.||.||||.||| .|...|||||.|..|. || .....||||.|  ..|||||.|.|.|||..|||.|||||.||.| ..|.||.|..|.
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

IAKIYICEIILALEALHNSNIVFRD-LKPSNVVLDKDGHACITDFGLAKQG-MQRGDITKSFCGSLAYLPPEMLNKTGHTQSLDWYL-LGVLMYELLEGM
 |. |..|||||.|.||..||..|| ||| |...||||| |.|||||.|.. ....|.||.|||. .||.||.||..|||.. ||.  ||..|||.. |.
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGR

PPYYSDNKQKLFDNIRNAPLKMP--KQASDAAKSLLKGLLSKDPIQRLG--SKGAEEVKSHPFF
||.|.......|..| |.|.|.|  .. |...|.|..|||.||| .|||  ...|.|.|.||.|
PPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase 14576.AA AGC 352-607 32 2.6e-175 457.85 In-house 1-395 (395) Show / Hide 
Range on Protein: 352-607
Range on HMM: 1-395/395
Sequence Identity: 32% (130 aa)

FTIVETLGKGAFGQVFLVQKK------DDKLFFAMKVLQKER---ILGKNILKYALTE------------RNVLSVMQ----------HPFIVS-LKYAF
| .. ..|||.||.|.||.||      | . ..|||||.|..   |. || .....||            ||.|. ..          |||||. |.|.|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTKNK--LYLVMDYCP---------GG-DLDNLLF---RKGRIPEPIAKIYICE-------IILALEALHN-SNIVFRD-LKPSNVVLDKDGHACITDFG
|.|..  ||.||.|.|         || .|   |.   ..|| .|. |..|..|       |.|||| ||.  .|. || ||| |..||.||| ..||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LAKQGMQRG--------------------------------------------------DITKSFCG--SLAYLPPEMLNKTGHTQSLDWY--LLGVLMY
|.|.||..|                                                  | |..|||  .  |..||.|    .... ||.  .||.|||
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

ELLEGMPPYYSDN----------KQKLFDNIR------NAPLKMP----------KQASDAAKSLLKGLLSKDPIQRLGSK-------GAEEVKSHPFF
|.| | ||.|.||          . ..|..|.      | ..|.|          .. |. ||.|.|.|| ||| .|||..       ||||.|.||.|
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 14576.AA SGK 352-607 46 3.4e-154 479.89 In-house 1-283 (283) Show / Hide 
Range on Protein: 352-607
Range on HMM: 1-283/283
Sequence Identity: 46% (132 aa)

FTIVETLGKGAFGQVFLVQKKDD------------------KLFFAMKVLQKERIL-------GKNILKYALTER-NVLSVMQHPFIVSLKYAFQTKNKL
| .  ..||| || |..|..|||                  . |.|||||||. |.        |.  |. ..|| ..|. | |||||.|.|||||| ||
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

YLVMDYCPGGDLDNLLFRKGRIPEPIAKIYICEIILALEALHNSNIVFRDLKPSNVVLDKDGHACITDFGLAKQGMQRGDITKSFCGSLAYLPPEMLNKT
|.||||  ||.. . | | .. ||. |..|  ||..||| || ..|..||||| |..|| .||.|.|||||.|.|..  | |..|||...|| ||.|.| 
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQ

GHTQSLDWYLLGVLMYELLEGMPPYYSDNKQKLFDNIRNAPLKMPKQASDAAKSLLKGLLSKDPIQRLGSK-GAEEVKSHPFF
.|  . ||..|| ..||.. |.||.|| ||| ..|||.| ||..|.| | .|..|..||| ||| .|||.| ...|.|.||||
PHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF
Kinase 14576.AA RSK-Unclassified 352-607 40 2.5e-134 424.57 In-house 1-283 (283) Show / Hide 
Range on Protein: 352-607
Range on HMM: 1-283/283
Sequence Identity: 40% (116 aa)

FTIVETLGKGAFGQVFLVQKKDDKLFFAMKVLQKERILGKNILKYALTERNVLSVMQHPFIVSLKYAFQTKNKLYLVMDYCPGGDLDNLLF--RKGRIPE
|     .|.| ||.|.||.||| .  .|||||.|.... .|  ||..||.|.... .||||| | ..|||. .|||.|.||.|||.   |   .. .. |
FIKHRLIGQGDFGKVYLVRKKDTQQIYAMKVLHKHKMIRHNKIKYVMTEQNIMATTNHPFIVTLYHSFQTQDYLYLCMEYCMGGDFFRHLQTRKEKCFCE

PIAKIYICEIILALEALHNSNIVFRDLKPSNVVLDKDGHACITDFGLAKQG---------------------MQRGDITKSFCGSLAYLPPEMLNKTGHT
  ...|. |...||| ||   ...||||| |.||...||.  |||.| .|.                     .  |  |.||||. .|| |||.   |||
DDVRFYASEVTAALEYLHKRDFIYRDLKPDNIVLHQEGHVMLTDFDLSIQAKDSKKPVMKGSAQSTYVDTKICDHGFRTNSFCGTEEYLAPEMIRRCGHT

QSLDWYLLGVLMYELLEGMPPYYSDNKQKLFDNIRNAPLKMP--KQASDAAKSLLKGLLSKDPIQRLGSK-G-AEEVKSHPFF
   ||..||..|||.| |.|||| .||  .| ||  ...|.|  .  |  ...|.| || . |  |||.| | |...| ||||
KAVDWWTLGIVMYEMLFGCPPYYGNNKNETFYNIEKNHVKFPHDSYISNNCRDLIKKLLQRNPAKRLGCKMGDADDIKRHPFF
Kinase 14576.AA AktR 352-607 45 2.5e-129 435.97 In-house 1-268 (268) Show / Hide 
Range on Protein: 352-607
Range on HMM: 1-268/268
Sequence Identity: 45% (122 aa)

FTIVETLGKGAFGQVFLVQKK-DDKLFFAMKVLQKERILGKNILKYALTERNVLS-VMQHPFIVSLKYAFQTKNKLYLVMDYCPGGDLDNLLFRKGRIPE
|.. . |||||||.|.||||| |.. ..|||.. |. |  .|  ....||||..   ..||||| |.|.||||.||...|.|||||.| . | .|... |
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

PIAKIYICEIILALEALHNS-NIVFRDLKPSNVVLDKDGHACITDFGLAK-QGMQ-RGDITKSFCGSLAYLPPEMLNK-TGHTQSLDWYLLGVLMYELLE
  |..|...|.|||| ||.  ||..||||| | .||.||| .||||||.| |.|  . ....||||. .|..|||..|  ||. | ||. .|.. ||.. 
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT

GMPPYYSDNKQKLFDNIRNAP---LKMPKQASDAAKSLLK-GLLSKDPIQRLG--SKGAEEVKSHPFF
|.|| |..|.. .|..|.. .    . |.. |...|.|.. .|| |.| .|||  ..|.||.||||.|
GCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase 14576.AA RSK 355-607 41 1.1e-118 400.57 In-house 1-278 (278) Show / Hide 
Range on Protein: 355-607
Range on HMM: 1-278/278
Sequence Identity: 41% (115 aa)

VETLGKGAFGQVFLVQKK---DDKLFFAMKVLQKERILGKNI-LKYALTERNVLSVMQ-HPFIVSLKYAFQTKNKLYLVMDYCPGGDLDNLLFRKGR---
.. ||.|..| |||..|.   | .  .|||||.|  |  ..  .....||||.|.  | |||||.|.|||||. ||||.|.||.||.|   | ....   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

IPEPIAKIYICEIILALEALHNSNIVFRDLKPSNVVLDK---DGHACITDFGLAKQGMQR-GDITKSFCGSLAYLPPEMLN----KTGHTQSLDWYLLGV
. |  |..|. ||.||.| ||   |..|||||.|...|    .||  .||||..||.  . .  |..||....|..||||.    . ||... ||. |||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LMYELLEGMPPYYS---DNKQKLFDNIRNAP--LKMP--KQASDAAKSLLKGLLSKDPIQRLG--SKGAEEVKSHPFF
||||.| | ||...   .|.......|...   |.||  .  |..||.|....| .|| .|||   ..|||.|.||.|
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 14576.AA RSK 352-607 37 1.8e-105 356.66 In-house 1-271 (271) Show / Hide 
Range on Protein: 352-607
Range on HMM: 1-271/271
Sequence Identity: 37% (102 aa)

FTIVETLGKGAFGQVFLVQKK---DDKLFFAMKVLQKERILGKNILKYALTERNVLSVMQHPFIVSLKYAFQTKNKLYLVMDYCPGGDLDNLLFRKGRIP
. . | .|.|.|. |....|.   | .  .|||...|  .  |    .. .||..|.  .||||| |.|.||.  |.|..|| . ||||   | ...  .
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDR-VCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFS

EPIAKIYICEIILALEALHNSNIVFRDLKPSNVVLDKD----GHACITDFGLAKQGMQRGDITKSFCGSLAYLPPEMLNKTGHTQSLDWYLLGVLMYELL
|  .|.| .|| ||.| ||   ||.|||||.|...| .    ||. |.|||.|||   .  ....||.. .|. ||.|.. ||.|. ||...|||||| |
EREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEVLKRQGHDQACDWWSFGVLMYEML

EGMPPYYSDNKQKLFDNIRNAPLKM-------PKQASDAAKSLLKGLLSKDPIQRLGS--KGAEEVKSHPFF
 | .|... ... ....| ...| |       .   || ||.|| ..|  || .|||.   |.|..|.||.|
TGCTPFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase 14576.AA S_TKc 352-607 33 1.1e-93 318.51 SMART 1-231 (231) Show / Hide 
Range on Protein: 352-607
Range on HMM: 1-231/231
Sequence Identity: 33% (91 aa)

FTIVETLGKGAFGQVFLVQKKDDKLFFAMKVLQKERILGKNILKYALTERNVLSVMQHPFIVSLKYAFQTKNKLYLVMDYCPG--GDLDNLLFRKGR---
..|....||||||.|.....|...  .|.|..           . .. |...|.  .||.|| |...||. ..||.||.||.|  |||  .. ..||   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---IPEPIAKIYICEIILALEALHNSNIVFRDLKPSNVVLDKDGHACITDFGLAKQGMQRGDITKSFCGSLAYLPPEMLNKTGHTQ-SLDWYLLGVLMYE
   .||  |. |...|..||| .|. .|. |||||.|. ||.  |  |.|||||.|        ..|||.. |..||.|   |..  . ||. .|...||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

LLEGMPPYYSDNKQKLFDNIRNAPLKMPKQASDAAKSLLKGLLSKDPIQRLGSKGAEE----VKSHPFF
.| | ||..  . |..|..|.          |. ||......| ||| .|..   | .    .|.||.|
MLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 14576.AA Pkinase 352-607 27 9.4e-86 295.99 Pfam 1-293 (293) Show / Hide 
Range on Protein: 352-607
Range on HMM: 1-293/293
Sequence Identity: 27% (83 aa)

FTIVETLGKGAFGQVFLVQKKDDKLFFAMKVLQKERILGKNILKYAL-TERNVLSVMQHPFIVSLKYAFQTKNKLYLVMDYCPGG----DLDNLLF--RK
..|....|.|.||.|.. ..|..   .|.|.. |...  .     .. .|  ..  ..||.|| |...|..|...|.||.||.||    ||  ..   |.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GRI--PEPIAKIYICEIILALEALHNSNIVFRDLKPSNVVLDKDGHA----CITDFGLAKQG-MQRGDITKSFCGSLAYLPPEMLN-KTGHTQSLDWYLL
|..  .|  .| |. .|. .|| .|. .|. |||||.|. .|..||     .|.|||||||    ..  ...|||.. |..|| ..  ...... |.. .
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVLMYELLEGMPPYYSD------NKQKLFDNIRNAPLKMPKQAS---------------------DAAKSLLKGLLSKDPIQRLGSKGAEEVKSHPFF
|...||.| | ||....      ........|. .||. . . .                     ...|...|..| ||| .|..   ||... ||.|
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT---AEQILQHPWF
Kinase 14576.AA NDR 352-510 40 7.2e-71 217.61 In-house 1-164 (350) Show / Hide 
Range on Protein: 352-510
Range on HMM: 1-164/350
Sequence Identity: 40% (67 aa)

FTIVETLGKGAFGQVFLVQKKDDKLFFAMKVLQKERILGKNILKYALTERNVLSVMQ--HPFIVSLKYAFQTKNKLYLVMDYCPGGDLDN---LLFRKGR
|.|....||||||.|.||.||| . ..|||.. |. .. || ..  ..|| .... .  .|..|.|.|.|| |. |||||.| ||||.     || ... 
FEIIKIIGKGAFGEVWLVRKKDTGHIYAMKIMRKSEMMWKNQVAHVRAERDIMAEADNKNPWVVKLYYSFQDKQYLYLVMEYHPGGDMMTYCYLLMKMDI

IPEPIAKIYICEIILALEALHNSNIVFRDLKPSNVVLDKDGHACITDFGLAKQGMQRGDITKSF
 .| .|. || |...|.|..|. ... ||.||.| ..|||||   |||||...||.|.  . ..
FTEDWARFYIAEMVCAIESVHKMGYIHRDIKPDNFLIDKDGHIKLTDFGLCTGGMIRRHWKQNK
Kinase 14576.AA MAST 352-500 45 2.6e-67 204.45 In-house 1-152 (337) Show / Hide 
Range on Protein: 352-500
Range on HMM: 1-152/337
Sequence Identity: 45% (69 aa)

FTIVETLGKGAFGQVFLVQKKDDKLFFAMKVLQKERILGKNILKYALTERNVLSVMQHPFIVSLKYAFQT--KNKLYLVMDYCPGGDLDNLLFRKG-RIP
| ... ..|||.|.|.||..|. . .|||||. .  .. || .. .  |||.|.. | ||.|.. |.|||  |..|..||.|  |||   ||   | . |
FEFIKCISKGAYGAVYLVKHKKTNDRFAMKVINCQDTIDKNQVDQVFVERNILTMYQNPFVVKMFYSFQTPCKKYLCMVMEYMEGGDCASLLRMYGNCMP

EPIAKIYICEIILALEALHNSNIVFRDLKPSNVVLDKDGHACITDFGLAKQG
| .||.|| |..|.|| ||.. || ||||| |...|..||  .|||||.| |
EWMAKMYIAETVLCLEYLHSYGIVHRDLKPDNMLIDSNGHIKLTDFGLSKVG
Kinase 14576.AA MAST 352-503 46 2.1e-65 209.68 In-house 1-152 (334) Show / Hide 
Range on Protein: 352-503
Range on HMM: 1-152/334
Sequence Identity: 46% (70 aa)

FTIVETLGKGAFGQVFLVQKKDDKLFFAMKVLQKERILGKNILKYALTERNVLSVMQHPFIVSLKYAFQTKNKLYLVMDYCPGGDLDNLLFRKGRIPEPI
|.... ..|||.|.|.|| .|. . .|||||. |   . || ..   .|||.|.. | ||.|.. |.|||||.|..||.|  |||.  ||   |. .|..
FEFIKPISKGAYGKVYLVKHKKTNDRFAMKVIKKSDMINKNMVDQVQVERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLHMYGYFDEWM

AKIYICEIILALEALHNSNIVFRDLKPSNVVLDKDGHACITDFGLAKQGMQR
||.|| |..|.|| ||.. || ||||| |...|..||  .|||||.| |. .
AKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFGLSKVGFMD
Kinase 14576.AA MAST 516-607 36 5.1e-39 116.4 In-house 234-337 (337) Show / Hide 
Range on Protein: 516-607
Range on HMM: 234-337/337
Sequence Identity: 36% (38 aa)

YLPPEMLNKTG-HTQSLDWYLLGVLMYELLEGMPPYYSDNKQK-LFDNIRN--APLKMPKQ--------ASDAAKSLLKGLLSKDPIQRLGSKGAEEVKS
|..|| ....| . ...||. .|. |||.| | ||   |. .. .|.|| |    .  |.          |. |. | | || ..| .|||..||.|.|.
YIAPEVILGQGTYGKPVDWWSMGIIMYEFLVGCPPFNGDTPEEMIFQNIINHDREIEWPEEGDPNDDDCMSPEAQDLIKKLLQPNPKKRLGANGADEIKQ

HPFF
||||
HPFF
Kinase 14576.AA MAST 508-607 38 1.8e-35 111.55 In-house 222-334 (334) Show / Hide 
Range on Protein: 508-607
Range on HMM: 222-334/334
Sequence Identity: 38% (43 aa)

KSFCGSLAYLPPEMLNKTG-HTQSLDWYLLGVLMYELLEGMPPYYSDNKQKLFDNIRNAP---LKMP--------KQASDAAKSLLKGLLSKDPIQRLGS
|. ||.. |..|| ....| | ...||  .|. |||.| | ||   |. ...|.|| |      . |        .  |  |. | . ||  || .|||.
KQCCGTPDYIAPEVILGQGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEGGDINDDEAMSPEAQDLIEKLLQPDPRKRLGA

K-GAEEVKSHPFF
. ||.|||.||||
NNGADEVKQHPFF
Kinase 14576.AA NDR 516-607 41 6e-33 98.45 In-house 247-350 (350) Show / Hide 
Range on Protein: 516-607
Range on HMM: 247-350/350
Sequence Identity: 41% (43 aa)

YLPPEMLNK-TGHTQSLDWYLLGVLMYELLEGMPPYYSDNKQKLFDNIRN--APL-----KMPKQA--SDAAKSLLKGLLSKDPIQRLGS--KGAEEVKS
|..||.... ||..|. ||  ||. |||.| | || .||. |. ...|.|    .       |..|  |. |. |.. |.  ||..||||  ||..|.||
YMAPEVFQQKTGYNQTCDWWSLGCIMYEMLVGYPPFCSDTPQETCMKIMNWKQTWDWPMTHFPPEANLSPEAWDLIRRLCCPDPDHRLGSHGKGVDEIKS

HPFF
||||
HPFF
Kinase 14576.AA TyrKc 352-607 21 1.4e-15 29.07 SMART 1-280 (280) Show / Hide 
Range on Protein: 352-607
Range on HMM: 1-280/280
Sequence Identity: 21% (64 aa)

FTIVETLGKGAFGQVFLVQKKDDKLFFAMKVLQKERILGKNILKYALTERNVLSVM--QHPFIVSLKYAFQTK-------NKLYLVMDYCPGGDLDNLL-
 |  ..|| ||||.|.. . |   .  | |.|...       ..  . | ....    .|| || |  .  ..         |..|| |.|.|||.. | 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

FRKGRIPEPIAKIYICEIILALEALHNSNIVFRDLKPSNVVLDKDGHACITDFGLAKQGMQR-------GDITKSF--CGS----LAYLPPEMLNKTGHT
 ...... .    .   |    | ||  |.. |||   |. ....... |.||||.. .            ..|.   .|     .  ..|| .|.   |
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

QSLDWYLLGVLMYELLE-GMPPYYS-----DNKQKLFDNIRNA-PLKMPKQ--------ASDAAKSLLKGLLSKDPIQRLGSKGAEEVKSHPFF
   | .  ||.|.|..  |..||.       . | .. ....   .. |.         ..|.  .. |     || .|   .       | .|
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-----HECF
Kinase 14576.AA Pkinase_Tyr 398-457 23 3e-05 18.39 Pfam 51-117 (270) Show / Hide 
Range on Protein: 398-457
Range on HMM: 51-117/270
Sequence Identity: 23% (16 aa)

LTERNVLSVM-QHPFIVSLKYAFQ-TKNK--LYLVMDYCPGGDLDNLLFRK---GRIPEPIAKIYIC
. | .... . .|| ||.|  .    .    .|.|| |.|.|||.. | ..   .. . .  .. .|
MREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMC
Kinase 14576.AA Pkinase_Tyr 352-368 47 0.002996 11.63 Pfam 1-17 (270) Show / Hide 
Range on Protein: 352-368
Range on HMM: 1-17/270
Sequence Identity: 47% (8 aa)

FTIVETLGKGAFGQVFL
 |. ..||.||||.|..
ITFGKKLGEGAFGEVYK
Kinase 14576.AA Pkinase_Tyr 480-498 36 0.069772 7.0 Pfam 141-159 (270) Show / Hide 
Range on Protein: 480-498
Range on HMM: 141-159/270
Sequence Identity: 36% (7 aa)

NVVLDKDGHACITDFGLAK
|. ....... |.|||||.
NCLVTENNVVKICDFGLAR