Gene 14385 (Tetrahymena)

14385

Species: Tetrahymena
Alias: 14385, TTHERM_00035510, 164, 2.m02031, PreTt14385, 3825.m02763
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CAMK
Family: CAMKL
Subfamily: MARK

Sequence

Name Sequence Type Origin Length Description Download
14385.AA Protein None 692 None Fasta, JSON
14385.kin_dom Protein Kinase Domain None 255 None Fasta, JSON
14385.NA RNA None 2079 None Fasta, JSON

Protein domain

Protein domains of 14385.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 14385.AA MARK 401-655 52 1.5e-168 554.84 In-house 1-262 (262) Show / Hide 
Range on Protein: 401-655
Range on HMM: 1-262/262
Sequence Identity: 52% (137 aa)

YKLGPLIGKGSYATVRLATDLATNEQVAIKFYEKFKLFDPQKKKNVQREISILKKISHPHCIGMQKTFE--NSKN-ICVVMEYVGKDSLYTYLKSFEGRK
||..  ||.||||.|.||... |...||||.||||||.|||..|||.|||.|.||..||..| . ...|  .... |...|||... .|| |.|......
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR

LPEEEAKRIFKQIIKGVSYLHTNNIIHRDMKLENLLMDDTK--NIKIIDFGFSIMIPPDKKLNIFCGTPSYMAPEIVSKKEYYGPPVDIWACGILLYVML
|.||||.|||.||. .|.|.| .||.|||.|.||.|.|. .  ||||||||||| |||..|||.|||||.||||||..||.|.||.||||..|..||.|.
LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMV

VGTFPFKAAD--DKTLYFKIRNGNYDLPPHVSVGARQILKKILNVNYHERATAEEILMDTWV
.|.|||....  .|.||.||..|.|| |.|||...|......|.|| .||.|.|||... |.
CGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase 14385.AA CAMKL 401-655 39 7.29999999999e-145 465.33 In-house 1-297 (297) Show / Hide 
Range on Protein: 401-655
Range on HMM: 1-297/297
Sequence Identity: 39% (117 aa)

YKLGPLIGKGSYATVRLATD-LATNEQVAIKFYEKFKLF-DPQKKKN-----------VQREISILKKIS---HPHCIGMQKTFENSKN------ICVVM
|..|. .||||...|.|||. . |.|.||||...|.|.  ||..|||           ..|||.|.|...   ||. | .  ..|....      |. ||
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EYVGKDS--LYTYLKSFEGRK--LPEEEAKRIFKQIIKGVSYLHTNNIIHRDMKLENLLMDDTK--NIKIIDFGFSIM-----IPPDKKLNIFCGTPSYM
||..  .  |. |... ..|.  .||.||.|.|.||. .|.|.| ..|.||| |.||.| |. .  ||||||||||.|     ..|..||..|||.|.||
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

APEIVSK--KEYYGPPVDIWACGILLYVMLVGTFPFKAADDK-------TLYFKIRNGNYDLPPHVSV-GARQILKKILNVNYHERATAEEILMDTWV
||||...  |.|.||.||||.||..||.|..|..||......       .|| ||. | |  |....|  .|....|.|.||  .|.|...|... |.
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVSDCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 14385.AA CAMK 406-655 25 1.8e-124 403.22 In-house 1-425 (425) Show / Hide 
Range on Protein: 406-655
Range on HMM: 1-425/425
Sequence Identity: 25% (110 aa)

LIGKGSYATVRLATDLATN------------EQVAIKFYEKFKLFD-------------------------PQKKKNVQREISILKK-------ISHPHC
 .|.||...|.|...  |.            ..||||...| || |                         |...|||.|||.|.||       ..||. 
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IGMQKTFE------------NSKN--------ICVVM---EYVGKD----SLYTYLKSFEG-------------RKLPEEEAKRIFKQIIKGVSYLHTNN
| .  ..|            . ..        .. ||   ||.        |. |... ..             ....|.||.|.|.||. .| |.| .|
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IIHRDMKLENLLMDDTK-----------------NIKIIDFGFSIMIPP------------------------DKKLNIFCGTPSYMA-PEIVSK-----
|.||| |.||.|.|| .                 |||||||||.....|                        ..|.. |||||.||| ||....     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

--------KEYYGPPVDIWACGILLYVMLVGTFPFKAA-------------DDKTLYFKIRNGNYD-LPPHVSV-----------------------GAR
        |.||||..|.|.||..||.||.|..|| .              .|. |. ||..|.||  ||..|                         ..
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

QILKKILNVNYHERATAEEILMDTWV
. ..|.|.|.  .|.|.|..| . |.
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 14385.AA AMPK 401-655 44 5.5e-99 294.5 In-house 1-254 (254) Show / Hide 
Range on Protein: 401-655
Range on HMM: 1-254/254
Sequence Identity: 44% (113 aa)

YKLGPLIGKGSYATVRLATDLATNEQVAIKFYEKFKLFDPQKKKNVQREISILKKISHPHCIGMQKTF-ENSKNICVVMEYVGKDSLYTYLKSFEGRKLP
| .|  ||.|..  | ..|   |.|.||||  .| |. | . .. .||||.|||.. ||| |       |  . | .|||||    |. |  .   ..|.
YIIGKTIGEGTFGKVKMGTHILTGEKVAIKILNKQKIKDQDMVERIQREIHILKLFRHPHIIQLYEVIIETPTDIFMVMEYVSGGELFDYIVKH--GRLQ

EEEAKRIFKQIIKGVSYLHTNNIIHRDMKLENLLMDDTKNIKIIDFGFSIMIPPDKKLNIFCGTPSYMAPEIVSKKEYYGPPVDIWACGILLYVMLVGTF
|.||.| |.||| ||.|.| ..| |||.|.||||.|. ||||| ||| | |    ..|   || | | |||..| | | || |||| ||. ||.|| |. 
EREACRFFQQIISGVEYCHRHMIVHRDLKPENLLLDHNKNIKIVDFGLSNMMKDGEFLKTACGSPCYAAPEMISGKLYCGPEVDIWSCGVILYAMLCGYL

PFKAADDKTLYFKIRNGNYDLPPHVSVGARQILKKILNVNYHERATAEEILMDTWV
||   .  ||| ||.|| | .| ..|  |....|..|.|.  .|.| ..|  . | 
PFDDENTPTLYKKIKNGEYYIPKFLSPEAKDLIKHMLQVDPMKRITIHDIRNHPWF
Kinase 14385.AA NuaK 401-655 43 1.9e-98 259.42 In-house 1-252 (252) Show / Hide 
Range on Protein: 401-655
Range on HMM: 1-252/252
Sequence Identity: 43% (110 aa)

YKLGPLIGKGSYATVRLATDLATNEQVAIKFYEKFKLFDPQKKKNVQREISILKKISHPHCIGMQKTFENSKNICVVMEYVGKDSLYTYLKSFEGRKLPE
|..    ||| |  |.|||.  |  .||||   | |  |.|    . ||| |.  . ||| |     |||.  | .||||  .  || |.   | ..|||
YEFQKTLGKGTYGKVKLATEHSTGREVAIKSIKKCKIEDEQDMVHIRREIEIMSSLNHPHIIHIYEVFENKDKIVIVMEYASGGELYDYIS--ECKSLPE

EEAKRIFKQIIKGVSYLHTNNIIHRDMKLENLLMDDTKNIKIIDFGFSIMIPPDKKLNIFCGTPSYMAPEIVSKKEYYGPPVDIWACGILLYVMLVGTFP
.||...| ||.  | | | ..|.|||.|||| |.|.  |.|| ||| | .   .| |. ||| | |  ||||  . | || || |. |.|||.|  || |
REARHFFRQIVSAVHYCHKHRICHRDLKLENILLDQNCNAKIADFGLSNYYHDQKFLHTFCGSPLYASPEIVNGQPYHGPEVDCWSLGVLLYTMVYGTMP

FKAADDKTLYFKIRNGNYDLPPHVSVGARQILKKILNVNYHERATAEEILMDTWV
|   | |.|   | .|.|  |.. |. |..   ..| || . ||| ..|    ||
FDGHDFKHLVKQISQGAYYEPCKPSD-ACMLIRWMLMVNPRRRATIYDICHHWWV
Kinase 14385.AA S_TKc 401-655 31 8.5e-96 325.47 SMART 1-231 (231) Show / Hide 
Range on Protein: 401-655
Range on HMM: 1-231/231
Sequence Identity: 31% (86 aa)

YKLGPLIGKGSYATVRLATDLATNEQVAIKFYEKFKLFDPQKKKNVQREISILKKISHPHCIGMQKTFENSKNICVVMEYVGK--DSLYTYLKSFEGRK-
|... .||||....|.....  |...||||             ....|||.||||  ||. . .  .|.. .....||||..    .|..|.|.  ... 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LPEEEAKRIFKQIIKGVSYLHTNNIIHRDMKLENLLMDDTKNIKIIDFGFSIMIPPDKKLNIFCGTPSYMAPEIVSKKEYYGP-PVDIWACGILLYV
   .|| .|.....||.... |.| ..||||| | ||.|.|.  .|||.|||..  .      . ||||| |||||..     ||. ..|.|.||..|| 
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYE

MLVGTFPFKAADDKTLYFKIRNGNYDLPPHVSVGARQILKKILNVNYHERATAEEILM-------DTWV
||.|  ||   ...... ||.          |  |.....|.|...  .| || |.|        . |.
MLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 14385.AA AGC 401-655 21 6.8e-93 239.82 In-house 1-395 (395) Show / Hide 
Range on Protein: 401-655
Range on HMM: 1-395/395
Sequence Identity: 21% (86 aa)

YKLGPLIGKGSYATVRLATDL------ATNEQVAIKFYEKFK-LFDPQ--KKKNVQRE------------ISILKKIS----------HPHCIG-MQKTF
...  .|||||. .|.|. .       .|... |.|  .| .   . .  . .....|              ||.|..          ||  .  .  .|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

ENSKN--ICVVMEY---------VGKD-SLYTYLKSF-EGRKLPEEEAKRIFKQ-------IIKGVSYLHT-NNIIHRD-MKLENLLMDDTKNIKIIDFG
.. ..  .. ||||         .| .  |...|.     ....||.|. .. .       |. .. |||  ..||||| .|.||.|.|.  .||. |||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

FSIMIPPD---------------------------------------------------KKLNIFCG--TPSYMAPEIVSKKEYYGPPVDIWA--CGILL
.. ... |                                                   .. . |||  || ||||||.     ||...|.|.   |.|.
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL-----YGKACDWWSFGLGCLM

YVMLVGTFPFKAA----------DDKTLYFKIR------NGNYDLP----------PHVSVGARQILKKILNVNYHERAT----------AEEILMDTWV
| ||.|  || .           . . .. ||.      | .  .|          ...|. |. ..|| |...  .| .          ||||    | 
YEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 14385.AA Pkinase 401-655 29 2.6e-91 314.43 Pfam 1-293 (293) Show / Hide 
Range on Protein: 401-655
Range on HMM: 1-293/293
Sequence Identity: 29% (88 aa)

YKLGPLIGKGSYATVRLATDLATNEQVAIKFYEKFKLFDPQKKKNVQ-REISILKKISHPHCIGMQKTFENSKNICVVMEYVGKD----SLYTYLKSFEG
|..|  ||.||...|.....  |...||.|  .| .  . ... ..  .||.|.|...||. . .  .||....|..||||....    .|..|..  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

RKL--PEEEAKRIFKQIIKGVSYLHTNNIIHRDMKLENLLMDDTKNI----KIIDFGFSIM--IPPDKKLNIFCGTPSYMAPEIVSKKEYYGPPVDIWAC
...  .|.|.|....||..|. |.| ..|||||.|.||.|.|.. .|    ||.|||..    . ..  .. ||||| |||||.. . .||||.||.|.|
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GILLYVMLVGTFPFKAA------DDKTLYFKIRNGNYDLPPHVS---------------------VGARQILKKILNVNYHERATAEEILMDTWV
|..|| || | .||. .      |.. ....|. . .. .   .                       .....|..|... ..| |||.|| . |.
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 14385.AA Ciliate-E2 401-655 25 1.2e-76 260.9 In-house 1-365 (365) Show / Hide 
Range on Protein: 401-655
Range on HMM: 1-365/365
Sequence Identity: 25% (96 aa)

YKLGPLIGKGSYATVRLATDLATNEQVAIK-----------------FYEKFKLFDPQKKKNVQREISILKKIS----------------HPHCIGMQKT
||.  .||.|....|.....  ...|.|||                 ..   | . ....... .||.|...|                 ||. | |  .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FE--NSKNICVVMEYVGKDSLYTYLKSF----------EGRKLPEEEAKRIFKQIIK---------------GVSYLHTNN-IIHRDMKLENLLMDDTKN
|.  . .||  ||||.   .|. |.|..          .  .. |.|.|.|.|||..               .. ||| .| ||||| |.||.|.     
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

IKIIDFGFSI----------------MIPPDK-----------------KLNIFCGTPSYMAPEIVSKKEY--------YGPPVDIWACGILLYVMLVGT
|||||||.|                 ...  |                   | .|||| ||||||...|.|        |.  .|||..|..|| || | 
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

FPFKAADDKTLYFKIRNGNYDLP------------------PHVSVGARQILKK----ILNVNYHERAT-AEEILMDTWV
.||        . .| ....|.|                   ..|  . ...||    .|...  .| | .|.||   | 
PPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 14385.AA QIK 401-655 35 1.3e-76 260.83 In-house 1-272 (272) Show / Hide 
Range on Protein: 401-655
Range on HMM: 1-272/272
Sequence Identity: 35% (96 aa)

YKLGPLIGKGSYATVRLATDLATNEQVAIKFYEKFKLFDPQKKKNVQREISILKKISHPHCIGMQKTFENSKNICVVMEYVGKDSLYTYLKSFEGR----
| ..  |||| .|.|.||.   | ..||||   | .| | .  . . ||. |.| ..||| |      |  . . .|.||     .. || .. ||    
YDIERTIGKGNFAVVKLARHRITKTKVAIKIIDKSQL-DEENLQKCYREVQIMKMLYHPHIIKLYQVMETDDMMYIVTEYCSNGEMFDYLCKH-GRKGVK

---------------KLPEEEAKRIFKQIIKGVSYLHTNNIIHRDMKLENLLMDDTKNIKIIDFGFSIMIPPDKKLNIFCGTPSYMAPEIVSKKEYYGPP
                ..|.||.|.|.||. .| |.|  ||.|||.| ||.|.|   ||||.|||||    ... |. .||.| | |||.   ||| || 
MVNSPDIGDQVLMGVPMAENEARRWFWQICSAVHYCHKRNIVHRDLKAENILLDNNMNIKIADFGFSNWFKQGQLLMTWCGSPPYAAPEMFEGKEYDGPK

VDIWACGILLYVMLVGTFPFKAADDKTLYFKIRNGNYDLPPHVSVGARQILKKILNVNYHERATAEEILMDTWV
||||  |..|||.  | .||    ...|  ..  | . .|. .|..  .. .. | |.   | | . |.   | 
VDIWSMGVVLYVLVCGALPFDGKTLQNLRQRVLSGKFRIPFFMSQDCEHLIRHMLVVDPEHRYTIMQICQHRWM
Kinase 14385.AA PLK 401-655 34 1.3e-72 235.81 In-house 1-258 (258) Show / Hide 
Range on Protein: 401-655
Range on HMM: 1-258/258
Sequence Identity: 34% (90 aa)

YKLGPLIGKGSYATVRLATDLATNEQVAIKFYEKFKLFDPQKKKNVQREISILKKISHPHCIGMQKTFENSKNICVVMEYVGKDSLYTYLKSFEGRKLPE
|. | ..|||  | .  .||..|....|||   |  .  |  .. ...|| | .  .||.  .... ||.. |. .|.||  . ||  |.|    ..| |
YERGHFLGKGGFAKCYEMTDIHTKQVYAIKVVPKSLMQKPHQREKMKQEIEIHRQLHHPNIVKFHHFFEDHENVYIVLEYCHNRSLMHYHKRR-AKRLTE

EEAKRIFKQIIKGVSYLHTNNIIHRDMKLENLLMDDTKNIKIIDFGFSIMIPPD-KKLNIFCGTPSYMAPEIV-SKKEYYGPPVDIWACGILLYVMLVGT
.|....  ||. |. ||| ..|||||.|| ||. .|  ..|| ||| . .. .|  . . .|||| | |||..  .|  ..  ||.|. |. .|..|.|.
PEVRYYMYQIVQGLKYLHQHRIIHRDLKLGNLFLNDNMHVKIGDFGLATRLEYDGERKKTMCGTPNYIAPEVLDGNKQGHSYEVDCWSLGCIMYTLLIGK

FPFKAADDKTLYFKIRNGNYDLPPH--VSVGARQILKKILNVNYHERATAEEILMDTWV
 || ..| |. | .|.. .| .| |  .|  |.....|.|| | .|| |...||.. . 
PPFETKDVKETYKRIKHNHYSFPEHCPISDEAKDLIQKMLNWNPDERPTIDQILQHPFF
Kinase 14385.AA Ciliate-E2-Unclassified 401-655 25 4e-72 245.92 In-house 1-352 (352) Show / Hide 
Range on Protein: 401-655
Range on HMM: 1-352/352
Sequence Identity: 25% (92 aa)

YKLGPLIGKGSYATVRLATDLATNEQV-----AIKFYEKFKLFDPQKKKNVQREISILKKIS-------------------HPHCIGMQKTFENSKNICV
||..  ||.|....|... .  .. |.     ..|. .. ..   .|. .  .|. ......                   ||. . |  .|.. .||. 
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

VMEYVGKDSLYTYLKSFEG---------------RKLPEEEAK-----RIFKQIIKGVSYLHTNN-IIHRDMKLENLLMDDTK---NIKIIDFGFSI---
||||.   .|  |.|....               ....|..||     ..|.||..| .||| .| ||||| |.||.|.|. .   .|||||||.|.   
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

-------------MIPPDKKLNIFCGTPSYM----APEIVSKKEYYGP---PVDIWACGILLYVMLVGTFPFKAADDKT----------------LYFKI
              |....... |||||.||    |||.  ...|...    .|||..|..|| || |..||.. ...                 || .|
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

RNGNYDLPP--------HVSVGARQILK----KILNVNYHERATAEEILMDTWV
 ..|.. |.        |.|  |  ...    |.|..|  .| |.|.||   | 
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 14385.AA TyrKc 401-654 22 9.9e-16 31.63 SMART 1-280 (280) Show / Hide 
Range on Protein: 401-654
Range on HMM: 1-280/280
Sequence Identity: 22% (65 aa)

YKLGPLIGKGSYATVRLATDLATNEQVAIKFYEKFKLFDPQKKKNVQREISILKKI--SHPHCIGMQKTFENS-------KNICVVMEYVGKDSLYTYLK
 .||  .| | . .|...|     .|||.|   . .      ..   ||..|..|.  .||. . .      .       . ...||||. . .|  ||.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

SFEGRKLPEEEAKRIFKQIIKGVSYLHTNNIIHRDMKLENLLMDDTKNIKIIDFGFSIMIPPD-----KKLNIFC----GTPS-----YMAPEIVSKKEY
. ... |. ..   .  || .| .||| .|.||||    | | .. . .|| ||| |  |  |      |  .      |. .      ||||   ..  
KHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGK

YGPPVDIWACGILLY-VMLVGTFPFKA-----ADDKTLYFKIRNGNYDLPPHV---------SVGARQILKKILNVNYHERATAEEILMDTW
. .  |.|. |.... ..  |  |         ... .. ....|..  .|.          .    || |.  . . ..| | .||  . .
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF
Kinase 14385.AA Pkinase_Tyr 401-526 25 1.6e-13 46.39 Pfam 1-136 (270) Show / Hide 
Range on Protein: 401-526
Range on HMM: 1-136/270
Sequence Identity: 25% (35 aa)

YKLGPLIGKGSYATVRLATDL----ATNEQVAIKFYEKFKLFDPQK--KKNVQREISILKKI-SHPHCIGMQKTFE-NSKN--ICVVMEYVGKDSLYTYL
 ..|  .|.|.. .|...|       |. .||.|        ...   ..   ||..|.|.. .||. . .       ..   |..||||. . .|..||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE--GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

KS--FEGRKLPEEEAKRIFKQIIKGVSYLHTNNIIHRD
..   ....|. ..   .  || || .||. .|.||||
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRD
RIO 14385.AA RIO 370-573 14 0.000955 -103.27 SMART 1-253 (253) Show / Hide 
Range on Protein: 370-573
Range on HMM: 1-253/253
Sequence Identity: 14% (36 aa)

EKRDFSDTQNFSLQDVTANN-QSTKSKNELDNYKLGPLIGKGSYATVRLATD---LATNEQVAIKFYEKFKLFDPQKKKNVQ------------------
.|.|. .| . ...  |.    ..  .. .... .  .|. |  | |  |.      . . .|.|.|   ..    .....|                  
DKEDY-ATYEEVFDPRTRMTLYKMVNRGYIEEINNHGCISTGKEANVYHAMGGDFDKNGNECAVKIYRTSTTEFKRMWRYIQGDFRFKHGYHHINWRKMV

-----REISILKKISHPHCIGMQKTFENSKNICVVMEYVGKDSLYTYLKSFEGRKLPEEEAK-RIFKQIIKGVSYLHTNN-IIHRDMKLENLLMD-----
     .|  .|... ... .   | ....... .|||..|.|..  .  . . ....|.. |  ...||.  .  .  .  ..| |.   |.| .     
RLWAEKEFRNLQRM-YEAGVPCPKPIAWRRHV-LVMEFIGDDGWPAPRLKDVEWEEWEMDFKWEYYWQIMEYMRKMYHECHLVHADLSEYNMLYHDLEDE

DTKNIKIIDFGFSIMIP-PD----------------KKLNIFCGT-PSYMAPEIVS
.   . |||.. |. .  |.                ..... |   . ..  .|..
NDCKVWIIDWSQSVECDHPMWLEFLERDIWNIINFFRRKGVDCDDIYREIFERITG