Gene 11744 (Tetrahymena)

11744

Species: Tetrahymena
Alias: 1.m00792, 11744, 937, PreTt11744, TTHERM_00011380
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CAMK
Family: CDPK

Sequence

Name Sequence Type Origin Length Description Download
11744.AA Protein None 853 None Fasta, JSON
11744.kin_dom Protein Kinase Domain None 247 None Fasta, JSON
11744.NA RNA None 2562 None Fasta, JSON

Protein domain

Protein domains of 11744.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 11744.AA CDPK 396-645 45 9.60000000001e-164 505.89 In-house 1-271 (271) Show / Hide 
Range on Protein: 396-645
Range on HMM: 1-271/271
Sequence Identity: 45% (123 aa)

LIM---LGRGGFGQVFLVKQKQGNKEER-AMKVIMKS-----VQ-ES-IREVMILKKFSHPNVLKIYEYFEDDQNIYVITE--RCYGYNLFDYIILRGKF
 ..   ||.|.||||..||.||....|| |||.|.||      | .. ..|..|||.. |||..||||...|..|.|...|   |.|..|||||| .|.|
YKIKKVLGKGHFGQVRKVKHKQKTNQERVAMKIIPKSRVKDKEQQQQFFNEIEILKQLDHPNIIKIYEFYQDEKNYYIVMETEYCTGGELFDYIIEKGHF

VEQETCKIADGVLRALAEAHKQNIVHRDVKPENIMLDFDETRQ--KFVVKLIDWGLAEEIKG------DYLSKRCGTLHYLAPEVLNKRYNEKVDLWSLG
 |.|...| . .|.|.. .|..||||||.|||||..|......  .. .|.||||.... ..      ...|.|||| .|.|||||.|.||||.|.||.|
TEKEAAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGTSKKFDQNQKIEDKKMSQRCGTPYYIAPEVLQKKYNEKCDIWSCG

MVLYTLIQGSPPICGKSQMDILEQVQEFRCDFKYRCWIDISDEAKDLILKLLERDFNKRISAAEALKHPWF
..||.|..|.||..||....|.|.|......|....| .||||||||| |.|..|..||.||..||.||||
VILYILLCGYPPFYGKNDQEIMEKVKKGKYSFEGPEWDHISDEAKDLIRKMLCYDPKKRMSAQQALQHPWF
Kinase 11744.AA Ciliate-E2a 394-645 38 1.2e-105 311.96 In-house 2-275 (275) Show / Hide 
Range on Protein: 394-645
Range on HMM: 2-275/275
Sequence Identity: 38% (105 aa)

KRLIMLGRGGFGQVFLVKQKQGNKEERAMKVIMKSVQES------IREVMILKKFSHPNVLKIYEYFEDDQNIYVITERCYGYNLFDYIILRGKFVEQ--
| . ..| | ||.|.|...|| .|.....|.| |  |.       ..|..|... .|||..|.||..||..|.| ..| |.|  |.|.|.  ..| |   
KFIKKIGKGNFGSVYLAQHKQTGKQFAMKKFIKKMYQQKKGKEYFMNEINIMRQLDHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKRFFEEIQ

ETCKIADGVL-RALAEAHKQNIVHRDVKPENIMLD-FDETR-QKFVVKLIDWGLAEEI--K-GDYLSKRCGTLHYLA------PEV-LNKRYNEKVDLWS
| |.|    |  .|.  |..||.||| |||||...  . .  |.. .|.||.|||. |  . ..|. ..||| .|.|      .|| ..|.| .|.|.||
EICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQKCGTPGYVAPEVLNNKEVLKHKQYDTKCDMWS

LGMVLYTLIQGSPPICGKSQMDILEQVQEFRCDFKYRC-WIDISDEAKDLILKLLERDFNKRISAAEALKHPWF
.| ..|.|. |.||  ||.  .||.|. .   || .   | ..|.|.|||. |.|| | .|||.|..||.||||
CGVIFYILLCGKPPFKGKTYNEILQQNKKCKIDFNCPECWEKCSKECKDLMKKMLEKDPKKRITAQQALNHPWF
Kinase 11744.AA CAMK 398-645 24 1.3e-98 318.43 In-house 1-425 (425) Show / Hide 
Range on Protein: 398-645
Range on HMM: 1-425/425
Sequence Identity: 24% (105 aa)

MLGRGGFGQVFLVKQKQGNK-----------EERAMKVIMKS--------------------------------VQESIREVMILKK-------FSHPNV
 ||||.||.|.|...|. ..           .. |.|.| |.                                 ..  ||. |.||        .|||.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LKIYEYFED-------------------DQNIYVIT---ERCYGY----NLFDYIILR---------------GKFVEQETCKIADGVLRALAEAHKQNI
.|.||..||                   |...| ..   | | |      |||||. .               |.| |.|....   .. |..  |..||
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHRDVKPENIMLDFDETRQK------------FVVKLIDWGLAEEIK-------------------------GDYLSKRCGTLHYLA-PEVLNKR-----
|||| |||||.|| ... .             . .|.||.|.| ...                         |. .. .|||..| | |||||.      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

----------YNEKVDLWSLGMVLYTLIQGSPPICGK-------------SQMDILEQVQEFRCDFK-----------YRCWID-ISDE--------AKD
          |..|.| ||.| .||..  | ||  |.             .. ...|.... ..||            . .| | ||||        .||
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LILKLLERDFNKRISAAEALKHPWF
|| |.|..| .||......|.|||.
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 11744.AA Ciliate-E2 393-645 27 6.3e-86 291.78 In-house 1-365 (365) Show / Hide 
Range on Protein: 393-645
Range on HMM: 1-365/365
Sequence Identity: 27% (104 aa)

GKRLIMLGRGGFGQVFLVKQ-KQGNKE---------------------ERAMKVIMKSVQESIRE---VM--------------ILKKFSHPNVLKIYEY
 | . ..|.|.||.|...|. |.....                     . |||...|.  |.|     .|              ||.. .|||..|.||.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FE--DDQNIYVITERCYGYNLFDYIILR-----------GKFVEQETCKIADGVLR---------------ALAEAHKQN-IVHRDVKPENIMLDFDETR
|.  ||.||| ..| | | .|||||. .           ..|.|.| ..|   .|.               || . |..| |.||| |||||..      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

QKFVVKLIDWGLAEEIK------------GDYLSKR----------------------CGTLHYLAPEVLN----------KRYNEKVDLWSLGMVLYTL
    .|.||.||. ...            . |.  .                      |||..|.|||.||          |.|..|.|.||||..|| .
----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEM

IQGSPPICGKSQMDILEQVQEFRCDFKYRC--------------WIDISDEAKDLILK----LLERDFNKRIS-AAEALKHPWF
. | ||         ..| ..  .||   .              | ..|.|.|||| |    .|..| .|||. . ..|.||||
LFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 11744.AA S_TKc 393-645 34 9.3e-85 288.8 SMART 1-231 (231) Show / Hide 
Range on Protein: 393-645
Range on HMM: 1-231/231
Sequence Identity: 34% (94 aa)

GKRLIMLGRGGFGQVFLVKQKQGNKEERAMKVIMKSVQESIREVMILKKFSHPNVLKIYEYFEDDQNIYVITERCYG--YNLFDYIILRGK------FVE
 . |  .|.|.||.|.... |   ... |.|.|    .  .||. ||||  |||. |.|..|.| ...|...| | |   .|||||  ||.      | |
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK---EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE

QETCKIADGVLRALAEAHKQNIVHRDVKPENIMLDFDETRQKFVVKLIDWGLAEEIKGDYLSKRCGTLHYLAPEVLNKRYNE-KVDLWSLGMVLYTLIQG
 ......  ...||.  |...|.|||.|||||.||        ..|..| ||| ..     .  |||..|.|||||   |.  |.| ||.| .|| .. |
-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------HIKICDFGLARQL-----TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCILYEMLCG

SPPICGKSQMDILEQVQEFRCDFKYRCWIDISDEAKDLILKLLERDFNKRISAAEALK-------HPWF
 || .   .. .....               |.||||.| |.|..| .||..| |||.       ||||
YPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 11744.AA CAMK1 398-645 32 1.6e-80 233.78 In-house 6-276 (276) Show / Hide 
Range on Protein: 398-645
Range on HMM: 6-276/276
Sequence Identity: 32% (90 aa)

MLGRGGFGQVFLVKQKQG--NKEERAMKVIM-KSVQES---------IREVMILKKF---SHPNVLKIYEYFEDDQNIYVITERCYGYNLFDYIILRGKF
..||| |..|.|...|.   |... |.|.|  |.. .           .|. |.||.   .|||. |.||..|.|  .| ..| . |  ||| |. .|..
EIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRIVEKGNY

VEQETCKIADGVLRALAEAHKQNIVHRDVKPENIMLDFDETR-QKFVVK--LIDWGLAEEIKGD--YLSKRCGTLHYLAPEVLN----KRYNEKVDLWSL
 |.. ..|   .| |.   |...||||| ||||. .   ..    . .|  ..| ||.  ...|  .....|||. | |||||.    | |  ..|.|| 
TEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLY---YDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKACDMWSI

GMVLYTLIQGSPPICGKS-QMDILEQVQEFRCDFKYRCWIDISDE-AKDLILKLLERDFNKRISAAEALKHPWF
| ..|.|  | ||  ... .. ..|.. .   .|    | .|||. |||.| ..|| | .||......|.|||.
GVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase 11744.AA AGC 394-645 23 2.7e-78 201.18 In-house 1-395 (395) Show / Hide 
Range on Protein: 394-645
Range on HMM: 1-395/395
Sequence Identity: 23% (93 aa)

KRLI-MLGRGGFGQVFLVKQKQ-----GNKEERAMKVIMKSV----------QESIRE------------VMILKKFS----------HPNVLK-IYEYF
 ... ..|.|.||.|.||. |      ....  ||||. |..          .  ..|              ||.| .          ||.. |  .  |
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

EDDQN--IYVITERCY---------GY-NLFDYII---LRGKFVEQETCKIAD-------GVLRALAEAHK-QNIVHRD-VKPENIMLDFDETRQKFVVK
.|...  .| . | .          |   || ..     .|.| |.... .|         .. ||   |. ..|.||| .|||||.|| |       .|
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDED-----GHIK

LIDWGLAEEIKGDY----------------------------------------------------LSKRCG--TLHYLAPEVLNKRYNEKVDLWS--LG
| | ||. |...|.                                                     .  ||  | .|.|||.|   |.  .| ||  ||
LTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL---YGKACDWWSFGLG

MVLYTLIQGSPPICGKS----------QMDILEQVQEFRCDFKYRCWID------------ISDEAKDLILKLLERDFNKRIS----------AAEALKH
 ..| .. | || .|..          .|.. ..... |. .. .  ..            .|.|||||| |||..| .||.           | |  .|
CLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNH

PWF
|||
PWF
Kinase 11744.AA Pkinase 393-645 32 1.4e-74 258.91 Pfam 1-293 (293) Show / Hide 
Range on Protein: 393-645
Range on HMM: 1-293/293
Sequence Identity: 32% (97 aa)

GKRLIMLGRGGFGQVFLVKQKQGNKEERAMKVIMKSVQESIR--------EVMILKKFSHPNVLKIYEYFEDDQNIYVITERCYGY----NLFDYII--L
 ...  .|.|.||.|.. . |  .| . |.|.| |. ..|          |. |.|...|||....|..|||...||...| | |      |||||    
YHIGRKIGSGSFGCVYKCHHKGTGK-IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

RGKF--VEQETCKIADGVLRALAEAHKQNIVHRDVKPENIMLDFDETRQKFVVKLIDWGLAE---EIKGDYLSKRCGTLHYLAPEVLN--KRYNEKVDLW
.|.|   |.| ....  .||.|.  |...|.|||.|||||..| ..   .  ||..|.|||.   . ..  .. .|||..|.||||..  . |  ||| |
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

SLGMVLYTLIQGSPPICGK------SQMDILEQVQEFRCDFKYRCWIDIS-----------------DEAKDLILKLLERDFNKRISAAEALKHPWF
|.| .|| .. | || .|.      .|| ..... . . .| .  |..||                 .|.||.| ..|..| .||..|...|.||||
SCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 11744.AA CAMKL 399-645 28 1.6e-74 237.21 In-house 7-297 (297) Show / Hide 
Range on Protein: 399-645
Range on HMM: 7-297/297
Sequence Identity: 28% (85 aa)

LGRGGFGQVFLVKQKQGNKEERAMKVIMKSVQESI-------------------REVMILKKFS---HPNVLKIYEYFEDDQN------IYVITERCYGY
||.|.||.| | . .. ..|. |.|.| |.    .                   ||. |.|...   |||. |.|| .|....      || ..| | | 
LGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCSGG

N--LFDYIILR----GKFVEQETCKIADGVLRALAEAHKQNIVHRDVKPENIMLDFDETRQKFVVKLIDWGLAEEIK------GDYLSKRCGTLHYLAPE
.  |||||. .    |.. | |....   .. |..  |...||||| |||||.|| .  .   ..|.|| |.. ...      |. |. .||...| |||
EMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN---NIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPE

VLNK--R-YN-EKVDLWSLGMVLYTLIQGSPPICGKS------QMDILEQVQEFRCDFKYRCWIDISDEAKDLILKLLERDFNKRISAAEALKHPWF
....  . |.  ||| ||.| .||... |  |  . .          ..  .. .. .... |...| ...||| |.|... .||... . ..|||.
IFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 11744.AA CAMK-Unique 393-645 25 1.8e-72 238.51 In-house 1-363 (363) Show / Hide 
Range on Protein: 393-645
Range on HMM: 1-363/363
Sequence Identity: 25% (92 aa)

GKRLIMLGRGGFGQVFLVKQKQGNKEERAMKVIMK-----SVQES-------------------IREVMILKKFSHPNVLKIYEY----FEDDQ------
 | .  .| |.|| |. .. .  .. ..|.|.. |     ..|                      ||. |.|. .||| .|.|..    |.|..      
YKMHRIIGHGNFGHVYECMDRE-TGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDL

---------NIYVITERCYGYNLFDYIIL--------------------RGKFVE--QETCKIADGVLRALAEAHKQNIVHRDVKPENIMLDFDET----
         ..| ..|.| |  |||.|.                     .|.| |   .|| |   .| |.| .|.|.||||| |.||||.   .     
IIKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNH

-------RQKFVVKLIDWGLAEEIKGDYLS----KRCGTLHYLAP--------------EVLN-KRYNEKV----DLWSLGMVLYTLIQGSPPICGKSQM
            .||.|.||. .. .   .    ..|||. |.||              ||.|  .| ...    |.|||| ..|... |.||  . .  
HRDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECED

--------DILEQVQEFRC-DFKYRCWID---ISDEAKDLILKLLERDFNKRISAAEALKHPWF
         |.|     .  .|. . | .   ||.||||.. .....| ..|.||.|.|.|.|.
RDYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase 11744.AA Ciliate-E2-Unclassified 399-645 25 4.9e-71 242.3 In-house 7-352 (352) Show / Hide 
Range on Protein: 399-645
Range on HMM: 7-352/352
Sequence Identity: 25% (89 aa)

LGRGGFGQVFLVKQKQGN----------KEERAMKVIMKSVQESIREVMILKKFS-------------------HPNVLKIYEYFEDDQNIYVITERCYG
.|.||||.|.....|. .          . ....| ||..  | ..|  .... .                   ||...| ...|.|.|||| ..| | |
IGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEG

YNLFDYIILRGK-----------------FVEQETC-----KIADGVLRALAEAHKQN-IVHRDVKPENIMLDFDETRQKFVVKLIDWGLAEEIK-----
 .|..||  |.|                 | ||...     ...  .| .|   |..| |.||| |||||..| .    .. .|.||.|.. ...     
GDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK--NYYIKIIDFGISKKYQQNNNC

------------GDYLSKRCGTLHYL----APEVLNK-RYN----EKVDLWSLGMVLYTLIQGSPPICGKSQMD----------------ILEQVQEFRC
             . .. .|||. |.    ||||| .  |.    .|.| ||||..|| .. | .|  .... .                .... ..  .
DTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNI

DFKYRCW----IDISDEAKDLIL----KLLERDFNKRISAAEALKHPWF
.|.   |     ..|.||||.|     |.|. . ||||.. ..|.||||
QFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 11744.AA RSK 396-645 31 3.9e-67 229.35 In-house 1-278 (278) Show / Hide 
Range on Protein: 396-645
Range on HMM: 1-278/278
Sequence Identity: 31% (89 aa)

LIMLGRGGFGQVFLVKQKQGNKEER--AMKVIMKSVQESI--------REVMILKKFS-HPNVLKIYEYFEDDQNIYVITERCYGYNLFDYIILRGK---
| .||.||.| |||.. ... . ..  ||||. |..            .|. ||.    ||.. . .. |.... .| |.| | |  ||. .  ..    
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FVEQETCKIADGVLRALAEAHKQNIVHRDVKPENIMLDFDETRQKFVVKLIDWGLAEE--IK-GDYLSKRCGTLHYLAPEVLN----KR-YNEKVDLWSL
| | | | ..  .  |.   |.| |.||| |||||..| ||. .   .||.| |.. .  .. .  . . |.|..|.|||.|.    .. ... .|.|||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYD-DES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSL

GMVLYTLIQGSPPICG---KSQMDILEQVQEFRCDFKYRCWIDISDEAKDLILKLLERDFNKRIS-----AAEALKHPWF
| ..|..  | ||  |   ... .|....|. . ...   |  .|.|||||| |.|.|| .||..     |.| ..||||
GVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 11744.AA TyrKc 393-649 20 1.7e-13 -4.58 SMART 1-280 (280) Show / Hide 
Range on Protein: 393-649
Range on HMM: 1-280/280
Sequence Identity: 20% (62 aa)

GKRLIMLGRGGFGQVFLVKQKQGNKEERAMKVIMKSVQES-----IREVMILKKF--SHPNVLKIYEYFEDD-------QNIYVITERCYGYNLFDYI-I
 . . .||.| ||.|.. . |        ..|  |...|.     .||  |..|.  .|||....| .  ..       . .....| . . .| ||.  
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

LRGKFVEQETCKIADGVLRALAEAHKQNIVHRDVKPENIMLDFDETRQKFVVKLIDWGLAEEIKGD--------YLSKR---CGT----LHYLAPEVLNK
 |.|.  .. ....  . .  .  |..|..|||    |.... .      .||  | ||. .|. |        | .|.   .|     .  .|||..|.
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY

R-YNEKVDLWSLGMVLY-TLIQGSPPICG-----KSQMDILEQVQEF-RCDFKYR-CWID-----ISDEAKDLILKLLERDFNKRISAAEALKHPWFHKF
. ...| | || | ...  .  | .|  |     .|  ...|.|..  | .     .         .||  .....  ..| ..| . .|       |..
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY--PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI------HEC

L
.
F
Kinase 11744.AA Pkinase_Tyr 394-465 24 6e-05 17.39 Pfam 2-87 (270) Show / Hide 
Range on Protein: 394-465
Range on HMM: 2-87/270
Sequence Identity: 24% (21 aa)

KRLIMLGRGGFGQVFLVKQKQGNKEERAMKVIMKSV-----QES------IREVMILKKF-SHPNVLKIYEYFE-DDQN--IYVITE
. . .||.| ||.|.. . |   ...  ..|  |..     .|       .||. |.|.. .|||... |     ...   ||...|
TFGKKLGEGAFGEVYKGTWKG-DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVME
Kinase 11744.AA Pkinase_Tyr 502-601 28 0.851631 3.32 Pfam 128-231 (270) Show / Hide 
Range on Protein: 502-601
Range on HMM: 128-231/270
Sequence Identity: 28% (31 aa)

HKQNIVHRDVKPENIMLDFDETRQKFVVKLIDWGLAEEI-KGDYL-SKRCGTL---HYLAPE-VLNKRYNEKVDLWSLGMVLYTLIQ-GSPP-ICGKSQM
. .|..|||.   |....      ..|||  | |||  | . ||   || |.      .|||   ......| | || | ... ..  |  |   | |  
ESKNCIHRDLAARNCLVT-----ENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNE

DILEQV-QE
...|.. ..
EVYEYIYED
Efhand 11744.AA efhand 695-723 31 8.5e-07 29.3 Pfam 1-29 (29) Show / Hide 
Range on Protein: 695-723
Range on HMM: 1-29/29
Sequence Identity: 31% (9 aa)

KYIEMFQALDTDKNGELSIEELKAGFSKI
.  |||. .|.|..|....||......|.
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
EFh 11744.AA EFh 695-723 31 6e-06 27.04 SMART 1-29 (29) Show / Hide 
Range on Protein: 695-723
Range on HMM: 1-29/29
Sequence Identity: 31% (9 aa)

KYIEMFQALDTDKNGELSIEELKAGFSKI
.  |||. .|.|..|... ||.|......
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
EFh 11744.AA EFh 774-802 31 3e-06 27.88 SMART 1-29 (29) Show / Hide 
Range on Protein: 774-802
Range on HMM: 1-29/29
Sequence Identity: 31% (9 aa)

QLLEAFQVFDKDRNGKISLNEIIQTLGIQ
.. |.|..||||..|.|...| .. .   
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
Efhand 11744.AA efhand 774-802 34 6e-06 26.07 Pfam 1-29 (29) Show / Hide 
Range on Protein: 774-802
Range on HMM: 1-29/29
Sequence Identity: 34% (10 aa)

QLLEAFQVFDKDRNGKISLNEIIQTLGIQ
.| |.|..||||..|.|...| .. .  .
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
EFh 11744.AA EFh 810-838 41 4e-07 30.9 SMART 1-29 (29) Show / Hide 
Range on Protein: 810-838
Range on HMM: 1-29/29
Sequence Identity: 41% (12 aa)

CFKKIIEQSDNNQDGEIDFEEFRQIMTNF
 ||....  | . ||.||||||...|...
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
Efhand 11744.AA efhand 810-838 37 1e-06 28.46 Pfam 1-29 (29) Show / Hide 
Range on Protein: 810-838
Range on HMM: 1-29/29
Sequence Identity: 37% (11 aa)

CFKKIIEQSDNNQDGEIDFEEFRQIMTNF
 .|..... | ..||.||||||...|...
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL