Gene 19957 (Tetrahymena)

19957

Species: Tetrahymena
Alias: 3830.m00608, 68.m00246, 114, 19957, TTHERM_00534000, PreTt19957
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: AGC
Family: MAST
Subfamily: MAST

Sequence

Name Sequence Type Origin Length Description Download
19957.AA Protein None 1243 None Fasta, JSON
19957.kin_dom Protein Kinase Domain None 329 None Fasta, JSON
19957.NA RNA None 3732 None Fasta, JSON

Protein domain

Protein domains of 19957.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 19957.AA MAST 817-1145 49 3.8e-242 748.66 In-house 1-337 (337) Show / Hide 
Range on Protein: 817-1145
Range on HMM: 1-337/337
Sequence Identity: 49% (166 aa)

FEFVRHLGAGAYGGVYLVKKKSSGDLFAMKVIDCSGKLDKKYLESLQSERNVFEIITGDYVVKAFYSFVH--ETYLCFVLEYMVGGDFTHILEMYT-ALQ
|||......||||.|||||.|...|.||||||.|....||........|||.........|||.||||..  ..|||.|.||| |||....|.||. ...
FEFIKCISKGAYGAVYLVKHKKTNDRFAMKVINCQDTIDKNQVDQVFVERNILTMYQNPFVVKMFYSFQTPCKKYLCMVMEYMEGGDCASLLRMYGNCMP

EWIVQIYMAELILAVEYLHSQGIVHRDLKPDNILLDSKGHVKLADFGLSEVGFNQKLNRTEKQKVAVDIFGSKKDNESKYKTEYQLLK---GVKKENKKD
||....|.||..|..|||||.|||||||||||.|.||.||.||.|||||.|||..|............|||....||......||...   |......|.
EWMAKMYIAETVLCLEYLHSYGIVHRDLKPDNMLIDSNGHIKLTDFGLSKVGFMDKTTNHYEGYFNTNIFGKNHFNEYHIQKNYQQFQQDFGINGNTNKN

IIDSKDEELQQKLAEEQLQNIVQQKKRIIGTPDYIAPEIINGESSSNPSLDWWSVGVIMYELLVGIPPFNDSTREK-VFENIVN--RRIEFPPTGDPNED
.|....|..|.....|.......|.|...|||||||||.|.|........||||.|.||||.|||.||||..|.|. .|.||.|  |.||.|..|||| |
QIQQQQEQPQCQQQNEMRPHNIHQNKQCCGTPDYIAPEVILGQGTYGKPVDWWSMGIIMYEFLVGCPPFNGDTPEEMIFQNIINHDREIEWPEEGDPN-D

ENCISEEAQDLMEKLLTLDHKQRLGARGADEIKKHPFF
..|.|.|||||..|||....|.||||.||||||.||||
DDCMSPEAQDLIKKLLQPNPKKRLGANGADEIKQHPFF
Kinase 19957.AA MAST 817-1145 48 1.4e-219 714.99 In-house 1-334 (334) Show / Hide 
Range on Protein: 817-1145
Range on HMM: 1-334/334
Sequence Identity: 48% (163 aa)

FEFVRHLGAGAYGGVYLVKKKSSGDLFAMKVIDCSGKLDKKYLESLQSERNVFEIITGDYVVKAFYSFVHETYLCFVLEYMVGGDFTHILEMYTALQEWI
|||..... ||||.|||||.|...|.||||||..|....|......|.|||.........|||.||||....|||.|.|||.|||....|.||....||.
FEFIKPISKGAYGKVYLVKHKKTNDRFAMKVIKKSDMINKNMVDQVQVERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLHMYGYFDEWM

VQIYMAELILAVEYLHSQGIVHRDLKPDNILLDSKGHVKLADFGLSEVGFNQKLNRTEKQKVAVDIFGSKKDNESKYKTEYQLLK---GVKKENKKDIID
...|.||..|..|||||.|||||||||||.|.||.||.||.|||||.|||...||..........||....|...|....|. ..   |......|..|.
AKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFGLSKVGFMDDLNMMYEGYTPPNIFNNSTDPMNKNQQDYSQFPGDFGINGNTNKNQIQ

SKDEELQQKLAEEQLQNIVQQKKRIIGTPDYIAPEIINGESSSNPSLDWWSVGVIMYELLVGIPPFNDSTREKVFENIVNRR---IEFPPTGDPNEDENC
...|..|..... .......|.|...|||||||||.|.|... ....||||.|.||||.|||.|||||.|.|..|.||.||.   ||.|..||.| |...
QQQEQPQCQQQN-MRPHNIHQNKQCCGTPDYIAPEVILGQGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEGGDIN-DDEA

ISEEAQDLMEKLLTLDHKQRLGAR-GADEIKKHPFF
.|.|||||.||||..|...||||. ||||.|.||||
MSPEAQDLIEKLLQPDPRKRLGANNGADEVKQHPFF
Kinase 19957.AA AGC 817-1145 28 2.5e-156 407.66 In-house 1-395 (395) Show / Hide 
Range on Protein: 817-1145
Range on HMM: 1-395/395
Sequence Identity: 28% (122 aa)

FEFVRHLGAGAYGGVYLVKKK------SSGDLFAMKVIDCSG---KLDKKYLESLQSE------------RNVFEIITG----------DYVVK-AFYSF
|||....| |..| ||||.||      ..|...||||.. .    ...|. .|  ..|            ||..| . .          ...||  .|||
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

VHETY--LCFVLEYMV--------GGDFTHILEMYT-----ALQEWIVQIYMAE-------LILAVEYLHS-QGIVHRD-LKPDNILLDSKGHVKLADFG
  ...  |.||.|||         ||..   | ..       . |  ...|.||       ..||.||||| .||.||| |||.|||||..||.||.|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LSEVGFNQ-----------KLNRTEKQKVAVDIFGSKKDNESKYKTEYQLLKGVKKENKKDIIDSKDEELQQKLAEEQLQN----------IVQQKKRII
|. .| |            |...  ..|          ...   . .                        ......| .|            .. . . 
LCKEGMNDGEKGQQSQSNMKFHW-HNKKY-Q-KS----NMD---T-N----------------------K-CNPNNWQRNNMSQEDDTTRKKRDRTWTFC

G--TPDYIAPEIINGESSSNPSLDWWS--VGVIMYELLVGIPPFNDST----------REKVFENIVNRR--IEFPPTGDPNE-----DENCISEEAQDL
|  ||.|.||||.      ... ||||  .|..|||.|.|.|||.. .          ....|..| |.|  |..... ...|     ..  .|.||.||
GPCTPEYMAPEIL-----YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDL

MEKLLTLDHKQRLGAR-------GADEIKKHPFF
..|||. | ..|||..       ||.|||.||.|
IKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 19957.AA NDR 817-1145 34 9.20000000001e-127 393.23 In-house 1-350 (350) Show / Hide 
Range on Protein: 817-1145
Range on HMM: 1-350/350
Sequence Identity: 34% (123 aa)

FEFVRHLGAGAYGGVYLVKKKSSGDLFAMKVIDCSGKLDKKYLESLQSERNVFEIIT--GDYVVKAFYSFVHETYLCFVLEYMVGGDFTH---ILEMYTA
||.....| ||.| |.||.||..|...|||..  | ...|  . ....|| .. .     ..|||..||| .. ||..| ||. |||.     .| ..  
FEIIKIIGKGAFGEVWLVRKKDTGHIYAMKIMRKSEMMWKNQVAHVRAERDIMAEADNKNPWVVKLYYSFQDKQYLYLVMEYHPGGDMMTYCYLLMKMDI

LQEWIVQIYMAELILAVEYLHSQGIVHRDLKPDNILLDSKGHVKLADFGLSEVGFNQKLNRTEKQKVAVDIFGSKKDNESKYKTEYQLLKGVKKENKKDI
. | . . |.||...|.|..|. |..|||.||||.|.|..||.|| ||||.  |.  . ..  |||. .    |     . .   || .|....... | 
FTEDWARFYIAEMVCAIESVHKMGYIHRDIKPDNFLIDKDGHIKLTDFGLCTGGMIRRHWKQNKQKKPM-TTYST-FHWTHNSWYYQNMKEHRPQDFMDN

IDSK----------DEELQQK------LAEEQLQNIVQQKKRIIGTPDYIAPEIINGESSSNPSLDWWSVGVIMYELLVGIPPFNDSTREKVFENIVNRR
..|.          ... | |       ... .||  .   ...|||||.|||.....   |.. ||||.|.||||.|||.|||...| ......| | .
WNSNPMNQKCKCHTQMKDQMKCNVKVLNNRSWKQNRRCLAYSTVGTPDYMAPEVFQQKTGYNQTCDWWSLGCIMYEMLVGYPPFCSDTPQETCMKIMNWK

IEF--PPTGDPNEDENCISEEAQDLMEKLLTLDHKQRLGA--RGADEIKKHPFF
. .  |.|..| | .  .|.||.|| ..|.. | ..|||.   |.||||.||||
QTWDWPMTHFPPEAN--LSPEAWDLIRRLCCPDPDHRLGSHGKGVDEIKSHPFF
Kinase 19957.AA S_TKc 817-1145 26 2.3e-92 314.07 SMART 1-231 (231) Show / Hide 
Range on Protein: 817-1145
Range on HMM: 1-231/231
Sequence Identity: 26% (89 aa)

FEFVRHLGAGAYGGVYLVKKKSSGDLFAMKVIDCSGKLDKKYLESLQSERNVFEIITGDYVVKAFYSFVHETYLCFVLEYMVG--GDFTHILEMYTA---
.|..|..| ||.| ||....|..| ..|.|.|.          |....|... .    ...|| ...|.. ..|..|.||. |  ||  .... .     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LQEWIVQIYMAELILAVEYLHSQGIVHRDLKPDNILLDSKGHVKLADFGLSEVGFNQKLNRTEKQKVAVDIFGSKKDNESKYKTEYQLLKGVKKENK
   . |  .. ||.....|.||.||.||.||||||.|||||.  |.|..||||. .                                            
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------------------------------------------

KDIIDSKDEELQQKLAEEQLQNIVQQKKRIIGTPDYIAPEIINGESSSNP-SLDWWSVGVIMYELLVGIPPFNDSTREKVFENIVNRRIEFPPTGDPNED
                           . ..|||.|.|||..    . .. . ||||.|.|.||.|.| |||   . ...|..|.               
---------------------------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG---------------

ENCISEEAQDLMEKLLTLDHKQRLGARGADE----IKKHPFF
    |.|| |...|.|. | ..|..|  | .    ||.||.|
----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 19957.AA AktR 817-1145 30 2.4e-86 293.14 In-house 1-268 (268) Show / Hide 
Range on Protein: 817-1145
Range on HMM: 1-268/268
Sequence Identity: 30% (102 aa)

FEFVRHLGAGAYGGVYLVKKK-SSGDLFAMKVIDCSGKLDKKYLESLQSERNVFE-IITGDYVVKAFYSFVHETYLCFVLEYMVGGDFTHILEMYTALQE
|.. ..|| ||.| ||||.||  .....|||.|. .   ...  . .. |||. | ..     || .|.|  ...| |..||. ||.  ..|     . |
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

WIVQIYMAELILAVEYLHSQ-GIVHRDLKPDNILLDSKGHVKLADFGLSEVGFNQKLNRTEKQKVAVDIFGSKKDNESKYKTEYQLLKGVKKENKKDIID
  ...|.|. .||.||||..  |. |||||.|||||. ||||..|||||.                                                  
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSK--------------------------------------------------

SKDEELQQKLAEEQLQNI---VQQKKRIIGTPDYIAPEIINGESSSNPSLDWWSVGVIMYELLVGIPPFNDSTREKVFENIVNRR-IEFPPTGDPNEDEN
              ||..    .  . . ||| |.|||.|. .   | | |||..|.  ||...|.|||... ..  |..| . . ..||..        
--------------LQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVTGCPPFYHKNQNQMFQKIKIKQQNKFPYP-------S

CISEEAQDLME-KLLTLDHKQRLG--ARGADEIKKHPFF
..|....|| . |||  . ..|||  . |..|||.||.|
YFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase 19957.AA RSK 820-1145 28 1.3e-81 277.4 In-house 1-278 (278) Show / Hide 
Range on Protein: 820-1145
Range on HMM: 1-278/278
Sequence Identity: 28% (100 aa)

VRHLGAGAYGGVYLVKKK---SSGDLFAMKVIDCSGKLDKKY-LESLQSERNVFEIIT-GDYVVKAFYSFVHETYLCFVLEYMVGGD-FTHILEMYTA--
.. || |.|| |.|..|.    .| ..||||.. .    ..  ..    |||. | ..    .|. .|.|  |..|  ..||. ||. |||...  .   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

LQEWIVQIYMAELILAVEYLHSQGIVHRDLKPDNILLDS---KGHVKLADFGLSEVGFNQKLNRTEKQKVAVDIFGSKKDNESKYKTEYQLLKGVKKENK
. |  ...||||..||||.||.|||.||||||.|||.|.    ||.|| |||..  . ... ..| .                                 
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMT---------------------------------

KDIIDSKDEELQQKLAEEQLQNIVQQKKRIIGTPDYIAPEIIN---GESSSNPSLDWWSVGVIMYELLVGIPPFND---STREKVFENIVNRRIEFPPTG
                              ..| .|.|||...   ...  . . |||| ||.|||.|.| |||     ..|......| . .. ..   
-----------------------------FCYTIEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPN

DPNEDENCISEEAQDLMEKLLTLDHKQRLG--ARGADEIKKHPFF
...     .|.||.||  |.|. | ..|||   ..|.|||.||.|
WQY-----LSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 19957.AA Ciliate-E2 817-1145 22 2e-72 246.93 In-house 1-365 (365) Show / Hide 
Range on Protein: 817-1145
Range on HMM: 1-365/365
Sequence Identity: 22% (96 aa)

FEFVRHLGAGAYGGVYLVKKKSSGDLFAMKVIDCSG------------------KLDKKYLESLQSERNVF----------------EIITGDYVVKAFY
..|.. .| |..| ||..|... . .||.|.||                      . |. .|.. .| ...                |..  ....| ..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

SFV--HETYLCFVLEYMVGGDFTHILE-----------------MYTAL--QEWIVQ-------IYMAELILAVEYLHSQG-IVHRDLKPDNILLDSKGH
.|    .... .|.||  |||  ....                 .. ..   . |.|        |.|..|||.|||||.. |.|||.||.|||.     
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

VKLADFGLSE------------VGFNQKLNRTEKQKVAVDIFGSKKDNESKYKTEYQLLKGVKKENKKDIIDSKDEELQQKLAEEQLQNIVQQK-KRIIG
.|..|||||             .. . ...   . ..   ...             |                                | |.  ..|.|
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMD-------------Q-------------------------------IIQQNMFNTICG

TPDYIAPEIINGESSSN--------PSLDWWSVGVIMYELLVGIPPFNDSTREKVFENIVNRRIEFPPTGDPNE---------DENCISEEAQDLMEK--
|| | ||||.||.. .|         . |.||.|||.||.| | |||        ...| .  |.||.    ..         . . .|.|..||. |  
TPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFG

--LLTLDHKQRLGARGADEIKKHPFF
  .|  | ..|..  |...|..||.|
KRMLQKDPEKRIT--GWEQILNHPWF
Kinase 19957.AA Akt 817-962 40 4.8e-52 164.62 In-house 1-148 (264) Show / Hide 
Range on Protein: 817-962
Range on HMM: 1-148/264
Sequence Identity: 40% (60 aa)

FEFVRHLGAGAYGGVYLVKKKSSGDLF-AMKVIDCSGKLDKKYLESLQSERNVFEIITGDYVVKAFYSFVHETYLCFVLEYMVGGDFTHILEMYTALQEW
|.|.. ||.|..| |.|||||...... ||||.  .  ..|...|  . |||. . .   ..|.  |||  ...|.||..|. ||.    |       | 
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

IVQIYMAELILAVEYLHSQGIVHRD-LKPDNILLDSKGHVKLADFGLS
    | ||.||| |.|||..|. || ||| |||.|..||..|.||||.
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLC
Kinase 19957.AA Pkinase 817-973 28 3.6e-49 174.47 Pfam 1-170 (293) Show / Hide 
Range on Protein: 817-973
Range on HMM: 1-170/293
Sequence Identity: 28% (49 aa)

FEFVRHLGAGAYGGVYLVKKKSSGDLFAMKVIDCSGKLDKKYLESLQS--ERNVFEIITGDYVVKAFYSFVHETYLCFVLEYMVGG----DFTHILE--M
....| .|.|..| ||. ..|..|...|.|.|. . . ... ....    |  .   .  ...|. ...|  ......|.||. ||    |  ....  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

YTAL--QEWIVQIYMAELILAVEYLHSQGIVHRDLKPDNILLDSKGHV----KLADFGLSEV--GFNQKLNRT
....  .|| .. || ... ..||.||.||.||||||.|||.|..||.    |..||||...    |.  . |
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTT
Kinase 19957.AA SGK 817-962 33 6.7e-49 148.88 In-house 1-172 (283) Show / Hide 
Range on Protein: 817-962
Range on HMM: 1-172/283
Sequence Identity: 33% (57 aa)

FEFVRHLGAGAYGGVYLVKKKSS------------------GDLFAMKVIDCSGKL-------DKKYLESLQSER-NVFEIITGDYVVKAFYSFVHETYL
|.|   .| | .| ||.||.|.                   ....||||.     .        ||     ..|| ..   .     |.  |.|  ...|
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

CFVLEYMVGGDFTHILEMYTALQEWIVQIYMAELILAVEYLHSQGIVHRDLKPDNILLDSKGHVKLADFGLS
 ||..|. ||.    |     . |  . .|.||...| |||||| |..|||||.|||||..||..| ||||.
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLC
Kinase 19957.AA RSK-Unclassified 817-962 37 1.2e-44 137.84 In-house 1-148 (283) Show / Hide 
Range on Protein: 817-962
Range on HMM: 1-148/283
Sequence Identity: 37% (55 aa)

FEFVRHLGAGAYGGVYLVKKKSSGDLFAMKVIDCSGKLDKKYLESLQSERNVFEIITGDYVVKAFYSFVHETYLCFVLEYMVGGDFTHILE--MYTALQE
|.  | .| |  | ||||.|| .  ..||||   .  . ..       |.|.  .    ..|. ..||  . ||  ..||  ||||   |       . |
FIKHRLIGQGDFGKVYLVRKKDTQQIYAMKVLHKHKMIRHNKIKYVMTEQNIMATTNHPFIVTLYHSFQTQDYLYLCMEYCMGGDFFRHLQTRKEKCFCE

WIVQIYMAELILAVEYLHSQGIVHRDLKPDNILLDSKGHVKLADFGLS
  |..|..| ..| |||| .... ||||||||.|.  |||.| ||.||
DDVRFYASEVTAALEYLHKRDFIYRDLKPDNIVLHQEGHVMLTDFDLS
Kinase 19957.AA SGK 1040-1145 37 1.8e-38 116.13 In-house 187-283 (283) Show / Hide 
Range on Protein: 1040-1145
Range on HMM: 187-283/283
Sequence Identity: 37% (40 aa)

GTPDYIAPEIINGESSSNPSLDWWSVGVIMYELLVGIPPFNDSTREKVFENIVNRRIEFPPTGDPNEDENCISEEAQDLMEKLLTLDHKQRLGAR-GADE
||| | |||.....  .. . |||. | ..||...|.||| .  ..  ..|| |  . .||          .| .| ||.. ||. | |.|||.. .. |
GTPEYLAPEVLRKQPHDR-TVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQ---------MSNDAWDLIQGLLQKDPKKRLGTKRDFME

IKKHPFF
||.||||
IKNHPFF
Kinase 19957.AA Akt 1040-1145 42 7.1e-34 105.61 In-house 164-264 (264) Show / Hide 
Range on Protein: 1040-1145
Range on HMM: 164-264/264
Sequence Identity: 42% (46 aa)

GTPDYIAPEIINGESSSNPSLDWWS-VGVIMYELLVGIPPFNDSTREKVFENIVNRRIEFPPTGDPNEDENCISEEAQDLMEKLLTLDHKQRLG--ARGA
||| |.||||.||      . |||. .|..|||.. | ||| .  ... |..| |  ..||       | . || |..|| ..||. | |.|||    .|
GTPEYLAPEILNG-NGHTKAVDWWGSLGCVMYEMMCGRPPFYNQDHHQMFKKIKNQPVKFP-------DKDWISPECKDLISGLLNKDPKKRLGGGPNDA

DEIKKHPFF
.||| ||.|
QEIKRHPWF
Kinase 19957.AA RSK-Unclassified 1039-1145 38 1.4e-33 102.51 In-house 183-283 (283) Show / Hide 
Range on Protein: 1039-1145
Range on HMM: 183-283/283
Sequence Identity: 38% (42 aa)

IGTPDYIAPEIINGESSSNPSLDWWSVGVIMYELLVGIPPFNDSTREKVFENIVNRRIEFPPTGDPNEDENCISEEAQDLMEKLLTLDHKQRLGA-RG-A
.|| .|.|||.| .        |||  |..|||.|.|.||.    .. .|.||    . ||       ... || ...||. |||.     |||. .| |
CGTEEYLAPEMIRRCGHTK-AVDWWTLGIVMYEMLFGCPPYYGNNKNETFYNIEKNHVKFP-------HDSYISNNCRDLIKKLLQRNPAKRLGCKMGDA

DEIKKHPFF
|.||.||||
DDIKRHPFF
Kinase 19957.AA Pkinase 1040-1145 29 2e-27 98.03 Pfam 173-293 (293) Show / Hide 
Range on Protein: 1040-1145
Range on HMM: 173-293/293
Sequence Identity: 29% (37 aa)

GTPDYIAPEIINGESSSNPSLDWWSVGVIMYELLVGIPPFNDS------TREKVFENIVNRRIEFPPTGDPN-------------EDENCISEEAQDLME
|||.|.|||.|.| .   |. |.||.|.|.||.| | ||| ..      .  .....|  ....|.   . .             .    .|||..|...
GTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTF-HNWSEECKDFIK

KLLTLDHKQRLGARGADEIKKHPFF
..|..| |.|..   |..|..||.|
WCLCKDPKKRPT---AEQILQHPWF
Kinase 19957.AA TyrKc 817-1032 17 1.7e-10 -52.88 SMART 1-280 (280) Show / Hide 
Range on Protein: 817-1032
Range on HMM: 1-280/280
Sequence Identity: 17% (50 aa)

FEFVRHLGAGAYGGVYLVKKKSSGDLFAMKVIDCSGKLDKKYLESLQSERNVFEII--TGDYVVKAFYSFVHE-------TYLCFVLEYMVGGDFTHILE
 .. . || ||.| ||. . |      | |..  .       .| . .| ..   .    . .|. .   ...         |. |.||| .||  . | 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

MYTA-LQEWIVQIYMAELILAVEYLHSQGIVHRDLKPDNILLDSKGHVKLADFGLSEVGFNQ-------KLNRT-----EKQKVAV----------DIFG
 .   |.      ..       |||||....||||   |.|......|| .|||||  . .        .  |.     .|  . .           .| 
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

SKKD--------------NESKY-------KTEYQLLKGVKKENKKDIIDS--------KDEELQQKLAEE-------------QLQNIV
.| |               .. |       .. ..... ||. .  .. ..          .|. | . ..             ..  . 
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHECF
Kinase 19957.AA Pkinase_Tyr 929-962 47 4.2e-10 34.85 Pfam 125-158 (270) Show / Hide 
Range on Protein: 929-962
Range on HMM: 125-158/270
Sequence Identity: 47% (16 aa)

EYLHSQGIVHRDLKPDNILLDSKGHVKLADFGLS
|||.|....||||   |.|......|| .||||.
EYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase 19957.AA Pkinase_Tyr 817-833 47 0.220131 5.31 Pfam 1-17 (270) Show / Hide 
Range on Protein: 817-833
Range on HMM: 1-17/270
Sequence Identity: 47% (8 aa)

FEFVRHLGAGAYGGVYL
 .| . ||.||.| ||.
ITFGKKLGEGAFGEVYK