18333

Species: Tetrahymena
Alias: 18333, TTHERM_00992710, 186.m00049, 849, PreTt18333
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: AGC
Family: PKA

Sequence

Name Sequence Type Origin Length Description Download
18333.AA Protein None 531 None Fasta, JSON
18333.kin_dom Protein Kinase Domain None 267 None Fasta, JSON
18333.NA RNA None 1596 None Fasta, JSON

Protein domain

Protein domains of 18333.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 18333.AA PKA 211-477 59 5.2e-189 634.2 In-house 1-263 (263) Show / Hide
Range on Protein: 211-477
Range on HMM: 1-263/263
Sequence Identity: 59% (164 aa)

FNIKTTLGTGSFGRVKLAKLKGNEKDVFALKMMKKIEIVKLKQVEHIKSEKKILSQIKHPFLV-ELKGTFQDEIYIYMLFEFVSGGEIFSRLRKEGRFSN
|.|..||||||||||.|.. |... . .|.||.|| |||.||||||...||.||..|||||.| ....||||. |.||..|.|.|||.||.|||.|||||
FEIIQTLGTGSFGRVMLCRHKHSG-NYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSN

DISLFYIT-EIYLALQYLHSQNIVYRDLKPENLLIDKEGHVKIADFGFAKIMDSARTYTLCGTPEYLAPEIIQGAKTGYGKSVDWWALGVLIFEMLSGHP
....||.. .|.|||.|||||||.||||||||.||||.||.||.|||||| .|. ||.|||||||||||||||. . |.||||||||||.||.|||.|.|
PHAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKKVDD-RTWTLCGTPEYLAPEIIQSKN-GHGKSVDWWALGILIYEMLAGYP

PFYDC--DPMGIYQKIVNSVINFPEFFSLRA---KDLVRKLLNPNIESRLGCQDQILSNVIDQDGNSIKNHKWF
||||.  |||.||.||.|  |.||..|. .|   |||..|||..... |.|....        ..|.|||||||
PFYDHNRDPMQIYEKICNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKN--------GVNDIKNHKWF

Kinase 18333.AA AGC 211-477 31 1.2e-175 458.76 In-house 1-395 (395) Show / Hide
Range on Protein: 211-477
Range on HMM: 1-395/395
Sequence Identity: 31% (129 aa)

FNIKTTLGTGSFGRVKLAKLKGNE-----KDVFALKMMKKIE-IVKLK--QVEHIKSE------------KKILSQIK----------HPFLVE-LKGTF
|......|.||||.| |.. |...     ....|.|..|| . ||..|  .|||...|            ..||....          |||.|  |. .|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QDEIY--IYMLFE----FVS-----GG-EIFSRLR---KEGRFSNDISLFYITE-------IYLALQYLHS-QNIVYRD-LKPENLLIDKEGHVKIADFG
||. .  .|.. |    .|.     || | |..|.   |||||. . . ||. |       | |||.|||| ..|..|| |||||.|.|..||.|..|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

FAKIMDS----------------------------------------------------ARTYTLCG--TPEYLAPEIIQGAKTGYGKSVDWWA--LGVL
..|.. .                                                    .||.|.||  ||||.||||.      |||..|||.  ||.|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL------YGKACDWWSFGLGCL

IFEMLSGHPPFYDC----------DPMGIYQKIV------NSVINFP----------EFFSLRAKDLVRKLLNPNIESRLGCQDQILSNVIDQDGNSIKN
..|||.|.||||.           .|| ..|||       |  . ||          ..||  ||||..|||... | ||||...  . .  .. . |||
MYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFG-D--KGAEEIKN

HKWF
|.||
HPWF

Kinase 18333.AA SGK 211-477 38 9.69999999999e-123 381.02 In-house 1-283 (283) Show / Hide
Range on Protein: 211-477
Range on HMM: 1-283/283
Sequence Identity: 38% (113 aa)

FNIKTTLGTGSFGRVKLAKLKGN-----------------EKDVFALKMMKKIEIV-------KLKQVEHIKSEK-KILSQIKHPFLVELKGTFQDEIYI
| .....| ||||.| ..| |.                  |....|.|  .|  |.       | |.. ||..|. .||. .||||.| |.  || . . 
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

YMLFEFVSGGEIFSRLRKEGRFSNDISLFYITEIYLALQYLHSQNIVYRDLKPENLLIDKEGHVKIADFGFAK--IMDSARTYTLCGTPEYLAPEIIQGA
|.  ..| ||| |. |..|..|. | . ||  || .|| |||||.|.||||||||.| | .||... ||| .|  | ..  | | ||||||||||...  
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLR--

KTGYGKSVDWWALGVLIFEMLSGHPPFYDCDPMGIYQKIVNSVINFPEFFSLRAKDLVRKLLNPNIESRLGCQDQILSNVIDQDGNSIKNHKWF
| .....|||| || . .||..| ||||. .    |..| |. ...| ..|  |.||   ||. . . |||  .         |.  |||| .|
KQPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTKR---------DFMEIKNHPFF

Kinase 18333.AA Akt 211-477 44 1.3e-119 384.03 In-house 1-264 (264) Show / Hide
Range on Protein: 211-477
Range on HMM: 1-264/264
Sequence Identity: 44% (123 aa)

FNIKTTLGTGSFGRVKLAKLKGNEKDVF-ALKMMKKIEIVKLKQVEHIKSEKKILSQIKHPFLVELKGTFQDEIYIYMLFEFVSGGEIFSRLRKEGRFSN
|...  || ||||.| |.| | ..| .. |.|. ||  |.. .||||.| |..||  ..|||.| |.  ||.. ..|.  ....|||.|. |....||| 
FDFLKVLGKGSFGKVFLVKKKDTQK-WYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSE

DISLFYITEIYLALQYLHSQNIVYRD-LKPENLLIDKEGHVKIADFGFAK---IMDSARTYTLCGTPEYLAPEIIQGAKTGYGKSVDWWA-LGVLIFEML
|   ||. || ||...|||.||.||| |||||.|.||.||....||| .|   | |  .|.|.|||||||||||..|  .|..|.||||. ||....||.
DRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNG--NGHTKAVDWWGSLGCVMYEMM

SGHPPFYDCDPMGIYQKIVNSVINFP--EFFSLRAKDLVRKLLNPNIESRLG-CQDQILSNVIDQDGNSIKNHKWF
 | ||||. |    ..|| |. ..||  ...|  .|||...||| . . |||   .         | . ||.| ||
CGRPPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPN---------DAQEIKRHPWF

Kinase 18333.AA AktR 211-477 41 1.7e-108 366.71 In-house 1-268 (268) Show / Hide
Range on Protein: 211-477
Range on HMM: 1-268/268
Sequence Identity: 41% (116 aa)

FNIKTTLGTGSFGRVKLAKLKGNEKDVFALKMMKKIEIVKLKQVEHIKSEKKILS-QIKHPFLVELKGTFQDEIYIYMLFEFVSGGEIFSRLRKEGRFSN
| .   || | ||.| |.. | ......|.|| || .|....| .|.  |..|.  ...|||.| |. .||.. ... . |.. |||.|. |.|...||.
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

DISLFYITEIYLALQYLHSQ-NIVYRDLKPENLLIDKEGHVKIADFGFAK---IM-DSARTYTLCGTPEYLAPEIIQGAKTGYGKSVDWWALGVLIFEML
. ..||. .| |||.|||.. ||.||||||||.|.|..|||||.||| .|   .| .. ..|..||||||.|||.|.    |..|||||||.|..|.||.
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKK-KGHNKSVDWWAFGIFIYEMV

SGHPPFYDCDPMGIYQKIVNSV---INFPEFFSLRAKDLVR-KLLNPNIESRLG--CQDQILSNVIDQDGNSIKNHKWF
.|.||||. .   ..||| ..    ...|. ||  .|||.  |||. | . |||  | .      ...    ||.|.||
TGCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNG------WEE----IKSHPWF

Kinase 18333.AA S_TKc 211-477 36 3.5e-99 336.71 SMART 1-231 (231) Show / Hide
Range on Protein: 211-477
Range on HMM: 1-231/231
Sequence Identity: 36% (100 aa)

FNIKTTLGTGSFGRVKLAKLKGNEKDVFALKMMKKIEIVKLKQVEHIKSEKKILSQIKHPFLVELKGTFQDEIYIYMLFEFVSG--GEIFSRLRKEGR--
. |  ..| |.||.|.... |.  . ..|.|..|          |||..| .||.. .||..| |...|||  ..|| .|...|  |. |....| ||  
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----FSNDISLFYITEIYLALQYLHSQNIVYRDLKPENLLIDKEGHVKIADFGFAKIMDSARTYTLCGTPEYLAPEIIQGAKTGYGK-SVDWWALGVLIF
    |.     ||. .| .||.|.||..|..|||||||.|.|.  |.||.|||.|...     .|.||||.|.|||..     |||| ..|||..|....
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL-----GYGKCKCDWWSCGCILY

EMLSGHPPFYDCDPMGIYQKIVNSVINFPEFFSLRAKDLVRKLLNPNIESRLGCQDQILSNVIDQDGNSIKNHKWF
|||.| |||.  ... ...||.          |  |||..||.|. . | |... .      . ||.  ||.| ||
EMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-E------ALQDEWDIKCHPWF

Kinase 18333.AA PKG 211-477 44 9e-99 334.45 In-house 1-260 (260) Show / Hide
Range on Protein: 211-477
Range on HMM: 1-260/260
Sequence Identity: 44% (121 aa)

FNIKTTLGTGSFGRVKLAKLKGNEKDVFALKMMKKIEIVKLKQVEHIKSEKKILSQIKHPFLVELKGTFQDEIYIYMLFEFVSGGEIFSRLRKEGRFSND
..|  ||| | |||| | .... . . ||||.|||..||. .| ||| |||.|. . . .| | |  || |. |.||| |   |||. . ||. |.| ..
LKIIATLGVGGFGRVELVQYNHQKSRTFALKCMKKRHIVDTRQQEHIMSEKNIMMECRCDFIVRLYRTFRDQKYVYMLMEACMGGELWTILRDRGHFDDK

ISLFYITEIYLALQYLHSQNIVYRDLKPENLLIDKEGHVKIADFGFAK-IMDSARTYTLCGTPEYLAPEIIQGAKTGYGKSVDWWALGVLIFEMLSGHPP
 . ||.  .  |. |||..||.|||||||||. |..| .|. |||||| |  . .|.| |||||| |||||     |   |||.||||.|..| | | ||
TTRFYCACVVEAFDYLHRKNIIYRDLKPENLMLDNRGYCKLVDFGFAKKIGQGRKTWTFCGTPEYVAPEII--LNKGHDRSVDYWALGILMCELLTGNPP

FYDCDPMGIYQKIVN--SVINFPEFFSLRAKDLVRKLLNPNIESRLGCQDQILSNVIDQDGNSIKNHKWF
|   ||| .|. |     .. || . . .|.....||   |   ||| | . ..         || ||||
FSGSDPMKTYNIILKGIDMWEFPRKITRWAQNMIKKLCRDNPTERLGYQKNGIND--------IKKHKWF

Kinase 18333.AA Ciliate-E2b 211-477 35 6.6e-96 291.88 In-house 1-272 (272) Show / Hide
Range on Protein: 211-477
Range on HMM: 1-272/272
Sequence Identity: 35% (101 aa)

FNIKTTLGTGSFGRVKLAKLKGNEKDVFALKMMKKIEIVKLKQVEHIKSEKKILSQIKHPFLVELKGTFQDEIYIYMLFEFVSGGEIFSRLRKEG--RFS
. .   || | || | | .   |.|  .|.|  .| .|..     |. .||..|  ..|||.. .. .|.|. ..|.. ||..|.|.|. .|  |   .|
MIYIKKLGFGQFGSVYLVWNTKNTKQYYAMKCISKNQIIQQNMEKHMLQEKNVLEKCNHPFIMKFIRSFKDDQHMYFMMEFCNGMELFDVIREIGRLLLS

NDISLFYITEIYLALQYLHSQNIVYRDLKPENLLIDKEGHVKIADFGFAKIMDSA-----RTYTLCGTPEYLAPEIIQ---GAKTGYGKSVDWWALGVLI
   |.||| .| |.|.|||.|||.|||.|||| ..|..|..|..|.| ||.|..      ||.|..|||.|.||||||       ||. .|| |..|.  
TYDSQFYIASICLCLEYLHNQNIIYRDIKPENIMVDHKGYMKLIDMGTAKHMYKKNEQMTRTFTIIGTPHYMAPEIIQSLQPGGKGYTYKVDIWSVGICL

FEMLSGHPPFYD--CDPMGIYQKIVNS--VINFPEFFSLRAK--DLVRKLLNPNIESRLGCQDQILSNVIDQDGNSIKNHKWF
.|...| .|.     ||  |||.|..    |.|| ... . .  .|. ..|. ..| |||   . |           |.|.||
YEFMCGYVPWAEDVQDPYEIYQEIIKKYDEIQFPSYCKDKMADKKLMLQCLQKMPEVRLGGSYSWL-----------KSHPWF

Kinase 18333.AA RSK 214-477 39 8.7e-94 317.89 In-house 1-278 (278) Show / Hide
Range on Protein: 214-477
Range on HMM: 1-278/278
Sequence Identity: 39% (112 aa)

KTTLGTGSFGRVKLAKLKG--NEKDVFALKMMKKIEIVKLKQ-VEHIKSEKKILSQIK-HPFLVELKGTFQDEIYIYMLFEFVSGGEIFSRLRKEGR---
   ||.|..| | | . ..  . . ..| |  || .||. .  ..| . | .||. .. |||.|.|. .||.| ..|.  |...||| | .|.||..   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FSNDISLFYITEIYLALQYLHSQNIVYRDLKPENLLIDK---EGHVKIADFGFAKIM--D-SARTYTLCGTPEYLAPEIIQ-GA-KTGYGKSVDWWALGV
|| |   ||. || ||...||.| |..||||||| | |    |||.|. ||||.|..  | . .|.| |.| ||.|||..  .  . |..|..||| |||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LIFEMLSGHPPFYD---CDPMGIYQKIVNSV--INFP--EFFSLRAKDLVRKLLNPNIESRLGCQDQILSNVIDQDGNSIKNHKWF
|..|||.|.|||.     ..  | ..| .     ..|  .. |  ||||.||.|  . . ||||          || . ||.|.||
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCG--------PQDAEEIKQHPWF

Kinase 18333.AA PKC 211-477 41 6.5e-90 291.61 In-house 1-262 (262) Show / Hide
Range on Protein: 211-477
Range on HMM: 1-262/262
Sequence Identity: 41% (111 aa)

FNIKTTLGTGSFGRVKLAKLKGNEKDVFALKMMKKIEIVKLKQVEHIKSEKKILSQ-IKHPFLVELKGTFQDEIYIYMLFEFVSGGEIFSRLRKEGRFSN
||  . || |||| | ||..||... ..| | .||  |..   ||    ||..|..  |||||..|  .|| . ...   |.| ||       . .||. 
FNFLKVLGKGSFGKVMLAERKGTDE-YYAIKVLKKDVIIQDDDVECTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRRFKE

DISLFYITEIYLALQYLHSQNIVYRDLKPENLLIDKEGHVKIADFGFAK--IMDSARTYTLCGTPEYLAPEIIQGAKTGYGKSVDWWALGVLIFEMLSGH
    ||  || .|||.||...|.||||| .| |.|.|||.|||||| .|  ... ..| | ||||.|.||||.|. .  |||||||||.||| .||. |.
EHARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDTTSTFCGTPDYIAPEILQYQE--YGKSVDWWAFGVLMYEMMAGQ

PPFYDCDPMGIYQKIVNSVINFPEFFSLRAKDLVRKLLNPNIESRLGCQDQILSNVIDQDGNSIKNHKWF
.||  .|   . | | .  . .|  .| .|...  .... | | ||||. |  .   |     |. |  |
SPFHGEDEDELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQD-----IREHPFF

Kinase 18333.AA Pkinase 211-477 31 7.4e-90 309.62 Pfam 1-293 (293) Show / Hide
Range on Protein: 211-477
Range on HMM: 1-293/293
Sequence Identity: 31% (97 aa)

FNIKTTLGTGSFGRVKLAKLKGNEKDVFALKMMKKIEIVKLKQVEHIK-SEKKILSQIKHPFLVELKGTFQDEIYIYMLFEFVSGG----EIFSRLR--K
. |. ..| ||||.|.... ||..| ..|.| .|| .. . |...|.. || .|.  ..||. |.|...|.|. .||| .|.. ||    . |....  .
YHIGRKIGSGSFGCVYKCHHKGTGK-IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

EGRF--SNDISLFYITEIYLALQYLHSQNIVYRDLKPENLLIDKEGHV----KIADFGFAK---IMDSARTYTLCGTPEYLAPEIIQGAKTGYGKSVDWW
.|.|  | .   ||...|  .|.|.||..|..|||||||.|||..||.    ||.|||.||   .  .  ..|.||||.|.|||.|.   ..||..||.|
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR-GGQYYGPKVDMW

ALGVLIFEMLSGHPPFYDC------DPMGIYQKIVNSVINFPEFFS---------------------LRAKDLVRKLLNPNIESRLGCQDQILSNVIDQD
..|....|||.|.|||...      |.| ....|    . |... .                       .||.....|... ..|..             
SCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-------------

GNSIKNHKWF
   |..|.||
AEQILQHPWF

Kinase 18333.AA Ciliate-E2 211-477 27 3.4e-87 295.97 In-house 1-365 (365) Show / Hide
Range on Protein: 211-477
Range on HMM: 1-365/365
Sequence Identity: 27% (107 aa)

FNIKTTLGTGSFGRVKLAKLKGNEKDV----------------------FALKMMKKIEIVKLKQVEHIK----------SEKKILSQIKHPFLVELKGT
...   .|.|.|| |...| . . |..                      .|.|.||| .|  .||..||            ||.||.|..||...... .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FQ--DEIYIYMLFEFVSGGEIFSRLR------------------KEGR-FSNDISL-------FYITEIYLALQYLHSQN-IVYRDLKPENLLIDKEGHV
||  |. .||. .|...||. |....                  || . ..  |         |||..| |||.||||.| |..||.||||.|.     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KIADFGFAKIMDS---------------------------------ARTYTLCGTPEYLAPEIIQGAK-------TGYGKSVDWWALGVLIFEMLSGHPP
||.|||..|. |                                    ..|.||||.|.||||..| |       .||....|.|.|||...|||.| ||
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FYDCDPMGIYQKIVNSVINFPEF------------------FSLRAKDLVRK----LLNPNIESRLGCQDQILSNVIDQDGNSIKNHKWF
|        .|.| .  |.||..                   |. .||| .|    .|. . | |..            . . |.||.||
F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT------------GWEQILNHPWF

Kinase 18333.AA Pkinase_Tyr 211-422 27 1.6e-18 63.35 Pfam 1-228 (270) Show / Hide
Range on Protein: 211-422
Range on HMM: 1-228/270
Sequence Identity: 27% (65 aa)

FNIKTTLGTGSFGRVKLAKLK----GNEKDVFALKMMKKIEIVKLKQ--VEHIKSEKKILSQI-KHPFLVELKGTFQ-DEIY--IYMLFEFVSGGEIFSR
  .  .|| |.||.|.....|    ... .| | ||.|  |    .|   |   .| ||..|. .|| .| | |    ..    ||. .|.. .|   . 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPV-AVKMLK--EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

LRK----EGRFSNDISLFYITEIYLALQYLHSQNIVYRDLKPENLLIDKEGHVKIADFGFAKIM-DSART-YTLCGTPE---YLAPEIIQGAKTGYGKSV
|||    .....    | . ..|  ...||.|.|.. |||   | |......|||.||| |. . .     ..  |..     .||| |.  |  .    
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGK--FTTKS

DWWALGVLIFEMLS-GHPP-FYDCDPMGIYQKI
| |. |||..|... |  | ......  .|..|
DVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYI

Kinase 18333.AA TyrKc 211-459 20 4.8e-16 36.78 SMART 1-280 (280) Show / Hide
Range on Protein: 211-459
Range on HMM: 1-280/280
Sequence Identity: 20% (59 aa)

FNIKTTLGTGSFGRVKLAKLKGNEKDVFALKMMKKIEIVKLKQVEHIKSEKKILSQI--KHPFLVELKGTFQDE-------IYIYMLFEFVSGGEIFSRL
   . .|| | ||.| ....|       | ||.|.        .| . .| .|....  .|| .| | |   ..         .....|....|   ..|
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

RKEGR-FSNDISLFYITEIYLALQYLHSQNIVYRDLKPENLLIDKEGHVKIADFGFAKIMDSA-------RTYTL----CGTP----EYLAPEIIQGAKT
|| .. ....  | . . |    .||||.|.. |||   | |......|||.||| ..  ..         .|.     .|        .||| |   ..
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI---NY

G-YGKSVDWWALGVLIFEMLS-GHPPFYD-----CDPMGIYQKIVNS-VINFPEF--------FSLRAKDLVRKLLNPNIESRLG---CQDQI
| .    | |. ||...|... | .| ..     ...  ..... .      |.          .    .. ..  . . |.|     . ...
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF

Kinase 18333.AA S_TK_X 478-531 21 1.2e-11 45.9 SMART 1-79 (79) Show / Hide
Range on Protein: 478-531
Range on HMM: 1-79/79
Sequence Identity: 21% (17 aa)

KGVNWDKIYH--KQIPSPWIPQLK----SIDDVSYFE-KYPESKDKQENPTKE-------------------IQKLFADF
.|..|||.|.  |.|. |..|..|    |  |.|.|. ...| ... . |. .                      ....|
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPM-LTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF