12974

Species: Tetrahymena
Alias: 4.m00373, PreTt12974, 464, TTHERM_00053930, 12974, 3707.m00021
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CAMK
Family: CDPK

Sequence

Name Sequence Type Origin Length Description Download
12974.AA Protein None 471 None Fasta, JSON
12974.kin_dom Protein Kinase Domain None 258 None Fasta, JSON
12974.NA RNA None 1416 None Fasta, JSON

Protein domain

Protein domains of 12974.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 12974.AA CDPK 30-287 51 1.3e-188 583.3 In-house 1-271 (271) Show / Hide
Range on Protein: 30-287
Range on HMM: 1-271/271
Sequence Identity: 51% (140 aa)

WSKKRTLGSGQFGSVVSCKLK-GTNDTR-AIKVIPKSRVRDPQ---QFLNEINIMKELDHPNVIRLYETFEDQRNVYLSME--LCSGGELFDVITAKKKF
. .|..||.|.||.|  .|.| .||..| |.|.||||||.|..   ||.|||.|.|.|||||.|..||...|..|.|. ||  .|.||||||.|..|..|
YKIKKVLGKGHFGQVRKVKHKQKTNQERVAMKIIPKSRVKDKEQQQQFFNEIEILKQLDHPNIIKIYEFYQDEKNYYIVMETEYCTGGELFDYIIEKGHF

SEEEARLVFNQIVSAVSYCHANNICHRDLKPENFLLLQKESLD----NIKVADFGLSCIFVDKQQK--KQDILGKTGSSYYMAPEVLQGIYNELCDVWSL
.| ||.....||.|||.||| |||.||||||||.|...|.. .    |||| |.|.|..|  . ||  ....  . |  ||.||||||. ||| ||.||.
TEKEAAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGTSKKFDQN-QKIEDKKMSQRCGTPYYIAPEVLQKKYNEKCDIWSC

GVILYILLSGIPPFFGSNDSKIFEKIEKGTYSFDFPQFQNVSENAKDLIRKCLVP-QDQRLKANEILKHPWC
||||||||.| |||.| ||..|.||..|| |||. |.....|..|||||||.|.. ...|..|...|.|||.
GVILYILLCGYPPFYGKNDQEIMEKVKKGKYSFEGPEWDHISDEAKDLIRKMLCYDPKKRMSAQQALQHPWF

Kinase 12974.AA CAMK 35-287 30 1.2e-125 407.07 In-house 1-425 (425) Show / Hide
Range on Protein: 35-287
Range on HMM: 1-425/425
Sequence Identity: 30% (130 aa)

TLGSGQFGSVVSCKLKGTN-DTR-----------AIKVIPKSRVR----------------------------DPQQFLNEINIMKE-------LDHPNV
|||.|.|| |  |. | |. ..|           |||.|.|....                            | .....||.|||        |||||.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IRLYETFED-------------------QRNVYLSM---ELCSGGEL----FDVITAK---------------KKFSEEEARLVFNQIVSAVSYCHANNI
|.|||..||                   ....|. |   |.||||||    || |...               ..|.|.||| .| ||.||| ||| .||
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

CHRDLKPENFLLLQKESLD--------------NIKVADFGLSCIFVDKQQKK--------------------QDILGKTGSSYYMA-PEVLQGI-----
.|||||||| || .... .              |||..|||....| .... .                    |      |. .||| ||||.|      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

----------YNELCDVWSLGVILYILLSGIPPFFGS-------------NDSKIFEKIEKGTYSFDFPQFQN------------VSEN--------AKD
          |.. ||.||.||||||.|.| ||| |.             ||...|||| || |.|. |.| .            .|..        .||
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LIRKCLVP-QDQRLKANEILKHPWC
||||.|..  ..|... ..|.||| 
LIRKMLQVDPEKRMTIEQCLNHPWM

Kinase 12974.AA CAMK1 33-287 41 2e-118 345.9 In-house 4-276 (276) Show / Hide
Range on Protein: 33-287
Range on HMM: 4-276/276
Sequence Identity: 41% (115 aa)

KRTLGSGQFGSVVSCKLKGT---NDTRAIKVIP-KSRVRDP-----QQFLNEINIMK---ELDHPNVIRLYETFEDQRNVYLSMELCSGGELFDVITAKK
. ..|.| |. |. |. | |   ..  |||.|  |. .        ....|||.|||   ..||||.| .|| .|. . .|| |||..|||||| |  |.
GKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRIVEKG

KFSEEEARLVFNQIVSAVSYCHANNICHRDLKPENFLLLQKESLDNIK--VADFGLSCIFVDKQQKKQDILGKT-GSSYYMAPEVLQGI----YNELCDV
...|..||..  ||.||| |.|...|.|||||||| |.  |.    ||  .|||||| || ..      .. .  |. .|.||||| ..    |   ||.
NYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDEN----LMKTACGTPGYVAPEVLECKKDKPYDKACDM

WSLGVILYILLSGIPPFFGSN-DSKIFEKIEKGTYSFDFPQFQNVSEN-AKDLIRKCLVPQ-DQRLKANEILKHPWC
|| |||.|||| | |||...| |...|||| |. | |. |.. |.|.  |||.|.. |..   .|. . ..|.||| 
WSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI

Kinase 12974.AA Ciliate-E2a 30-287 39 7.6e-111 327.5 In-house 1-275 (275) Show / Hide
Range on Protein: 30-287
Range on HMM: 1-275/275
Sequence Identity: 39% (109 aa)

WSKKRTLGSGQFGSVVSCKLKGTNDT-RAIKVIPKSRVRD--PQQFLNEINIMKELDHPNVIRLYETFEDQRNVYLSMELCSGGELFDVITAKKKFSEE-
 .... .|.|.||||.  ..|.|..  ...|.| | .. .   ..| ||||||..|||||.|.|||..|| .| || ||.|.||||.| |  .|.| || 
YKFIKKIGKGNFGSVYLAQHKQTGKQFAMKKFIKKMYQQKKGKEYFMNEINIMRQLDHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKRFFEEI

-EARLVFNQIVS-AVSYCHANNICHRDLKPENFLLL--QKES--LDNIKVADFGLSCIFVDKQQKKQD--ILGKTGSSYYMA------PEVLQGI-YNEL
 |.. .  |. . ...|.| .|| ||||||||.|.    |.|  . .||..||||.    ....|..   .  | |. .|.|      .|||..  | . 
QEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLA----TFIDKDEKKYMFQKCGTPGYVAPEVLNNKEVLKHKQYDTK

CDVWSLGVILYILLSGIPPFFGSNDSKIFEKIEKGTYSFDFPQ-FQNVSENAKDLIRKCLVPQ-DQRLKANEILKHPWC
||.||.|||.||||.| ||| | . . |.....|  ..|. |. ....| ..|||..| |...  .|..|...|.||| 
CDMWSCGVIFYILLCGKPPFKGKTYNEILQQNKKCKIDFNCPECWEKCSKECKDLMKKMLEKDPKKRITAQQALNHPWF

Kinase 12974.AA AGC 30-287 24 2.3e-108 280.75 In-house 1-395 (395) Show / Hide
Range on Protein: 30-287
Range on HMM: 1-395/395
Sequence Identity: 24% (99 aa)

WSKKRTLGSGQFGSVVSCKLK------GTNDTRAIKVIPKSR--------VRDPQQ----------FLNEINIMKELD----------HPNVIR-LYETF
   ....| | || |  .. |      .|..  |.||. |..          .  .          . .| ||.....          ||.... |. .|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

EDQRN--VYLSMELCS---------GG-ELFDVIT---AKKKFSEEEARLVFNQ-------IVSAVSYCHA-NNICHRD-LKPENFLLLQKESLDNIKVA
.|...  .|. ||...         || |||  .     ...|.||.||  . .       ||.|. | |  ..| ||| ||||| || ..    .|| .
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDED---GHIKLT

DFGLSCIFVD-----------------------------------KQQKK----------QDILGKT--G--SSYYMAPEVLQGIYNELCDVWS--LGVI
||||......                                   .|...          .. . .|  |  .  |||||.|   |.  || ||  ||..
DFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL---YGKACDWWSFGLGCL

LYILLSGIPPFFGSNDS----------KIFEKIEKGTYSFDFPQF------------QNVSENAKDLIRKCLV-PQDQRLK----------ANEILKHPW
.| .|.|.|||.| |.           ..|.||..| | . ...             ...|..|||||.|.|.   ..||           |.|| .|||
MYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPW

C
 
F

Kinase 12974.AA S_TKc 30-287 37 1.1e-102 348.36 SMART 1-231 (231) Show / Hide
Range on Protein: 30-287
Range on HMM: 1-231/231
Sequence Identity: 37% (102 aa)

WSKKRTLGSGQFGSVVSCKLKGTNDTRAIKVIPKSRVRDPQQFLNEINIMKELDHPNVIRLYETFEDQRNVYLSMELCSG--GELFDVITAKKK------
. . |..|.| ||.|  |. |.|.   |||.|.       .....||.|.|. .|||...||..|.|  ..|. ||.|.|  |.|||.|  ...      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

FSEEEARLVFNQIVSAVSYCHANNICHRDLKPENFLLLQKESLDNIKVADFGLSCIFVDKQQKKQDILGKTGSSYYMAPEVLQGIYNE-LCDVWSLGVIL
|.| .|| .. ||..|. ||| ..|.|||||||| || .     .||..||||....              |. .|||||||   |.   ||.||.|.||
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL----------TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCIL

YILLSGIPPFFGSNDSKIFEKIEKGTYSFDFPQFQNVSENAKDLIRKCLV-PQDQRLKANEILK-------HPWC
|..|.| |||   .. ..|.||               |. |||.|||||.   ..|. | |.|.       ||| 
YEMLCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase 12974.AA CAMKL 30-287 36 1.8e-95 305.16 In-house 1-297 (297) Show / Hide
Range on Protein: 30-287
Range on HMM: 1-297/297
Sequence Identity: 36% (111 aa)

WSKKRTLGSGQFGSVVSCKL-KGTNDTRAIKVIPKSRVR-DPQQFLN--------------EINIMKELD---HPNVIRLYETFEDQRN------VYLSM
.   .||| | || |  ..  . |.   |||.| |.. . ||.   |              ||.||| |.   |||.|.|||..|....      .|| |
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

ELCSGGE--LFDVITAK----KKFSEEEARLVFNQIVSAVSYCHANNICHRDLKPENFLLLQKESLDNIKVADFGLSCIFVD-----KQQKKQDILGKTG
|.|||||  ||| | ..    ....|.|||  | ||||||.||| ..|.|||.|||| || .. .  |||..|||.| .. .      |  |       |
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN-NIKIIDFGFSNMYRPCIFGPGQKLKTFC----G

SSYYMAPEVLQG--I-YN-ELCDVWSLGVILYILLSGIPPFFGSN-------DSKIFEKIEKGTYSFDFPQFQNVSENAKDLIRKCLVP-QDQRLKANEI
|  |||||..||    |.    |.||.||||| .. |  || . .       .   ........  . .| .  ||  ..||||| |..  ..| .. .|
SPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG--YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQI

LKHPWC
..|||.
MNHPWM

Kinase 12974.AA Pkinase 30-287 35 1.6e-93 321.82 Pfam 1-293 (293) Show / Hide
Range on Protein: 30-287
Range on HMM: 1-293/293
Sequence Identity: 35% (105 aa)

WSKKRTLGSGQFGSVVSCKLKGTNDTRAIKVIPKSRVRD--PQQFLN--EINIMKELDHPNVIRLYETFEDQRNVYLSMELCSGG----ELFDVIT--AK
. ..|..||| ||.|  |. |||... |.|.|.|.. ..  .|. ..  || |||.|.|||..|||..||| ...|. ||.| ||    .|||.|.  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KKF--SEEEARLVFNQIVSAVSYCHANNICHRDLKPENFLLLQKESL-DNIKVADFGLSCIF-VDKQQKKQDILGKTGSSYYMAPEVLQ--GIYNELCDV
..|  ||.|.. .. ||.... |||...|.||||||||.|. ..  . . .|..||||.. |   ...  ...   .|...||||||..    |   .|.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTF---CGTPWYMAPEVIRGGQYYGPKVDM

WSLGVILYILLSGIPPFFGS------NDSKIFEKIEKGTYSFDFPQFQNVS-----------------ENAKDLIRKCLVP-QDQRLKANEILKHPWC
||.|.|||..|.| ||| |.      .. .....| .. ..||.|.  ..|                 |..||.|..|| .   .|. | .||.||| 
WSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF

Kinase 12974.AA CAMK-Unique 30-287 27 1e-90 299.67 In-house 1-363 (363) Show / Hide
Range on Protein: 30-287
Range on HMM: 1-363/363
Sequence Identity: 27% (102 aa)

WSKKRTLGSGQFGSVVSCKLKGTNDTRAIKVIPK----SRVRDPQ----------------QFLNEINIMKELDHPNVIRLYET----FEDQR-------
. . | .|.| || |  |. . | . .|.|.. |    . ....|                .. .|..|.| .|||| |.||..    |.| .       
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI

--------NVYLSMELCSGGELFDVITA--------------------KKKFSE--EEARLVFNQIVSAVSYCHANNICHRDLKPENFLLLQK-------
        . |. ||.| ||.|||.| .                    . .|||   ...... ...|||.| | ..| |||||.|| ..          
IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHH

------ESLDNIKVADFGLSCIFVDKQQKKQD-ILGKT-GSSYYMAP--------------EVLQ-GIYNELC----DVWSLGVILYILLSGIPPFFGSN
      .|  .||..||||.|   .....| . .. .. |...||||              ||.    | . |    | ||||||.|..|.|.||| ...
RDFPYDWSNWHIKLCDFGLCC---HYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCEC

DS--------KIFEKIEKGTY-SFDFPQFQN---VSENAKDLIRKCLVPQ-DQRLKANEILKHPWC
.         .|||.| || | .|| ....    .|..|||.. .|..   |.|..|.|.|.|.| 
EDRDYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI

Kinase 12974.AA Ciliate-E2 30-287 26 3.8e-88 299.15 In-house 1-365 (365) Show / Hide
Range on Protein: 30-287
Range on HMM: 1-365/365
Sequence Identity: 26% (103 aa)

WSKKRTLGSGQFGSVVSCKLKGTNDTR------------------AIKVIPKSRV--RDPQQFLNEINIMK----------------ELDHPNVIRLYET
  . . .|.|.||||  || . ..                     .|| . . ..  .. .|...||.||.                .|.|||.|..||.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FE--DQRNVYLSMELCSGGELFDVIT------------AKKKFSEEEARLVFNQIVS---------------AVSYCHANN-ICHRDLKPENFLLLQKES
|.  |. |.|| ||.|.||.||| |             . |.|.|.|.. .. ||..               |. |.| .| |.|||.|||| |.     
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

LDNIKVADFGLSCIFVDKQQKKQDILGKTG-----------------------------SSYYMAPEVLQGI----------YNELCDVWSLGVILYILL
   ||..||||| .. |..|.... .   .                             . .|||||.|.|           |.. ||.||||||||..|
---IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEML

SGIPPFFGSNDSKIFEKIEKGTYSFDFP--------------QFQNVSENAKDLIRK----CLVPQ-DQRLK-ANEILKHPWC
.| |||        ...|... ..|..|               ....|...||||.|    .|. . ..|.  ...||.||| 
FGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF

Kinase 12974.AA RAD53 30-287 35 1.5e-86 257.71 In-house 1-305 (305) Show / Hide
Range on Protein: 30-287
Range on HMM: 1-305/305
Sequence Identity: 35% (110 aa)

WSKKRTLGSGQFGSVVSCKLKGTNDTRAIKVIPK-------SRV-RDPQQFLNEINIMKELDHPNVIRLYETFED-QRNVYLSMELCSGGELFDVITAKK
 .  ..|||| ||.|  .. | |  . ||| | |       ...  .. |. ||..|.| | ||..||.|. |.. |...|. .|| .|||||. | . |
YYMSKELGSGNFGTVKLAYEKKTCQKVAIKIIDKKKFFIRCMHTIKKMDQVMNEVEILKKLNHPCIIRIYDIFDTPQKYYYMVLELMTGGELFNKIVSNK

K----FSEEEARLVFNQIVSAVSYCHANNICHRDLKPENFLLL-QKESL--------------DNIKVADFGLSCIFVDKQQKKQDILGKT--GSSYYMA
.    |.| .... | |.. ||.| | |.|||||||||| |.  |.|                . ||..||||| . ....      . ||  |.  | |
RCQMGFDEDTCKYYFYQMCDAVKYLHDNGICHRDLKPENILCNHQDEECPQVQLGPWDEDEISFLIKITDFGLSKFVGEGS------FMKTMCGTPQYVA

PEVLQ----------------GIYNELCDVWSLGVILYILLSGIPPFF-GSND----SKIFEKIEK-GTYSFDFPQFQNVSENAKDLIRKCL-VPQDQRL
|||.                 . |.  .|.||.|.||||.|.| |||  .. .     ..||.| . | |.|. |.   .||.|||||.. | |  . |.
PEVITSKGHNCYHENEERQVQVGYTKKVDCWSMGCILYICLCGYPPFSDDYTQEMHCMQLFEQIKNQGKYHFPHPYWDRISEEAKDLIKWMLCVDPEKRY

KANEILKHPWC
 ..|.| ||| 
TIDEALNHPWM

Kinase 12974.AA RSK 33-287 36 8.2e-83 281.43 In-house 1-278 (278) Show / Hide
Range on Protein: 33-287
Range on HMM: 1-278/278
Sequence Identity: 36% (103 aa)

KRTLGSGQFGSVVSCKLK---GTNDTRAIKVIPKSRVRDPQQ----FLNEINIMKELD-HPNVIRLYETFEDQRNVYLSMELCSGGELFDVITAKKK---
 . || | .|.|  |. .    |.   | ||. |. ..  |      . |.||...   ||....|...|...  .|| ||.|.|||||. .  .|    
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FSEEEARLVFNQIVSAVSYCHANNICHRDLKPENFLLLQKESL-DNIKVADFGLSCIF-VDKQQKKQDILGKTGSSYYMAPEVLQ----GI-YNELCDVW
|||.||. .. .||.||.. |   | |||||||| |. ...     ||. |||....|  |. |. .      ..  |||||.|     .  ... ||.|
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFC---YTIEYMAPEMLKRANQQGGHDKACDWW

SLGVILYILLSGIPPFFG---SNDSKIFEKIEKGTYSFDFPQFQNVSENAKDLIRKCL-VPQDQRLK-----ANEILKHPWC
||||..| .|.| ||| |   .| ..|...|.||..|...|  |..|..|||||||.| .   .||.     |.||..||| 
SLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF

Kinase 12974.AA TyrKc 30-285 24 2.7e-21 78.0 SMART 1-280 (280) Show / Hide
Range on Protein: 30-285
Range on HMM: 1-280/280
Sequence Identity: 24% (71 aa)

WSKKRTLGSGQFGSVVSCKLKGTNDTRAIKVIPKSRVRDPQQFLNEINIMKEL--DHPNVIRLYETFEDQ-------RNVYLSMELCSGGELFDVITAKK
 .....||.|.|| |. ...|    . |.|.. ..     . |..|..||..|  .|||..|||    .|         ... ||....| | | . ...
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

K-FSEEEARLVFNQIVSAVSYCHANNICHRDLKPENFLLLQKESLDNIKVADFGLSCIFVDK-------QQKKQD--ILGKT-GSSYYMAPEVL-QGIYN
. .. ..      || .  .| | .|. ||||   | |.  .     .|..|||||    |.       . ...     |||      ||||..  |...
PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

ELCDVWSLGVILY-ILLSGIPPFFG-----SNDSKIFEKIEKGTYSFDFPQFQN--------VSENAKDLIRKCLVP-QDQRLKANEILKHP
.  |||| || .. |.  | .|  |      ... ..|....| .    || .|         ..   .....|     ..|   .|| .  
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRM---PQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF

Kinase 12974.AA Pkinase_Tyr 30-112 29 8.1e-16 54.2 Pfam 1-94 (270) Show / Hide
Range on Protein: 30-112
Range on HMM: 1-94/270
Sequence Identity: 29% (28 aa)

WSKKRTLGSGQFGSVVSCKLK----GTNDTRAIKVIPKSRVRDP----QQFLNEINIMKEL-DHPNVIRLYETFE-DQRN--VYLSMELCSGGEL
 .. ..||.|.||.|. ...|    .|. . |.|.. |    ..    . |..|..|||.| .|||..|||     ...   .|. ||.. .| |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDL

Kinase 12974.AA Pkinase_Tyr 198-245 34 0.029624 8.26 Pfam 181-232 (270) Show / Hide
Range on Protein: 198-245
Range on HMM: 181-232/270
Sequence Identity: 34% (18 aa)

MAPE-VLQGIYNELCDVWSLGVILYILLS-GIPP-FFGSNDSKIFEKI-EKG
||||    |....  |||| || .. ... |  | . |  .. ..|.| |.|
MAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDG

Efhand 12974.AA efhand 332-360 44 2e-06 27.73 Pfam 1-29 (29) Show / Hide
Range on Protein: 332-360
Range on HMM: 1-29/29
Sequence Identity: 44% (13 aa)

DLGKQFKQLDKNGDGVLSIEEITEGMKNF
.| . ||..||.||| ...||  |.||..
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL

EFh 12974.AA EFh 332-360 34 0.000236 21.71 SMART 1-29 (29) Show / Hide
Range on Protein: 332-360
Range on HMM: 1-29/29
Sequence Identity: 34% (10 aa)

DLGKQFKQLDKNGDGVLSIEEITEGMKNF
.. . |. .||.||| .. ||  ..||..
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL

EFh 12974.AA EFh 366-394 24 4.3e-07 30.81 SMART 1-29 (29) Show / Hide
Range on Protein: 366-394
Range on HMM: 1-29/29
Sequence Identity: 24% (7 aa)

QLLEIIKEIDTDKNGQIEYSEFIAASMDK
.. |.....|.|..|.|.. ||... . .
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL

Efhand 12974.AA efhand 366-394 34 1e-06 28.49 Pfam 1-29 (29) Show / Hide
Range on Protein: 366-394
Range on HMM: 1-29/29
Sequence Identity: 34% (10 aa)

QLLEIIKEIDTDKNGQIEYSEFIAASMDK
.| |..||.|.|..|.|.. ||... ...
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL

Efhand 12974.AA efhand 402-430 31 2e-06 27.69 Pfam 1-29 (29) Show / Hide
Range on Protein: 402-430
Range on HMM: 1-29/29
Sequence Identity: 31% (9 aa)

KLYQAFKALDIDGSGSISKDELKQVLDSD
.| ..|| .| ||.| |...|..... . 
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL

EFh 12974.AA EFh 402-430 31 1e-05 26.23 SMART 1-29 (29) Show / Hide
Range on Protein: 402-430
Range on HMM: 1-29/29
Sequence Identity: 31% (9 aa)

KLYQAFKALDIDGSGSISKDELKQVLDSD
.. ..|. .| ||.| |...|.|... | 
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL

EFh 12974.AA EFh 440-468 44 4.3e-08 34.12 SMART 1-29 (29) Show / Hide
Range on Protein: 440-468
Range on HMM: 1-29/29
Sequence Identity: 44% (13 aa)

YWKSVIQEADKDGNGEIDYEEFVEMMVPS
 .| .....||||.|.||.|||..||   
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL

Efhand 12974.AA efhand 440-468 51 1.2e-07 32.42 Pfam 1-29 (29) Show / Hide
Range on Protein: 440-468
Range on HMM: 1-29/29
Sequence Identity: 51% (15 aa)

YWKSVIQEADKDGNGEIDYEEFVEMMVPS
 .| ...|.||||.|.||.|||.|||   
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL