Gene 4576 (Tetrahymena)
4576
Sequence
Protein domains of 4576.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 4576.AA | CDPK | 31-300 | 53 | 1.1e-198 | 614.76 | In-house | 2-271 (271) | Show / Hide |
Range on Protein: 31-300 Range on HMM: 2-271/271 Sequence Identity: 53% (150 aa) QKKDNLGEGSYGVVYKATMK-STGQIR-AVKVINKSRVKHQE---RLKNEIEIMSTLDHPNIIRLYETYEDQKNIYLVIE--YCEGGELFDRIAERGYYT ..|..||.|..|.|.|...| .|.|.| |.|.|.|||||..| ...|||||...|||||||..||.|.|.||.|.|.| ||.||||||.|.|.|..| KIKKVLGKGHFGQVRKVKHKQKTNQERVAMKIIPKSRVKDKEQQQQFFNEIEILKQLDHPNIIKIYEFYQDEKNYYIVMETEYCTGGELFDYIIEKGHFT EQDAVALFRQIMSAINYCHSRKICHRDLKPENFLFCTKDDNS----IIKVIDFGLSKTYGQVLDSPLKKKPLELTQVQSGVMKTRAGTPYYIAPEVLDGK |..| .|||.||.|||||..|.||||||||.||..|.|.| .|||||.|.|| ..| ... .. .|..|.|||||||||||..| EKEAAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGTSKKFDQN-QKI-----------EDKKMSQRCGTPYYIAPEVLQKK YDEKCDIWSAGVTLYIILCGYPPFYGETDKEILQAVKKGEYEYEGDEWDIVSDECKNLIKKMLSK-PELRFSSEMVMASKWI |.|||||||.|| |||.|||||||||..|.||...||||.|..||.|||..|||.|.||.||| . |. |.|...... .|. YNEKCDIWSCGVILYILLCGYPPFYGKNDQEIMEKVKKGKYSFEGPEWDHISDEAKDLIRKMLCYDPKKRMSAQQALQHPWF |
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| Kinase | 4576.AA | CAMK1 | 27-300 | 45 | 1.9e-149 | 437.61 | In-house | 1-276 (276) | Show / Hide |
Range on Protein: 27-300 Range on HMM: 1-276/276 Sequence Identity: 45% (134 aa) YDFDQKKDNLGEGSYGVVYKATMKST---GQIRAVKVIN-KSRVKH-----QERLKNEIEIMST---LDHPNIIRLYETYEDQKNIYLVIEYCEGGELFD | |. . .|.|. ..||..|.|.| |. |.|.|. |. .|. ||.|.|||||| . .|||||| .|| ||. . .||| |.. |||||| YEFGKE---IGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFD RIAERGYYTEQDAVALFRQIMSAINYCHSRKICHRDLKPENFLFCTKDDNSIIK--VIDFGLSKTYGQVLDSPLKKKPLELTQVQSGVMKTRAGTPYYIA || |.|.|||.||. . .|| ||..|.||. |.|||||||| |. .||..|.|| ..|||||| ... . .|||. |||.|.| RIVEKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDEN----------------LMKTACGTPGYVA PEVLDGK----YDEKCDIWSAGVTLYIILCGYPPFYGET-DKEILQAVKKGEYEYEGDEWDIVSDE-CKNLIKKMLSK-PELRFSSEMVMASKWI |||| .| || .||.||.|| .||.||||||||.|. |.|... .||.|||. ..|| .||. |..||.|| . |. |.. | . . .|| PEVLECKKDKPYDKACDMWSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI |
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| Kinase | 4576.AA | CAMK | 35-300 | 31 | 2.4e-133 | 432.36 | In-house | 1-425 (425) | Show / Hide |
Range on Protein: 35-300
Range on HMM: 1-425/425
Sequence Identity: 31% (134 aa)
NLGEGSYGVVYKATMKSTG------------QIRAVKVINKSRVK----------------------------HQERLKNEIEIMST-------LDHPNI
||.||.|.|.... |.|. | |.|.|.|...| ......|||||.. ||||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI
IRLYETYED-------------------QKNIYLVI---EYCEGGEL----FDRIAER---------------GYYTEQDAVALFRQIMSAINYCHSRKI
|.|||.||| .|..|.| |||.|||| ||.| |. |..||..| .|||| ||..||||..|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI
CHRDLKPENFLFCTKDDNS--------------IIKVIDFGLSKTYGQVLDSPLKKKPLELTQVQSG---------VMKTRAGTPYYIA-PEVLDGK---
.|||||||| |.....|.| ||.||||... . . .. .... . . . . |||. |||.|.| |||| ||
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC
------------YDEKCDIWSAGVTLYIILCGYPPFYGE-------------TDKEILQAVKKGEYEYEGDE------------WDIVSDE--------C
|..|||.||.|| ||| |||||||||. .|.|... ..||.|... .. || .||| |
NMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQEC
KNLIKKMLSK-PELRFSSEMVMASKWI
|.||.||| . || |.. | ... .|.
KDLIRKMLQVDPEKRMTIEQCLNHPWM
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| Kinase | 4576.AA | Ciliate-E2a | 27-300 | 43 | 3.1e-125 | 370.59 | In-house | 1-275 (275) | Show / Hide |
Range on Protein: 27-300 Range on HMM: 1-275/275 Sequence Identity: 43% (126 aa) YDFDQKKDNLGEGSYGVVYKATMKSTGQI-RAVKVINKSRVKH--QERLKNEIEIMSTLDHPNIIRLYETYEDQKNIYLVIEYCEGGELFDRIAERG-YY |.| | .|.|..|.||.|. | ||. ...|.|.| .... .| ..||| ||..|||||||.|||.||| .|.||| ||||||||.|.| . . . YKFIKK---IGKGNFGSVYLAQHKQTGKQFAMKKFIKKMYQQKKGKEYFMNEINIMRQLDHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKRFF TE-QDAVALFRQIMS-AINYCHSRKICHRDLKPENFLF--CTKDD--NSIIKVIDFGLSKTYGQVLDSPLKKKPLELTQVQSGVMKTRAGTPYYIA---- .| |.. . .|. . ...|.|.|.| ||||||||.|| | |.. || ||.|||||.. . . . .|... |||.|.| EEIQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKD---------------EKKYMFQKCGTPGYVAPEVL --PEVLDGK-YDEKCDIWSAGVTLYIILCGYPPFYGETDKEILQAVKKGEYEYEGDE-WDIVSDECKNLIKKMLSK-PELRFSSEMVMASKWI .||| .| ||.|||.||.|| .|| |||.|||.|.| .|||| .|| .. ... | | .|.|||.|.|||| | |. |.. . ..| NNKEVLKHKQYDTKCDMWSCGVIFYILLCGKPPFKGKTYNEILQQNKKCKIDFNCPECWEKCSKECKDLMKKMLEKDPKKRITAQQALNHPWF |
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| Kinase | 4576.AA | S_TKc | 30-300 | 34 | 4.7e-107 | 362.88 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 30-300 Range on HMM: 1-231/231 Sequence Identity: 34% (98 aa) DQKKDNLGEGSYGVVYKATMKSTGQIRAVKVINKSRVKHQERLKNEIEIMSTLDHPNIIRLYETYEDQKNIYLVIEYCEG--GELFDRIAERGY------ .. . .|.|..|.|||.. |.||.| |.|.|. |....||.|.. .||||..||....| ...|.| |||.| |.|||.| .||. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP YTEQDAVALFRQIMSAINYCHSRKICHRDLKPENFLFCTKDDNSIIKVIDFGLSKTYGQVLDSPLKKKPLELTQVQSGVMKTRAGTPYYIAPEVLDGKYD ..| .| ...|| .|..||||..|.|||||||| |... ||..||||.. . .| |||.|.||||| .|. FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL-----------------------TTFCGTPWYMAPEVL--GYG E-KCDIWSAGVTLYIILCGYPPFYGETDKEILQAVKKGEYEYEGDEWDIVSDECKNLIKKMLS-KPELRFSSEMVMA-------SKWI |||.|| |..||. |||||||. ....... .. |.|.|..|.|.| || | . ... |. KCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 4576.AA | CAMKL | 29-300 | 38 | 3.2e-101 | 323.79 | In-house | 1-297 (297) | Show / Hide |
Range on Protein: 29-300 Range on HMM: 1-297/297 Sequence Identity: 38% (121 aa) FDQKKDNLGEGSYGVVYKATM-KSTGQIRAVKVINKSRVK-HQERLKN--------------EIEIMSTLD---HPNIIRLYETYEDQKN------IYLV .. | ||.||.|.| || . ||. |.|.|.|.. . . .|| ||.||. |. |||||.|||..|.... |||| YRIGK-TLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV IEYCEGGE--LFDRIAERGY----YTEQDAVALFRQIMSAINYCHSRKICHRDLKPENFLFCTKDDNSIIKVIDFGLSKTYG-QVLDSPLKKKPLELTQV |||.||| |||.| ..|. .| .| .||||.||.|||||..|.|||.|||| |. ...| ||.||||.| | . . MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN-NIKIIDFGFSNMYRPC--------------IF QSG-VMKTRAGTPYYIAPEVLDG--K-YD-EKCDIWSAGVTLYIILCGYPPFYGETDK------EILQAVKKGEYEYEGDEWDIVSDECKNLIKKMLSK- ..| .||. |.| | |||.. | | || | ||||.||.|| ..||| || ..|.. . |. . |. . | || .|..||.||| . GPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVN PELRFSSEMVMASKWI || |.. . .| .| PEKRPTIHQIMNHPWM |
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| Kinase | 4576.AA | MAPKAPK | 30-300 | 35 | 8.3e-98 | 303.4 | In-house | 1-292 (292) | Show / Hide |
Range on Protein: 30-300 Range on HMM: 1-292/292 Sequence Identity: 35% (106 aa) DQKKDNLGEGSYGVVYKATMKSTGQIRAVKVINKSRVKHQERLKNEIEI-MSTLDHPNIIRLYETYED----QKNIYLVIEYCEGGELFDRIAE--RGYY |. ||||.|| | ... |.||| |||.. .. .. .| |. . . .||||... . .|. .|. ||| | ||||||..| . .... KLWKEVLGEGIYGKVQTCVHKRTGQEYAVKILEDQPGHSRQKARREVELHWHCQGHPNIVQIIDWFENMYQFDKCFYLVMECMEGGELFQHIQQRGHKHF TEQDAVALFRQIMSAINYCHSRKICHRDLKPENFLFCTKDDNSIIKVIDFGLSKTYGQVLDSPLKKKPLELTQ-VQSGVMKTRAGTPYYIAPEVLDG-K- ||. |. . ..| ||. ..||. | |||||||| |. ....|...| |||. | . ..|. ... ..| .||||.||||.. | TEREASQIMKDICSAVDFLHSMNIAHRDLKPENILCTDTNHNCPVKLCDFGFAKE---------IHLNHDCTTPITTPELMTPCYTPYYMAPEVVGAFKE ---YDEKCDIWSAGVTLYIILCGYPPFYGETD-----KE-----------ILQAVKKGEYEYEGDEWDIVSDECKNLIKKML-SKPELRFSSEMVMASKW || .||.|| || .||.||||||||.... . . ..|.|| ||. .|.| |.||.|.| .|. | . |.||...| AHTYDKSCDMWSLGVIMYIMLCGYPPFYSNCGDEDCSWDRGEACRDCQNMMFHRIQEGQYEFPDEEWSHISEEAKDLIRKLLRRDPTQRLTIEQVMNHPW I | I |
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| Kinase | 4576.AA | Pkinase | 31-300 | 34 | 1.3e-95 | 328.8 | Pfam | 2-293 (293) | Show / Hide |
Range on Protein: 31-300 Range on HMM: 2-293/293 Sequence Identity: 34% (106 aa) QKKDNLGEGSYGVVYKATMKSTGQIRAVKVINKSRVKHQER--LKN--EIEIMSTLDHPNIIRLYETYEDQKNIYLVIEYCEGG----ELFDRIA--ERG ... .|.||.|.|||.. |.||.| |||.|.|.. |.... . . ||.|| |.||||.|||...|| ..||.| |||||| .|||.| ..| HIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHG YY--TEQDAVALFRQIMSAINYCHSRKICHRDLKPENFLFCTKDDN-SIIKVIDFGLSKTYGQVLDSPLKKKPLELTQVQSGVMKTRAGTPYYIAPEVLD . .|... ..|| ....||||..|.||||||||.|. .... ...|..||||.| . .. |.|..|||.|.||||. CFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---------------Y-NNS-MTTFCGTPWYMAPEVIR --GKYDEKCDIWSAGVTLYIILCGYPPFYGE------TDKEILQAVKKGEYEYEGDEWDIVS-----------------DECKNLIKKMLSK-PELRFSS .|. |.|.||.|..||. |||.|||.|. ....... ......... ..|. .| .||| .||..| | |. | . GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTA EMVMASKWI | .. ..|. EQILQHPWF |
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| Kinase | 4576.AA | Ciliate-E2 | 27-300 | 29 | 7.7e-95 | 321.39 | In-house | 1-365 (365) | Show / Hide |
Range on Protein: 27-300
Range on HMM: 1-365/365
Sequence Identity: 29% (115 aa)
YDFDQKKDNLGEGSYGVVYKATMKSTG-----------------------QIRAVKVINKSRVKHQERLKNEIE-------------IMSTLDHPNIIRL
|.| .| .|.|..|.|||.. .... .| |.|...|. ...... .... |...|.|||||..
YKFIKK---IGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKM
YETYE--DQKNIYLVIEYCEGGELFDRIAER-----------GYYTEQDAVALFRQIMS---------------AINYCHSRK-ICHRDLKPENFLFCTK
||... |..||||| |||.||.|||.| .. .|.||. . ...|| . |..|.||.. |.|||.|||| ||
YECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---
DDNSIIKVIDFGLSKTYGQVLDSPLKKKPLELTQVQSG-----------------VMKTRAGTPYYIAPEVLDGK----------YDEKCDIWSAGVTLY
||.||||||| | . . .. |.. . . . .| .|||.| |||.| || ||.||||||.||.||
-----IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILY
IILCGYPPFYGETDKEILQAVKKGEYEYEGDE--------------WDIVSDECKNLIKK----MLSK-PELRFS-SEMVMASKWI
. |.|.||| .| |...... | |. .|.|||.|||| || | || |.. | .. .|.
EMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
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| Kinase | 4576.AA | CAMK-Unique | 36-300 | 28 | 5.7e-93 | 307.26 | In-house | 7-363 (363) | Show / Hide |
Range on Protein: 36-300 Range on HMM: 7-363/363 Sequence Identity: 28% (104 aa) LGEGSYGVVYKATMKSTGQIRAVKVINK----SRVKHQ----------------ERLKNEIEIMSTLDHPNIIRLYET----YEDQK------------- .|.|..|.||... ..|| ..|.|...| . ...| ||.|..|. ..||||||.||.. ..| | IGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLIIKTPRA --NIYLVIEYCEGGELFDRIAE--------------------RGYYTE--QDAVALFRQIMSAINYCHSRKICHRDLKPENFLFCTK-DD---------- ..|.| |||.||.||| |.. .|...| |. ..... ||..| || .| |||||.|| ..|. .| LPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHHRDFPYD --NSIIKVIDFGLSKTYGQVLDSPLKKKPLELTQVQSGVMKTRAGTPYYIAP--------------EVLD-GKYDEKC----DIWSAGVTLYIILCGYPP |. ||..||||.. | .. .. .|.|. |||.|.|| ||.. .||..| |||| ||..|. |||.|| WSNWHIKLCDFGLCCHYNHNKMCH--------------MMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPP FYGETDK--------EILQAVKKGEY-EYEGDEWDI---VSDECKNLIKKML-SKPELRFSSEMVMASKWI |..|... ||... .||.| ... . |.. .|.| |...|. . ..| | |.. . || FDCECEDRDYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI |
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| Kinase | 4576.AA | RSK | 32-300 | 30 | 5.2e-84 | 285.4 | In-house | 1-278 (278) | Show / Hide |
Range on Protein: 32-300 Range on HMM: 1-278/278 Sequence Identity: 30% (90 aa) KKDN--LGEGSYGVVYKATMKSTGQIRAVKVINKSRVKH----QERLKNEIEIMSTLD-HPNIIRLYETYEDQKNIYLVIEYCEGGELFDRIAERGY--- |. .| |.. .. | |.. |||| |.||..|. .. ... . |..|... ||.|..|........ .||. |||.|||||... .... LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC YTEQDAVALFRQIMSAINYCHSRKICHRDLKPENFLFCTKDDN-SIIKVIDFGLSKTYGQVLDSPLKKKPLELTQVQSGVMKTRAGTPYYIAPEVLD--- .| .| . ...| .|. . |...| |||||||| |. .. | ||..|||..| ... ..| .| |.|||.| FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQF---------------RCDHNQWTMTFCYTIEYMAPEMLKRAN -GK-YDEKCDIWSAGVTLYIILCGYPPFYG---ETDKEILQAVKKGEYEYEGDEWDIVSDECKNLIKKMLSK-PELRFS-----SEMVMASKWI .. .|. ||.|| || .| | |.|||.| .. |||.. ..||.. ....|. .|.|.|.||.||| . |. | . | . ...|. QQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF |
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| Kinase | 4576.AA | RAD53 | 27-179 | 35 | 4.7e-63 | 186.44 | In-house | 1-178 (305) | Show / Hide |
Range on Protein: 27-179 Range on HMM: 1-178/305 Sequence Identity: 35% (64 aa) YDFDQKKDNLGEGSYGVVYKATMKSTGQIRAVKVINK-------SRV-KHQERLKNEIEIMSTLDHPNIIRLYETYED-QKNIYLVIEYCEGGELFDRIA |... . || | .|.|..| |.|.| |.| |.| ... | ... ||.||. | ||.|||.|. ... ||. |.|.|. .|||||..|. YYMSKE---LGSGNFGTVKLAYEKKTCQKVAIKIIDKKKFFIRCMHTIKKMDQVMNEVEILKKLNHPCIIRIYDIFDTPQKYYYMVLELMTGGELFNKIV ERGY----YTEQDAVALFRQIMSAINYCHSRKICHRDLKPENFLFCTKDDNS---------------IIKVIDFGLSKTYG ... ..| .. ..|.|. |..| |.. |||||||||| |. ..|.. .||. ||||||. | SNKRCQMGFDEDTCKYYFYQMCDAVKYLHDNGICHRDLKPENILCNHQDEECPQVQLGPWDEDEISFLIKITDFGLSKFVG |
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| Kinase | 4576.AA | RAD53 | 200-300 | 37 | 1.2e-36 | 106.27 | In-house | 182-305 (305) | Show / Hide |
Range on Protein: 200-300 Range on HMM: 182-305/305 Sequence Identity: 37% (46 aa) VMKTRAGTPYYIAPEVLDGK----------------YDEKCDIWSAGVTLYIILCGYPPFY-GETD----KEILQAVKK-GEYEYEGDEWDIVSDECKNL .||| ||| | ||||. .| | |.|.||.|..|||.||||||| . |. . . . .|. | |... .|| .|.| |.| FMKTMCGTPQYVAPEVITSKGHNCYHENEERQVQVGYTKKVDCWSMGCILYICLCGYPPFSDDYTQEMHCMQLFEQIKNQGKYHFPHPYWDRISEEAKDL IKKMLS-KPELRFSSEMVMASKWI ||.|| || |.. . .. . |. IKWMLCVDPEKRYTIDEALNHPWM |
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| Kinase | 4576.AA | Pkinase_Tyr | 27-112 | 37 | 3.3e-18 | 62.27 | Pfam | 1-94 (270) | Show / Hide |
Range on Protein: 27-112 Range on HMM: 1-94/270 Sequence Identity: 37% (36 aa) YDFDQKKDNLGEGSYGVVYKATMK----STGQIRAVKVINKSRVKHQ---ERLKNEIEIMSTL-DHPNIIRLYETYE-DQKN--IYLVIEYCEGGEL |..| ||||..|.|||.|.| .|.. |||... . ..| | . .|..||..| .||||.||| ... ||.| ||...| | ITFGKK---LGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDL |
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| Kinase | 4576.AA | TyrKc | 30-300 | 25 | 7e-18 | 66.43 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 30-300 Range on HMM: 1-280/280 Sequence Identity: 25% (76 aa) DQKKDNLGEGSYGVVYKATMKSTGQIRAVKVINKSRVKHQERLKNEIEIMSTL--DHPNIIRLYETYEDQ-------KNIYLVIEYCEGGELFDRIAERG .... |||| .|.|||.|.| . |||..... .| . .|..||. | .||||.||| .| . ...| ||...| | |.. ... ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR Y-YTEQDAVALFRQIMSAINYCHSRKICHRDLKPENFLFCTKDDNSIIKVIDFGLSKTYGQV-LDSPLKKKPLELTQVQSGVMKTRA--GTP-----YYI . .| . || . .| ||... |||| | | . ..|. |||||. . . . . ... |. PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQG-----------ESKDYYRKKEHKGGKTMLPIRWM APEVL-DGKYDEKCDIWSAGVTLY-IILCGYPPFYG-----ETDKEILQAVKKGEYEYEGDE--WDI----VSDECKNLIKKMLSK-PELRFSSEMVMAS |||.. .||. .| |.|| ||... | | .| .| ...|... ||.|.. .. . .|| ...|. || | . . . APECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYP-MSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--H KWI . . ECF |
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| Kinase | 4576.AA | Pkinase_Tyr | 212-259 | 32 | 6.1e-05 | 17.36 | Pfam | 182-233 (270) | Show / Hide |
Range on Protein: 212-259 Range on HMM: 182-233/270 Sequence Identity: 32% (17 aa) APE-VLDGKYDEKCDIWSAGVTLYIILC-GYPP-FYGETDKEILQAV-KKGE ||| .||. .| |.|| ||... |. | | ..| .. |..... ..|. APECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGY |
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| Efhand | 4576.AA | efhand | 346-374 | 24 | 0.2418 | 9.33 | Pfam | 1-29 (29) | Show / Hide |
Range on Protein: 346-374 Range on HMM: 1-29/29 Sequence Identity: 24% (7 aa) PIAKQFILIDKDFDGCLTLQELINGTQDS . . | ..||| || ....|.... .. ELKEMFKEFDKDGDGYIDFEEFCEMMKKL |
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| Efhand | 4576.AA | efhand | 418-446 | 27 | 0.00371 | 15.97 | Pfam | 1-29 (29) | Show / Hide |
Range on Protein: 418-446 Range on HMM: 1-29/29 Sequence Identity: 27% (8 aa) IIRQAFKIFDKNNIGKISPNHLNELFLDN ....||.|||.. |.|. . . |.. . ELKEMFKEFDKDGDGYIDFEEFCEMMKKL |
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| Efhand | 4576.AA | efhand | 456-484 | 37 | 0.00378 | 15.94 | Pfam | 1-29 (29) | Show / Hide |
Range on Protein: 456-484 Range on HMM: 1-29/29 Sequence Identity: 37% (11 aa) YWVDMVKCCDFKNDGVIDYEEFSKMIYEN . .| | | .|| ||.||| .|. . ELKEMFKEFDKDGDGYIDFEEFCEMMKKL |
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