Gene 18168 (Tetrahymena)

18168

Species: Tetrahymena
Alias: 104.m00100, TTHERM_00684550, PreTt18168, 332, 3732.m00014, 18168
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: AGC
Family: NDR

Sequence

Name Sequence Type Origin Length Description Download
18168.AA Protein None 2529 None Fasta, JSON
18168.kin_dom Protein Kinase Domain None 330 None Fasta, JSON
18168.NA RNA None 7590 None Fasta, JSON

Protein domain

Protein domains of 18168.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 18168.AA NDR 1988-2317 39 2.1e-199 621.44 In-house 1-350 (350) Show / Hide 
Range on Protein: 1988-2317
Range on HMM: 1-350/350
Sequence Identity: 39% (138 aa)

FEFLKLISKGAFGRVWLVKKKNTDNVYAMKIVNLAEKMNKNNLMSLQNERDIFGIVS--GDFFVKAVYTFAHESYLCFVMEYMIGGDLGS---IQQQFGV
||..|.|.|||||.||||.||.|...|||||.. .|.|.||.......||||. ...   ...||..|.| ...||..||||..|||...   .......
FEIIKIIGKGAFGEVWLVRKKDTGHIYAMKIMRKSEMMWKNQVAHVRAERDIMAEADNKNPWVVKLYYSFQDKQYLYLVMEYHPGGDMMTYCYLLMKMDI

LEESVARFYIA-----CSQLHKAGIVHRDLKPDNLLLDSKGHLKLTDFGLSDMGMRSRNMENSKQKK--------FRQEYNNLKRGMDRISSIKGADKIF
..|..||||||     ....|| |..|||.||||.|.|..||.|||||||...||..|.....||||        ...........|....  .  |...
FTEDWARFYIAEMVCAIESVHKMGYIHRDIKPDNFLIDKDGHIKLTDFGLCTGGMIRRHWKQNKQKKPMTTYSTFHWTHNSWYYQNMKEHRPQDFMDNWN

SSLTPQSKSDKTRELKQMKTNLDVILNKETKKMKNKKKFRIIGTPDYIPPEVIKGSNNLNCATLDWWSVGVILFEMLVGIPPFNDETVEKIFDNIINMRV
|. ..|.....|.. .|||.|..|. |...|...... ....|||||..|||... ......| ||||.|.|..|||||.|||...|.......|.|.. 
SNPMNQKCKCHTQMKDQMKCNVKVLNNRSWKQNRRCLAYSTVGTPDYMAPEVFQQ-KTGYNQTCDWWSLGCIMYEMLVGYPPFCSDTPQETCMKIMNWKQ

PWDQINIGYGEDE-VSPEAEDLIKKLMDPNPQTRLGANG--VEEVQSHPFF
 ||.......... .||||.|||..|. |.|..|||..|  |.|..|||||
TWDWPMTHFPPEANLSPEAWDLIRRLCCPDPDHRLGSHGKGVDEIKSHPFF
Kinase 18168.AA AGC 1988-2317 27 2.1e-153 399.92 In-house 1-395 (395) Show / Hide 
Range on Protein: 1988-2317
Range on HMM: 1-395/395
Sequence Identity: 27% (121 aa)

FEFLKLISKGAFGRVWLVKKK------NTDNVYAMKIVNLAE---KMNKNNLMSLQNE------------RDIFGIVSG----------DFFVK-AVYTF
|||||.|.||.||.|.||.||       |. .||||... ..   ...|| .   ..|            |.|.  ...          .| ||   |.|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

AHESY--LCFVMEYMI---------GG-DLGSIQQ---QFGVLEESVARFYIA------------CSQLHK-AGIVHRD-LKPDNLLLDSKGHLKLTDFG
  ...  |.||||||.         || .| ...|   . |...|..||||.|               ||.  ||.||| |||.|.|||..||.||||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LSDMGMRS-----------RNMENSKQKKFRQEYNNLKRGMDRISSIKGADKIFSSLTPQSKSDKTRELKQMKTNLDVILNKETKKM----------KNK
|. .||..           .... ...|. ...      .||     . .                            ..|.. ..           |..
LCKEGMNDGEKGQQSQSNMKFHW-HNKKY-QKS------NMD-----T-N-------------------------K-CNPNNWQRNNMSQEDDTTRKKRD

KKFRIIG--TPDYIPPEVIKGSNNLNCATLDWWS--VGVILFEMLVGIPPFNDETVE----------KIFDNIINMR--VPWDQINIGY------GEDEV
.   . |  ||.|..||..         . ||||  .|....|||.|.|||......          ..|..|.| |   .|..    .      .....
RTWTFCGPCTPEYMAPEIL------YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWF

SPEAEDLIKKLMDPNPQTRLGAN-------GVEEVQSHPFF
|||| ||||||. ..|  |||..       |.||...||.|
SPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 18168.AA MAST 1988-2317 38 2.4e-144 444.27 In-house 1-337 (337) Show / Hide 
Range on Protein: 1988-2317
Range on HMM: 1-337/337
Sequence Identity: 38% (138 aa)

FEFLKLISKGAFGRVWLVKKKNTDNVYAMKIVNLAEKMNKNNLMSLQNERDIFGIVSGDFFVKAVYTFAH--ESYLCFVMEYMIGGDLGSIQQQFG-VLE
|||.|.|||||.|.|.|||.|.|   .|||. |   .. || . ... ||.|. .....| ||. |.| .  . |||.|||||.||| .|. . .|  ..
FEFIKCISKGAYGAVYLVKHKKTNDRFAMKVINCQDTIDKNQVDQVFVERNILTMYQNPFVVKMFYSFQTPCKKYLCMVMEYMEGGDCASLLRMYGNCMP

ESVARFYIA-----CSQLHKAGIVHRDLKPDNLLLDSKGHLKLTDFGLSDMGMRSRNMENSKQK--------------KFRQEYNNLKRGMDRISSIKGA
|. |..|||        ||. |||||||||||.|.||.||.|||||||| .|  ..     ...              .. ..|. ..            
EWMAKMYIAETVLCLEYLHSYGIVHRDLKPDNMLIDSNGHIKLTDFGLSKVGFMDKTTNHYEGYFNTNIFGKNHFNEYHIQKNYQQFQQD----------

DKIFSSLTPQSKSDKTRELKQMKTNLDVILNKETKKMKNKKKFRIIGTPDYIPPEVIKGSNNLNCATLDWWSVGVILFEMLVGIPPFNDETVEK-IFDNI
       .   .  .. . .| . ..  ..  | .    ... ...||||||.|||| |    . ...||||.|.|..| |||.||||..|.|. ||.||
-------FGINGNTNKNQIQQQQEQPQCQQQNEMRPHNIHQNKQCCGTPDYIAPEVILGQGT-YGKPVDWWSMGIIMYEFLVGCPPFNGDTPEEMIFQNI

IN--MRVPWDQINIGYGE--DEVSPEAEDLIKKLMDPNPQTRLGANGVEEVQSHPFF
||   .. |  . .|...  |..|||| |||||| .||| .||||||..|. .||||
INHDREIEW--PEEGDPNDDDCMSPEAQDLIKKLLQPNPKKRLGANGADEIKQHPFF
Kinase 18168.AA MAST 1988-2317 38 8.3e-134 433.88 In-house 1-334 (334) Show / Hide 
Range on Protein: 1988-2317
Range on HMM: 1-334/334
Sequence Identity: 38% (140 aa)

FEFLKLISKGAFGRVWLVKKKNTDNVYAMKIVNLAEKMNKNNLMSLQNERDIFGIVSGDFFVKAVYTFAHESYLCFVMEYMIGGDLGSIQQQFGVLEESV
||| |.|||||.|.|.|||.|.|   .|||... ....||| . ..| ||.|. .....| ||. |.| ...|||.|||||.|||..|. . .| ..|. 
FEFIKPISKGAYGKVYLVKHKKTNDRFAMKVIKKSDMINKNMVDQVQVERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLHMYGYFDEWM

ARFYIA----CSQ-LHKAGIVHRDLKPDNLLLDSKGHLKLTDFGLSDMGMRS--RNMENSK----QKKFRQEYNNLKRGMDRISSIKGADKIFSSLTPQS
|..|||    | . ||. |||||||||||.|.||.|| |||||||| .|...   .|....                              . .| .| .
AKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFGLSKVGFMDDLNMMYEGYTPPNI-------------------------FNNSTDPMN

KSDKTREL----------------KQMKTNLDVILNKETKKMKNKKKFRIIGTPDYIPPEVIKGSNNLNCATLDWWSVGVILFEMLVGIPPFNDETVEKI
|...  .                 .| . ..  ..    ..   ... ...||||||.||||.|    .  ..||||.|.|..| |||.|||||.|.|.|
KNQQDYSQFPGDFGINGNTNKNQIQQQQEQPQCQQQN-MRPHNIHQNKQCCGTPDYIAPEVILGQGT-HGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEI

FDNIINMR---VPWDQINIGYGE--DEVSPEAEDLIKKLMDPNPQTRLGAN-GVEEVQSHPFF
|.||.| .   . |     |...  .. |||| |||.|| .|.| .||||| |..||..||||
FQNILNRNCNEIEWPEG--GDINDDEAMSPEAQDLIEKLLQPDPRKRLGANNGADEVKQHPFF
Kinase 18168.AA S_TKc 1988-2317 25 1.1e-76 262.03 SMART 1-231 (231) Show / Hide 
Range on Protein: 1988-2317
Range on HMM: 1-231/231
Sequence Identity: 25% (89 aa)

FEFLKLISKGAFGRVWLVKKKNTDNVYAMKIVNLAEKMNKNNLMSLQNERDIFGIVSGDFFVKAVYTFAHESYLCFVMEYMIG--GDLGSIQQQFGV---
.|.|..| |||||.|.....|.|. ..|.||..           ....|..|      .. ||  ..| . ..|..||||. |  ||| .. .. |    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LEESVARFYIAC-----SQLHKAGIVHRDLKPDNLLLDSKGHLKLTDFGLSDMGMRSRNMENSKQKKFRQEYNNLKRGMDRISSIKGADKIFSSLTP
   . | .||||..        .|. ||.||||||.|.|||.  |.|..||||.                                              
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------------------------------------------

QSKSDKTRELKQMKTNLDVILNKETKKMKNKKKFRIIGTPDYIPPEVIKGSNNLNCATLDWWSVGVILFEMLVGIPPFNDETVEKIFDNIINMRVPWDQI
                                   ..|||.|..|||.      ...  ||||.|.||.|||.| |||   .....|..|          
---------------------------------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG---------

NIGYGEDEVSPEAEDLIKKLMDPNPQTRLGANGVEE----VQSHPFF
         |||| |.|.|... .|. |..|  . .    . .||.|
---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 18168.AA AktR 1988-2317 29 6.2e-74 251.94 In-house 1-268 (268) Show / Hide 
Range on Protein: 1988-2317
Range on HMM: 1-268/268
Sequence Identity: 29% (101 aa)

FEFLKLISKGAFGRVWLVKKK-NTDNVYAMKIVNLAEKMNKNNLMSLQNERDIFG-IVSGDFFVKAVYTFAHESYLCFVMEYMIGGDLGSIQQQFGVLEE
|...|.. |||||.| ||.|| ... .||||..   .  ..|    ...||.|   ...  |.|| .|.|. ...| |.|||. ||.| .. .. . ..|
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

SVARFYIACSQ-------LHKA-GIVHRDLKPDNLLLDSKGHLKLTDFGLSDMGMRSRNMENSKQKKFRQEYNNLKRGMDRISSIKGADKIFSSLTPQSK
..||||.|  |       ||.   |. |||||.|.|||. ||.|.||||||                                                 
EQARFYFA--QILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSK------------------------------------------------

SDKTRELKQMKTNLDVILNKETKKMKNKKKFRIIGTPDYIPPEVIKG--SNNLNCATLDWWSVGVILFEMLVGIPPFNDETVEKIFDNIINMR-VPWDQ-
                    . .. .. |   . ||| |..||.|.     | ..   |||..|. ..||..|.|||...  . .|..|.. . .. .. 
-------------------LQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSV---DWWAFGIFIYEMVTGCPPFYHKNQNQMFQKIKIKQQNKFPYP

INIGYGEDEVSPEAEDLIK-KLMDPNPQTRLG--ANGVEEVQSHPFF
...       |... |||. ||.. ||. |||  .|| ||. |||.|
SYF-------SSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase 18168.AA RSK 1991-2317 26 2.7e-67 229.9 In-house 1-278 (278) Show / Hide 
Range on Protein: 1991-2317
Range on HMM: 1-278/278
Sequence Identity: 26% (95 aa)

LKLISKGAFGRVWLVKKK---NTDNVYAMKIVNLAEKMNKNN-LMSLQNERDIFGIVS-GDFFVKAVYTFAHESYLCFVMEYMIGGDLG-SIQ--QQFGV
||.  .|..| | |..|.   .|. .||||... |. ....  .     ||.|   .    | |.  |.|  |..|  .|||. ||.|.  .|  ..|| 
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

LEESVARFYI-----ACSQLHKAGIVHRDLKPDNLLLDS---KGHLKLTDFGLSDMGMRSRNMENSKQKKFRQEYNNLKRGMDRISSIKGADKIFSSLTP
. |. |.||.     | . ||. ||.||||||.| |.|.    ||.||||||..  .                                           
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQF-------------------------------------------

QSKSDKTRELKQMKTNLDVILNKETKKMKNKKKFRIIGTPDYIPPEVIKGSNNLNC---ATLDWWSVGVILFEMLVGIPPFND---ETVEKIFDNIINMR
     . .. ....|                     ..| .|..||..|  |  ..   .  |||| ||...|||.| |||     .. ..|...| . .
-----RCDHNQWTMT--------------------FCYTIEYMAPEMLKRAN-QQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGK

VPWDQINIGYG-EDEVSPEAEDLIKKLMDPNPQTRLG--ANGVEEVQSHPFF
     .. . .  ...|.|| |||.|..  .|. |||   ...||...||.|
-----FSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 18168.AA DMPK 1988-2126 43 1.7e-57 140.18 In-house 1-145 (270) Show / Hide 
Range on Protein: 1988-2126
Range on HMM: 1-145/270
Sequence Identity: 43% (63 aa)

FEFLKLISKGAFGRVWLVKKKNTDNVYAMKIVNLAEKMNKNNLMSLQNERDIFGIVSGDFFVKAVYTFAHESYLCFVMEYMIGGDLGSIQQQFG-VLEES
||.||.| .|.|| | .|. |.|. |||||. | .| . . .      ||||  . .    ..  | |  | || .|||||.|||| .   ... ...|.
FEILKVIGRGHFGEVQVVRHKQTNDVYAMKMMNKWEMLKRAETACFWEERDIMVHGNSRWITQLHYAFQDENYLYMVMEYMPGGDLLTLMSRYEDRIPED

VARFYI-----ACSQLHKAGIVHRDLKPDNLLLDSKGHLKLTDFG
 ||||.     |   .|. | |||| |||| |||. ||.|| |||
MARFYLAEMVLAIHSIHQMGYVHRDIKPDNMLLDRHGHIKLADFG
Kinase 18168.AA SGK 1988-2128 34 5.6e-48 145.97 In-house 1-172 (283) Show / Hide 
Range on Protein: 1988-2128
Range on HMM: 1-172/283
Sequence Identity: 34% (60 aa)

FEFLKLISKGAFGRVWLVKKKNT------------------DNVYAMKIVNLAEKM-------NKNNLMSLQNER-DIFGIVSGDFFVKAVYTFAHESYL
|.|||.| || ||.| .||.| .                  | .||||. . .          .|.     . || .|   ..  | |.  | |  . .|
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

CFVMEYMIGGDLGSIQQQFGVLEESVARFYI-----ACSQLHKAGIVHRDLKPDNLLLDSKGHLKLTDFGLS
 |||.|. ||....  |  . . |..||||      |   ||.  |..|||||.|.|||..||..||||||.
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLC
Kinase 18168.AA Akt 1988-2128 41 3.4e-45 142.36 In-house 1-148 (264) Show / Hide 
Range on Protein: 1988-2128
Range on HMM: 1-148/264
Sequence Identity: 41% (62 aa)

FEFLKLISKGAFGRVWLVKKKNTDNVY-AMKIVNLAEKMNKNNLMSLQNERDIFGIVSGDFFVKAVYTFAHESYLCFVMEYMIGGDLGSIQQQFGVLEES
|.|||.. ||.||.| |||||.|...| |||.       .|| .   . || |   .   | |. .| |  . .|.|||.|. ||.| .  |. ..  |.
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

VARFYI-----ACSQLHKAGIVHRD-LKPDNLLLDSKGHLKLTDFGLS
 ||||.     |   ||. .|. || ||| |.|.|..||..||||||.
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLC
Kinase 18168.AA ROCK 1988-2126 42 2.7e-40 134.77 In-house 1-143 (263) Show / Hide 
Range on Protein: 1988-2126
Range on HMM: 1-143/263
Sequence Identity: 42% (61 aa)

FEFLKLISKGAFGRVWLVKKKNTDNVYAMKIVNLAEKMNKNNLMSLQNERDIFGIVSGDFFVKAVYTFAHESYLCFVMEYMIGGDLGSIQQQFGVLEESV
|...|.| .|||| | ||..| . .|||||...  | . .        ||||      .. |.  | |  . ||  ||.|| |||| ..  .. | |   
FHMIKVIGRGAFGEVQLVRHKSSKKVYAMKMLSKFEMIKRSDSAFFWEERDIMAHANSEWIVQLHYAFQDDRYLYMVMDYMPGGDLVNLMSNYDVPEK-W

ARFY-----IACSQLHKAGIVHRDLKPDNLLLDSKGHLKLTDFG
||||      |   .|  | .||| ||||.|||..||||| |||
ARFYTMEVVLALDAIHSMGFIHRDVKPDNMLLDKYGHLKLADFG
Kinase 18168.AA DMPK 2211-2317 37 1.3e-35 84.83 In-house 162-270 (270) Show / Hide 
Range on Protein: 2211-2317
Range on HMM: 162-270/270
Sequence Identity: 37% (43 aa)

IGTPDYIPPEVIKGSNN-------LNCATLDWWSVGVILFEMLVGIPPFNDETVEKIFDNIINMRVPWDQINIGYGED-EVSPEAEDLIKKLMDPNPQTR
.|||||| ||| .  .          |   |||||||...|||.|  || .... . . .| |     ....    .  .||.|| |||..|   ....|
VGTPDYISPEVLQAMEDDGKGRYGPEC---DWWSVGVCMYEMLYGETPFYADSLVETYGKIMNHC--KNHLSFPDDPKWDVSEEAKDLICQLL-CDREER

LGANGVEEVQSHPFF
|| ||.|. . ||||
LGRNGYEDFKCHPFF
Kinase 18168.AA Pkinase 1988-2128 28 2.1e-31 112.09 Pfam 1-159 (293) Show / Hide 
Range on Protein: 1988-2128
Range on HMM: 1-159/293
Sequence Identity: 28% (45 aa)

FEFLKLISKGAFGRVWLVKKKNTDNVYAMKIVNLAEKMNKNNLMSLQN--ERDIFGIVSGDFFVKAVYTFAHESYLCFVMEYMIGG----DLGSIQQ--Q
..... | .|.||.|.. ..|.|  ..|.||...  . ... .... .  |  |   .. .. |.  ..|  ......||||. ||    || .. .  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

FGVL--EESVARFYIAC-----SQLHKAGIVHRDLKPDNLLLDSKGHL----KLTDFGLS
 |..  .| ...||.         .|. ||.||||||.|.|.|..||.    |..||||.
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLA
Kinase 18168.AA SGK 2212-2317 37 7.7e-31 92.11 In-house 187-283 (283) Show / Hide 
Range on Protein: 2212-2317
Range on HMM: 187-283/283
Sequence Identity: 37% (40 aa)

GTPDYIPPEVIKGSNNLNCATLDWWSVGVILFEMLVGIPPFNDETVEKIFDNIINMRVPWDQINIGYGEDEVSPEAEDLIKKLMDPNPQTRLGAN-GVEE
||| |  |||...    .  | |||. | .|.||..|.||| .  ..  .|||||       ..|      .|..| |||. |   .|. |||.. . .|
GTPEYLAPEVLRKQPHDR--TVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQ-----PLQI---PPQMSNDAWDLIQGLLQKDPKKRLGTKRDFME

VQSHPFF
...||||
IKNHPFF
Kinase 18168.AA Akt 2212-2317 35 5e-26 80.12 In-house 164-264 (264) Show / Hide 
Range on Protein: 2212-2317
Range on HMM: 164-264/264
Sequence Identity: 35% (39 aa)

GTPDYIPPEVIKGSNNLNCATLDWWS-VGVILFEMLVGIPPFNDETVEKIFDNIINMRVPWDQINIGYGE--DEVSPEAEDLIKKLMDPNPQTRLG--AN
||| |..||...|  |    . |||. .|....||. | ||| .. ... |..| |  |             | .|||. |||..|   .|  |||   |
GTPEYLAPEILNG--NGHTKAVDWWGSLGCVMYEMMCGRPPFYNQDHHQMFKKIKNQPVKF--------PDKDWISPECKDLISGLLNKDPKKRLGGGPN

GVEEVQSHPFF
...|...||.|
DAQEIKRHPWF
Kinase 18168.AA ROCK 2211-2317 38 7.3e-25 81.37 In-house 160-263 (263) Show / Hide 
Range on Protein: 2211-2317
Range on HMM: 160-263/263
Sequence Identity: 38% (42 aa)

IGTPDYIPPEVIK--GSNNLNCATLDWWSVGVILFEMLVGIPPFNDETVEKIFDNIINMRVPWDQINIGYGEDEVSPEAEDLIKKLMDPNPQTRLGANGV
.|||||| |||.|  | ..      ||||||| ..|||||  ||  ...   . .|.. .      .    . |.| .| |||.| .  . ..||| |||
VGTPDYISPEVLKSQGQDGEYGRECDWWSVGVFIYEMLVGDTPFYADSLVGTYSKIMDHKNSLKFPD----DVEISKQAKDLICKFLT-DREQRLGRNGV

EEVQSHPFF
.... |.||
DDIKQHKFF
Kinase 18168.AA Pkinase 2212-2317 27 6.3e-23 82.14 Pfam 173-293 (293) Show / Hide 
Range on Protein: 2212-2317
Range on HMM: 173-293/293
Sequence Identity: 27% (34 aa)

GTPDYIPPEVIKGSNNLNCATLDWWSVGVILFEMLVGIPPFNDE------TVEKIFDNIINMRVPWDQINIGYGE-------------DEVSPEAEDLIK
|||.|..||||. ...      |.||.|.||.||| | ||| ..      .  .....|   ....|  .   .              ...|.|. |.||
GTPWYMAPEVIR-GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIK

KLMDPNPQTRLGANGVEEVQSHPFF
.. ...|. |..    |..  ||.|
WCLCKDPKKRPT---AEQILQHPWF
Kinase 18168.AA TyrKc 1988-2191 15 3.3e-07 -106.17 SMART 1-280 (280) Show / Hide 
Range on Protein: 1988-2191
Range on HMM: 1-280/280
Sequence Identity: 15% (44 aa)

FEFLKLISKGAFGRVWLVKKKNTDNVYAMKIVNLAEKMNKNNLMSLQNERDIFGIV--SGDFFVKAVYTFAHE-------SYLCFVMEYMIGGDLGSIQQ
 ...| .  ||||.|.. . |   .| | | ..         .. . .|  |   .  . .  |. .    ..         |. ||||| .||| .  .
ITLGKKLGEGAFGEVYKGTWK--IQV-AVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

QFGVLEESVARFYIACSQ-------LHKAGIVHRDLKPDNLLLDSKGHLKLTDFGLSDMGMRS-------RNMENSK--QKK-------------FRQEY
  .    ... .   | |       ||. ...||||   | |...... | .|||||  .               ..  ..|             .  ..
KHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

NN--------------------LKRG-----MDRISSIKGADKIFSSLTPQS--------KSDKTREL---------------KQMKTNL
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TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 18168.AA S_TK_X 2318-2367 24 8e-06 26.63 SMART 1-79 (79) Show / Hide 
Range on Protein: 2318-2367
Range on HMM: 1-79/79
Sequence Identity: 24% (20 aa)

NNFDWDNVR----KMNAPVIPKVK----NVLDTSNFDKQIEYTE----REKIDP-------------------FYGLSKGQ
 ..|||...    .. .| .||.|    .  ||||||.  |.||       .||                   | |...  
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDP--EFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase 18168.AA Pkinase_Tyr 2097-2128 37 0.002877 11.69 Pfam 127-158 (270) Show / Hide 
Range on Protein: 2097-2128
Range on HMM: 127-158/270
Sequence Identity: 37% (12 aa)

LHKAGIVHRDLKPDNLLLDSKGHLKLTDFGLS
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LESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase 18168.AA Pkinase_Tyr 1988-2004 41 0.387035 4.48 Pfam 1-17 (270) Show / Hide 
Range on Protein: 1988-2004
Range on HMM: 1-17/270
Sequence Identity: 41% (7 aa)

FEFLKLISKGAFGRVWL
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ITFGKKLGEGAFGEVYK