Gene 3020 (Tetrahymena)

3020

Species: Tetrahymena
Alias: 696, 106.m00160, 3020, PreTt03020, 3674.m00073, TTHERM_00691820
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: AGC
Family: Akt

Sequence

Name Sequence Type Origin Length Description Download
3020.AA Protein None 890 None Fasta, JSON
3020.kin_dom Protein Kinase Domain None 256 None Fasta, JSON
3020.NA RNA None 2673 None Fasta, JSON

Protein domain

Protein domains of 3020.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Ank 3020.AA Ank 219-251 27 0.000184 20.35 Pfam 1-33 (33) Show / Hide 
Range on Protein: 219-251
Range on HMM: 1-33/33
Sequence Identity: 27% (9 aa)

NGWNSLHYASYLEFDDICRKLIIEGADLNKPTS
.|.  ||.|..    .... |.  |||.|  . 
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank 3020.AA Ank 252-272 47 0.002276 16.41 Pfam 1-21 (33) Show / Hide 
Range on Protein: 252-272
Range on HMM: 1-21/33
Sequence Identity: 47% (10 aa)

DDWTPLQLAVFKNNLKVVKVL
| .||| ||.......||| |
DGFTPLHLACRCGHTEVVKML
Ank 3020.AA Ank 288-318 29 0.015062 13.45 Pfam 4-33 (33) Show / Hide 
Range on Protein: 288-318
Range on HMM: 4-33/33
Sequence Identity: 29% (9 aa)

TALHLASAKGFIKIVQYLVLDKNANPELKHP
|.||||. .| ...|..|.  ..|.. ..  
TPLHLACRCGHTEVVKMLLQ-HGADVNAQDD
PH 3020.AA PH 369-471 15 6.8e-08 31.11 Pfam 1-92 (92) Show / Hide 
Range on Protein: 369-471
Range on HMM: 1-92/92
Sequence Identity: 15% (16 aa)

PMIRGYVFRQHDIFPCICQKRFLEINSDSCTLQMYREEDDVPLRPQLVISLTDILDVDLLPRHWPMQKDLIYVRIIFQNSMVIAFKTKEAAEHWIDKLNE
....|......  .    .||.. . .   .| .|....    ||. .|.| |. .|. .|.    ..  ...|.  ... ...... | ...|.. ...
VIKEGWLHKKG--KRKSWKKRWFVLFN--NCLYYYKDDK---YRPKGSIPLSDC-QVTKVPDN--KRPHCFQIRT-DRRTYYFQAESEEEMNDWMQAIQS

AIA
|..
ACR
PH 3020.AA PH 369-473 14 1.1e-07 32.75 SMART 1-82 (82) Show / Hide 
Range on Protein: 369-473
Range on HMM: 1-82/82
Sequence Identity: 14% (15 aa)

PMIRGYVFRQHDIFPCICQKRFLEINSDSCTLQMYREEDDVPLRPQLVISLTDILDVDLLPRHWPMQKDLIYVRIIFQNSMVIAFKTKEAAEHWIDKLNE
. ..|.. ...       .||.. . .   .|  |...     .|. .|.|.|.  |.  |         ....   . .........| .. |.. ...
VIKEGWLYKKS---K-RWKKRWFVLFN--DCLYYYKDK-----KPKGSIPLSDC-TVRE-P--------CFEIHH-DR-TYYFQCESEEEMQEWMQAIQK

AIAYA
||. .
AIHNN
Kinase 3020.AA Akt 573-828 54 3.8e-189 609.86 In-house 1-264 (264) Show / Hide 
Range on Protein: 573-828
Range on HMM: 1-264/264
Sequence Identity: 54% (144 aa)

FTILGALGKGSFGRVFLVQQNSTEELF-AMKMLKKVSLIMKRQLKYAVTECNILKRCKNPFVVGLHYAFQTPNHLYMVLDYCNGGVLLQHIQRESRFSEL
|..|  |||||||.||||....|.... |||.|||  .|.|.|.....||.|||..|..||.|.|||.|||...||.|.|||||| | .|.||. |||| 
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

TARFFVCEIILAIEYLHSQNILYRD-LKPENILISSDGHIKLTDFGLSKEH-VADFDVTKSFCGSPAYLSPEMLLGKGFSKASDIYG-IGCVLYEMLTGQ
.|||...|||||||.|||.|| ||| |||||||...||||.||||||.||. . |.|.||.|||.|.||.||.|.|.|..||.|..| .|||.|||..|.
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGR

PPFFHEDIKQLYSGIKSEDPQLP--KYLSNSAKTLIIQLLKKNPKERLG--YNSIQQIKSHEFF
|||...|..|..  ||... . |  ...|. .|.||..||.|.||.|||  .| .|.||.|..|
PPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase 3020.AA AGC 573-828 31 3.1e-178 465.61 In-house 1-395 (395) Show / Hide 
Range on Protein: 573-828
Range on HMM: 1-395/395
Sequence Identity: 31% (125 aa)

FTILGALGKGSFGRVFLVQQN------STEELFAMKMLK---KVSLIMKRQLKYAVTE------------CNILKRCK----------NPFVVG-LHYAF
| .|  .||||||.|.||. .      .|....|||.||   |. ...|...... ||             |||..|.          .||.|  |||.|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTPNH--LYMVLDYCN---------GG-VLLQHIQ---RESRFSELTARFFVCE-------IILAIEYLHS-QNILYRD-LKPENILISSDGHIKLTDFG
|...|  ||.|..|..         ||  |..|.|   .| ||.| .|||. .|       |.||.||||| ..| .|| |||||||. .||||||||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LSKEHVADF--------------------------------------------------DVTKSFCG--SPAYLSPEMLLGKGFSKASDIYG--IGCVLY
|.|| . |                                                   | |..|||  .| |..||.|     .|| |...   ||..|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMLTGQPPFFHE----------DIKQLYSGIK------SEDPQLP----------KYLSNSAKTLIIQLLKKNPKERLGYNS-------IQQIKSHEFF
|||||.|||...          . ....  |.      ......|          ...|. || || .||.|.|..|||..        ...||.|..|
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 3020.AA SGK 573-828 44 8.8e-142 440.87 In-house 1-283 (283) Show / Hide 
Range on Protein: 573-828
Range on HMM: 1-283/283
Sequence Identity: 44% (126 aa)

FTILGALGKGSFGRVFLVQQNST------------------EELFAMKMLKKVSLI-------MKRQLKYAVTEC-NILKRCKNPFVVGLHYAFQTPNHL
| .|  .||||||.|..|.  ..                  . ..||| |.| . |        | . |.  .|  .|||  | || |.|||||||.  |
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

YMVLDYCNGGVLLQHIQRESRFSELTARFFVCEIILAIEYLHSQNILYRDLKPENILISSDGHIKLTDFGLSKEHVADFDVTKSFCGSPAYLSPEMLLGK
|.|.|| ||| .  |.||| .|.|  ||| . ||..|.||||||.| ||||||||||  ..||..||||||.|| ... | |..|||.|.|| ||.|...
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQ

GFSKASDIYGIGCVLYEMLTGQPPFFHEDIKQLYSGIKSEDPQLPKYLSNSAKTLIIQLLKKNPKERLGYN-SIQQIKSHEFF
..... | . .|||||||..| |||.. . .|.|  | ... |.|.. ||.|. || .||.|.||.||| .    .||.| ||
PHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF
Kinase 3020.AA AktR 573-828 45 4.5e-131 441.75 In-house 1-268 (268) Show / Hide 
Range on Protein: 573-828
Range on HMM: 1-268/268
Sequence Identity: 45% (123 aa)

FTILGALGKGSFGRVFLVQQN-STEELFAMKMLKKVSLIMKRQLKYAVTECNILK-RCKNPFVVGLHYAFQTPNHLYMVLDYCNGGVLLQHIQRESRFSE
|...  |||| ||.|.||| .  . ...||||.||  .| ..| ... || ||..  |..|| | |||.||| ..|. ...|| || |.||.... .|||
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

LTARFFVCEIILAIEYLHSQ-NILYRDLKPENILISSDGHIKLTDFGLSK-EHVA-DFDVTKSFCGSPAYLSPEMLLG-KGFSKASDIYGIGCVLYEMLT
 .|||. ..|.||.||||.. || ||||||||||. .|||.|.||||||| . .  . ....||||.|.|..|||..  ||  |..|.. .|...|||.|
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT

GQPPFFHEDIKQLYSGIKSED---PQLPKYLSNSAKTLII-QLLKKNPKERLG--YNSIQQIKSHEFF
|.|||.|.. .|..  ||...   .. |.|.|. .| ||  .||.|||..|||   |....|||| .|
GCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase 3020.AA RSK 576-828 42 9.3e-113 380.9 In-house 1-278 (278) Show / Hide 
Range on Protein: 576-828
Range on HMM: 1-278/278
Sequence Identity: 42% (117 aa)

LGALGKGSFGRVFLVQQN---STEELFAMKMLKKVSLIMKRQ-LKYAVTECNILKRCK-NPFVVGLHYAFQTPNHLYMVLDYCNGGVLLQHIQRESR---
|  ||.|..| |||..      |. ..||| |||  .. .   .... || |||.||.  ||.| |||||||. .||....||.|| |. |.|.| .   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FSELTARFFVCEIILAIEYLHSQNILYRDLKPENILISS---DGHIKLTDFGLSKEHVAD-FDVTKSFCGSPAYLSPEMLL----GKGFSKASDIYGIGC
||| .|.|   ||.||.|.||.| | .|||||||||  .   .|||||||||..|. ..|    |..||.. .|. ||||     ..| .|| |..  |.
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

VLYEMLTGQPPFFH---EDIKQLYSGIKSED--PQLP--KYLSNSAKTLIIQLLKKNPKERLG--YNSIQQIKSHEFF
..||||||.||| .   .. |..   |.. .  . .|  .|||. || || ..|...|. |||   . ...||.|..|
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 3020.AA RSK-Unclassified 573-828 37 6.5e-104 327.35 In-house 1-283 (283) Show / Hide 
Range on Protein: 573-828
Range on HMM: 1-283/283
Sequence Identity: 37% (105 aa)

FTILGALGKGSFGRVFLVQQNSTEELFAMKMLKKVSLIMKRQLKYAVTECNILKRCKNPFVVGLHYAFQTPNHLYMVLDYCNGGVLLQHIQ--RESRFSE
|   . .|.|.||.|.||..  |. ..||| |.|  .| ..  ||. || ||.   . ||.| | ..|||   ||....|| || . .| |  .| .|.|
FIKHRLIGQGDFGKVYLVRKKDTQQIYAMKVLHKHKMIRHNKIKYVMTEQNIMATTNHPFIVTLYHSFQTQDYLYLCMEYCMGGDFFRHLQTRKEKCFCE

LTARFFVCEIILAIEYLHSQNILYRDLKPENILISSDGHIKLTDFGLSKEH---------------------VADFDVTKSFCGSPAYLSPEMLLGKGFS
  .||.. |...| |||| . . ||||||.||.   .||..||||.||..                      . .   |.||||. .|| |||. . |  
DDVRFYASEVTAALEYLHKRDFIYRDLKPDNIVLHQEGHVMLTDFDLSIQAKDSKKPVMKGSAQSTYVDTKICDHGFRTNSFCGTEEYLAPEMIRRCGHT

KASDIYGIGCVLYEMLTGQPPFFHEDIKQLYSGIKSEDPQLP--KYLSNSAKTLIIQLLKKNPKERLGYNSI--QQIKSHEFF
|| | .  | |.|||| | ||.  .    ... |  .. ..|  .|.|| .. ||  ||..||  |||  .   . || | ||
KAVDWWTLGIVMYEMLFGCPPYYGNNKNETFYNIEKNHVKFPHDSYISNNCRDLIKKLLQRNPAKRLGCKMGDADDIKRHPFF
Kinase 3020.AA S_TKc 573-828 36 1.1e-103 351.73 SMART 1-231 (231) Show / Hide 
Range on Protein: 573-828
Range on HMM: 1-231/231
Sequence Identity: 36% (97 aa)

FTILGALGKGSFGRVFLVQQNSTEELFAMKMLKKVSLIMKRQLKYAVTECNILKRCKNPFVVGLHYAFQTPNHLYMVLDYCNG--GVLLQHIQRESR---
..||  .|||.||.|.... ..| ...|.|..|          . .  | .|||. . |..| |...||. .|||||..||.|  | |...|..  |   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FSELTARFFVCEIILAIEYLHSQNILYRDLKPENILISSDGHIKLTDFGLSKEHVADFDVTKSFCGSPAYLSPEMLLGKGFSK-ASDIYGIGCVLYE
   |.| .|||....|..|.||.||..|..|||||||||...  |||..||||...        ..|||.| |..||.|   |..| ..|.. .||.|||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

MLTGQPPFFHEDIKQLYSGIKSEDPQLPKYLSNSAKTLIIQLLKKNPKERLGYNSIQQ----IKSHEFF
||.|.|||   ......  |.          | .|| .| ..|.|.|..|..   . |    ||.|..|
MLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 3020.AA PKC 573-828 41 2.7e-98 319.2 In-house 1-262 (262) Show / Hide 
Range on Protein: 573-828
Range on HMM: 1-262/262
Sequence Identity: 41% (109 aa)

FTILGALGKGSFGRVFLVQQNSTEELFAMKMLKKVSLIMKRQLKYAVTECNILKRC-KNPFVVGLHYAFQTPNHLYMVLDYCNGGVLLQHIQRESRFSEL
|. |  ||||||| |.|. .  |.|..|.| |||   |.      . ||  .|    |.|| ..||  |||...|. |. |.||| |  |||.  ||.| 
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRRFKEE

TARFFVCEIILAIEYLHSQNILYRDLKPENILISSDGHIKLTDFGLSKEHVADFDVTKSFCGSPAYLSPEMLLGKGFSKASDIYGIGCVLYEMLTGQPPF
 |||  .|||.|  .||...| ||||| .|.|. ..||||..|||..||.. . | |..||| | |..|| | ..  .|. |    |  .|||. ||.||
HARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDTTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQSPF

FHEDIKQLYSGIKSEDPQLPKYLSNSAKTLIIQLLKKNPKERLGY-----NSIQQIKSHEFF
  ||  .|   |  ..|  |..||  |. .. ....|||..|||      .  | |..| ||
HGEDEDELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF
Kinase 3020.AA PKA 573-828 41 1.7e-97 330.23 In-house 1-263 (263) Show / Hide 
Range on Protein: 573-828
Range on HMM: 1-263/263
Sequence Identity: 41% (110 aa)

FTILGALGKGSFGRVFLVQQNSTEELFAMKMLKKVSLIMKRQLKYAVTECNILKRCKNPFVVG-LHYAFQTPNHLYMVLDYCNGGVLLQHIQRESRFSEL
| |.  ||.|||||| |... .... .|||||||   .  .|     .| |||. .|.||.|  . . ||....||||..|..|| .  ..... |||. 
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

TARFFVC-EIILAIEYLHSQNILYRDLKPENILISSDGHIKLTDFGLSKEHVADFDVTKSFCGSPAYLSPEMLLGK-GFSKASDIYGIGCVLYEMLTGQP
.|.| .. .|.||.|||||||| ||||||||||| ..||||.|||| .|. .    .|.. || | || ||....| |  |. |    |.. ||||.| |
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKKVDD---RTWTLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYP

PFFHE--DIKQLYSGIKSEDPQLPKYLSNSA---KTLIIQLLKKNPKERLGYNSI--QQIKSHEFF
||. .  |  |.|  | . . . | .... |   | || .|| .....|.|  .   ..|| |..|
PFYDHNRDPMQIYEKICNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase 3020.AA RSK 573-828 34 2.4e-96 326.37 In-house 1-271 (271) Show / Hide 
Range on Protein: 573-828
Range on HMM: 1-271/271
Sequence Identity: 34% (95 aa)

FTILGALGKGSFGRVFLVQQN---STEELFAMKMLKKVSLIMKRQLKYAVTECNILKRCKNPFVVGLHYAFQTPNHLYMVLDYCNGGVLLQHIQRESRFS
. ..  .|.|||. |....      |. ..||| .|| ..  | .  .. .| .||     ||.| |||.||.  ..||..| . || |. .....  ||
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDR-VCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFS

ELTARFFVCEIILAIEYLHSQNILYRDLKPENILISSD----GHIKLTDFGLSKEHVADFDVTKSFCGSPAYLSPEMLLGKGFSKASDIYGIGCVLYEML
|  ..|  .|| || |||||| | .|||||||||....    ||||..|||..|.  ..   ...||.. .|. ||.|  .|...|.|..  | ..||||
EREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEVLKRQGHDQACDWWSFGVLMYEML

TGQPPFFHEDIKQLYSGIKSEDPQL-------PKYLSNSAKTLIIQLLKKNPKERLGY--NSIQQIKSHEFF
|| .|| . . . .   |.  .  .       . ..|  || |. ..|. .|  |||   | ..|||.| .|
TGCTPFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase 3020.AA p70 573-828 37 9.8e-96 324.36 In-house 1-299 (299) Show / Hide 
Range on Protein: 573-828
Range on HMM: 1-299/299
Sequence Identity: 37% (113 aa)

FTILGALGKGSFGRVFLVQQNS---TEELFAMKMLKKVSLIM-------KR-------------------QLKYAVTECNILKRCKNPFVVGLHYAFQTP
|  |  |||| .| ||.|       |  ..||| |.| . .        .|                   .|  .  | |||   | ||.. ||||||| 
FELLKVLGKGGYGKVFQVRKVTGEDTGKIYAMKVLRKAKIVRNQKDTAHTREDEDKNDGNNNDNDDGLSKRLERTFAERNILEEVKHPFICDLHYAFQTN

NHLYMVLDYCNGGVLLQHIQRESRFSELTARFFVCEIILAIEYLHSQNILYRDLKPENILISSDGHIKLTDFGLSKEHVADFDV----------TKSFCG
  || .|.|  || |  |  |.. . | ||.|.  |||.|.|.||.. | ||||||||.. .. ||..||||||.||.. |  |          | .|||
GKLYLILEYLHGGELFMHLERHGIWMEDTACFYLSEIICALEHLHQHGIIYRDLKPENCMLNQQGHVVLTDFGLCKESIHDGAVDEEDPENVNATHTFCG

SPAYLSPEMLLGKGFSKASDIYGIGCVLYEMLTGQPPFFHEDIKQLYSGIKSED--PQLPKYLSNSAKTLIIQLLKKNPKERLG--YNSIQQIKSHEFF
 . |  ||.|...|...| | .  || .| ||||.|||  |  |.    |      ..|| ||..... || .|||..|..|.|   . ...|..|.||
TIEYMAPEILMRCGHNHAVDWWSLGCLMYDMLTGGPPFTGENRKKTIDKILKGKQGLKLPPYLTHEMRDLIKKLLKRHPTQRWGAGPEDAADIQEHPFF
Kinase 3020.AA Pkinase 573-828 31 3.4e-94 324.02 Pfam 1-293 (293) Show / Hide 
Range on Protein: 573-828
Range on HMM: 1-293/293
Sequence Identity: 31% (94 aa)

FTILGALGKGSFGRVFLVQQNSTEELFAMKMLKKVSLIMKRQLKYAVT--ECNILKRCKNPFVVGLHYAFQTPNHLYMVLDYCNGG----VLLQHIQ--R
..|.. .|.||||.|.. .  .|....|.| .||.  . . ......   |. |.||.. |..| |...|....|.|||..||.||     |  .|.  |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

ESRF--SELTARFFVCEIILAIEYLHSQNILYRDLKPENILISSDGHI----KLTDFGLSKEH-VADFDVTKSFCGSPAYLSPEMLL-GKGFSKASDIYG
. .|  || ...|.. .|. ..||.||..|..||||||||||...|||    |..||||.| .       ...|||.| |..|| .. |.. ....|...
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

IGCVLYEMLTGQPPFFHE------DIKQLYSGIKSEDPQLPKYLS---------------------NSAKTLIIQLLKKNPKERLGYNSIQQIKSHEFF
.||.|||||.|.||| ..      | .|..  |.. ..  . . .                      ..| .|  .|.|.||.|..   ..||. |..|
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT---AEQILQHPWF
Kinase 3020.AA TyrKc 573-828 22 1.4e-16 45.48 SMART 1-280 (280) Show / Hide 
Range on Protein: 573-828
Range on HMM: 1-280/280
Sequence Identity: 22% (65 aa)

FTILGALGKGSFGRVFLVQQNSTEELFAMKMLKKVSLIMKRQLKYAVTECNILKRC--KNPFVVGLHYAFQTP-------NHLYMVLDYCNGGVLLQHIQ
 | .  || | ||.|.. . .   .  | ||||. .      ..    | .|...   ..| .| |. .  ..         |..|. |. .| |.....
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

RESR-FSELTARFFVCEIILAIEYLHSQNILYRDLKPENILISSDGHIKLTDFGLSKEHVAD-------FDVTKSF--CG---SP-AYLSPEMLLGKGFS
.  . ..  .   |   |    |||||.|.  |||   |.|.......| .|||||...  |          .|.   .|    |   ..|| .  . |.
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

KASDIYGIGCVLYEMLT-GQPPFFH-----EDIKQLYSGIKSE-DPQLPKY--------LSNSAKTLIIQLLKKNPKERLGYNSIQQIKSHEFF
 .||..  | ...|..| ||.|         . ....  .|.   .  |..         .    ... |  . .|..|   . |     ||.|
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-----HECF
Kinase 3020.AA Pkinase_Tyr 573-792 24 2.5e-13 45.75 Pfam 1-237 (270) Show / Hide 
Range on Protein: 573-792
Range on HMM: 1-237/270
Sequence Identity: 24% (58 aa)

FTILGALGKGSFGRVFLVQQN----STEELFAMKMLKKVSLIMKRQ--LKYAVTECNILKRC-KNPFVVGLHYAFQ-TPNH--LYMVLDYCNGGVLLQHI
 |..  ||.|.||.|..   .    .|.   | ||||     |..|  ..    | .|.|   ..| .| |. .      .  .|.|. |. .| || . 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE--GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

QR----ESRFSELTARFFVCEIILAIEYLHSQNILYRDLKPENILISSDGHIKLTDFGLSKEH-VADFD-VTKSFCGSP-AYLSPEMLLGKGFSKASDIY
..    . ...  .   .  .|  . |||.|.|.  |||   |.|.......| .||||.. .   |   .... .  |   ..|| .  . |. .||..
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVW

GIGCVLYEMLT-GQPP-FFHEDIKQLYSGIKSEDPQLPK
  | ...|..| |. | .   .  ..|  |. .  ..|.
SFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPC