Gene 3690 (Tetrahymena)

3690

Species: Tetrahymena
Alias: 3690, 5, PreTt03690, 96.m00159, TTHERM_00655960
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: AGC
Family: NDR

Sequence

Name Sequence Type Origin Length Description Download
3690.AA Protein None 2818 None Fasta, JSON
3690.kin_dom Protein Kinase Domain None 334 None Fasta, JSON
3690.NA RNA None 8457 None Fasta, JSON

Protein domain

Protein domains of 3690.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 3690.AA NDR 2313-2646 38 6.9e-201 626.13 In-house 1-350 (350) Show / Hide 
Range on Protein: 2313-2646
Range on HMM: 1-350/350
Sequence Identity: 38% (135 aa)

FDFLKLISKGAFGRVWLVRKKNTEDIYAMKIVNFAEKMNKNHLDSLKKENEILSKVQ--GDYVVKAVYTFTHESYICFVMEYMIGGDLGS---IISSYGV
|...|.|.|||||.|||||||.|..||||||....|.|.||.......|..|.....   ..|||..|.| ...|...||||..|||...   ... ...
FEIIKIIGKGAFGEVWLVRKKDTGHIYAMKIMRKSEMMWKNQVAHVRAERDIMAEADNKNPWVVKLYYSFQDKQYLYLVMEYHPGGDMMTYCYLLMKMDI

LEESMAKFYIAEIVVAIHNLHQIGIIHRDLKPDNLLLDSQGHLKLTDFGLSDMGLQRRNKTASEKKKE-------KLKIFNNLQKNNKAFQKFDDRINQN
..|..|.|||||.|.||...|..|.||||.||||.|.|..||.|||||||...|..||.......||.       . ........|.| ....|.. |.|
FTEDWARFYIAEMVCAIESVHKMGYIHRDIKPDNFLIDKDGHIKLTDFGLCTGGMIRRHWKQNKQKKPMTTYSTFHWTHNSWYYQNMKEHRPQDFMDNWN

DKFDKQKKP-IRQEILEMKKNVDSLNILKLNNKISKPANRIIGTPDYIAPEILKGEGLQNPAIDWWSVGVMLFELLIGIPPFNDDTVEKIFDNIKNYRIA
.....||.. ..|.. .||.||..||. . ...  . |....|||||.|||........|...||||.|....|.|.|.|||..||.......|.|... 
SNPMNQKCKCHTQMKDQMKCNVKVLNNRSWKQNRRCLAYSTVGTPDYMAPEVFQQKTGYNQTCDWWSLGCIMYEMLVGYPPFCSDTPQETCMKIMNWKQT

WDQIPVGDGEDE-VSQKSVNLIKKLMHPDPKQRLGS--QGIIQIQSDPFF
||.......... .|.. ..||..|..|||..||||  .|. .|.| |||
WDWPMTHFPPEANLSPEAWDLIRRLCCPDPDHRLGSHGKGVDEIKSHPFF
Kinase 3690.AA AGC 2313-2646 27 1e-158 413.95 In-house 1-395 (395) Show / Hide 
Range on Protein: 2313-2646
Range on HMM: 1-395/395
Sequence Identity: 27% (124 aa)

FDFLKLISKGAFGRVWLVRKK------NTEDIYAMKIVNFAE---KMNKNHLDSLKKE------------NEILSKVQG----------DYVVK-AVYTF
|.|||.|.||.||.|.|||||       |...||||... ..   ...|| ..  . |             .||.|...          ...||   |.|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

THESY--ICFVMEYMI---------GG-DLGSIIS---SYGVLEESMAKFYIAE-------IVVAIHNLHQ-IGIIHRD-LKPDNLLLDSQGHLKLTDFG
  ...  ..||||||.         || .| ...     .|...|..|.||.||       || |.. ||.  |||||| |||.|.|||..||.||||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LSDMGLQR-----------RNKTASEKKKEKLKIFNNLQKNNKAFQKFDDRINQNDKFDKQKKPIRQEILEMKKNVDSLNILKLNNKISKP---------
|. .| ..           .... ..||. . |.            ..|   . |                        . ...||. ..          
LCKEGMNDGEKGQQSQSNMKFHW-HNKKY-Q-KS------------NMD---T-N------------------------K-CNPNNWQRNNMSQEDDTTR

-----ANRIIG--TPDYIAPEILKGEGLQNPAIDWWS--VGVMLFELLIGIPPFNDDTVE----------KIFDNIKNYR--IAWDQIPVGD------GE
     .. . |  ||.|.|||||      ..| ||||  .|....|.|.|.|||..|...          ..|..|.|.|  | |..    .      ..
KKRDRTWTFCGPCTPEYMAPEIL-----YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPED

DEVSQKSVNLIKKLMHPDPKQRLGSQ-------GIIQIQSDPFF
...|.  ..|||||...||..|||..       |. .|.. |.|
RWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 3690.AA MAST 2313-2646 40 7.79999999999e-147 452.0 In-house 1-337 (337) Show / Hide 
Range on Protein: 2313-2646
Range on HMM: 1-337/337
Sequence Identity: 40% (142 aa)

FDFLKLISKGAFGRVWLVRKKNTEDIYAMKIVNFAEKMNKNHLDSLKKENEILSKVQGDYVVKAVYTFTH--ESYICFVMEYMIGGDLGSIISSYG-VLE
|.|.|.|||||.|.|.||..|.| |..|||. |   .. || .|... |  ||. .|...|||. |.| .  . | |.|||||.||| .|....||  ..
FEFIKCISKGAYGAVYLVKHKKTNDRFAMKVINCQDTIDKNQVDQVFVERNILTMYQNPFVVKMFYSFQTPCKKYLCMVMEYMEGGDCASLLRMYGNCMP

ESMAKFYIAEIVVAIHNLHQIGIIHRDLKPDNLLLDSQGHLKLTDFGLSDMGLQRRNKTASEKK------KEKLKIFNNLQKNNKAFQ-----KFDDRIN
|.|||.||||.| ..  ||  ||.||||||||.|.|| ||.|||||||| .|.  . .   | .       ..   . . |||.. ||     .    .|
EWMAKMYIAETVLCLEYLHSYGIVHRDLKPDNMLIDSNGHIKLTDFGLSKVGFMDKTTNHYEGYFNTNIFGKNHFNEYHIQKNYQQFQQDFGINGNTNKN

QNDKFDKQKKPIRQEILEMKKNVDSLNILKLNNKISKPANRIIGTPDYIAPEILKGEGLQNPAIDWWSVGVMLFELLIGIPPFNDDTVEK-IFDNIKN--
| .. ..|. ...|.              .. . . .. ....|||||||||.. |.| .....||||.|....|.|.|.||||.||.|. ||.||.|  
QIQQQQEQPQCQQQN--------------EMRPHNIHQNKQCCGTPDYIAPEVILGQGTYGKPVDWWSMGIIMYEFLVGCPPFNGDTPEEMIFQNIINHD

YRIAWDQIPVGDGE--DEVSQKSVNLIKKLMHPDPKQRLGSQGIIQIQSDPFF
 .| |  ...||..  |..|     ||||| .|.||.|||..|  .| . |||
REIEW--PEEGDPNDDDCMSPEAQDLIKKLLQPNPKKRLGANGADEIKQHPFF
Kinase 3690.AA MAST 2313-2646 40 9.3e-142 459.95 In-house 1-334 (334) Show / Hide 
Range on Protein: 2313-2646
Range on HMM: 1-334/334
Sequence Identity: 40% (137 aa)

FDFLKLISKGAFGRVWLVRKKNTEDIYAMKIVNFAEKMNKNHLDSLKKENEILSKVQGDYVVKAVYTFTHESYICFVMEYMIGGDLGSIISSYGVLEESM
|.| |.|||||.|.|.||..|.| |..|||... ....||| .|... |  ||. .|...|||. |.| ...|.|.|||||.|||..|....|| ..|.|
FEFIKPISKGAYGKVYLVKHKKTNDRFAMKVIKKSDMINKNMVDQVQVERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLHMYGYFDEWM

AKFYIAEIVVAIHNLHQIGIIHRDLKPDNLLLDSQGHLKLTDFGLSDMGLQRRNKTASEKKKEKLKIFNNLQKNNKAFQKFDDRINQNDKFDKQKKPIRQ
||.||||.| ..  ||. ||.||||||||.|.|| || |||||||| .|. .. ... .. .    ||||   .    |. . .. ..    ....   .
AKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFGLSKVGFMDD-LNMMYEGYTPPNIFNNSTDPMNKNQQDYSQFPGDFGINGNTNKNQI

EILEMKKNVDSLNILKLNNKISKPANRIIGTPDYIAPEILKGEGLQNPAIDWWSVGVMLFELLIGIPPFNDDTVEKIFDNIKNYR---IAWDQIPVGDGE
. .. ..  .  | .. .|.  .. ....|||||||||...|.| .....||||.|....|.|.|.|||||||.|.||.||.|..   | |     ||..
QQQQEQPQCQQQN-MRPHNI--HQNKQCCGTPDYIAPEVILGQGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEG--GDIN

--DEVSQKSVNLIKKLMHPDPKQRLGSQ-GIIQIQSDPFF
  .. |  .  ||.|| .|||..|||.. |  .... |||
DDEAMSPEAQDLIEKLLQPDPRKRLGANNGADEVKQHPFF
Kinase 3690.AA S_TKc 2313-2646 26 2.9e-87 297.13 SMART 1-231 (231) Show / Hide 
Range on Protein: 2313-2646
Range on HMM: 1-231/231
Sequence Identity: 26% (91 aa)

FDFLKLISKGAFGRVWLVRKKNTEDIYAMKIVNFAEKMNKNHLDSLKKENEILSKVQGDYVVKAVYTFTHESYICFVMEYMIG--GDLGSIISSYGV---
...|..| |||||.|...|.|.|  |.|.||..          .....| .||.| . ...||  ..| . .....||||. |  ||| ..| ..|    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LEESMAKFYIAEIVVAIHNLHQIGIIHRDLKPDNLLLDSQGHLKLTDFGLSDMGLQRRNKTASEKKKEKLKIFNNLQKNNKAFQKFDDRINQNDKFD
   . | .|.||...|. |.  .|. |||||||||.|.|||.  |.|..||||.                                              
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------------------------------------------

KQKKPIRQEILEMKKNVDSLNILKLNNKISKPANRIIGTPDYIAPEILKGEGLQNPAIDWWSVGVMLFELLIGIPPFNDDTVEKIFDNIKNYRIAWDQIP
                                 . ..|||.|.|||.|   |   ...||||.|..|.|.| | |||   .....|..|.          
---------------------------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG----------

VGDGEDEVSQKSVNLIKKLMHPDPKQRLGSQGIIQ----IQSDPFF
        |.   ..|.|... ||..|..   . |    | ..|.|
--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 3690.AA DMPK 2313-2456 46 1.3e-76 188.5 In-house 1-145 (270) Show / Hide 
Range on Protein: 2313-2456
Range on HMM: 1-145/270
Sequence Identity: 46% (67 aa)

FDFLKLISKGAFGRVWLVRKKNTEDIYAMKIVNFAEKMNKNHLDSLKKENEILSKVQGDYVVKAVYTFTHESYICFVMEYMIGGDLGSIISSYG-VLEES
|..||.| .|.|| | .|| |.|.|.||||. | .| . .      . |  |...     ...  | |  | |  .|||||.|||| . .|.|. ...|.
FEILKVIGRGHFGEVQVVRHKQTNDVYAMKMMNKWEMLKRAETACFWEERDIMVHGNSRWITQLHYAFQDENYLYMVMEYMPGGDLLTLMSRYEDRIPED

MAKFYIAEIVVAIHNLHQIGIIHRDLKPDNLLLDSQGHLKLTDFG
||.||.||.|.||| .||.| .||| |||| |||..||.|| |||
MARFYLAEMVLAIHSIHQMGYVHRDIKPDNMLLDRHGHIKLADFG
Kinase 3690.AA RSK 2316-2646 28 3.9e-74 252.59 In-house 1-278 (278) Show / Hide 
Range on Protein: 2316-2646
Range on HMM: 1-278/278
Sequence Identity: 28% (100 aa)

LKLISKGAFGRVWLVRKK---NTEDIYAMKIVNFAEKMNKNH-LDSLKKENEILSKVQ-GDYVVKAVYTFTHESYICFVMEYMIGGDLGSIISSYGV---
||.  .|..| | |.||.   .|. |||||... |. ....  .   ..| .||. .|    .|.  |.|  |...  .|||. ||.|.  ..  .    
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

LEESMAKFYIAEIVVAIHNLHQIGIIHRDLKPDNLLLDS---QGHLKLTDFGLSDMGLQR-RNKTASEKKKEKLKIFNNLQKNNKAFQKFDDRINQNDKF
. |. |.||.||||.|.  ||| |||||||||.| |.|.   .||.||||||..  .  .  ..| .                                 
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMT---------------------------------

DKQKKPIRQEILEMKKNVDSLNILKLNNKISKPANRIIGTPDYIAPEILK---GEGLQNPAIDWWSVGVMLFELLIGIPPFND---DTVEKIFDNIKNYR
                                     ..| .|.|||.||   ..|  . | |||| || ..|.| | |||     .. ..|...|.. .
------------------------------------FCYTIEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGK

IAWDQIPVGDGEDEVSQKSVNLIKKLMHPDPKQRLG--SQGIIQIQSDPFF
.     . ..  ...||   .||.|..| ||..|||   |.. .|...|.|
FS----LTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 3690.AA AktR 2313-2646 28 5.4e-73 248.82 In-house 1-268 (268) Show / Hide 
Range on Protein: 2313-2646
Range on HMM: 1-268/268
Sequence Identity: 28% (97 aa)

FDFLKLISKGAFGRVWLVRKK-NTEDIYAMKIVNFAEKMNKNHLDSLKKENEILS-KVQGDYVVKAVYTFTHESYICFVMEYMIGGDLGSIISSYGVLEE
|...|.. |||||.| ||.|| .. ..||||..   .  ..|  . .  |  |.  ...    || .|.|  .... |.|||. ||.| ..... . ..|
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

SMAKFYIAEIVVAIHNLHQI-GIIHRDLKPDNLLLDSQGHLKLTDFGLSDMGLQRRNKTASEKKKEKLKIFNNLQKNNKAFQKFDDRINQNDKFDKQKKP
..|.||.|.|. |.  |||   || |||||.|.|||. ||.|.||||||                                                   
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSK--------------------------------------------------

IRQEILEMKKNVDSLNILKLNNKISK--PANRIIGTPDYIAPEILKG-EGLQNPAIDWWSVGVMLFELLIGIPPFNDDTVEKIFDNIKNYR-IAWDQIPV
                   | .....  .|. . ||| |.|||...  .|  | ..|||..|. ..|...|.|||...  . .|..||... .  .. . 
-------------------LQFMMHYDEKAYSFCGTPEYMAPEMITKKKGH-NKSVDWWAFGIFIYEMVTGCPPFYHKNQNQMFQKIKIKQQNKFPYPS-

GDGEDEVSQKSVNLIK-KLMHPDPKQRLG--SQGIIQIQSDPFF
     ..|..  .||. ||.  .|..|||  . |. .| | |.|
-----YFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase 3690.AA Akt 2313-2470 40 2.6e-63 201.23 In-house 1-161 (264) Show / Hide 
Range on Protein: 2313-2470
Range on HMM: 1-161/264
Sequence Identity: 40% (66 aa)

FDFLKLISKGAFGRVWLVRKKNTEDIY-AMKIVNFAEKMNKNHLDSLKKENEILSKVQGDYVVKAVYTFTHESYICFVMEYMIGGDLGSIISSYGVLEES
|||||.. ||.||.| ||.||.|...| |||.       .||..   | |. || ...  ..|. .| |  . ...|||.|. ||.| . ..  ..  |.
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

MAKFYIAEIVVAIHNLHQIGIIHRD-LKPDNLLLDSQGHLKLTDFGLSDMG-LQRRNKTAS
 |.||.|||. ||  ||. .|| || ||| |.|.|..||..||||||. .. ...  || .
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKT
Kinase 3690.AA SGK 2313-2470 34 1.5e-55 169.78 In-house 1-184 (283) Show / Hide 
Range on Protein: 2313-2470
Range on HMM: 1-184/283
Sequence Identity: 34% (63 aa)

FDFLKLISKGAFGRVWLVRKKNT------------------EDIYAMKIVNFAEKM-------NKNHLDSLKKEN-EILSKVQGDYVVKAVYTFTHESYI
|||||.| || ||.| .|..| .                  ...||||. . .          .|..    . |   ||...     |.  | |  . . 
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

CFVMEYMIGGDLGSIISSYGVLEESMAKFYIAEIVVAIHNLHQIGIIHRDLKPDNLLLDSQGHLKLTDFGLSDMGLQRRNKTAS
 |||.|. ||.... .   . . |. |.|| |||| |.  || . ||.|||||.|.|||.|||..||||||.  | .  ..| .
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFT
Kinase 3690.AA GEK 2313-2456 44 3.2e-49 163.17 In-house 1-145 (269) Show / Hide 
Range on Protein: 2313-2456
Range on HMM: 1-145/269
Sequence Identity: 44% (64 aa)

FDFLKLISKGAFGRVWLVRKKNTEDIYAMKIVNFAEKMNKNHLDSLKKENEILSKVQGDYVVKAVYTFTHESYICFVMEYMIGGDLGSIISSYG-VLEES
|. ||.| .|||| |  |. |||...|||||.|  | . .      . | ..| .    .. .  | |  | |. .||.| .||||  ..| ..  | |.
FEILKVIGRGAFGEVAVVKMKNTDQVYAMKILNKWEMLKRAETACFREERDVLVNGDRRWITNLHYAFQDENYLYLVMDYYVGGDLLTLLSKFEDRLPED

MAKFYIAEIVVAIHNLHQIGIIHRDLKPDNLLLDSQGHLKLTDFG
||.|||||.|.||. .||.. .|||.||||.||| .||..| |||
MARFYIAEMVMAIDSVHQLHYVHRDIKPDNVLLDMNGHIRLADFG
Kinase 3690.AA Pkinase 2313-2458 32 1.9e-41 147.62 Pfam 1-159 (293) Show / Hide 
Range on Protein: 2313-2458
Range on HMM: 1-159/293
Sequence Identity: 32% (52 aa)

FDFLKLISKGAFGRVWLVRKKNTEDIYAMKIVNFAEKMNKNHLDSLKK--ENEILSKVQGDYVVKAVYTFTHESYICFVMEYMIGG----DLGSIIS--S
. ... | .|.||.|.. ..|.|..|.|.||..  .. ... . .. .  | .|. ... ...|.  ..|. ...|..||||. ||    || ..||  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIK-KRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

YGVL--EESMAKFYIAEIVVAIHNLHQIGIIHRDLKPDNLLLDSQGHL----KLTDFGLS
.|..  .|  .|||. .|. ..  .|. |||||||||.|.|.|..||.    |..||||.
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLA
Kinase 3690.AA DMPK 2541-2646 34 1.4e-30 72.1 In-house 162-270 (270) Show / Hide 
Range on Protein: 2541-2646
Range on HMM: 162-270/270
Sequence Identity: 34% (39 aa)

IGTPDYIAPEILKGEGLQ-----NPAIDWWSVGVMLFELLIGIPPFNDDTVEKIFDNIKNYRIAWDQIPVGDGED-EVSQKSVNLIKKLMHPDPKQRLGS
.||||||.||.|.  .        |  ||||||| ..|.| |  || .|.. . . .| |.    ...   | .  .||..  .||..|   |...||| 
VGTPDYISPEVLQAMEDDGKGRYGPECDWWSVGVCMYEMLYGETPFYADSLVETYGKIMNHC--KNHLSFPDDPKWDVSEEAKDLICQLL-CDREERLGR

QGIIQIQSDPFF
 |. ...  |||
NGYEDFKCHPFF
Kinase 3690.AA SGK 2542-2646 36 1.9e-29 87.69 In-house 187-283 (283) Show / Hide 
Range on Protein: 2542-2646
Range on HMM: 187-283/283
Sequence Identity: 36% (39 aa)

GTPDYIAPEILKGEGLQNPAIDWWSVGVMLFELLIGIPPFNDDTVEKIFDNIKNYRIAWDQIPVGDGEDEVSQKSVNLIKKLMHPDPKQRLGSQ-GIIQI
||| | |||.|....  . . |||. |  |.|...|.||| .  ..  .||| |  .   |||       .| .   ||. | . |||.|||.  . ..|
GTPEYLAPEVLRKQPHDR-TVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPL---QIP-----PQMSNDAWDLIQGLLQKDPKKRLGTKRDFMEI

QSDPFF
.. |||
KNHPFF
Kinase 3690.AA Akt 2542-2646 37 2e-25 78.14 In-house 164-264 (264) Show / Hide 
Range on Protein: 2542-2646
Range on HMM: 164-264/264
Sequence Identity: 37% (40 aa)

GTPDYIAPEILKGEGLQNPAIDWWS-VGVMLFELLIGIPPFNDDTVEKIFDNIKNYRIAWDQIPVGDGEDEVSQKSVNLIKKLMHPDPKQRLG--SQGII
||| |.|||||.| | .  | |||. .|. ..|.. | ||| .. ... |..|||  .   ..|     | .|..  .||..| . |||.|||  .... 
GTPEYLAPEILNGNG-HTKAVDWWGSLGCVMYEMMCGRPPFYNQDHHQMFKKIKNQPV---KFPDK---DWISPECKDLISGLLNKDPKKRLGGGPNDAQ

QIQSDPFF
.|...|.|
EIKRHPWF
Kinase 3690.AA GEK 2527-2646 35 3.3e-22 70.97 In-house 148-269 (269) Show / Hide 
Range on Protein: 2527-2646
Range on HMM: 148-269/269
Sequence Identity: 35% (44 aa)

LKLNNKISKPANRIIGTPDYIAPEILK----GEGLQNPAIDWWSVGVMLFELLIGIPPFNDDTVEKIFDNIKNYRIAWDQIPVGDGEDEVSQKSVNLIKK
|..|.  .  .|  .||||||.||||.    |.|   |  ||||.||...|.| |  ||  . .   .  | |..    |.|  . . .||...  ||..
LRMNKDGMVQSNVAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKDHF-QFPSQETDWDVSEEAKDLIRQ

LMHPDPKQRLGSQGIIQIQSDPFF
|. . . .|||  ||   .  |||
LICS-QEHRLGRNGIQDFKKHPFF
Kinase 3690.AA Pkinase 2542-2646 26 1.6e-19 70.08 Pfam 173-293 (293) Show / Hide 
Range on Protein: 2542-2646
Range on HMM: 173-293/293
Sequence Identity: 26% (33 aa)

GTPDYIAPEILKGEGLQNPAIDWWSVGVMLFELLIGIPPFNDD------TVEKIFDNIKNYRIAWDQIPVGDGE-------------DEVSQKSVNLIKK
|||.|.|||...|     |..|.||.|..|.|.| | ||| ..      .  .....|.  .. .|     ..              ...|.    .||.
GTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKW

LMHPDPKQRLGSQGIIQIQSDPFF
. ..|||.|..   . ||  .|.|
CLCKDPKKRPT---AEQILQHPWF
Kinase 3690.AA TyrKc 2313-2524 16 5.1e-10 -60.65 SMART 1-280 (280) Show / Hide 
Range on Protein: 2313-2524
Range on HMM: 1-280/280
Sequence Identity: 16% (47 aa)

FDFLKLISKGAFGRVWLVRKKNTEDIYAMKIVNFAEKMNK-NHLDSLKKENEILSKV--QGDYVVKAVYTFTHE-------SYICFVMEYMIGGDLGSII
  ..| .  ||||.|.. . |          .. | || | ...  . .| .|..|.  . . .|. .   |..         .. ||||| .||| . .
ITLGKKLGEGAFGEVYKGTWK----------IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

SSYGV-LEESMAKFYIAEIVVAIHNLHQIGIIHRDLKPDNLLLDSQGHLKLTDFGLSDMGLQR-------RNKTASEKKKEK--------------LKIF
 ...  |  .    .   |      ||. ..|||||   | |...... | .|||||  .            ....|.| .|               ..|
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

NN----------------------LQ-----KNNKAFQKFDDRINQNDKFDK--------QKKPIRQEILE-----------MKKNVDSL
.                              ..|.   .. .. .  .. .           . . | ...           ..  .. .
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 3690.AA S_TK_X 2647-2715 21 1e-06 29.26 SMART 1-79 (79) Show / Hide 
Range on Protein: 2647-2715
Range on HMM: 1-79/79
Sequence Identity: 21% (18 aa)

TGIDWNNLK----KTPAPIIPEVK----NILDTSNFDKDKVY-----QEGEQ-IDPFFGLPKGVETVKEAKKLLDQTGFSVKR
 ||||..|     ....|..|..|    .  ||||||..        .  .. . .  . .. .||    .  ..  ||. ..
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNE-METE---IPPDPFRGFTYVF
Kinase 3690.AA Pkinase_Tyr 2427-2458 40 0.00021 15.54 Pfam 127-158 (270) Show / Hide 
Range on Protein: 2427-2458
Range on HMM: 127-158/270
Sequence Identity: 40% (13 aa)

LHQIGIIHRDLKPDNLLLDSQGHLKLTDFGLS
|.....|||||   | |...... | .||||.
LESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase 3690.AA Pkinase_Tyr 2313-2398 27 0.00061 13.97 Pfam 1-94 (270) Show / Hide 
Range on Protein: 2313-2398
Range on HMM: 1-94/270
Sequence Identity: 27% (26 aa)

FDFLKLISKGAFGRVWLVRKK----NTEDIYAMKIVNFAEKMNKNH--LDSLKKENEILSKV-QGDYVVKAVYTFT-HESY--ICFVMEYMIGGDL
  |.| . .||||.|.. . |    ||.   | |..   |.  . .  .... .| .|...  . . .|. .   | ..    |. ||||| .|||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML--KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDL