Gene 19190 (Tetrahymena)

19190

Species: Tetrahymena
Alias: TTHERM_00616410, PreTt19190, 19190, 351, 85.m00183, 3725.m00074
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: AGC
Family: RSK
Subfamily: RSK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
19190.AA Protein None 1318 None Fasta, JSON
19190.kin_dom Protein Kinase Domain None 259 None Fasta, JSON
19190.NA RNA None 3957 None Fasta, JSON

Protein domain

Protein domains of 19190.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Ank 19190.AA Ank 833-865 42 1.4e-08 35.24 Pfam 1-33 (33) Show / Hide 
Range on Protein: 833-865
Range on HMM: 1-33/33
Sequence Identity: 42% (14 aa)

QLITPLMFACKEGHEDVCQLLITAGADINNFDS
   |||. ||. ||..|...|. .|||.|  | 
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank 19190.AA Ank 800-832 30 7.4e-08 32.6 Pfam 1-33 (33) Show / Hide 
Range on Protein: 800-832
Range on HMM: 1-33/33
Sequence Identity: 30% (10 aa)

EQNTALHYAAQNGNAQLVNFLLFNEANIDSQNK
. .|.||.|...|... | .|| . |... |..
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank 19190.AA Ank 866-904 28 0.001602 16.96 Pfam 1-33 (33) Show / Hide 
Range on Protein: 866-904
Range on HMM: 1-33/33
Sequence Identity: 28% (11 aa)

KENTALHYASINCHKKVVDILLRKPSLFFKKKNLNNQEA
  .|.||.|... |..||  ||       .  ..| |  
DGFTPLHLACRCGHTEVVKMLLQ------HGADVNAQDD
Kinase 19190.AA RSK-Unclassified 1007-1265 59 1.7e-219 696.88 In-house 1-283 (283) Show / Hide 
Range on Protein: 1007-1265
Range on HMM: 1-283/283
Sequence Identity: 59% (167 aa)

FIVHGLIGKGSFGEVYLVEKKGSQMLYAMKVLHKSKIIRHNLTKYAMTERNVMSLTNHPFIVKLNYAFQTSDKLFLIMDYCPGGDLGEHLQ--KEKKFSE
||.|.|||.|.||.||||.||..|..||||||||.|.||||..||.|||.|.|..|||||||.|...|||.|.|.|.|.||.|||...|||  |||.|.|
FIKHRLIGQGDFGKVYLVRKKDTQQIYAMKVLHKHKMIRHNKIKYVMTEQNIMATTNHPFIVTLYHSFQTQDYLYLCMEYCMGGDFFRHLQTRKEKCFCE

ELVKIYLAETILALEDLHKRDVIFRDLKPDNIVLDYEGHVKLTDFGLSKEG--------------------VLDHSSGARSFCGSVAYLAPEMLKRCGHG
..|..|..|...|||.|||||.|.||||||||||..||||.||||.||...                    ..||.....||||...||||||..||||.
DDVRFYASEVTAALEYLHKRDFIYRDLKPDNIVLHQEGHVMLTDFDLSIQAKDSKKPVMKGSAQSTYVDTKICDHGFRTNSFCGTEEYLAPEMIRRCGHT

KAVDWYLLGVVMYELLVGIPPYYANNRDELFYNIEKAPLKIP--SYLSNEARSLLKALLQRNPAKRLGSGKGDAEEIKAHPFF
|||||..||.||||.|.|.||||.||..|.||||||...|.|  ||.||..|.|.|.|||||||||||...|||..||.||||
KAVDWWTLGIVMYEMLFGCPPYYGNNKNETFYNIEKNHVKFPHDSYISNNCRDLIKKLLQRNPAKRLGCKMGDADDIKRHPFF
Kinase 19190.AA AGC 1007-1265 34 7.29999999999e-188 491.06 In-house 1-395 (395) Show / Hide 
Range on Protein: 1007-1265
Range on HMM: 1-395/395
Sequence Identity: 34% (139 aa)

FIVHGLIGKGSFGEVYLVEKK------GSQMLYAMKVLHKSK---IIRHNLTKYAMTE------------RNVMSLTN----------HPFIVK-LNYAF
| .. .|||||||.||||.||      ... .|||||| |..   |...|  ...|||            ||.... |          |||||| | |.|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTSDK--LFLIMDYCP---------GG-DLGEHLQ---KEKKFSEELVKIYLAE-------TILALEDLHK-RDVIFRD-LKPDNIVLDYEGHVKLTDFG
|. |.  |...|.|.|         || .|  |||   ||..|.|| ...|.||       ..|||| ||. ...| || |||.||.|| .||.||||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LSKEGVLDHSSG-------------------------------------------------ARSFCG--SVAYLAPEMLKRCGHGKAVDWY--LLGVVMY
|.|||. |.. |                                                 . .|||  .  |.|||.|    .|||.||.  .||..||
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

ELLVGIPPYYANN----------RDELFYNIE------KAPLKIP----------SYLSNEARSLLKALLQRNPAKRLGSGKGD-----AEEIKAHPFF
|.|.|.||.|..|          ..|.| .|.      . ..|.|          ...|.||..|.| ||...|.||||.|..|     |||||.||.|
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 19190.AA Akt 1007-1265 50 1.5e-157 507.29 In-house 1-264 (264) Show / Hide 
Range on Protein: 1007-1265
Range on HMM: 1-264/264
Sequence Identity: 50% (132 aa)

FIVHGLIGKGSFGEVYLVEKKGSQMLY-AMKVLHKSKIIRHNLTKYAMTERNVMSLTNHPFIVKLNYAFQTSDKLFLIMDYCPGGDLGEHLQKEKKFSEE
| .  ..|||||| |.||.|| .| .| ||||| |..|| .|  ....||||.   .||||||.|.|.|||.|||...||||.||.|  |||....|||.
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

LVKIYLAETILALEDLHKRDVIFRD-LKPDNIVLDYEGHVKLTDFGLSKEGVLDHSSGARSFCGSVAYLAPEMLKRCGHGKAVDWYL-LGVVMYELLVGI
  . | || |||.| ||....|.|| ||| ||..|..||..||||||.||... .   . .|||. .|||||.|.  ||.|||||.  ||.||||.. | 
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGR

PPYYANNRDELFYNIEKAPLKIP--SYLSNEARSLLKALLQRNPAKRLGSGKGDAEEIKAHPFF
||.|. .....| .|  .|.|.|  ...|.|...|.. ||...| ||||.|..||.|||.||.|
PPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase 19190.AA SGK 1007-1265 45 8.10000000001e-156 485.0 In-house 1-283 (283) Show / Hide 
Range on Protein: 1007-1265
Range on HMM: 1-283/283
Sequence Identity: 45% (130 aa)

FIVHGLIGKGSFGEVYLVEKKGS------------------QMLYAMKVLHKSKII-------RHNLTKYAMTER-NVMSLTNHPFIVKLNYAFQTSDKL
|.   .|||||||.||.|..|.                   . .|||||| |  ||       . .. |. |.|| ..... .|||||.| ||||| .||
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

FLIMDYCPGGDLGEHLQKEKKFSEELVKIYLAETILALEDLHKRDVIFRDLKPDNIVLDYEGHVKLTDFGLSKEGVLDHSSGARSFCGSVAYLAPEMLKR
.. |||  ||... |||.||.|.|  ...| || ..||| ||. |.|.|||||.||.|| .||..||||||.|||.  .. .  .|||...|||||.|. 
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGI-KTNDTTFTFCGTPEYLAPEVLRK

CGHGKAVDWYLLGVVMYELLVGIPPYYANNRDELFYNIEKAPLKIPSYLSNEARSLLKALLQRNPAKRLGSGKGDAEEIKAHPFF
 .|...|||..|| |.||...|.||.| .|. ... || . ||.|| . ||.|..|.. |||..| ||||. | |..||| ||||
QPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGT-KRDFMEIKNHPFF
Kinase 19190.AA RSK 1010-1265 48 2.4e-153 515.75 In-house 1-278 (278) Show / Hide 
Range on Protein: 1010-1265
Range on HMM: 1-278/278
Sequence Identity: 48% (136 aa)

HGLIGKGSFGEVYLVEKK---GSQMLYAMKVLHKSKIIRHNL-TKYAMTERNVMSLTN-HPFIVKLNYAFQTSDKLFLIMDYCPGGDLGEHLQKEKK---
. . |.|..|.|.|. |.    ....||||||.|.||....  |...|||||...... |||||.|.||||| .||.|||.||.||.|..||||||    
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FSEELVKIYLAETILALEDLHKRDVIFRDLKPDNIVLDY---EGHVKLTDFGLSKEGVLDHSSGARSFCGSVAYLAPEMLK----RCGHGKAVDWYLLGV
|||. ...|.|| .||.| ||....|.|||||.||..|    |||.||||||..|....||.. . .||....|.||||||    ..||.||.||. |||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

VMYELLVGIPPYYA---NNRDELFYNIEKAP--LKIP--SYLSNEARSLLKALLQRNPAKRLGSGKGDAEEIKAHPFF
.|||.|.| ||...   |||.|.. .|.|.   |..|  .|||.||..|....|.|.|.||||.|..||||||.||.|
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 19190.AA AktR 1007-1265 50 2.2e-146 492.58 In-house 1-268 (268) Show / Hide 
Range on Protein: 1007-1265
Range on HMM: 1-268/268
Sequence Identity: 50% (135 aa)

FIVHGLIGKGSFGEVYLVEKK-GSQMLYAMKVLHKSKIIRHNLTKYAMTERNVMS-LTNHPFIVKLNYAFQTSDKLFLIMDYCPGGDLGEHLQKEKKFSE
| |. ..||| ||.||||.||  .| .||||...|.|||. |. ... ||||.|  . |||||||| |.||| .|||.||.|||||.|  ||.|.|||||
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

ELVKIYLAETILALEDLHKR-DVIFRDLKPDNIVLDYEGHVKLTDFGLSK-EGVLDHSSGARSFCGSVAYLAPEMLKR-CGHGKAVDWYLLGVVMYELLV
| ...| |. .|||| ||.. ..|.|||||.||.|| .||||.||||||| ... . .  |.||||...|.||||...  ||.|.|||. .|.. ||...
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT

GIPPYYANNRDELFYNIEKAP---LKIPSYLSNEARSLLK-ALLQRNPAKRLGSGKGDAEEIKAHPFF
|.|| |..|. ..| .| . .    ..|||.|.....|..  ||..|| ||||... ..|||| ||.|
GCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase 19190.AA RSK 1007-1265 40 5.6e-125 421.51 In-house 1-271 (271) Show / Hide 
Range on Protein: 1007-1265
Range on HMM: 1-271/271
Sequence Identity: 40% (111 aa)

FIVHGLIGKGSFGEVYLVEKK---GSQMLYAMKVLHKSKIIRHNLTKYAMTERNVMSLTNHPFIVKLNYAFQTSDKLFLIMDYCPGGDLGEHLQKEKKFS
...|  ||.|||..||.. |.    ....||||.. |...       .. .||....  .|||||||.|.||.  |...||| . ||||. .|.|.| ||
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDR-VCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFS

EELVKIYLAETILALEDLHKRDVIFRDLKPDNIVLDYE----GHVKLTDFGLSKEGVLDHSSGARSFCGSVAYLAPEMLKRCGHGKAVDWYLLGVVMYEL
|. ||.|.||  ||.| ||. ....|||||.||..| |    ||.|..|||..|. ..|.  .. .||....|.|||.||| ||..|.||...||.||| 
EREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQ-LRDENGMLMTFCYTANYMAPEVLKRQGHDQACDWWSFGVLMYEM

LVGIPPYYANNRDELFYNIEKAPLKI-------PSYLSNEARSLLKALLQRNPAKRLGSGKGDAEEIKAHPFF
| | .|.....||... .| ...| .       ....| || .|| ..| |.|..|||.|  ..|.|| ||.|
LTGCTPFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase 19190.AA p70 1007-1265 41 1e-106 360.8 In-house 1-299 (299) Show / Hide 
Range on Protein: 1007-1265
Range on HMM: 1-299/299
Sequence Identity: 41% (123 aa)

FIVHGLIGKGSFGEVYLVEKKG---SQMLYAMKVLHKSKIIRHNL-TKYAM-------------------------TERNVMSLTNHPFIVKLNYAFQTS
|    ..||| .| |..| |     .  .|||||| | ||.|    |  .                           |||. .  .||||..| ||||| 
FELLKVLGKGGYGKVFQVRKVTGEDTGKIYAMKVLRKAKIVRNQKDTAHTREDEDKNDGNNNDNDDGLSKRLERTFAERNILEEVKHPFICDLHYAFQTN

DKLFLIMDYCPGGDLGEHLQKEKKFSEELVKIYLAETILALEDLHKRDVIFRDLKPDNIVLDYEGHVKLTDFGLSKEGVLDHSS---------GARSFCG
 ||.|| .| .|| |  || ..  . |. .. ||.| |.||| ||....|.|||||.|. |.  |||.||||||.|| . | .             .|||
GKLYLILEYLHGGELFMHLERHGIWMEDTACFYLSEIICALEHLHQHGIIYRDLKPENCMLNQQGHVVLTDFGLCKESIHDGAVDEEDPENVNATHTFCG

SVAYLAPEMLKRCGHGKAVDWYLLGVVMYELLVGIPPYYANNRDELFYNIEKAP--LKIPSYLSNEARSLLKALLQRNPAKRLGSGKGDAEEIKAHPFF
   | |||.| ||||..||||. ||. ||  |.| ||. . || .    | |.   ||.| ||..|.| |.|.|| |.|..|.|.| .||..|..||||
TIEYMAPEILMRCGHNHAVDWWSLGCLMYDMLTGGPPFTGENRKKTIDKILKGKQGLKLPPYLTHEMRDLIKKLLKRHPTQRWGAGPEDAADIQEHPFF
Kinase 19190.AA PKC 1007-1265 43 1.9e-105 342.81 In-house 1-262 (262) Show / Hide 
Range on Protein: 1007-1265
Range on HMM: 1-262/262
Sequence Identity: 43% (115 aa)

FIVHGLIGKGSFGEVYLVEKKGSQMLYAMKVLHKSKIIRHNLTKYAMTERNVMSL-TNHPFIVKLNYAFQTSDKLFLIMDYCPGGDLGEHLQKEKKFSEE
|  .  .|||||| | |.|.||.. .||.||| |  ||       .|||. |..| ..||| ..|   ||| |.|| .| |. ||||  | |. ..|.||
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRRFKEE

LVKIYLAETILALEDLHKRDVIFRDLKPDNIVLDYEGHVKLTDFGLSKEGVLDHSSGARSFCGSVAYLAPEMLKRCGHGKAVDWYLLGVVMYELLVGIPP
  . | || |.||  ||....| |||| ||. ||.|||.|..|||..||....  . ...|||   |.||| |.    ||.|||  .|| |||...| .|
HARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNG-DTTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQSP

YYANNRDELFYNIEKAPLKIPSYLSNEARSLLKALLQRNPAKRLGSGKGD---AEEIKAHPFF
  . . |||| .| .    .| .|| || |..|.....||.||||... .   ...|..||||
FHGEDEDELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF
Kinase 19190.AA PKA 1007-1265 38 1.7e-98 333.52 In-house 1-263 (263) Show / Hide 
Range on Protein: 1007-1265
Range on HMM: 1-263/263
Sequence Identity: 38% (104 aa)

FIVHGLIGKGSFGEVYLVEKKGSQMLYAMKVLHKSKIIRHNLTKYAMTERNVMSLTNHPFIV-KLNYAFQTSDKLFLIMDYCPGGDLGEHLQKEKKFSEE
|    ..|.|||| |.|. .|.|   ||||.| |..|.| . .   ..|.|......||||| |. . ||....|...|.|.|||..  .|.|...||. 
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

LVKIYLA-ETILALEDLHKRDVIFRDLKPDNIVLDYEGHVKLTDFGLSKEGVLDHSSGARSFCGSVAYLAPEMLKRC-GHGKAVDWYLLGVVMYELLVGI
  |.| | . .|||| ||. . | ||||| || .| .||.|.|||| .|. .   ..   . ||   |||||....  ||||.|||  ||.. ||.|.|.
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKKVDD-RTW---TLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGY

PPYYAN--NRDELFYNIEKAPLKIPSYLSNEA---RSLLKALLQRNPAKRLGSGKGDAEEIKAHPFF
|| |..  .  ...  | .. .| |..... |   ..|.| |||... ||.|. |.... || |..|
PPFYDHNRDPMQIYEKICNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase 19190.AA S_TKc 1007-1265 32 1.4e-95 324.71 SMART 1-231 (231) Show / Hide 
Range on Protein: 1007-1265
Range on HMM: 1-231/231
Sequence Identity: 32% (88 aa)

FIVHGLIGKGSFGEVYLVEKKGSQMLYAMKVLHKSKIIRHNLTKYAMTERNVMSLTNHPFIVKLNYAFQTSDKLFLIMDYCPG--GDLGEHLQKEKK---
. .. .||||.||.||.. .|... ..|.|...          . .. |.....  .||.|||| ..||. |.|...|.||.|  ||| ....| ..   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FSEELVKIYLAETILALEDLHKRDVIFRDLKPDNIVLDYEGHVKLTDFGLSKEGVLDHSSGARSFCGSVAYLAPEMLKRCGHGK-AVDWYLLGVVMY
   |.|  .. |......||| .|.. .| |||||.|| ||   |.|..||||...         ..|||.  |.|||.|   |.|| ..||. .|...|
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

ELLVGIPPYYANNRDELFYNIEKAPLKIPSYLSNEARSLLKALLQRNPAKRLGSGKGDA--EEIKAHPFF
|.|.| ||..  . ...| .|           | ||..... .||..|.||..  .  .  ..||.||.|
EMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 19190.AA Pkinase 1007-1265 29 1.6e-85 295.2 Pfam 1-293 (293) Show / Hide 
Range on Protein: 1007-1265
Range on HMM: 1-293/293
Sequence Identity: 29% (88 aa)

FIVHGLIGKGSFGEVYLVEKKGSQMLYAMKVLHKSKIIRHNLTKYAM-TERNVMSLTNHPFIVKLNYAFQTSDKLFLIMDYCPGG----DLGEHLQ--KE
. ... ||.||||.||.  .||.. ..|.|.. |...    .   .  .|  .|   |||.||.| ..|...|.. ..|.||.||    || ....  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KKF--SEELVKIYLAETILALEDLHKRDVIFRDLKPDNIVLDYEGHV----KLTDFGLSK--EGVLDHSSGARSFCGSVAYLAPEMLK-RCGHGKAVDWY
..|  ||. .| |. ... .|| .|.. .| |||||.|| .| .||.    |..||||.|  .  . ..| . .|||.  |.||| .. . ..|..||..
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

LLGVVMYELLVGIPPYYAN------NRDELFYNIEKAPLKIPSYLS---------------------NEARSLLKALLQRNPAKRLGSGKGDAEEIKAHP
 .|...||.| | ||..        . ......| ..||. ... .                      |.....| .|...|.||..     ||.|. ||
SCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-----AEQILQHP

FF
.|
WF
Kinase 19190.AA TyrKc 1007-1265 22 4.5e-14 4.92 SMART 1-280 (280) Show / Hide 
Range on Protein: 1007-1265
Range on HMM: 1-280/280
Sequence Identity: 22% (66 aa)

FIVHGLIGKGSFGEVYLVEKKGSQMLYAMKVLHKSKIIRHNLTKYAMTERNVMSLT--NHPFIVKLNYAFQTS-------DKLFLIMDYCPGGDLGEHLQ
      .| | |||||. . |   .  | |.|....       .  | | ..|.    .|| ||.|  .  ..       . |...| |.|.||| ..|.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

KEKK-FSEELVKIYLAETILALEDLHKRDVIFRDLKPDNIVLDYEGHVKLTDFGLSKEGVLD------HSSGARSF--CGS----VAYLAPEMLKRCGHG
| .. .. .    .        | ||.. .| |||   |. .. ...|| .|||||...  |      ..    .   .|     .  .||| .. .   
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

KAVDWYLLGVVMYELL-VGIPPYYA-----NNRDELFYNIEKA-PLKIPSY--------LSNEARSLLKALLQRNPAKRLGSGKGDAEEIKAHPFF
 . | .  ||.|.|..  | .||.       . .|.. ....   ...| .         . |  .. |   ...|..|        .||  | .|
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRP-----TFSEI--HECF
Kinase 19190.AA Pkinase_Tyr 1007-1098 27 3e-06 21.85 Pfam 1-100 (270) Show / Hide 
Range on Protein: 1007-1098
Range on HMM: 1-100/270
Sequence Identity: 27% (28 aa)

FIVHGLIGKGSFGEVYLVEKK----GSQMLYAMKVLHKSKIIRHN-LTKYAMTERNVMSLT-NHPFIVKLNYAFQ-TSDK--LFLIMDYCPGGDLGEHLQ
 .    .|.|.|||||. . |    . ..  | |.| | .   .. . .  | | ..|.   .|| ||.|  .    ..   ....| |.|.||| ..|.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

K
|
K
Kinase 19190.AA S_TK_X 1266-1317 18 0.000399 11.35 SMART 1-79 (79) Show / Hide 
Range on Protein: 1266-1317
Range on HMM: 1-79/79
Sequence Identity: 18% (15 aa)

GDVDWNTVYQ--RKLKPP-RPNRK-----IRISTKFDPNLFSETDYKGDKDY-------------------IAGWSFVS
 ..||...|.  ....|| .|. |      .    |||   .||.   . |                     .|...| 
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase 19190.AA Pkinase_Tyr 1135-1153 36 0.465019 4.21 Pfam 141-159 (270) Show / Hide 
Range on Protein: 1135-1153
Range on HMM: 141-159/270
Sequence Identity: 36% (7 aa)

NIVLDYEGHVKLTDFGLSK
|. .. ...|| .||||..
NCLVTENNVVKICDFGLAR