Gene 3983 (Tetrahymena)

3983

Species: Tetrahymena
Alias: 142.m00080, TTHERM_00825190, 646, PreTt03983, 3683.m00013, 3983
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: AGC
Family: Akt

Sequence

Name Sequence Type Origin Length Description Download
3983.AA Protein None 513 None Fasta, JSON
3983.NA RNA None 1542 None Fasta, JSON
3983.kin_dom Protein Kinase Domain None 258 None Fasta, JSON

Protein domain

Protein domains of 3983.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PH_Akt_basal 3983.AA PH_Akt_basal 35-118 47 4.2e-51 176.08 In-house 1-90 (90) Show / Hide 
Range on Protein: 35-118
Range on HMM: 1-90/90
Sequence Identity: 47% (43 aa)

IYKFNDYKRRQERNLLITTHAIYNLN---GSTIKRKIDMSKIKALTVS-TLGTEFVIHVPDEYDYRYA--STDKWDRIIMSIVKAYNLRC
..|.|.|..||||||.||....||..   ...||..|...||.....| | |.||||||||||||||.  |.|....|||....||. .|
VIKYNRYNKRQERNLMITSKHVYNCKPNKKHSIKWCIPLQKIYGIHQSTTEGCEFVIHVPDEYDYRYCMHSEDQRQCIIMVLCRAYCCYC
Kinase 3983.AA Akt 197-454 55 3.2e-193 623.11 In-house 1-264 (264) Show / Hide 
Range on Protein: 197-454
Range on HMM: 1-264/264
Sequence Identity: 55% (146 aa)

FNVLKVLGAGAFGTVLLVEEKQKGEWF-AMKVIKKDVILEKGQFEHTKTEKMILEHVNHPYLVNLVYAFQDPSRLFFVMQFMKGGELFQHLRIARRFEEK
|..|||||.|.|| |.||..|. ..|. ||||.|||.|..|.|.||||||..||.|.|||..|||.|.||.. .|.|||....|||||.||. .||| |.
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

RAKFYAAQLSLGLGHLHSKNIVYRD-LKLENILMDDFGNVYVSDFGMAK-M-IKQNELAMTFCGTPEYLSPEVILGHGCDQTTDWWS-LGILTYEMMFGL
||.||.|...|...|||||||.||| ||.||||||  |.... |||..| . ||... ..|||||||||.||...|.|.....|||. ||...||||.|.
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGR

PPFYNKQQATMFKLIKEAELKFPEKPVVSAEAKDFISKCLNRDRRLRLG-AKNDLQEIMQHPWF
|||||... .|||.||....|||.|...| |.||.||..||.|. .||| ..||.|||..||||
PPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase 3983.AA AGC 197-454 32 8e-178 464.5 In-house 1-395 (395) Show / Hide 
Range on Protein: 197-454
Range on HMM: 1-395/395
Sequence Identity: 32% (129 aa)

FNVLKVLGAGAFGTVLLVEEK------QKGEWFAMKVIKKDV-ILEKG--QFEHTKTE------------KMILEHVN----------HPYLVN-LVYAF
|..|||.| |.||.| ||..|      . |. .||||.||.. |..|   . |||.||            . |||..|          ||..|. | |.|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QDPSR--LFFVMQFMK---------GG-ELFQHLR---IARRFEEKRAKFYAAQ-------LSLGLGHLHS-KNIVYRD-LKLENILMDDFGNVYVSDFG
||...  |.|||..|.         || |||.||.     .||.|.||.||||.       . |.| .||| ..|..|| ||.||||.|. |..  .|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

MAKMIK---------------------------------------------------QNELAMTFCG--TPEYLSPEVILGHGCDQTTDWWS--LGILTY
..|...                                                   ..... ||||  ||||..||..    .... ||||  ||.| |
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMMFGLPPFYNK----------QQATMFKLIK------EAELKFP--------EKPVVSAEAKDFISKCLNRDRRLRLGAKND------LQEIMQHPWF
||..|.||||..          ... ||..|.      . ..|||        | . .| ||||.|.|.|..|.. |||....       .||..||||
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 3983.AA SGK 197-454 42 4.4e-134 416.66 In-house 1-283 (283) Show / Hide 
Range on Protein: 197-454
Range on HMM: 1-283/283
Sequence Identity: 42% (122 aa)

FNVLKVLGAGAFGTVLLVEEKQK------------------GEWFAMKVIKKDVIL-------EKGQFEHTKTEK-MILEHVNHPYLVNLVYAFQDPSRL
|  |||.| | || |..|. |..                  .  .||||..|. |.        | .  |...|.  ||  ..|| .||| |||| .  |
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

FFVMQFMKGGELFQHLRIARRFEEKRAKFYAAQLSLGLGHLHSKNIVYRDLKLENILMDDFGNVYVSDFGMAK-MIKQNELAMTFCGTPEYLSPEVILGH
.||| .. |||.| ||. ...| | ||.||||.. . |..|||..|.||||| |||| |. |..   ||| .|  ||.|.   ||||||||| |||....
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQ

GCDQTTDWWSLGILTYEMMFGLPPFYNKQQATMFKLIKEAELKFPEKPVVSAEAKDFISKCLNRDRRLRLGAKNDLQEIMQHPWF
..| | |||.||.. ||||.||||||..  ..|.  |   .|..|  | .|..|.| |   |..|.. |||.|.|  || .||.|
PHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIP--PQMSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF
Kinase 3983.AA AktR 197-454 48 6.8e-133 447.79 In-house 1-268 (268) Show / Hide 
Range on Protein: 197-454
Range on HMM: 1-268/268
Sequence Identity: 48% (129 aa)

FNVLKVLGAGAFGTVLLVEEK-QKGEWFAMKVIKKDVILEKGQFEHTKTEKMILE-HVNHPYLVNLVYAFQDPSRLFFVMQFMKGGELFQHLRIARRFEE
| |.|.|| ||||.| ||..| . .. .|||.|||  | |. |..|| ||. |.| ..||| .|.|.|.||. . |||.|....||||||||.  ..|.|
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

KRAKFYAAQLSLGLGHLHSK-NIVYRDLKLENILMDDFGNVYVSDFGMAK---MIKQNELAMTFCGTPEYLSPEVILG-HGCDQTTDWWSLGILTYEMMF
..|.||.||  |.| .||.. ||.||||| ||||.|  |.|. .|||..|   |.  .|.| .|||||||..||.|.   | . . |||..||. |||..
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT

GLPPFYNKQQATMFKLIKEAE-LKFPEKPVVSAEAKDFIS-KCLNRDRRLRLG-AKNDLQEIMQHPWF
|.||||.|.| .||..||. . .|||. . .| ..||.|  |.|... . ||| ..|. .||  ||||
GCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase 3983.AA RSK 200-454 42 1.7e-110 373.37 In-house 1-278 (278) Show / Hide 
Range on Protein: 200-454
Range on HMM: 1-278/278
Sequence Identity: 42% (118 aa)

LKVLGAGAFGTVLLVEEK---QKGEWFAMKVIKKDVILEKGQ-FEHTKTEKMILEHVN-HPYLVNLVYAFQDPSRLFFVMQFMKGGELFQHLRIARR---
||||| |..| | |. ..   ..|  .||||.|| .|  .    .||.||  |||... || .|.| ||||... |. .|....||||| ||.  ..   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FEEKRAKFYAAQLSLGLGHLHSKNIVYRDLKLENILMDD---FGNVYVSDFGMAKM--IKQNELAMTFCGTPEYLSPEVIL----GHGCDQTTDWWSLGI
| |..|.||.|...| . |||.. |..||||.|||| ||    | . ..||| .|   ...|...||||.| ||. ||..     . | |.  ||||||.
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LTYEMMFGLPPFYN---KQQATMFKLIKEAE--LKFPEKPVVSAEAKDFISKCLNRDRRLRLGA-KNDLQEIMQHPWF
| ||| .| |||..   ....  .| |....  |..|. . .|.||||.|.|.| ||   |||. ..|..|| |||||
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 3983.AA S_TKc 197-454 38 3.1e-106 360.14 SMART 1-231 (231) Show / Hide 
Range on Protein: 197-454
Range on HMM: 1-231/231
Sequence Identity: 38% (104 aa)

FNVLKVLGAGAFGTVLLVEEKQKGEWFAMKVIKKDVILEKGQFEHTKTEKMILEHVNHPYLVNLVYAFQDPSRLFFVMQFMKG--GELFQHLRIARR---
. .|...| ||||.| .. .|  |. .|.|.||          ||.. |  ||.. .||..|.| ..||| ..|..|| .. |  |.||....  .|   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FEEKRAKFYAAQLSLGLGHLHSKNIVYRDLKLENILMDDFGNVYVSDFGMAKMIKQNELAMTFCGTPEYLSPEVILGHGCDQ-TTDWWSLGILTYEM
   | | .|.||..|. ..| ..||..|..|||| ||||.|.  .. ..|||.|. .      .||||||.|..|||.   | .    ||||.|.. |||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

MFGLPPFYNKQQATMFKLIKEAELKFPEKPVVSAEAKDFISKCLNRDRRLRLGAKNDLQ---EIMQHPWF
. | |||.  |...|||.|.            | ||||||.|||..| . |..|   ||   .|..||||
LCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 3983.AA PKA 197-454 43 1e-103 350.9 In-house 1-263 (263) Show / Hide 
Range on Protein: 197-454
Range on HMM: 1-263/263
Sequence Identity: 43% (116 aa)

FNVLKVLGAGAFGTVLLVEEKQKGEWFAMKVIKKDVILEKGQFEHTKTEKMILEHVNHPYLVN-LVYAFQDPSRLFFVMQFMKGGELFQHLRIARRFEEK
|. ...|| | ||.| |. .|. |. .|||..||. |    | ||...|| ||  ..||..|. . . |||.. |..|| .  |||.| .||  .|| ..
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

RAKFYAA-QLSLGLGHLHSKNIVYRDLKLENILMDDFGNVYVSDFGMAKMIKQNELAMTFCGTPEYLSPEVILGH-GCDQTTDWWSLGILTYEMMFGLPP
 |||||| |  | |  |||.||.||||| ||||.|. |.. . ||| || ..     .| ||||||| ||.|... |     |||.|||| |||..| ||
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKKVDD--RTWTLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYPP

FYNK--QQATMFKLIKEAELKFPEKPVVSAEA---KDFISKCLNRDRRLRLGA-KNDLQEIMQHPWF
||..  ... ... | ....|||.   ..  |   ||.|.| |..|.  |.|  ||. . |  |.||
FYDHNRDPMQIYEKICNGKIKFPRH--FDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase 3983.AA PKC 197-454 41 1.8e-98 319.82 In-house 1-262 (262) Show / Hide 
Range on Protein: 197-454
Range on HMM: 1-262/262
Sequence Identity: 41% (109 aa)

FNVLKVLGAGAFGTVLLVEEKQKGEWFAMKVIKKDVILEKGQFEHTKTEKMILEH-VNHPYLVNLVYAFQDPSRLFFVMQFMKGGELFQHLRIARRFEEK
|| ||||| | || |.|.| |.. | .|.||.|||||..    | | ||| .|.   .||.|..|   || ..|||||| . .|| |  |   .|||.|.
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRRFKEE

RAKFYAAQLSLGLGHLHSKNIVYRDLKLENILMDDFGNVYVSDFGMAKM-IKQNELAMTFCGTPEYLSPEVILGHGCDQTTDWWSLGILTYEMMFGLPPF
.|.||||  ...|  ||.|.|.||||||.|.|.|  | .   ||||.|  . . . . ||||||.|..||.. .    .  |||..|.| |||| | .||
HARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDTTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQSPF

YNKQQATMFKLIKEAELKFPEKPVVSAEAKDFISKCLNRDRRLRLGAKNDL----QEIMQHPWF
  .   ..|. | . .  .|     | ||.. ... ....   |||.. .     |.|..|| |
HGEDEDELFQSIMHDNPHYPR--WLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF
Kinase 3983.AA Pkinase 197-454 33 4.2e-93 320.41 Pfam 1-293 (293) Show / Hide 
Range on Protein: 197-454
Range on HMM: 1-293/293
Sequence Identity: 33% (99 aa)

FNVLKVLGAGAFGTVLLVEEKQKGEWFAMKVIKKDVILEKGQFEHTK-TEKMILEHVNHPYLVNLVYAFQDPSRLFFVMQFMKGG----ELFQHLR--IA
. .....|.|.||.| .  .|  |. .|.|.|||. . .. . .|.. .|  |. ..|||. | | ..|.|.... .|| .. ||    .|| ...    
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

RRF--EEKRAKFYAAQLSLGLGHLHSKNIVYRDLKLENILMDDFGNV----YVSDFGMAKM--IKQNELAMTFCGTPEYLSPEVIL-GHGCDQTTDWWSL
..|  .|. .|||. |.  || ..||..|..||||.||||.|. |..     ..||| ||   .  |. ..||||||.|..||||. | . ..  |.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GILTYEMMFGLPPFYNK------QQATMFKLIKEAELKFPEKPVVS-------------------AEAKDFISKCLNRDRRLRLGAKNDLQEIMQHPWF
|.. |||..| |||...       |  |...|....|.|..    |                    |.||||..||..|   |..     ..|.|||||
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT----AEQILQHPWF
Kinase 3983.AA RSK 197-454 39 5.4e-92 311.94 In-house 1-271 (271) Show / Hide 
Range on Protein: 197-454
Range on HMM: 1-271/271
Sequence Identity: 39% (107 aa)

FNVLKVLGAGAFG---TVLLVEEKQKGEWFAMKVIKKDVILEKGQFEHTKTEKMILEHVNHPYLVNLVYAFQDPSRLFFVMQFMKGGELFQHLRIARRFE
.......| |.|.    .  .. |. .  .|||.|||...  | .   ...|  ||....||. | | |.|||   .. .| ||.||.|| .|   . | 
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDR-VCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFS

EKRAKFYAAQLSLGLGHLHSKNIVYRDLKLENILMDDF----GNVYVSDFGMAK-MIKQNELAMTFCGTPEYLSPEVILGHGCDQTTDWWSLGILTYEMM
|. .|||.| . | . .|||. ||.|||| |||| ||     | . . ||| || .. .|...||||.| .|. |||.   | ||  ||||.|.| ||| 
EREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEVLKRQGHDQACDWWSFGVLMYEML

FGLPPFYNKQQATMFKLIKEAELKF-----PEKPVVSAEAKDFISKCLNRDRRLRLGA-KNDLQEIMQHPWF
 | .||.||   |.. .|. . |       . .  .|.|||| ... | ||   ||||  |. ..| |||||
TGCTPFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase 3983.AA Delta 197-454 42 1.3e-88 300.75 In-house 1-259 (259) Show / Hide 
Range on Protein: 197-454
Range on HMM: 1-259/259
Sequence Identity: 42% (111 aa)

FNVLKVLGAGAFGTVLLVEEKQKGEWFAMKVIKKDVILEKGQFEHTKTEKMILE-HVNHPYLVNLVYAFQDPSRLFFVMQFMKGGELFQHLRIARRFEEK
|...|||| |.|| |.|.| |.| ...|.| .||||.||    | |  |. .|   ..||.|  |. .||  . ||||| .. ||.|  |.   .||.||
FHFHKVLGKGSFGKVMLAELKGKNKYYAIKCLKKDVVLEDDDVECTMVERRVLALAWEHPFLCHLFCTFQTKEHLFFVMEYLNGGDLMYHIQQCHRFDEK

RAKFYAAQLSLGLGHLHSKNIVYRDLKLENILMDDFGNVYVSDFGMAKM-IKQNELAMTFCGTPEYLSPEVILGHGCDQTTDWWSLGILTYEMMFGLPPF
||.|||. . .||  ||.|.|.||||||.|.|.|  | . . ||||.|  . ... | ||||||.|..||.| |.   .  |||| |.| |||. |  ||
RARFYACEIICGLQFLHKKGIIYRDLKLDNVLLDCDGHIKIADFGMCKENMYGEKKASTFCGTPDYIAPEIIKGQKYNHSVDWWSFGVLMYEMLIGQSPF

YNKQQATMFKLIKEAELKFPEKPVVSAEAKDFISKCLNRDRRLRLGA-KNDLQEIMQHPWF
  ..   .|. | . .  .|    ...|||| ..| ..||   |||  .    .| ||..|
HGEDEDELFWSICNDRPWYPR--WITKEAKDCLKKLFERDPEKRLGVQYCPKGDIRQHCFF
Kinase 3983.AA Ciliate-E2-Unclassified 197-454 29 4.1e-88 299.05 In-house 1-352 (352) Show / Hide 
Range on Protein: 197-454
Range on HMM: 1-352/352
Sequence Identity: 29% (105 aa)

FNVLKVLGAGAFGTVLLVEEKQKGEWFAMKVIKKDVILEKGQFEH---------TKTEKM-------------ILEHVNHPYLVNLVYAFQDPSRLFFVM
....|..| |.||.| ....|.... .||| .||  |  . | ..         .  .|.             || . .||..|...|.|||   ...||
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

QFMKGGELFQHLRI-----------------ARRFEEKRAK-----FYAAQLSLGLGHLHSKN-IVYRDLKLENILMDDFG---NVYVSDFGMAKMIKQN
....||.|.|....                  ..|.|. ||     ||.||. .|| .||.|| |..||.|.||||.|. |   .. ..||| .| ..||
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

----------------ELAMTFCGTPEYL----SPEVILGHGCDQT----TDWWSLGILTYEMMFGLPPFYNKQQAT----------------MFKLIKE
                ... ||||||.|.    .|||. |.. |..     |.||||.. |||.|| .||| ...                  ... ||.
NNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQ

AELKFPEKP------VVSAEAKDFIS----KCLNRDRRLRLGAKNDLQEIMQHPWF
 ...||. |       .| ||||||.    |.|. .   |.    ....|..||||
KNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRI----TFEQILNHPWF
Kinase 3983.AA TyrKc 197-448 22 1.8e-16 43.52 SMART 1-280 (280) Show / Hide 
Range on Protein: 197-448
Range on HMM: 1-280/280
Sequence Identity: 22% (64 aa)

FNVLKVLGAGAFGTVLLVEEKQKGEWFAMKVIKKDVILEKGQFEHTKTEKMILEHV--NHPYLVNLVYAFQDP-------SRLFFVMQFMKGGELFQHLR
   .|.|| ||||.| . . |   .  | |..|.|    .  | .   |  |. ..  .|| .|.|. .  ..         |. || .|..| | ..||
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMR---EARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

IARR-FEEKRAKFYAAQLSLGLGHLHSKNIVYRDLKLENILMDDFGNVYVSDFGMAKMIKQN--------ELAMTF--CGTP----EYLSPEVILGHGCD
  |. .  |    .. | . |  .|||||.. |||   |.| .. . | .||||... |.             ..   .|        ..||.|  . . 
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

QTTDWWSLGILTYEMM-FGLPPFYN-----KQQATMFKLIKEAELKFPEKPV-------VSAEAKDFISKCLNRDRRLRLGAKNDLQEI
  .| || |.. .|.. .| .| ..     .  . .....|. .   . . .        ..|  . ...| ..|   |   ..  ...
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 3983.AA S_TK_X 455-512 26 4.4e-14 54.04 SMART 1-79 (79) Show / Hide 
Range on Protein: 455-512
Range on HMM: 1-79/79
Sequence Identity: 26% (21 aa)

KDIDWNALLN--KQIEPPFKPNVS----DERWLDNFDKDFTSMKPVLDEQGRNVSKNGNDP---------------FDN
..|||..|.|  |.|||||||...    ... . |||..||...|.|. . ...|.. . .               ...
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase 3983.AA Pkinase_Tyr 197-408 24 4.9e-14 48.17 Pfam 1-231 (270) Show / Hide 
Range on Protein: 197-408
Range on HMM: 1-231/270
Sequence Identity: 24% (60 aa)

FNVLKVLGAGAFGTVLLVEEKQKGEWF----------AMKVIKKDVILE---KGQFEHTKTEKMILEHV-NHPYLVNLVYAFQ---DPSRLFFVMQFMKG
   .|.||.||||.|       ||.|.          | |..| .   |   .  | .   |  |. .  .|| .|.|. .     .|.... || .|..
ITFGKKLGEGAFGEVY------KGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMR---EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPH

GELFQHLRI----ARRFEEKRAKFYAAQLSLGLGHLHSKNIVYRDLKLENILMDDFGNVYVSDFGMAKMI-------KQNELAMTFCGTPEYLSPEVILG
| |  .||      ...  |.   ...| . |. .|.|||.. |||   |.| .. . | ..|||.|. |       .. . .. .      ..||.|  
GDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGK-LP--IKWMAPECINY

HGCDQTTDWWSLGILTYEMMF-GLPP-FYNKQQATMFKLI-KE
  .   .| || |.| .|..  |  | ...   . ....| ..
GKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYED
Kinase 3983.AA Pkinase_C 474-513 29 3.5e-05 21.56 Pfam 1-40 (46) Show / Hide 
Range on Protein: 474-513
Range on HMM: 1-40/46
Sequence Identity: 29% (12 aa)

NVSDERWLDNFDKDFTSMKPVLD-EQGRNVSKNGNDPFDNF
.|....   |||..||...|..    .|  |.. ..|| .|
QVKSPTDTSNFDPEFTDEPPMDTPPDWR-MSSGDQEPFRGF