Gene 19784 (Tetrahymena)

19784

Species: Tetrahymena
Alias: 19784, TTHERM_00637810, PreTt19784, 14, 91.m00199
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: AGC
Family: Akt

Sequence

Name Sequence Type Origin Length Description Download
19784.AA Protein None 436 None Fasta, JSON
19784.kin_dom Protein Kinase Domain None 253 None Fasta, JSON
19784.NA RNA None 1311 None Fasta, JSON

Protein domain

Protein domains of 19784.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 19784.AA Akt 76-328 59 4.6e-193 622.6 In-house 4-264 (264) Show / Hide 
Range on Protein: 76-328
Range on HMM: 4-264/264
Sequence Identity: 59% (156 aa)

IHVLGKGSFGKVVLVEKKDTKELY-AMKILKKDYIQYTNQKFNTQQERDILVKMNSPFIVKLHYAFQTADKLYIVMDFMIGGELFYHLRRSPIFTEEKAA
..||||||||||.||.||||...| |||.||||||.. ||. .|..|| ||...|.||||.|||.|||.||||.|||.. ||||||||.| ..|.|..| 
LKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSEDRAR

YYSAEIILGIEALHSNNIIYRD-LKPENILIDHKGHLRLADFGLSKKG-VKDHERTNSLCGTPEYLAPEILLNNGHTKMVDWWS-LGAIIYEMLTGAPPF
.| |||||.||.|||.|||||| |||||||.|..||..|.||||.|.. .|||..|...||||||||||||..|||||.||||. ||...|||..|.|||
FYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGRPPF

YNKNQKQMFKDRFLKPIEMK--EWFSPAAKSLLSGLLNINPELRLG--FKGIQEIKEHEFY
||....||||  . .|....  .|.||..|.|.||||| .|..|||  ....||||.|...
YNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase 19784.AA AGC 74-328 35 1.4e-183 479.71 In-house 1-395 (395) Show / Hide 
Range on Protein: 74-328
Range on HMM: 1-395/395
Sequence Identity: 35% (141 aa)

FGIH-VLGKGSFGKVVLVEKK------DTKELYAMKILKKDY-IQYTN--QKFNTQQE------------RDILVKMN----------SPFIVK-LHYAF
| .. |.|||||||| ||.||      ||...||||.|||.. |. ..  .  .|. |            |.||.|.|          .||||| |||.|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTADK--LYIVMDFMI---------GG-ELFYHLR---RSPIFTEEKAAYYSAE-------IILGIEALHS-NNIIYRD-LKPENILIDHKGHLRLADFG
|. |.  ||.||..|.         || |||.||.   .. .|.|| | .| ||       |.|..| ||| ..||.|| |||||||.|..||..|.|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LSKKGVKDH--------------------------------------------------ERTNSLCG--TPEYLAPEILLNNGHTKMVDWWS--LGAIIY
|.|.|..|.                                                  .||...||  ||||.|||||    ..| .||||  ||...|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMLTGAPPFYNKN----------QKQMFKDRF------LKPIEMK----------EWFSPAAKSLLSGLLNINPELRLGFK-------GIQEIKEHEFY
||||| ||||..|          ...||.          .....           .|||| ||.|...||. .|| ||| .       |..|||.|.. 
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 19784.AA SGK 76-328 46 6.5e-150 466.44 In-house 4-283 (283) Show / Hide 
Range on Protein: 76-328
Range on HMM: 4-283/283
Sequence Identity: 46% (131 aa)

IHVLGKGSFGKVVLVEKKDT------------------KELYAMKILKKDYIQ-------YTNQKFNTQQER-DILVKMNSPFIVKLHYAFQTADKLYIV
..|.|||||||| .|..||.                  . .||||.|.|. |          ..  ... || .||..|..||||.|||||||..||| |
LKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKLYFV

MDFMIGGELFYHLRRSPIFTEEKAAYYSAEIILGIEALHSNNIIYRDLKPENILIDHKGHLRLADFGLSKKGVKDHERTNSLCGTPEYLAPEILLNNGHT
||.. |||.||||.|  .| | .|  | |||.. .| ||| .|||||||||||| ||.||..| ||||.| |.|. . | . ||||||||||.|.  .| 
MDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQPHD

KMVDWWSLGAIIYEMLTGAPPFYNKNQKQMFKDRFLKPIEMKEWFSPAAKSLLSGLLNINPELRLGFK-GIQEIKEHEFY
. ||||.||.. |||..|.||||..| .||.  .  .|. ..  .|..|..|. |||. .|. ||| | .  |||.| | 
RTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF
Kinase 19784.AA AktR 76-328 50 1.5e-133 450.01 In-house 4-268 (268) Show / Hide 
Range on Protein: 76-328
Range on HMM: 4-268/268
Sequence Identity: 50% (133 aa)

IHVLGKGSFGKVVLVEKK-DTKELYAMKILKKDYIQYTNQKFNTQQERDILV-KMNSPFIVKLHYAFQTADKLYIVMDFMIGGELFYHLRRSPIFTEEKA
. .|||| ||||.||.|| |....||||..||  |.  ||.  |..||.|.  ..| ||||||||.||| .||...|... |||||.||...  |.||.|
YKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSEEQA

AYYSAEIILGIEALHSN-NIIYRDLKPENILIDHKGHLRLADFGLSK-KGVK-DHERTNSLCGTPEYLAPEILLN-NGHTKMVDWWSLGAIIYEMLTGAP
  |.|.|.|..| ||.. |||||||||||||.|  ||....||||||  ... . |...|.||||||.|||....  ||.|.||||..|. ||||.|| |
RFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVTGCP

PFYNKNQKQMFKDRFLKP-IEMKEW--FSPAAKSLLS-GLLNINPELRLG--FKGIQEIKEHEFY
|||.|||.|||.    |. .. ..   ||...|.|.  .||. ||. |||   .|..|||.| . 
PFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase 19784.AA RSK 76-328 43 1.8e-116 393.21 In-house 1-278 (278) Show / Hide 
Range on Protein: 76-328
Range on HMM: 1-278/278
Sequence Identity: 43% (121 aa)

IHVLGKGSFGKVVLVEKK---DTKELYAMKILKKDYIQYTNQ-KFNTQQERDILVKMN-SPFIVKLHYAFQTADKLYIVMDFMIGGELFYHLRRSPI---
. |||.|..||| |. |.   ||. .||||.|||  |  ..     | .||.||   . .||||.||||||| .|||..|... |||||.||..  .   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FTEEKAAYYSAEIILGIEALHSNNIIYRDLKPENILIDH---KGHLRLADFGLSKKGVKD-HERTNSLCGTPEYLAPEILL----NNGHTKMVDWWSLGA
|.|. |..| |||.| .| ||.  ||.||||||||| |.    ||..| |||..|... |  ..|.. |.| ||.|||.|     ..||.| .||||||.
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

IIYEMLTGAPPFYN---KNQKQMFKDRFLKP--IEMK--EWFSPAAKSLLSGLLNINPELRLG--FKGIQEIKEHEFY
..||||||.|||..   .|.|. .|    .    .|.  .  |..||.|....|  .|. |||   ....|||.|.. 
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 19784.AA RSK 74-328 40 4.6e-110 371.95 In-house 1-271 (271) Show / Hide 
Range on Protein: 74-328
Range on HMM: 1-271/271
Sequence Identity: 40% (110 aa)

FGIH-VLGKGSFGKVVLVEKK---DTKELYAMKILKKDYIQYTNQKFNTQQERDILVKMNSPFIVKLHYAFQTADKLYIVMDFMIGGELFYHLRRSPIFT
. .| ..|.|||.|| .. |.   ||. .|||||.||. .  . .   .  ||.||   ..||||||||.||.. |.|..|||| ||.|| .| . . |.
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDR-VCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFS

EEKAAYYSAEIILGIEALHSNNIIYRDLKPENILIDHK----GHLRLADFGLSKKGVKDHER-TNSLCGTPEYLAPEILLNNGHTKMVDWWSLGAIIYEM
|.... | ||| |  | |||  |..|||||||||.| .    ||....|||..|. ..|..  . . |.| .|.|||.|   ||.. .||||.|.. |||
EREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQ-LRDENGMLMTFCYTANYMAPEVLKRQGHDQACDWWSFGVLMYEM

LTGAPPFYNKNQKQMFKDRFLKPIEM-------KEWFSPAAKSLLSGLLNINPELRLGF--KGIQEIKEHEFY
|||..||.||. . ..      .  |       ..  |. ||.||...| ..|. |||    |...||.| ..
LTGCTPFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase 19784.AA RSK-Unclassified 76-328 39 2.3e-106 335.18 In-house 4-283 (283) Show / Hide 
Range on Protein: 76-328
Range on HMM: 4-283/283
Sequence Identity: 39% (111 aa)

IHVLGKGSFGKVVLVEKKDTKELYAMKILKKDYIQYTNQKFNTQQERDILVKMNSPFIVKLHYAFQTADKLYIVMDFMIGGELFYHLR--RSPIFTEEKA
.  .|.|.|||| ||.||||. .||||.|.|. .   |       |..|.   | ||||.| ..||| |.|| .|..  ||..| ||   ..  |.|...
HRLIGQGDFGKVYLVRKKDTQQIYAMKVLHKHKMIRHNKIKYVMTEQNIMATTNHPFIVTLYHSFQTQDYLYLCMEYCMGGDFFRHLQTRKEKCFCEDDV

AYYSAEIILGIEALHSNNIIYRDLKPENILIDHKGHLRLADFGLSKKG-------VK--------------DHERTNSLCGTPEYLAPEILLNNGHTKMV
 .| .|...  | ||   .|||||||.||. .. || .| ||.||...       .|              .  |||| ||| ||||||..  .|||| |
RFYASEVTAALEYLHKRDFIYRDLKPDNIVLHQEGHVMLTDFDLSIQAKDSKKPVMKGSAQSTYVDTKICDHGFRTNSFCGTEEYLAPEMIRRCGHTKAV

DWWSLGAIIYEMLTGAPPFYNKNQKQMFKDRFLKPIEMK--EWFSPAAKSLLSGLLNINPELRLGFK-G-IQEIKEHEFY
||| || ..|||| | ||.|  |.  .|.    ... .   .  |  ...|.  ||. ||  ||| | |  ..|| | |.
DWWTLGIVMYEMLFGCPPYYGNNKNETFYNIEKNHVKFPHDSYISNNCRDLIKKLLQRNPAKRLGCKMGDADDIKRHPFF
Kinase 19784.AA PKA 73-328 45 5.8e-106 358.33 In-house 1-263 (263) Show / Hide 
Range on Protein: 73-328
Range on HMM: 1-263/263
Sequence Identity: 45% (122 aa)

TFGIHVLGKGSFGKVVLVEKKDTKELYAMKILKKDYIQYTNQKFNTQQERDILVKMNSPFIV-KLHYAFQTADKLYIVMDFMIGGELFYHLRRSPIFTEE
   | .||.||||.| |. .|.... ||||.|||..|  ..|.  .  |. ||  ...|||| |. . ||....|| ||..  |||.|..||.|  |.. 
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

KAAYYSA-EIILGIEALHSNNIIYRDLKPENILIDHKGHLRLADFGLSKKGVKDHERTNSLCGTPEYLAPEILLNN-GHTKMVDWWSLGAIIYEMLTGAP
 |  | | .|.| .| ||| ||||||||||||||| .||. ..||| .|| |.|  || .||||||||||||...  || | ||||.|| .|||||.| |
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKK-VDD--RTWTLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYP

PFYNK--NQKQMFKDRFLKPIEMKEWFSPAA---KSLLSGLLNINPELRLG-FK-GIQEIKEHEFY
|||..  .. |...      |.. . |...|   |.|.. ||. ... |.| .| |.. ||.|.. 
PFYDHNRDPMQIYEKICNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase 19784.AA S_TKc 73-328 36 2e-103 350.85 SMART 1-231 (231) Show / Hide 
Range on Protein: 73-328
Range on HMM: 1-231/231
Sequence Identity: 36% (97 aa)

TFGIHVLGKGSFGKVVLVEKKDTKELYAMKILKKDYIQYTNQKFNTQQERDILVKMNSPFIVKLHYAFQTADKLYIVMDFMIG--GELFYHLRRSPI---
   . ..|||.|||| .. .|.|....|.||.|           ....|..|| | . |.||||...||. |.||.||... |  |.|| .... .    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FTEEKAAYYSAEIILGIEALHSNNIIYRDLKPENILIDHKGHLRLADFGLSKKGVKDHERTNSLCGTPEYLAPEILLNNGHTK-MVDWWSLGAIIYE
   |.|  |..| ..|....| .||..||.|||||||||.|.  |. ..||||...        ...||||.|.|||.|   |..|  .||||.| |.||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

MLTGAPPFYNKNQKQMFKDRFLKPIEMKEWFSPAAKSLLSGLLNINPELRLGFKGIQE----IKEHEFY
||.| |||.  ....|||             || ||......|. .|| |..   . .    || |.. 
MLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 19784.AA PKC 76-328 42 7.79999999999e-101 327.58 In-house 4-262 (262) Show / Hide 
Range on Protein: 76-328
Range on HMM: 4-262/262
Sequence Identity: 42% (111 aa)

IHVLGKGSFGKVVLVEKKDTKELYAMKILKKDYIQYTNQKFNTQQERDILVK-MNSPFIVKLHYAFQTADKLYIVMDFMIGGELFYHLRRSPIFTEEKAA
. ||||||||||.|.|.|.|.|.||.|.|||| |  .     |. |. .|    . || ..||  ||| |.|. || .  || | .|  ..  | ||.|.
LKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRRFKEEHAR

YYSAEIILGIEALHSNNIIYRDLKPENILIDHKGHLRLADFGLSKKGVKDHERTNSLCGTPEYLAPEILLNNGHTKMVDWWSLGAIIYEMLTGAPPFYNK
 |.||||..   ||...||||||| .|.|.|| || ..||||..| .. . ..|.. ||||.|.|||||     .| ||||..|   |||. | .||  .
FYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDTTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQSPFHGE

NQKQMFKDRFLKPIEMKEWFSPAAKSLLSGLLNINPELRLGF-----KGIQEIKEHEFY
.  ..|.    . .    |.|  |.|...|... ||| |||      .| |.|.|| |.
DEDELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF
Kinase 19784.AA p70 76-328 37 8.7e-98 331.17 In-house 4-299 (299) Show / Hide 
Range on Protein: 76-328
Range on HMM: 4-299/299
Sequence Identity: 37% (112 aa)

IHVLGKGSFGKVVLVEKKD---TKELYAMKILKKDYIQYTNQKFNTQQ--------------------------ERDILVKMNSPFIVKLHYAFQTADKL
. ||||| .||| .| |     |  .|||| |.|  |  .                                  || ||   ..|||..|||||||  ||
LKVLGKGGYGKVFQVRKVTGEDTGKIYAMKVLRKAKIVRNQKDTAHTREDEDKNDGNNNDNDDGLSKRLERTFAERNILEEVKHPFICDLHYAFQTNGKL

YIVMDFMIGGELFYHLRRSPIFTEEKAAYYSAEIILGIEALHSNNIIYRDLKPENILIDHKGHLRLADFGLSKKGVKDHER----------TNSLCGTPE
| . ... |||||.|| |  |. |. | .| .|||. .| ||.  ||||||||||.. ...||. | ||||.|. ..| .           | ..|||.|
YLILEYLHGGELFMHLERHGIWMEDTACFYLSEIICALEHLHQHGIIYRDLKPENCMLNQQGHVVLTDFGLCKESIHDGAVDEEDPENVNATHTFCGTIE

YLAPEILLNNGHTKMVDWWSLGAIIYEMLTGAPPFYNKNQKQMFKDRFLKP--IEMKEWFSPAAKSLLSGLLNINPELRLG--FKGIQEIKEHEFY
| |||||.  || . |||||||. .| ||||.|||   | |.  .        ...    .. .. |.  ||  .| .|.|     ...|.||.|.
YMAPEILMRCGHNHAVDWWSLGCLMYDMLTGGPPFTGENRKKTIDKILKGKQGLKLPPYLTHEMRDLIKKLLKRHPTQRWGAGPEDAADIQEHPFF
Kinase 19784.AA Pkinase 76-328 30 2.4e-90 311.23 Pfam 4-293 (293) Show / Hide 
Range on Protein: 76-328
Range on HMM: 4-293/293
Sequence Identity: 30% (90 aa)

IHVLGKGSFGKVVLVEKKDTKELYAMKILKKDYIQYTNQKFNTQ-QERDILVKMNSPFIVKLHYAFQTADKLYIVMDFMIGG----ELFYHLR--RSPIF
. ..|.||||.| .  .|.| ...|.||.||. .    .. ..  .|  |. ..|.|.||.|...|.. |..|.||... ||    .|| ...  |.  |
GRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCF

--TEEKAAYYSAEIILGIEALHSNNIIYRDLKPENILIDHKGHL----RLADFGLSKKG-VKDHERTNSLCGTPEYLAPEILL-NNGHTKMVDWWSLGAI
  .|. .  |  .|. |.| .||..||.|||||||||||..||.    ...||||.|.      . ....||||.|.|||... ...... ||.||.| |
YFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCI

IYEMLTGAPPFYNK------NQKQMFKDRFLKPIEMKEWFS---------------------PAAKSLLSGLLNINPELRLGFKGIQEIKEHEFY
.||||.| |||...      .|.||.. .  .|..  .. .                     ...|......|. .|. |..   ...|..|.. 
LYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT---AEQILQHPWF
Kinase 19784.AA S_TK_X 329-388 31 1.3e-15 59.08 SMART 1-79 (79) Show / Hide 
Range on Protein: 329-388
Range on HMM: 1-79/79
Sequence Identity: 31% (27 aa)

ASINWDKLYK--KEIPPPYKPKLS----SKYDLSHFSKQFTTETVKDTPYCGKTIKDS-------------------YNDFTYQR
..|.|||||.  |||.||.|||..    |  |.| | . || ||..       |  |.                   . .||| .
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPM------LTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase 19784.AA TyrKc 73-327 23 7.7e-14 1.11 SMART 1-280 (280) Show / Hide 
Range on Protein: 73-327
Range on HMM: 1-280/280
Sequence Identity: 23% (68 aa)

TFGIHVLGKGSFGKVVLVEKKDTKELYAMKILKKDYIQYTNQKFNTQQERDILVKM--NSPFIVKLHYAFQTA-------DKLYIVMDFMIGGELFYHLR
   ...|| | ||.|.. . |   .  | | ||.|       .    .|  |. |   . | ||.|. .  .        . |.||| .| .| |  .||
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

RSPI-FTEEKAAYYSAEIILGIEALHSNNIIYRDLKPENILIDHKGHLRLADFGLSKKGVKD------HERTNSLC--GTPE-----YLAPEILLNNGHT
..   .. ..  ...  |  | | |||.|.| |||   |.|...... . .|||||...  |      ..   .    |.        .||| .  .  |
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

KMVDWWSLGAIIYEMLT-GAPPFYN-----KNQKQMF---KDRFLKPIEMKEW------FSPAAKSLLSGLLNINPELRLGFKGIQEIKEHEF
   | || |  ..|..| |..| ..     .. ....   |...  |.            ...  .. .   . .|| |  |. |     ..|
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI----HECF
Kinase 19784.AA Pkinase_Tyr 76-281 27 1.2e-07 26.54 Pfam 4-226 (270) Show / Hide 
Range on Protein: 76-281
Range on HMM: 4-226/270
Sequence Identity: 27% (61 aa)

IHVLGKGSFGKVVLVEKK----DTKELYAMKILKKDYIQYT--NQKFNTQQERDILVKM-NSPFIVKLHYAFQ-TADK--LYIVMDFMIGGELFYHLRR-
...||.|.||.|.. . |    .||   | |.|| .. .     ..|   .|  |. .. . | ||.|. .     .   .|||| .| .| |  .||. 
GKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDF--MREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKH

---SPIFTEEKAAYYSAEIILGIEALHSNNIIYRDLKPENILIDHKGHLRLADFGLSKKG-VKDHE-RTNSLCGTP-EYLAPEILLNNGHTKMVDWWSLG
    . .| .    ....|  | | |.|.|.| |||   |.|...... . .||||..    .|   |. . .  |   .||| . ..  |   | || |
REDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFG

AIIYEMLT-GAPP-FYNKNQKQMFK
  ..|..| |. | ...    ....
VLMWEIFTYGEQPTYPGMSNEEVYE
Kinase 19784.AA Pkinase_C 348-371 41 0.000142 19.43 Pfam 1-24 (46) Show / Hide 
Range on Protein: 348-371
Range on HMM: 1-24/46
Sequence Identity: 41% (10 aa)

KLSSKYDLSHFSKQFTTETVKDTP
...|. | |.| ..|| |...|||
QVKSPTDTSNFDPEFTDEPPMDTP