Gene 3866 (Tetrahymena)

3866

Species: Tetrahymena
Alias: 51.m00232, TTHERM_00445970, 3866, PreTt03866, 3704.m00087, 476
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: AGC
Family: AktR

Sequence

Name Sequence Type Origin Length Description Download
3866.AA Protein None 416 None Fasta, JSON
3866.kin_dom Protein Kinase Domain None 270 None Fasta, JSON
3866.NA RNA None 1251 None Fasta, JSON

Protein domain

Protein domains of 3866.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 3866.AA AGC 79-348 32 1e-153 400.73 In-house 1-395 (395) Show / Hide 
Range on Protein: 79-348
Range on HMM: 1-395/395
Sequence Identity: 32% (133 aa)

YQKLANLGSGAYGEVSLVRKKK-----D-GKLYAMKVVKKEK--VAINRKMVEATLLE------------QKILKKSR----------HPFIVK-LSQSF
.. |  .| |..|.| |||||.     | ||.|||||.||..  | ....||| |. |             .||.| .          |||||| |  ||
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTEGK--LYIIMEYMA---------NG-DLYSVLQ---KVKRFDENTARFIFAENQMLSSCFEISYEHVILGLQYLHEEQNTMYRD-LKPENILIGEDCH
|.. .  ||..||||           | .|.. ||   | .||||..|||..|| . .  |.     ...|.|.|||....  .|| |||||||. || |
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAE-MQKI-CG-----CIVLALEYLHSHMGIIHRDYLKPENILLDEDGH

IKLSDFGLAKQFVNKE--------------------------------------------------DKENAFLG--TPQYLAPEIVLQKPYDKNIDLWT-
|||.||||.|...|..                                                  |. . | |  ||.|.||||.    |.|  | |. 
IKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSF

-LGILLFELLSGKPPFGSG-----------KNLMKDIII-------NKPIFP----------SYFSAQAVDLIKKLLQNIGNKRLGSNN-------FAEL
 ||.|..|.|.|.||| .            .. | . |.       .|. ||          ..|| .|.|||||||.   .||||...       . |.
GLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEI

KSHPFF
|.||.|
KNHPWF
Kinase 3866.AA AktR 79-348 44 1.9e-151 509.44 In-house 1-268 (268) Show / Hide 
Range on Protein: 79-348
Range on HMM: 1-268/268
Sequence Identity: 44% (125 aa)

YQKLANLGSGAYGEVSLVRKK-KDGKLYAMKVVKKEKVAINRKMVEATLLEQKILK-KSRHPFIVKLSQSFQTEGKLYIIMEYMANGDLYSVLQKVKRFD
.. ...||.||.|.| ||.|| ...|.||||..|| |  |.|.. ..|..|..|.. ...||||||| ..|||. ||..||||...|.|...|.| |.|.
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKK-KKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFS

ENTARFIFAENQMLSSCFEISYEHVILGLQYLHEEQNTMYRDLKPENILIGEDCHIKLSDFGLAK-QFVN-KEDKENAFLGTPQYLAPEIVLQ-KPYDKN
|..|||.||.              ..|.|.|||...| .||||||||||..||.|.|..||||.| ||.. ...|.. |.|||.|.|||.... |...|.
EEQARFYFAQ--------------ILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKS

IDLWTLGILLFELLSGKPPFGSGK----NLMKDIII-NKPIFPSYFSAQAVDLIK-KLLQNIGNKRLG--SNNFAELKSHPFF
.|.|..||...|...| ||| ...    .....|.  ||. .||||| |. |||. |||..  |||||  .|.. |.||||.|
VDWWAFGIFIYEMVTGCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase 3866.AA SGK 79-348 39 1.3e-100 311.4 In-house 1-283 (283) Show / Hide 
Range on Protein: 79-348
Range on HMM: 1-283/283
Sequence Identity: 39% (117 aa)

YQKLANLGSGAYGEVSLVRKKKD------------------GKLYAMKVVKKEKVA------INRKMVEATLLEQ-KILKKSRHPFIVKLSQSFQTEGKL
 . |  .| | .|.| .|..|.|                  .|.||||| .|. .       ...| .  .. |  .|||. .|||||.|  .|||. ||
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

YIIMEYMANGDLYSVLQKVKRFDENTARFIFAENQMLSSCFEISYEHVILGLQYLHEEQNTMYRDLKPENILIGEDCHIKLSDFGLAKQFVNKEDKENAF
|  |.|.  |.. . ||. |.| |  |||  ||              ... | ||| .|.. |||||||||| . . |..| ||||.|. . ..|.   |
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAE--------------IVCALEYLH-SQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTF

LGTPQYLAPEIVLQKPYDKNIDLWTLGILLFELLSGKPPFGSG-KNLMKDIIINKPI-FPSYFSAQAVDLIKKLLQNIGNKRLGSN-NFAELKSHPFF
 ||| |||||. . .|.|.  | | ||..|.|...|.||| |  |..| | |||.|. .| ..|..| |||. |||    ||||..  |.| |.||||
CGTPEYLAPEVLRKQPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF
Kinase 3866.AA RSK 82-348 40 3e-94 319.42 In-house 1-278 (278) Show / Hide 
Range on Protein: 82-348
Range on HMM: 1-278/278
Sequence Identity: 40% (119 aa)

LANLGSGAYGEVSLVRKK---KDGKLYAMKVVKKEKVAINRKMVEATLLEQKILKKSR-HPFIVKLSQSFQTEGKLYIIMEYMANGDLYSVLQKVKR---
|  || |.||.|.|.||.   . |..|||||.|| |.. . | .. |. |..||. .. |||||.|  .||||||||.||||.  |.|.  ||| |.   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FDENTARFIFAENQMLSSCFEISYEHVILGLQYLHEEQNTMYRDLKPENILIGE---DCHIKLSDFGLAKQFVNK-EDKENAFLGTPQYLAPEIVL---Q
|.|..|.|..||              ..| ...||. .   .|||||||||  .   . ||||.|||..|||... . . . | .| .|.|||..    |
FSEDEACFYMAE--------------IVLAVEHLHQQG-IIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQ

KP-YDKNIDLWTLGILLFELLSGKPPFGS-----GKNLMKDIIINK--PIFP--SYFSAQAVDLIKKLLQNIGNKRLG--SNNFAELKSHPFF
.  .||. |.|.||.|..|.|.|.||| .      | .|| |  .|  . .|  .| |. | |||.|.|.   .||||   .  .|.|.||.|
QGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 3866.AA Akt 85-348 42 1.1e-92 296.63 In-house 7-264 (264) Show / Hide 
Range on Protein: 85-348
Range on HMM: 7-264/264
Sequence Identity: 42% (118 aa)

LGSGAYGEVSLVRKKKDGKLY-AMKVVKKEKVAINRKMVEATLLEQKILKKSRHPFIVKLSQSFQTEGKLYIIMEYMANGDLYSVLQKVKRFDENTARFI
||.|..| | ||.||...|.| |||| ||..  |... || |. | .||.. .|||||.|  ||||. |||..|.|.  |.|.. ||. .||.|..||| 
LGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYI-IQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSEDRARFY

FAENQMLSSCFEISYEHVILGLQYLHEEQNTMYRD-LKPENILIGEDCHIKLSDFGLAKQFVNKE-DKENAFLGTPQYLAPEIVLQKPYDKNIDLWT-LG
 ||              .||....||. .| .||| |||||||. .| ||.| ||||.|. . |. || . | ||| |||||| ... ..|  | |. ||
CAE--------------IILAIEHLHS-KNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLG

ILLFELLSGKPPFGSGKN---LMKDIIINKPIFP--SYFSAQAVDLIKKLLQNIGNKRLG--SNNFAELKSHPFF
....|.. | ||| . ..   ..| |  ..  ||  ...| .. |||..||.   .||||  .|   |.|.||.|
CVMYEMMCGRPPFYN-QDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase 3866.AA S_TKc 79-348 35 1.3e-87 298.3 SMART 1-231 (231) Show / Hide 
Range on Protein: 79-348
Range on HMM: 1-231/231
Sequence Identity: 35% (100 aa)

YQKLANLGSGAYGEVSLVRKKKDGKLYAMKVVKKEKVAINRKMVEATLLEQKILKKSRHPFIVKLSQSFQTEGKLYIIMEYMAN--GDLYSVLQKVKR--
|..|  .|.||.|.| ..|.||.|...|.|..|           | .. | .|||| .||.||||  .||. ..||..|||. .  |||.....| .|  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----FDENTARFIFAENQMLSSCFEISYEHVILGLQYLHEEQNTMYRDLKPENILIGEDCHIKLSDFGLAKQFVNKEDKENAFLGTPQYLAPEIVLQKPY
    |.| .|||....              ....|.|.|.  . ..|||||||||. |  |||..|||||.|.       . | ||| |.|||..   .|
LRFPFPE-HARFYMYQ--------------ICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GY

DK-NIDLWTLGILLFELLSGKPPFGSGKNLMKDIIINKPIFPSYFSAQAVDLIKKLLQNIGNKRLGSNNFAE----LKSHPFF
.|  .| | .|..|.|.|.|.|||    ..| ..|          | .| |.|.|.||   .||..     .     |.||.|
GKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 3866.AA Ciliate-E2b 78-348 32 5.9e-83 251.91 In-house 2-272 (272) Show / Hide 
Range on Protein: 78-348
Range on HMM: 2-272/272
Sequence Identity: 32% (93 aa)

DYQKLANLGSGAYGEVSLVRK-KKDGKLYAMKVVKKEKVAINRKMVEATLLEQKILKKSRHPFIVKLSQSFQTEGKLYIIMEYMANGDLYSVLQKVK--R
.| |.  ||.|..| | ||.. |.. ..||||...| .. | . |    | | ..|.|  ||||.|. .||... ..| .||.   ..| .|.  ..   
IYIKK--LGFGQFGSVYLVWNTKNTKQYYAMKCISKNQI-IQQNMEKHMLQEKNVLEKCNHPFIMKFIRSFKDDQHMYFMMEFCNGMELFDVIREIGRLL

FDENTARFIFAENQMLSSCFEISYEHVILGLQYLHEEQNTMYRDLKPENILIGEDCHIKLSDFGLAKQFVNKED---KENAFLGTPQYLAPEIVL-----
. .. ..|..|.              ..|.|.||| .|| .|||.|||||.. .. ..|| |.|.|| .  |..   .     ||| |.||||.      
LSTYDSQFYIAS--------------ICLCLEYLH-NQNIIYRDIKPENIMVDHKGYMKLIDMGTAKHMYKKNEQMTRTFTIIGTPHYMAPEIIQSLQPG

QKPYDKNIDLWTLGILLFELLSGKPPFGSGKN----LMKDIIIN--KPIFPSYFSAQAV--DLIKKLLQNIGNKRLGSNNFAELKSHPFF
.|.|  . |.| .|| |.|...|..|..  .     ....|| .  .  ||||.. .    .|. ..|| .   |||   .. |||||.|
GKGYTYKVDIWSVGICLYEFMCGYVPWAEDVQDPYEIYQEIIKKYDEIQFPSYCKDKMADKKLMLQCLQKMPEVRLG-GSYSWLKSHPWF
Kinase 3866.AA PKA 79-348 39 7.6e-81 274.9 In-house 1-263 (263) Show / Hide 
Range on Protein: 79-348
Range on HMM: 1-263/263
Sequence Identity: 39% (112 aa)

YQKLANLGSGAYGEVSLVRKKKDGKLYAMKVVKKEKVAINRKMVEATLLEQKILKKSRHPFIV-KLSQSFQTEGKLYIIMEYMANGDLYSVLQKVKRFDE
.. .. ||.| .| | |.|.|..|. ||||. ||... . .| || .. | .||.  .||||| |. ..||.. .|| .||| . |.. | |.|..||..
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEI-VRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSN

NTARFIFAENQMLSSCFEISYEH-VILGLQYLHEEQNTMYRDLKPENILIGEDCHIKLSDFGLAKQFVNKEDKENAFLGTPQYLAPEIVLQK-PYDKNID
 .|.|. |                ..| |.|||  || .||||||||||| .. |||. ||| ||  ..         |||.||||||.. | .. | .|
PHAKFYAA--------------SQIVLALEYLH-SQNIIYRDLKPENILIDKNGHIKITDFGFAKKVDD---RTWTLCGTPEYLAPEIIQSKNGHGKSVD

LWTLGILLFELLSGKPPFGSG----KNLMKDIIINKPIFPSYFSAQA---VDLIKKLLQNIGNKRLGSNNF--AELKSHPFF
 |.|||| .|.|.|.|||         . . |.  |  ||..|. .|    ||||||||.  .||.|.  .     | |..|
WWALGILIYEMLAGYPPFYDHNRDPMQIYEKICNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase 3866.AA p70 79-348 33 7.6e-78 264.93 In-house 1-299 (299) Show / Hide 
Range on Protein: 79-348
Range on HMM: 1-299/299
Sequence Identity: 33% (104 aa)

YQKLANLGSGAYGEVSLVRKKK---DGKLYAMKVVKKEKVAINRKMVEATL-------------------------LEQKILKKSRHPFIVKLSQSFQTE
.. |  || |.|| | .||| .    ||.||||| .| |. .| |  . |                           | .||    ||||..|  .|||.
FELLKVLGKGGYGKVFQVRKVTGEDTGKIYAMKVLRKAKIVRNQKDTAHTREDEDKNDGNNNDNDDGLSKRLERTFAERNILEEVKHPFICDLHYAFQTN

GKLYIIMEYMANGDLYSVLQKVKRFDENTARFIFAENQMLSSCFEISYEHVILGLQYLHEEQNTMYRDLKPENILIGEDCHIKLSDFGLAKQFVNKEDK-
|||| | ||.  | |.  | .   ..|.||.|  .|              .|. |..|| ..   ||||||||..  .  |..| |||| |. ...  . 
GKLYLILEYLHGGELFMHLERHGIWMEDTACFYLSE--------------IICALEHLH-QHGIIYRDLKPENCMLNQQGHVVLTDFGLCKESIHDGAVD

---------ENAFLGTPQYLAPEIVLQKPYDKNIDLWTLGILLFELLSGKPPFGSG--KNLMKDIIINK--PIFPSYFSAQAVDLIKKLLQNIGNKRLG-
            | ||. | ||||.. . .....| | ||.|..  | |.|||     |  .. |. .|  .  | | .. . |||||||     .|.| 
EEDPENVNATHTFCGTIEYMAPEILMRCGHNHAVDWWSLGCLMYDMLTGGPPFTGENRKKTIDKILKGKQGLKLPPYLTHEMRDLIKKLLKRHPTQRWGA

-SNNFAELKSHPFF
  .  |. ..||||
GPEDAADIQEHPFF
Kinase 3866.AA Ciliate-E2 79-348 24 1.4e-75 257.45 In-house 1-365 (365) Show / Hide 
Range on Protein: 79-348
Range on HMM: 1-365/365
Sequence Identity: 24% (96 aa)

YQKLANLGSGAYGEVSLVRKKKDGKLYAMKV-------------VKKEKVAINRKM---VEATLLEQKILKKSR----------------HPFIVKLSQS
| ..  .|.|..| | .....|..|..|.|.             ||. ..|.....   .|... |..|... .                ||.|.|.  .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FQ--TEGKLYIIMEYMANGDLYSVLQKV-----------KRFDENTARFIFAENQ--------MLSSCFEISYEHVILGLQYLHEEQNTMYRDLKPENIL
||  .. ..|..|||   |||.. ...            |.|.|. ...|...          .   |       .||.|.|||.. | ..||.||||||
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIAC-------IILALEYLHSKNNIIHRDIKPENIL

IGEDCHIKLSDFGLAKQFVNKEDKE-------------------------------NAFLGTPQYLAPEIVLQKP---------YDKNIDLWTLGILLFE
.     ||..||||.|.. ......                               | ..||| |.||||.  |.         ||. .|.| ||..|.|
F-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYE

LLSGKPPFGSGKNLMKDIIINKPIFP------------------SYFSAQAVDLIKK----LLQNIGNKRLGSNNFAELKSHPFF
.|.|||||      .. |. .|  ||                   . | .. |||||    .||   .||..  .. ... ||.|
MLFGKPPF------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT--GWEQILNHPWF
Kinase 3866.AA AGC-Unique 79-348 34 2.4e-74 253.33 In-house 1-270 (270) Show / Hide 
Range on Protein: 79-348
Range on HMM: 1-270/270
Sequence Identity: 34% (100 aa)

YQKLANLGSGAYGEVSLVRKK---KDGKLYAMKVVKKEKVAINRKMVEA-TLLEQKILKKSRHPFIVKLSQSFQTEGKLYIIMEYMANGDLYSVLQKVKR
.  |  .|.|.||.| .||.|     .|.|||||  | .    . ||.  |  | .||    |||..... |||..  | ..|.|   ||.   .|.   
FEILKHIGVGSYGRVYAVRRKNGCDTEKFYAMKVMNKRDMSKHKQMVHHNT--EWMILTTMHHPFFMRMHYSFQNKDHLFMCMDYVPGGDMFHHMQNAEC

FDENTARFIFAENQMLSSCFEISYEHVILGLQYLHEEQNTMYRDLKPENILIGEDCHIKLSDFGLAKQFVNKEDKENA---------FLGTPQYLAPEIV
| |  |.|  .|              || .. ||| |..  .|| |||||||..| ||.. |.|| |  .  .|             | ||. |.|||| 
FIEESAHFYICE--------------VICSIHYLH-ENHIIHRDIKPENILIDNDGHIMITDYGLSKTGCDSVDAIQNGGEGGFATTFCGTRHYMAPEIH

LQKPYDKNIDLWTLGILLFELLSGKPPF-GSGKNLMKDIIINK-PIFPSYFSAQAVDLIKKLLQNIGNKRLG--SNNFAELKSHPFF
. | . |  | |  ||......... || .| .| | |  | | |  |   |  . |.. ||.    |.|||   . |.| |||..|
TEKKHGKSCDWWSVGITYCDMRTDRSPFDASNRNDMYDSMIQKRPRMPMFLSPDEQDFVNKLIVRDPNQRLGNSPQGFEEIKSHDMF
Kinase 3866.AA Pkinase 201-348 30 5.3e-43 153.14 Pfam 117-293 (293) Show / Hide 
Range on Protein: 201-348
Range on HMM: 117-293/293
Sequence Identity: 30% (55 aa)

VILGLQYLHEEQNTMYRDLKPENILIGEDCHI----KLSDFGLAKQF-VNKEDKENAFLGTPQYLAPEIVL-QKPYDKNIDLWTLGILLFELLSGKPPFG
.. ||.|.|. .. ..|||||||||| ...||    |..||||||||   .    . | ||| |.|||... ...|.. .| | .|..|.|.|.|.||| 
ILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFP

SG--------KNLMKDIIINKPIFPSYFS---------------------AQAVDLIKKLLQNIGNKRLGSNNFAELKSHPFF
.         . ... |   .. |... .                       . |.||..|.   .||..   ..... ||.|
GHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT---AEQILQHPWF
Kinase 3866.AA Pkinase 79-186 27 5.5e-31 110.64 Pfam 1-116 (293) Show / Hide 
Range on Protein: 79-186
Range on HMM: 1-116/293
Sequence Identity: 27% (32 aa)

YQKLANLGSGAYGEVSLVRKKKDGKLYAMKVVKKEKVAINRKMVEATLL--EQKILKKSRHPFIVKLSQSFQTEGKLYIIMEYMANG----DLYSVLQ--
|...  .|||..|.| . ..|..||..|.|..||.   .. .. .. ..  | .|.|. .||.||.|  .|......|..|||. .|    ||.....  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR--HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW

KVKRF--DENTARFIFAE
. ..|  .|....|.. .
RHGCFYFSEWECKFYMYQ
Kinase 3866.AA TyrKc 79-348 22 3.6e-14 6.45 SMART 1-280 (280) Show / Hide 
Range on Protein: 79-348
Range on HMM: 1-280/280
Sequence Identity: 22% (71 aa)

YQKLANLGSGAYGEVSLVRKKKDGKLYAMKVVKKEKVAINRKMVEATLLEQKILKKS--RHPFIVKLSQSFQTE-------GKLYIIMEYMANGDLYSVL
 ...  ||.||.||| . . |      | |..|...       .|. . | .|..|   .|| ||.|     ..       . |.|.||||..||| . |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

QKVKRFDENTARFIFAENQMLSSCFEISYEHVILGLQYLHEEQNTMYRDLKPENILIGEDCHIKLSDFGLAKQFVNK-------EDKENAF--LGTP---
.| ..         .   ..|| |. |.      | .|||.  |   |||   |.|.||. ..| |||||..   ..       . .  .    |     
RKHRPK--------LCMKDLLSFCWQIA-----CGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLP

-QYLAPEIVLQKPYDKNIDLWTLGILLFELLS--GKPPFG------SGKNLMKDIIIN-KPIFPSY--------FSAQAVDLIKKLLQNIGNKRLGSNNF
   .|||    . .    | |  |....|...  ..|. |      | . .....     .  | .         ..   ...|.  .   ..|    .|
IRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRP---TF

AELKSHPFF
.|.  | .|
SEI--HECF
Kinase 3866.AA Pkinase_Tyr 79-171 32 4.6e-07 24.56 Pfam 1-100 (270) Show / Hide 
Range on Protein: 79-171
Range on HMM: 1-100/270
Sequence Identity: 32% (33 aa)

YQKLANLGSGAYGEVSLVRKK----KDGKLYAMKVVKKEKVAI-NRKMVEATLLEQKILKKS-RHPFIVKLSQSFQ-TEGK--LYIIMEYMANGDLYSVL
 ...  ||.||.||| . . |    ...   | |..|       |  . |. . | ||.|.  .|| ||.|       ..   .||.||||..|||.. |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQN--CREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

QK
.|
RK
Kinase 3866.AA Pkinase_Tyr 223-241 47 0.000501 14.26 Pfam 141-159 (270) Show / Hide 
Range on Protein: 223-241
Range on HMM: 141-159/270
Sequence Identity: 47% (9 aa)

NILIGEDCHIKLSDFGLAK
|.|..|. ..| .|||||.
NCLVTENNVVKICDFGLAR