Gene 18079 (Tetrahymena)

18079

Species: Tetrahymena
Alias: TTHERM_00723190, 710, 18079, 3671.m00028, 116.m00104, PreTt18079
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: AGC
Family: Akt

Sequence

Name Sequence Type Origin Length Description Download
18079.AA Protein None 987 None Fasta, JSON
18079.kin_dom Protein Kinase Domain None 256 None Fasta, JSON
18079.NA RNA None 2964 None Fasta, JSON

Protein domain

Protein domains of 18079.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Ank 18079.AA Ank 250-282 36 3e-06 26.97 Pfam 1-33 (33) Show / Hide 
Range on Protein: 250-282
Range on HMM: 1-33/33
Sequence Identity: 36% (12 aa)

RGSNPLHVAVYNQFYELTKELVERGANVNVPSN
 |  |||.|...  .|  |.|...||.||.  .
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank 18079.AA Ank 283-316 23 0.016261 13.33 Pfam 1-33 (33) Show / Hide 
Range on Protein: 283-316
Range on HMM: 1-33/33
Sequence Identity: 23% (8 aa)

QGWTSVQIAIFKNNIKILKLLLDSQSLDLNYVSS
 |.|   .|.........|.||. .  |.| .  
DGFTPLHLACRCGHTEVVKMLLQ-HGADVNAQDD
Ank 18079.AA Ank 319-348 23 63.176462 0.38 Pfam 4-33 (33) Show / Hide 
Range on Protein: 319-348
Range on HMM: 4-33/33
Sequence Identity: 23% (7 aa)

TPLTVCCQFSKAQALDLVLKKNPDLSILDQ
||| . |.   .. . . |... |. . | 
TPLHLACRCGHTEVVKMLLQHGADVNAQDD
PH 18079.AA PH 405-508 23 1.5e-09 38.94 SMART 1-82 (82) Show / Hide 
Range on Protein: 405-508
Range on HMM: 1-82/82
Sequence Identity: 23% (25 aa)

PIVTGTLFKIGAFLFNMRERFFVINPDEGTLIRYKNKSHYPLKPLEVIPLKDINLIQTIKKSWFMSSDYTYFEINYPNR-QVLACKHEQAAKKWVEYLFS
.|  |.| | .  . . ..|.||. .  ..|. ||.|     || ..|||.|.  ..  .          .||| . .|  ...|. |. ...|.. . .
VIKEGWLYKKS--K-RWKKRWFVLFN--DCLYYYKDK-----KPKGSIPLSDC-TVRE-P----------CFEIHH-DRTYYFQCESEEEMQEWMQAIQK

ACVYS
|.  .
AIHNN
PH 18079.AA PH 405-506 22 2.1e-08 32.99 Pfam 1-92 (92) Show / Hide 
Range on Protein: 405-506
Range on HMM: 1-92/92
Sequence Identity: 22% (23 aa)

PIVTGTLFKIGAFLFNMRERFFVINPDEGTLIRYKNKSHYPLKPLEVIPLKDINLIQTIKKSWFMSSDYTYFEINYPN--RQVLACKHEQAAKKWVEYLF
.|  | |.| | .. . ..|.||. .  ..|. ||...    .|  .|||.|.  . .....     .  .|.| . .  . ..... |. .. |.. . 
VIKEGWLHKKG-KRKSWKKRWFVLFN--NCLYYYKDDK---YRPKGSIPLSDC-QVTKVPDN----KRPHCFQIRT-DRRTYYFQAESEEEMNDWMQAIQ

SACV
||| 
SACR
Kinase 18079.AA Akt 671-926 54 7.2e-188 605.72 In-house 1-264 (264) Show / Hide 
Range on Protein: 671-926
Range on HMM: 1-264/264
Sequence Identity: 54% (143 aa)

FQILKVLGAGSFGKVFLAKKKDSGNIY-AIKALKKRPLIMKRQLRYAVTEANVLKMCNHPFILGLHYALQTPNYLYLVLDYCSGGDISSHLAYKRRFSEE
|..|||||.||||||||.||||....| |.|.|||. .|.|.|.....|| |.|..|||||| .|||. ||...||.|.|||.||.. .||..||||||.
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

EALFYIAELVLAIQHIHEKDVVYRD-LKPENILIASDGHIKLADFGLSKDN-VTDQSKTKSFCGTPAYLSPEMLNNKGATKASDLYG-IGAVLYEMLTGD
.| ||.||..|||.| |.|...||| |||||||. .||||.|.||||.|.| ..|. |||.|||||.||.||.||..|.|||.| .| .|.|.|||..| 
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGR

PPYYNDDIPTMYKKIKEGNLTYP--SYVSQKARNIINGLLDRNPKTRLG--AQDREQLKRDPFF
||.||.|...|.||||.... .|  ...|......|.||| ..|| |||   .| ...||.|.|
PPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase 18079.AA AGC 671-926 30 3.1e-172 449.71 In-house 1-395 (395) Show / Hide 
Range on Protein: 671-926
Range on HMM: 1-395/395
Sequence Identity: 30% (120 aa)

FQILKVLGAGSFGKVFLAKKK------DSGNIYAIKALKKRP-LIMKR--QLRYAVTE------------ANVLKMCN----------HPFILG-LHYAL
|..|||.| ||||||.|..||      |.| .||.| |||.   ..|.  ..... ||             |.|..||          ||||   |||. 
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTPNY--LYLVLDYCS---------GG-DISSHLA---YKRRFSEEEALFYIAE-------LVLAIQHIHE-KDVVYRD-LKPENILIASDGHIKLADFG
|....  ||.|..|..         || .  .||     ..||.||.| ||.||       .|||....|. .....|| |||||||. .||||||.|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LSKDNVTDQ--------------------------------------------------SKTKSFCG--TPAYLSPEMLNNKGATKASDLYG--IGAVLY
|.| ...|.                                                   .|..|||  || |..||.|     .|| | ..   |...|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMLTGDPPYYND----------DIPTMYKKIK------EGNLTYP----------SYVSQKARNIINGLLDRNPKTRLGAQDR-------EQLKRDPFF
||||| ||.|.|          .   |..||.      . ....|          ...|. |...|..|| ..|. |||....       |..|. |.|
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 18079.AA SGK 671-926 40 1.7e-133 414.8 In-house 1-283 (283) Show / Hide 
Range on Protein: 671-926
Range on HMM: 1-283/283
Sequence Identity: 40% (115 aa)

FQILKVLGAGSFGKVFLAKKKDS------------------GNIYAIKALKKRPLI-------MKRQLRYAVTEA-NVLKMCNHPFILGLHYALQTPNYL
|..|||.| ||||||...|.||                   . .||.| |.|   |        | . ..  .|  ..||  .|||| .|||| ||. .|
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

YLVLDYCSGGDISSHLAYKRRFSEEEALFYIAELVLAIQHIHEKDVVYRDLKPENILIASDGHIKLADFGLSKDNVTDQSKTKSFCGTPAYLSPEMLNNK
|.|.||  ||.  .||   ..|.| .| || ||.|.|. . |..|..||||||||||  ..||..| ||||.| .. .. .|..|||||.|| ||.|. .
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQ

GATKASDLYGIGAVLYEMLTGDPPYYNDDIPTMYKKIKEGNLTYPSYVSQKARNIINGLLDRNPKTRLGAQ-DREQLKRDPFF
.  .. | . .|.|||||..| ||.|. .  .|| .|  . |  | ..| .|. .|.||| ..|| |||.  | .. |. |||
PHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF
Kinase 18079.AA AktR 671-926 44 4.6e-124 418.45 In-house 1-268 (268) Show / Hide 
Range on Protein: 671-926
Range on HMM: 1-268/268
Sequence Identity: 44% (118 aa)

FQILKVLGAGSFGKVFLAKKK-DSGNIYAIKALKKRPLIMKRQLRYAVTEANVLK-MCNHPFILGLHYALQTPNYLYLVLDYCSGGDISSHLAYKRRFSE
|...|.|| | ||||.|..|| |.. .||.| .||  .| ..| ... || |... .||||||  |||. || ..|.....|| ||.. .||  |..|||
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

EEALFYIAELVLAIQHIHEK-DVVYRDLKPENILIASDGHIKLADFGLSK-DNVT-DQSKTKSFCGTPAYLSPEMLNN-KGATKASDLYGIGAVLYEMLT
|.|.||.|. .||... |.. ...||||||||||. .|||.|..||||||  ..  .  |..||||||.|..|||... || .|..|.. .|...|||.|
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT

GDPPYYNDDIPTMYKKIKEGN---LTYPSYVSQKARNIIN-GLLDRNPKTRLG--AQDREQLKRDPFF
| || |...  .|..|||. .    .||||.|......|. .||..||. |||  . . |..|. |.|
GCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase 18079.AA RSK 674-926 44 1.8e-114 386.59 In-house 1-278 (278) Show / Hide 
Range on Protein: 674-926
Range on HMM: 1-278/278
Sequence Identity: 44% (124 aa)

LKVLGAGSFGKVFLAKKK---DSGNIYAIKALKKRPLIMKRQ-LRYAVTEANVLKMCN-HPFILGLHYALQTPNYLYLVLDYCSGGDISSHLAYKRR---
||||| |..||||| .|.   |.| ||| | |||. .. .   .|.. || |.|..|. ||||  |||| ||. .|||...||.||.   ||  ...   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FSEEEALFYIAELVLAIQHIHEKDVVYRDLKPENILIAS---DGHIKLADFGLSKDNVTD-QSKTKSFCGTPAYLSPEMLN----NKGATKASDLYGIGA
|||.|| ||.||.|||..|.|......||||||||| ..   .||||| |||..| .. |  ..|..||.| .|. ||||.    ..| .|| |..  |.
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

VLYEMLTGDPPYYN---DDIPTMYKKIKEGN--LTYP--SYVSQKARNIINGLLDRNPKTRLG--AQDREQLKRDPFF
..|||||| ||...   ..     |.|..|.  || |  .|.|| |...|...| |.|. |||   || |..|..|.|
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 18079.AA RSK-Unclassified 671-926 39 8.4e-108 339.78 In-house 1-283 (283) Show / Hide 
Range on Protein: 671-926
Range on HMM: 1-283/283
Sequence Identity: 39% (111 aa)

FQILKVLGAGSFGKVFLAKKKDSGNIYAIKALKKRPLIMKRQLRYAVTEANVLKMCNHPFILGLHYALQTPNYLYLVLDYCSGGDISSHLA--YKRRFSE
|   . .| |.||||.| .|||.  |||.| |.|  .| ..  .|. || |.. . |||||  | .. ||  ||||...|| |||.  ||    ...|.|
FIKHRLIGQGDFGKVYLVRKKDTQQIYAMKVLHKHKMIRHNKIKYVMTEQNIMATTNHPFIVTLYHSFQTQDYLYLCMEYCMGGDFFRHLQTRKEKCFCE

EEALFYIAELVLAIQHIHEKDVVYRDLKPENILIASDGHIKLADFGLSKDN---------------------VTDQSKTKSFCGTPAYLSPEMLNNKGAT
... ||..| ..|  . | .|..||||||.||.   .||..| ||.||..                      . . ..|.||||| .|| |||.   | |
DDVRFYASEVTAALEYLHKRDFIYRDLKPDNIVLHQEGHVMLTDFDLSIQAKDSKKPVMKGSAQSTYVDTKICDHGFRTNSFCGTEEYLAPEMIRRCGHT

KASDLYGIGAVLYEMLTGDPPYYNDDIPTMYKKIKEGNLTYP--SYVSQKARNIINGLLDRNPKTRLGAQDR--EQLKRDPFF
|| | .  | |.|||| | |||| .    ... |  ...  |  ||.|...|  |  || |||  |||.     .  || |||
KAVDWWTLGIVMYEMLFGCPPYYGNNKNETFYNIEKNHVKFPHDSYISNNCRDLIKKLLQRNPAKRLGCKMGDADDIKRHPFF
Kinase 18079.AA S_TKc 671-926 33 2.8e-101 343.7 SMART 1-231 (231) Show / Hide 
Range on Protein: 671-926
Range on HMM: 1-231/231
Sequence Identity: 33% (91 aa)

FQILKVLGAGSFGKVFLAKKKDSGNIYAIKALKKRPLIMKRQLRYAVTEANVLKMCNHPFILGLHYALQTPNYLYLVLDYCSG--GDISSHLAYKRR---
..||...| |.||||.....|..| |.||| .|          . .  | ..||. .||.|  |... |. ..||.|..||.|  ||  ...  ..|   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FSEEEALFYIAELVLAIQHIHEKDVVYRDLKPENILIASDGHIKLADFGLSKDNVTDQSKTKSFCGTPAYLSPEMLNNKGATK-ASDLYGIGAVLYE
   |.| .| ||......|....|.. ...|||||||||. .  |||..||||..         ..||||| |..||.|   | .| ..| . .| .|||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

MLTGDPPYYNDDIPTMYKKIKEGNLTYPSYVSQKARNIINGLLDRNPKTRLGAQDREQ----LKRDPFF
||.| ||..  .. .|.|||.          |. |...|...|...|. |..| .  |     | .|.|
MLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 18079.AA RSK 671-926 35 2.7e-99 336.18 In-house 1-271 (271) Show / Hide 
Range on Protein: 671-926
Range on HMM: 1-271/271
Sequence Identity: 35% (97 aa)

FQILKVLGAGSFGKVFLAKKK---DSGNIYAIKALKKRPLIMKRQLRYAVTEANVLKMCNHPFILGLHYALQTPNYLYLVLDYCSGGDISSHLAYKRRFS
. .....| |||.||.. ||.   |..  ||.| .||  .  | .  .. .| ..|   .||||  |||. |.  ..|...| . |||.  .|  .. ||
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDR-VCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFS

EEEALFYIAELVLAIQHIHEKDVVYRDLKPENILIASD----GHIKLADFGLSKDNVTDQSK-TKSFCGTPAYLSPEMLNNKGATKASDLYGIGAVLYEM
|.|. || ||. || .. |....|.|||||||||....    ||||..|||..|  . |. . ...||.| .|. ||.|. .| ..|.| .  |...|||
EREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQ-LRDENGMLMTFCYTANYMAPEVLKRQGHDQACDWWSFGVLMYEM

LTGDPPYYNDDIPTMYKKIKEGNLTY-------PSYVSQKARNIINGLLDRNPKTRLGA--QDREQLKRDPFF
||| .|..| .  |.  .|.   |         ....|. |   . ..|.|.|  ||||  .. || |. |.|
LTGCTPFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase 18079.AA PKA 671-926 39 5.8e-97 328.44 In-house 1-263 (263) Show / Hide 
Range on Protein: 671-926
Range on HMM: 1-263/263
Sequence Identity: 39% (106 aa)

FQILKVLGAGSFGKVFLAKKKDSGNIYAIKALKKRPLIMKRQLRYAVTEANVLKMCNHPFILG-LHYALQTPNYLYLVLDYCSGGDISSHLAYKRRFSEE
|.|...|| ||||.| |...|.|||.||.| |||.  .  .|     .| |.|. ..||||   . .  |...|||.|..|..||.. |.|  ..|||. 
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

EALFYIA-ELVLAIQHIHEKDVVYRDLKPENILIASDGHIKLADFGLSKDNVTDQSKTKSFCGTPAYLSPEMLNNK-GATKASDLYGIGAVLYEMLTGDP
.|.||.| . |||.. .| .. .||||||||||| ..||||..||| .| .|.|   |.. |||| || ||....| |  |. |    | . ||||.| |
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAK-KVDD--RTWTLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYP

PYYND--DIPTMYKKIKEGNLTYPSYVSQKA---RNIINGLLDRNPKTRLGAQDR--EQLKRDPFF
| |..  |   .|.|| .| . .|......|   .  |. || .... |.| ..   .. |. ..|
PFYDHNRDPMQIYEKICNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase 18079.AA Pkinase 671-926 29 2.6e-94 324.41 Pfam 1-293 (293) Show / Hide 
Range on Protein: 671-926
Range on HMM: 1-293/293
Sequence Identity: 29% (87 aa)

FQILKVLGAGSFGKVFLAKKKDSGNIYAIKALKKRPLIMKRQLRYAVT--EANVLKMCNHPFILGLHYALQTPNYLYLVLDYCSGG----DISSHLA--Y
..|....|.||||.|.....|..| |.|.| .|||  . . ......   |. ..|..|||.|. |... ......|.|..|| ||    | ....   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

KRRF--SEEEALFYIAELVLAIQHIHEKDVVYRDLKPENILIASDGHI----KLADFGLSKDN-VTDQSKTKSFCGTPAYLSPEMLN-NKGATKASDLYG
...|  ||.|. ||. ... .....|.. ...|||||||||| ..|||    |..||||.|      .| ...||||| |..|| .. ... ....| ..
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

IGAVLYEMLTGDPPYYND------DIPTMYKKIKEGNLTYPSYVS---------------------QKARNIINGLLDRNPKTRLGAQDREQLKRDPFF
.| .|||||.| ||....      |   |...|... | .... .                     . .. .|...|...|| |..    ||.. .|.|
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT---AEQILQHPWF
Kinase 18079.AA PKC 671-926 41 9.6e-94 304.24 In-house 1-262 (262) Show / Hide 
Range on Protein: 671-926
Range on HMM: 1-262/262
Sequence Identity: 41% (109 aa)

FQILKVLGAGSFGKVFLAKKKDSGNIYAIKALKKRPLIMKRQLRYAVTEANVLKMC-NHPFILGLHYALQTPNYLYLVLDYCSGGDISSHLAYKRRFSEE
|. ||||| ||||||.||..|..  .||||.|||   |.      . ||  ||    .|||  .||   ||...|. |. |. |||   |    |||.||
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRRFKEE

EALFYIAELVLAIQHIHEKDVVYRDLKPENILIASDGHIKLADFGLSKDNVTDQSKTKSFCGTPAYLSPEMLNNKGATKASDLYGIGAVLYEMLTGDPPY
 | || || ..| |  |||...||||| .|.|. ..||||.||||..|.|... ..|..||||| |..|| |  .  .|. |    |  .|||. | .| 
HARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDTTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQSPF

YNDDIPTMYKKIKEGNLTYPSYVSQKARNIINGLLDRNPKTRLGA--QD---REQLKRDPFF
  .|  .. . | . |  || . |..| .|. |....||..|||.  |.   ..  .. |||
HGEDEDELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF
Kinase 18079.AA p70 671-926 34 5.4e-90 305.29 In-house 1-299 (299) Show / Hide 
Range on Protein: 671-926
Range on HMM: 1-299/299
Sequence Identity: 34% (104 aa)

FQILKVLGAGSFGKVFLAKKKD---SGNIYAIKALKKRP-LIMKRQLRYAV-------------------------TEANVLKMCNHPFILGLHYALQTP
|. ||||| | .||||. .|     .| ||| | |.|.  ..  . .. .                           | |.|   .||||  |||| || 
FELLKVLGKGGYGKVFQVRKVTGEDTGKIYAMKVLRKAKIVRNQKDTAHTREDEDKNDGNNNDNDDGLSKRLERTFAERNILEEVKHPFICDLHYAFQTN

NYLYLVLDYCSGGDISSHLAYKRRFSEEEALFYIAELVLAIQHIHEKDVVYRDLKPENILIASDGHIKLADFGLSKDNVTDQSK----------TKSFCG
  |||.|.| .||    ||  .  . |. | || .| ..|..| |.....||||||||..  . ||..| ||||.|  . | ..          | .|||
GKLYLILEYLHGGELFMHLERHGIWMEDTACFYLSEIICALEHLHQHGIIYRDLKPENCMLNQQGHVVLTDFGLCKESIHDGAVDEEDPENVNATHTFCG

TPAYLSPEMLNNKGATKASDLYGIGAVLYEMLTGDPPYYNDDIPTMYKKIKEGN--LTYPSYVSQKARNIINGLLDRNPKTRLG--AQDREQLKRDPFF
|. |  ||.|  .|  .| | .  |. .| |||| ||.  .      .||  |   |. | | .. .| .|. || |.|..|.|   .| .. ...|||
TIEYMAPEILMRCGHNHAVDWWSLGCLMYDMLTGGPPFTGENRKKTIDKILKGKQGLKLPPYLTHEMRDLIKKLLKRHPTQRWGAGPEDAADIQEHPFF
Kinase 18079.AA TyrKc 671-920 21 3.7e-17 54.72 SMART 1-280 (280) Show / Hide 
Range on Protein: 671-920
Range on HMM: 1-280/280
Sequence Identity: 21% (62 aa)

FQILKVLGAGSFGKVFLAKKKDSGNIYAIKALKKRPLIMKRQLRYAVTEANVLKMC--NHPFILGLHYALQTP-------NYLYLVLDYCSGGDISSHLA
 . .|.|| | ||.|.... |      |.| ||.        ..    ||.....   .|| |. |. .  ..         |..|. |...||  ..| 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

YKRR-FSEEEALFYIAELVLAIQHIHEKDVVYRDLKPENILIASDGHIKLADFGLSKDNVTD-------QSKTKSF--CGTP----AYLSPEMLNNKGAT
..|. .. .. | .        ...|.| .. |||   |.|.......| .|||||.|   |       . ..|.   .|        ..|| .| .  |
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

KASDLYGIGAVLYEMLT-GDPPYYN-----DDIPTMYKKIKEG-NLTYPSY--------VSQKARNIINGLLDRNPKTRLGAQD-REQL
 .|| .  | ...|..| |..||..      .   .....|.|  .  | .         ...  .|.    ...|. |   .. .|..
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 18079.AA Pkinase_Tyr 671-885 24 3.4e-15 52.1 Pfam 1-233 (270) Show / Hide 
Range on Protein: 671-885
Range on HMM: 1-233/270
Sequence Identity: 24% (58 aa)

FQILKVLGAGSFGKVFLAKKK----DSGNIYAIKALKKRPLIMKRQ--LRYAVTEANVLKMC-NHPFILGLHYALQ--TPN-YLYLVLDYCSGGDISSHL
 ...|.||.|.||.|.... |    . .   |.| ||     |..|  ..    ||...|   .|| |. |. .        ..|.|. |. .||  ..|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE--GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

AY----KRRFSEEEALFYIAELVLAIQHIHEKDVVYRDLKPENILIASDGHIKLADFGLSKDN-VTDQS-KTKSFCGTP-AYLSPEMLNNKGATKASDLY
      |.... .. | . ..   . .. ..|  . |||   |.|.......| .||||..|   .|.  .... .  |   ..|| .|..  | .|| .
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVW

GIGAVLYEMLT-GDPP-YYNDDIPTMYKKI-KEGN
  | ...|..| |. | |.. .   .|..| ..|.
SFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGY