Gene 12411 (Tetrahymena)

12411

Species: Tetrahymena
Alias: 65.m00229, 3717.m00108, TTHERM_00522960, PreTt12411, 12411, 385
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Atypical
Family: HisK

Sequence

Name Sequence Type Origin Length Description Download
12411.AA Protein None 1363 None Fasta, JSON
12411.kin_dom Protein Kinase Domain None 121 None Fasta, JSON
12411.NA RNA None 4092 None Fasta, JSON

Protein domain

Protein domains of 12411.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
HisKA 12411.AA HisKA 388-407 55 0.0002 18.41 Pfam 1-20 (69) Show / Hide 
Range on Protein: 388-407
Range on HMM: 1-20/69
Sequence Identity: 55% (11 aa)

YKDLVLANAAHDLRQPLTAL
 |   |||..|.||.||||.
AKRQFLANMSHELRTPLTAI
HisKA 12411.AA HisKA 388-524 15 0.000375 13.74 SMART 1-89 (89) Show / Hide 
Range on Protein: 388-524
Range on HMM: 1-89/89
Sequence Identity: 15% (23 aa)

YKDLVLANAAHDLRQPLTALNYTILEAKKLFKKLKSQNIYSFLYQYHPDQFYMLAELNPDLNNLILNNLTTSKINQAETIIQQLQNNYQLLGVKPTLAPD
 |.  |||..|.||.||||.  ..  ... . |                                                       | .. ...| |.
AKRQFLANMSHELRTPLTAIRGYAELLQDWYYK-------------------------------------------------------QRYHHWTDLDPE

ST-------DFQMIFDLLEMADVSGSSLKYLINDILDHAKLREE
 .          .. ..|| .. .. ..  ||||.|| ......
QRLPMLRREFNCEYREYLETIQREADRMQRLINDLLDLSRIEAG
HisKA 12411.AA HisKA 496-524 27 0.156508 8.33 Pfam 41-69 (69) Show / Hide 
Range on Protein: 496-524
Range on HMM: 41-69/69
Sequence Identity: 27% (8 aa)

DLLEMADVSGSSLKYLINDILDHAKLREE
..|| .. .. ..  ||||.|| ......
EYLETIQREAQRMQRLINDLLDFSRIEAG
Kinase 12411.AA HisK 564-684 32 4.5e-53 182.65 In-house 1-164 (164) Show / Hide 
Range on Protein: 564-684
Range on HMM: 1-164/164
Sequence Identity: 32% (54 aa)

TDQQRLQQVLVNLISNSLKFT-----PSNKYIILHITKV------------IKQVHNR-------EVSLLKISVLDQGCGMSSEQLQQIFKPYV------
.|..|..|.|.|||||.||||     |. .|| . ...             |..  ..       .  |..||| | ||||. ||...|||..       
SDPNRIKQILINLISNALKFTQKGGIPFQGYIKIKVEQINTQNNIKYNSIFIQKIQENMVQEQLQQKNLIQISVQDTGCGMPEEQQKKIFKMFGNIDDQH

-----SFNNNNL--NIEGIGLGLNICRSIIGLLGPY------PKLYVKSKQNEGTKFSFYIYHQ
     .||..|   | .|.||||.||......|||.       ...|.|....|..||||||..
QMIKKTFNHQNKKNNQHGCGLGLTICNNLAKGLGPEHNQNGNRGIQVQSEVGKGSTFSFYIYNN
Kinase 12411.AA HATPase_c 564-685 23 1.7e-23 85.26 SMART 1-130 (130) Show / Hide 
Range on Protein: 564-685
Range on HMM: 1-130/130
Sequence Identity: 23% (35 aa)

TDQQRLQQVLVNLISNSLKFTPS-------------NKYIILHITKVIKQVHNREVSLLKISVLDQGCGMSS------EQLQQIFKPYVSFNN-------
.|. ||.||| ||..|..|.||.             .  | ...                |.| | |.|..       |....|| |.... .       
GDPDRLRQVLWNLLDNAIKHTPEGHADPDLHDGKPGGGRITVRVH--------------RITVEDNGPGIPPEMHKSIEDIPRIFEPFYRTDDSPSRMCP

--NNLNIEG--IGLGLNICRSIIGLLGPYPKLYVKSKQNEGTKFSFYIYHQL
  .. ...|   |||| ||..|. ..|    . |       |.|.|..  ..
DSRSRKYGGGLTGLGLSICKRIVEQHGGT--IWVE------TTFTFTLPLER
Kinase 12411.AA HATPase_c 564-684 28 2.1e-23 83.66 Pfam 1-120 (120) Show / Hide 
Range on Protein: 564-684
Range on HMM: 1-120/120
Sequence Identity: 28% (37 aa)

TDQQRLQQVLVNLISNSLKFTPSNKYIILHITKVIKQVHNREVSLLKISVLDQGCGMSS------EQLQQIFKPYVSFNN--NNLNIEG--IGLGLNICR
.|. ||.||. ||..|..|.||... | .....            . |.| | |.|..       |....|| |.... .  .  ...|   |||| |||
GDPDRLHQVVWNLVDNAIKHTPEGGHITVRVHRDD--------DHVRITVEDNGPGIPPEMHSIAEDIPRIFEPFYRTDPDSR-RKYGGGLTGLGLYICR

SIIGLLGPYPKLYVKSKQNEGTKFSFYIYHQ
 |. ..|    . | |. ..||.|.|..  .
RIVEQHGGT--IWVESEPGGGTTFTFTLPLE
Response_reg 12411.AA Response_reg 1227-1303 29 3.5e-09 35.46 Pfam 1-70 (115) Show / Hide 
Range on Protein: 1227-1303
Range on HMM: 1-70/115
Sequence Identity: 29% (23 aa)

VLIADDDPFNISILKMMLKKSDQFTF-QIKDCNNGSESLSEFQKRNNPSSSKAFSLVISDIHMPVMDGFESTKQM-RKL
|||.||.| . ..|. .|..  .  .  .  . .| | |  .|..        . |.| || || |||.| .... |..
VLIVDDHPLMREGLRQILEQ--KEGYEVVAEADDGEEALEWWQEHH-------PDLIIMDINMPGMDGLELCRRIRRQH
REC 12411.AA REC 1225-1355 20 6.5e-09 36.86 SMART 1-150 (150) Show / Hide 
Range on Protein: 1225-1355
Range on HMM: 1-150/150
Sequence Identity: 20% (34 aa)

LQVLIADDD----PFNISILK------MMLKKSDQF-----TFQIKDCNNGS-------ESLSEFQKRN-------NPSSSKAFSLVISDIHMP------
. .||.|||    | .  .|.      ..|.| .         ..  . .|        | |  .|. .           |. . |.| || ||      
MRILIVDDDPAMAPVIREMLRNYTVIQRLLEKEGYENKMWMVEVVDEA-DGETLMNEIWEALELLQEHRDKKEDATTD-QSEPPDLIIMDIMMPGDPFED

-VMDGFESTKQMRKLIQEQSFQKTVFIGVSGMDQETIANDPDLKEDFKVFDVVLSKPFNEQEIINTI
  |||.| ....|             | ... |.|  .     .      |  ..|||. .|.. .|
GGMDGIELCRRIR-----------PIIMLTAHDDEEDR----VRALEAGADDYITKPFDPEELLARI
Response_reg 12411.AA Response_reg 1342-1356 33 0.377977 6.68 Pfam 101-115 (115) Show / Hide 
Range on Protein: 1342-1356
Range on HMM: 101-115/115
Sequence Identity: 33% (5 aa)

LSKPFNEQEIINTIN
..|||...|... |.
ITKPFDPDELHAAIR