Gene 29299 (Tetrahymena)
29299
Sequence
Protein domains of 29299.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| VWA | 29299.AA | VWA | 40-230 | 18 | 5e-06 | 27.24 | SMART | 1-193 (193) | Show / Hide |
Range on Protein: 40-230
Range on HMM: 1-193/193
Sequence Identity: 18% (40 aa)
SCDLMIVLDCTGSM-QSWISACKQNILKIIQNVKQQFQGSELRVGIVAYRDHCDTQRIEMYPFINQDYENLEKFISSLKA----TGGGDEPEDLAGALET
|...|.|..||| .... . || | |.... |||||.. | ..|.| . ||.. ..| | .|. . . . ... ||..
WLDIVFVIDGSGSMGPNNFQQVKQFI-KFVEQLD------GDRVGIVQFSD---DVRVEFPLN-YQDKDDVLKAIDNLQYKGKHDYFMGGGTNTG-ALQY
AINL-----FEWKSQA----------KTMIIITDAPCHGDTYHNSNDHYPQGCPNGIDIEEYIYIIGKKGIDLNVIDIQS-QTNKMYEIFSKIYED----
|.. . .| | .|..|| . . ||.. . ..|. . ||.. . . .. .| |. ..
AMQNLFHERQG-RRGAGRPTKFWNVPKVIIVFTDGYSNDG------------PHDPEDIRKAARELRRSGVKIFVIGVGNDDM-ELRQIASCP-GEHHFF
----ARGKPMIRLKLGQNTL
| |. .. .. .
DVYDYDDLPDIFQHIIDWLC
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| Kinase | 29299.AA | VWL | 443-650 | 53 | 2e-137 | 412.07 | In-house | 1-206 (206) | Show / Hide |
Range on Protein: 443-650 Range on HMM: 1-206/206 Sequence Identity: 53% (112 aa) LTSKIKVMKKYFAEGAMRYAFYAYDQVLNLKLVAKLHKEMKHNS---NLELMKRDSMSLIACHYFAEEFNSRLLLKTEVDVNQNSILLNFVNSTIYEIIG . |... . |||||||||..| | || |.|||. | . . | | |..| | . | . .||.|. | |. .||||...|||... IKTKVRISNIPFAEGAMRYAYHAKDTYLNQKMVAKQYKKQHKQNPKINKEDMIKDIESQFVCQHIVNCFNDRV---SEH-VQTTANILNFVHCYIYEVTH HPNKEIKYYFVENLIEGDYQKYNNNAGWTNLTTSSDFNKITQAFSHFTWQYSHGQLLVVDIQGGENGILTDPQIHTKNRSKLYGQGDLGYEGMLRFFYTH |.|..||||||||.||||||||||||||.|.|.. ..|...|||||||||||.|....||.||.|.|.|||||||....|...|||.||||||||||.|| HYNHNIKYYFVENYIEGDYQKYNNNAGWCNQTDM-EYNQLSQAFSHFTWQYSQGYCMIVDLQGNEDGMLTDPQIHCLDQSHKFGQGNLGYEGMLRFFMTH ECNLYCQKFNL .|| ||||..| QCNKYCQKLQL |
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| Kinase | 29299.AA | Alpha | 443-645 | 45 | 5.70000000001e-109 | 311.22 | In-house | 1-215 (215) | Show / Hide |
Range on Protein: 443-645 Range on HMM: 1-215/215 Sequence Identity: 45% (98 aa) LTSKIKVMKKYFAEGAMRYAFYAYDQVLNLKLVAKLHK--EMKHNSNLELMKRDSMSLIACHYFAEEFNSRLLLKTEVDVN---QNSILLNFVNSTIYEI . ||.. . |.|||||||..| | |. |.|.|.|| . . . . . ...| . . ||. |||.|| . ...||...|||. QCTKIQMSSYPFMEGAMRYAMHAWDCWLHQKMVKKQHKKQWKSFKYVWHHWIKDVERQMVCHHCVREFNQRLWEQEYTTHFNQMKPQPIKQFVHCYIYEL IGHPNKEIKYYFVENLIEGDYQKYNNNAGWTN-LTTSSDFNKITQAFSHFTWQYSHGQLLVVDIQ-GGENGILTDPQIHT---KNRSKLYGQGDLGYEGM | ..|..||||.||| .||.||||||||||.. ||....||...|||||.|||||.|||.|||.| | ....|||||||. ..... .|.|..||||| IHCHNHNIKYYSVENYMEGEYQKYNNNAGWVDFLTDDNEFNQLMQAFSHWTWQYSNGQLMVVDLQWGVGEWKLTDPQIHCPAKLDQGMKFGDGNCGYEGM LRFFYTH--ECNLYC .|||||| .|| || FRFFYTHHVQCNHYC |
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| Kinase | 29299.AA | Alpha_kinase | 454-645 | 33 | 4.7e-76 | 263.78 | Pfam | 1-225 (225) | Show / Hide |
Range on Protein: 454-645 Range on HMM: 1-225/225 Sequence Identity: 33% (78 aa) FAEGAMRYAFYAYDQ-----VLNLKLVAKLHKEMKHNSNL--------ELMKRDSMSLIACHYFAEEFNSRLLLKTEVDVNQNSILLNFVNST-IYEIIG ||.||||..|.. |. .| ..|||..|..| | | .....| .. . |....|.||..| .... .. . |. . .||.. FAQGAMRWCFRMFDTWDPNWRNNQNCVAKWYKKIK-NYNQKQSIYVEEDYYFQDCKMQMICQQWMEKFNQKLQ-EHNNPPPPIE----FYDCCIVYELED HPN-------------KEIKYYFVENLIEG-DYQKYNNNAGWT--NLTTSSDFNKITQAFSHFTWQYSHGQLLVVDIQGGE-NG---ILTDPQIHTKNRS |.. ...||...|. ||| ...|||||.||. | .....|.. |||||||...|.||..|.||||. |. .|||||||||. . HNKPDCYQGFFSYRTDWGGKYWYMEPYIEGCEFVKYNNNYGWVYDNMDRNDPWNQYMQAFSHFTYHRSNGQMMVCDIQGVGYNNKCYYLTDPQIHTKD-G KL---Y--GQGDLGYEGMLRFFY-THECNLYC . . |.|.||.||...|| .|.|| .| NYEMDFDEGMGNLGQEGIEKFFQNQHKCNHIC |
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| Alpha_kinase | 29299.AA | Alpha_kinase | 435-645 | 27 | 1.1e-46 | 162.3 | SMART | 1-255 (255) | Show / Hide |
Range on Protein: 435-645 Range on HMM: 1-255/255 Sequence Identity: 27% (74 aa) DPQIKIQQLTSKIKVMKKYFAEGAMRYAFYAYDQ-------VLNLKLVAKLHKEMKHNSN-----LE----LMKRDSMSLIACHYFAEEFNSRLLLKTEV | . . | ...|| .| ||.|||| .... | . ..|||..| ... . | || .| ..|.|||. .. ... DNKWTCQETCVKI-KEPKPFAKGAMRWCYWGCDWSEHMHCFCHGWECVAKYFKKEYKRTWDEERYFHETLHLCLRDVEMQMMCKHWANEFNQEAQ-HNPC DVNQNSILLNFVNSTIYEII-----GHPNKEIKY----------------YFVENLIEGDYQKYNNNAGWTN-----LTTSSDFNKIT------QAFSHF . |. ... ... . .. ... ...| ..||...||||| || | .|| |. | |||||. P-----KKIDFIPCYVFHFPRRIPAEYDRNIPYWFSYRTTDQMMVMCCCIFHMEPFMEGEFVKYNNNNGWVNDCMRWTTT-SQ-R-RTEMFEYCQAFSHW TWQYSHGQLLVVDIQGG---ENG--ILTDPQIHTKNR-SKLYGQGDLGYEGMLRFFYTHECNLYC |...| .|.||.|||| .. ..|||||||. . . .|.| || ||. .|| ||.|| .| TYEWSNHQMLVCDIQGVIHKNGDLYYYTDPQIHTEDQNGYGFGMGNLGQEGIEKFFQTHQCNQIC |
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| Kinase | 29299.AA | Alpha-Unclassified | 541-645 | 29 | 6e-29 | 91.42 | In-house | 100-215 (215) | Show / Hide |
Range on Protein: 541-645 Range on HMM: 100-215/215 Sequence Identity: 29% (35 aa) PNKEIK-YYFVENLIEGDYQKYNNNAG--WTNLTTSSDFNKITQAFSHFTWQYSHGQLLVVDIQG--GENG----ILTDPQIHTKNRSKLYG--QGDLGY ..| || . || ..| . ||.|| | . ... ....|.|.| . ....|.| || .||. .|||||||. . |. .. |. EDKNIKGCISVEPYLIGEFVKYSNNTGKEINFVKWEYEAYQYCCTYQHWTYQWTNHCDIVCDLQGWVDENDKKTWKMTDPQIHTIRQR--YQGFKTNCGM EGMLRFFYTH--ECNLYC .. ..| | .|| || RFIDYWFNNHHVQCNHYC |
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| Kinase | 29299.AA | ChaK | 550-645 | 36 | 3.8e-14 | 52.29 | In-house | 122-219 (219) | Show / Hide |
Range on Protein: 550-645 Range on HMM: 122-219/219 Sequence Identity: 36% (37 aa) VENLIEGDYQKYNNNAGWTNLTTSSDFNKITQAFSHFTWQYSHGQLLVVDIQG-GENGILTDPQI----HTKNRSKLYGQGDLGYEGMLRFFYTHECNLY .|. . |.. ||||| | .. | ||||.|. | | |||.|.|| ||| |||| . . . .| || . . | | || IEKCMTGEFRKYNNNNG-DEIIPTNTLEEIMLAFSHWTYEYTRGELLVLDLQGVGEN--LTDPSVIKPEEKQSCDMVFGPANLGEDAIRNFRAKHHCNSC C | C |
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