Gene 5812 (Tetrahymena)

5812

Species: Tetrahymena
Alias: TTHERM_00579190, 3733.m00078, 998, 5812, PreTt05812, 78.m00184
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CAMK
Family: CDPK

Sequence

Name Sequence Type Origin Length Description Download
5812.AA Protein None 715 None Fasta, JSON
5812.kin_dom Protein Kinase Domain None 257 None Fasta, JSON
5812.NA RNA None 2148 None Fasta, JSON

Protein domain

Protein domains of 5812.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 5812.AA CDPK 272-528 61 1.7e-210 651.51 In-house 1-271 (271) Show / Hide 
Range on Protein: 272-528
Range on HMM: 1-271/271
Sequence Identity: 61% (168 aa)

YKIGEVLGEGAFGQVSKVVHK-STGMIR-AMKTIKKSSIIKEEE-DRLFSEMNILKNLDHPNILRLIELFQDNKNYYLVTE--YCSGGELFDKIKSMTHF
|||..|||.|.|||| ||.|| .|...| |||.|.||.....|. ...| |..|||.||||||... | .||.||||.|.|  ||.||||||.|... ||
YKIKKVLGKGHFGQVRKVKHKQKTNQERVAMKIIPKSRVKDKEQQQQFFNEIEILKQLDHPNIIKIYEFYQDEKNYYIVMETEYCTGGELFDYIIEKGHF

TEKMAADYMKQILSAVVYCHQNNIVHRDLKPENLLFDSDKKNA----NLKVIDFGTSRKYDKA-----KKMSKRLGTPYYIAPEVLDQNYDEKCDVWSCG
|||.||..|.||||||.|||.||||||||||||.||||.|...    |.||||.|||.|.|..     ||||.|.|||||||||||...|.||||.||||
TEKEAAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGTSKKFDQNQKIEDKKMSQRCGTPYYIAPEVLQKKYNEKCDIWSCG

VILYILLCGYPPFGGRSEDEILKKVRLGKFKFEPEDWDRISEEAKNLIKKMLTYDPKKRISAEQALNDAWI
|||||||||||||.|... ||..||. ||..|| ..|| ||.|||.||.|||.||||||.||.|||.. |.
VILYILLCGYPPFYGKNDQEIMEKVKKGKYSFEGPEWDHISDEAKDLIRKMLCYDPKKRMSAQQALQHPWF
Kinase 5812.AA CAMK1 272-528 44 8.99999999999e-155 453.38 In-house 1-276 (276) Show / Hide 
Range on Protein: 272-528
Range on HMM: 1-276/276
Sequence Identity: 44% (122 aa)

YKIGEVLGEGAFGQVSKVVHKST---GMIRAMKTIK-KSSIIKEEE---DRLFSEMNILKN---LDHPNILRLIELFQDNKNYYLVTEYCSGGELFDKIK
|..|...|.|||..| ...||.|   |   |.| |. |... |...   ..|  | .|.|.   .|||||  ..| ..... .|||.|...||||||.| 
YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRIV

SMTHFTEKMAADYMKQILSAVVYCHQNNIVHRDLKPENLLFDSDKKNANLK--VIDFGTSRKYDKAK-KMSKRLGTPYYIAPEVLDQ----NYDEKCDVW
  ...||| |.. |||||||| |.|...||||||||||||. . . .. .|  ..||| |...|    .|... |||.|.||||| .     || .||.|
EKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKACDMW

SCGVILYILLCGYPPFGGRS-EDEILKKVRLGKFKFEPEDWDRISEE-AKNLIKKMLTYDPKKRISAEQALNDAWI
|.|||.|||||||||| . . ..|...|.  ... |    || ||.. ||..||.||. |||||...||.||. ||
SIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase 5812.AA Ciliate-E2a 272-528 46 8.99999999999e-149 441.02 In-house 1-275 (275) Show / Hide 
Range on Protein: 272-528
Range on HMM: 1-275/275
Sequence Identity: 46% (129 aa)

YKIGEVLGEGAFGQVSKVVHKSTGMI-RAMKTIKKSSIIKEEEDRLFSEMNILKNLDHPNILRLIELFQDNKNYYLVTEYCSGGELFDKIKSMTHFTEK-
||.  ..|.|.||.| .. || ||   ...| ||| ...|...  .. | ||...||||||..|.| ..|..|||||.|||.||||.||||    |.|. 
YKFIKKIGKGNFGSVYLAQHKQTGKQFAMKKFIKKMYQQKKGKEYFMNEINIMRQLDHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKRFFEEI

-MAADYMKQILS-AVVYCHQNNIVHRDLKPENLLFDS-DKKN---ANLKVIDFGTSRKY--DKAKKMSKRLGTPYYIA------PEVLDQN-YDEKCDVW
  ..|.|.|.|. .. |.||.||.||||||||.||.. .|..   ...|.||||.....  |. |.| .. |||.|.|      .||| .. ||.|||.|
QEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQKCGTPGYVAPEVLNNKEVLKHKQYDTKCDMW

SCGVILYILLCGYPPFGGRSEDEILKKVRLGKFKFEPED-WDRISEEAKNLIKKMLTYDPKKRISAEQALNDAWI
|||||.||||||.||| |....|||....  |. |.  . |  .| |.|.|.|||| .||||||.|.||||. | 
SCGVIFYILLCGKPPFKGKTYNEILQQNKKCKIDFNCPECWEKCSKECKDLMKKMLEKDPKKRITAQQALNHPWF
Kinase 5812.AA CAMK 277-528 31 2.5e-138 448.67 In-house 1-425 (425) Show / Hide 
Range on Protein: 277-528
Range on HMM: 1-425/425
Sequence Identity: 31% (133 aa)

VLGEGAFGQVSKVVHK-STGMIR-----------AMKTIKKSSII--------------------------KEEEDRLFSEMNILKN-------LDHPNI
.||.|.||.| ...|| .||..|           |.| |.|. .                            . ......|..|.|.       ||||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LRLIELFQD-------------------NKNYYLVT---EYCSGGEL----FDKIKSMTH---------------FTEKMAADYMKQILSAVVYCHQNNI
..|.| ..|                   .|..|.|.   ||||||||    ||.|.. ..               |||. |. |..||.||| |||..||
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHRDLKPENLLFDSDKKN--------------ANLKVIDFGTSRKYDKAK------------------------KMSKRLGTPYYIA-PEVLDQN-----
|||||||||.|.|.....              .|.|.|||| ..|.|. .                        ||. . |||.|.| |||| ..     
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

----------YDEKCDVWSCGVILYILLCGYPPFGGR-------------SEDEILKKVRLGKFKFEPED------------WDRISEE--------AKN
          |..|||.|||||||||.||||||| |              .. |...|.. ||. |.|.             ||.||.|        .|.
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LIKKMLTYDPKKRISAEQALNDAWI
||.|||..||.||...||.||. |.
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 5812.AA S_TKc 272-528 41 2.9e-119 403.44 SMART 1-231 (231) Show / Hide 
Range on Protein: 272-528
Range on HMM: 1-231/231
Sequence Identity: 41% (113 aa)

YKIGEVLGEGAFGQVSKVVHKSTGMIRAMKTIKKSSIIKEEEDRLFSEMNILKNLDHPNILRLIELFQDNKNYYLVTEYCSG--GELFDKIKSMTH----
|.|....|.||||.| |..||.|| | |.| ||         ... .|..|||. .|||| .|.. ||| ...|.|.|||.|  |.||| ||.. .    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--FTEKMAADYMKQILSAVVYCHQNNIVHRDLKPENLLFDSDKKNANLKVIDFGTSRKYDKAKKMSKRLGTPYYIAPEVLDQNYDE-KCDVWSCGVILYI
  |.| .|. ||.||..|. |||...|.||||||||.|.|.     ..|..||| .|..      .   |||.|.|||||   |.  |||.||||.|||.
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL------TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCILYE

LLCGYPPFGGRSEDEILKKVRLGKFKFEPEDWDRISEEAKNLIKKMLTYDPKKRISAEQALN-------DAWI
.|||||||    .....||..              |.|||..|.|.|..||.||..| .||.       . |.
MLCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 5812.AA CAMKL 272-528 37 2.2e-113 363.22 In-house 1-297 (297) Show / Hide 
Range on Protein: 272-528
Range on HMM: 1-297/297
Sequence Identity: 37% (112 aa)

YKIGEVLGEGAFGQVSKVVH-KSTGMIRAMKTIKKSSII--------------KEEEDRLFSEMNILKNLD---HPNILRLIELFQDNKN------YYLV
|.||..||.|.||.|   .| . ||   |.| |.|. |               .  . |.. |..|.| |.   |||| .| | ... ..      .|||
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV

TEYCSGGE--LFDKIKSMTH----FTEKMAADYMKQILSAVVYCHQNNIVHRDLKPENLLFDSDKKNANLKVIDFGTSRKYDK-----AKKMSKRLGTPY
.|||||||  |||.|..  |    ..|. |  | .||.||| |||...|||||.||||.|.|....| |.|.|||| | .|..      .|.. . |.| 
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN-NIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPP

YIAPEVLDQ--N-YD-EKCDVWSCGVILYILLCGYPPFGGRSE------DEILKKVRLGKFKFEPEDWDRISEEAKNLIKKMLTYDPKKRISAEQALNDA
| |||..      ||  | |.|||||||| ..||| || . .       .  ... .  .  ..|  | ..| ....||.|||. .|.||....| .|. 
YMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHP

WI
| 
WM
Kinase 5812.AA Pkinase 272-528 39 7.89999999999e-112 382.62 Pfam 1-293 (293) Show / Hide 
Range on Protein: 272-528
Range on HMM: 1-293/293
Sequence Identity: 39% (116 aa)

YKIGEVLGEGAFGQVSKVVHKSTGMIRAMKTIKKSSIIKEEEDRLFS--EMNILKNLDHPNILRLIELFQDNKNYYLVTEYCSGG----ELFDKIK--SM
|.||...|.|.||.| | .||.|| | |.|.|||... .... ...   |  |.|.|.||||.||.. |.|....|.|.||| ||    .||| |.  . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

THF--TEKMAADYMKQILSAVVYCHQNNIVHRDLKPENLLFDSDKKN-ANLKVIDFGTSRK--YDKAKKMSKRLGTPYYIAPEVLD--QNYDEKCDVWSC
. |  .|. . .||.|||... |||...|.||||||||.|.|..  . | .|..||| ...  | .   |. . |||.|.||||.   | |. |.|.|||
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVILYILLCGYPPFGGR------SEDEILKKVRLGKFKFEPEDWDRIS-----------------EEAKNLIKKMLTYDPKKRISAEQALNDAWI
|.|||..|||.||| |.      .......... ....|. . |..||                 ||.| .||..|..|||||..|||.|.. |.
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 5812.AA Ciliate-E2 272-528 31 6e-110 371.58 In-house 1-365 (365) Show / Hide 
Range on Protein: 272-528
Range on HMM: 1-365/365
Sequence Identity: 31% (122 aa)

YKIGEVLGEGAFGQVSKVVHKSTG-----------------------MIRAMKTIKKS-SIIKEEEDRLF----------SEMNILKNLDHPNILRLIEL
||. ...|.|.||.| |. .....                       .| |||..||.  .... |....           |.|||..|.||||....| 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FQ--DNKNYYLVTEYCSGGELFDKIKSMTH-----------FTEKMAADYMKQILS---------------AVVYCHQNN-IVHRDLKPENLLFDSDKKN
||  |..|.|||.|||.||.||| ||.. .           |||| ....|||||.               |. |.|..| |.|||.||||.||      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

ANLKVIDFGTSRKYDKA-----------KKMSKR----------------------LGTPYYIAPEVLD-QN---------YDEKCDVWSCGVILYILLC
  .|.||||.|.|||.            ..|  .                      .|||.| |||.|  ..         ||.|||.||.|||||..|.
--IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF

GYPPFGGRSEDEILKKVRLGKFKFEPE--------------DWDRISEEAKNLIKK----MLTYDPKKRIS-AEQALNDAWI
|.|||        ...   .|..| ..              .|. .|.|.|.||||    || .||.|||. .||.||  |.
GKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 5812.AA CAMK-Unique 272-528 30 7.50000000001e-108 357.16 In-house 1-363 (363) Show / Hide 
Range on Protein: 272-528
Range on HMM: 1-363/363
Sequence Identity: 30% (111 aa)

YKIGEVLGEGAFGQVSKVVHKSTGMIRAMKTIKK---SSIIKEE---------------EDRLFSEMNILKNLDHPNILRLIEL----FQDNK-------
|| ....|.|.|| | ..  ..|| ..|.| .||   ..... .               .  |  | .|.| .|||||..| .     |.| |       
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI

--------NYYLVTEYCSGGELFDKIKS--------------------MTHFTE--KMAADYMKQILSAVVYCHQNNIVHRDLKPENLLFDSDKK-----
        ..|.|.||| ||.|||.| .                     .||.|    .. .| ..|||| | |...|||||||.||... .  |     
IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHH

--------NANLKVIDFGTSRKYDKAKKMS---KRLGTPYYIAP--------------EVLD-QNYDEKC----DVWSCGVILYILLCGYPPFGGRSED-
        | ..|..||| ...|.  |. .   .. |||.|.||              ||.. | ||..|    | ||.|||.|..|||.||| . .|| 
RDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDR

-------EILKKVRLGKF-KFEPEDWDR---ISEEAKNLIKKMLTYDPKKRISAEQALNDAWI
       ||... . |.. .|. . |..   ||.|||...|. .|.||..|.||...|   ||
DYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase 5812.AA RAD53 272-528 36 7.6e-108 322.38 In-house 1-305 (305) Show / Hide 
Range on Protein: 272-528
Range on HMM: 1-305/305
Sequence Identity: 36% (111 aa)

YKIGEVLGEGAFGQVSKVVHKSTGMIRAMKTIKK---S---SIIKEEEDRLFSEMNILKNLDHPNILRLIELFQD-NKNYYLVTEYCSGGELFDKIK-SM
| ....|| |.||.| ... |.|.   |.| |.|   .   .     .|.. .| .|||.| ||.| |... |..  |.||.| |. .|||||.||. . 
YYMSKELGSGNFGTVKLAYEKKTCQKVAIKIIDKKKFFIRCMHTIKKMDQVMNEVEILKKLNHPCIIRIYDIFDTPQKYYYMVLELMTGGELFNKIVSNK

TH---FTEKMAADYMKQILSAVVYCHQNNIVHRDLKPENLLFDSDKKNA---------------NLKVIDFGTSRKYDKAKKMSKRLGTPYYIAPEVLD-
.    |.|  . .| .|.. || | | |.|.|||||||| |.......                 .|. ||| |.  ..   |    ||| | ||||.  
RCQMGFDEDTCKYYFYQMCDAVKYLHDNGICHRDLKPENILCNHQDEECPQVQLGPWDEDEISFLIKITDFGLSKFVGEGSFMKTMCGTPQYVAPEVITS

---------------QNYDEKCDVWSCGVILYILLCGYPPFG-GRSE----DEILKKVRL-GKFKFEPEDWDRISEEAKNLIKKMLTYDPKKRISAEQAL
                 |  |.|.|| |.||||.|||||||. .. .    . . ....  ||. |....|||||||||.|||.||. ||.||.....||
KGHNCYHENEERQVQVGYTKKVDCWSMGCILYICLCGYPPFSDDYTQEMHCMQLFEQIKNQGKYHFPHPYWDRISEEAKDLIKWMLCVDPEKRYTIDEAL

NDAWI
|  |.
NHPWM
Kinase 5812.AA Ciliate-E2-Unclassified 272-528 34 1.5e-106 360.31 In-house 1-352 (352) Show / Hide 
Range on Protein: 272-528
Range on HMM: 1-352/352
Sequence Identity: 34% (120 aa)

YKIGEVLGEGAFGQVSKVVHKSTGMIRAMKTIKKSSIIK-----------EEEDRLFS-----------EMN-ILKNLDHPNILRLIELFQDNKNYYLVT
|||....|.|.||.| |..||... . |||..||. |.|            |......           .|. ||.|..||.|..... ||| .| |.|.
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

EYCSGGELFDKIKSMTH-----------------FTEKMAA-----DYMKQILSAVVYCHQNN-IVHRDLKPENLLFDSDKKNANLKVIDFGTSRKYD--
||| ||.|.. ||.. .                 |||. |.     .|..|||..  |.|..| |.|||.||||.|||...|| ..|.|||| |.||.  
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

--------------KAKKMSKRLGTPYYI----APEVLDQ-NYD----EKCDVWSCGVILYILLCGYPPFGGRSEDE----------------ILKKVRL
              | ..|. . |||.|.    |||||.. |||    .|||.||.||||| .| ||.||.......                ....   
NNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQ

GKFKFEPEDW----DRISEEAKNLIK----KMLTYDPKKRISAEQALNDAWI
....| ...|    ...|.|||..|.    ||| ..|.|||..||.||  |.
KNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 5812.AA RSK 274-528 37 2.3e-96 326.45 In-house 1-278 (278) Show / Hide 
Range on Protein: 274-528
Range on HMM: 1-278/278
Sequence Identity: 37% (106 aa)

IGEV--LGEGAFGQVSKVVHKSTGMIRAMKTIKKSSIIKEEED--RLFSEMNILKNLD-HPNILRLIELFQDNKNYYLVTEYCSGGELFDKIKSMTH---
. .   .| |.. .. |..|. ||.| ||| .||. |.. . |  . . | |||.    ||.| .| . ||...  ||..|||.|||||....   |   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FTEKMAADYMKQILSAVVYCHQNNIVHRDLKPENLLFDSDKKN-ANLKVIDFGTSRK--YDKAKKMSKRLGTPYYIAPEVLD----QN-YDEKCDVWSCG
|.|. |..|| .| .|| . ||  |.|||||||| |.|... | . .|..||| ...   |. ... .  .|  |.|||.|     |. .|. ||.|| |
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLG

VILYILLCGYPPFGG---RSEDEILKKVRLGKFKFEPEDWDRISEEAKNLIKKMLTYDPKKRIS-----AEQALNDAWI
|..| .| |.||| |    . .||.|... ||| .. . |. .|.|||.||.|||. ||.||..     ||. ....|.
VLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 5812.AA TyrKc 272-526 25 1.5e-22 82.17 SMART 1-280 (280) Show / Hide 
Range on Protein: 272-526
Range on HMM: 1-280/280
Sequence Identity: 25% (73 aa)

YKIGEVLGEGAFGQVSKVVHKSTGMIRAMKTIKKSSIIKEEEDRLFSEMNILKNL--DHPNILRLIELFQDN-------KNYYLVTEYCSGGELFDKIKS
 . |..|||||||.| | . |   .  | |..|...     .  . .|..|...|  .||||.||.    .        . ...|.||...| | | ...
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

MTH-FTEKMAADYMKQILSAVVYCHQNNIVHRDLKPENLLFDSDKKNANLKVIDFGTSRKYDKA-------KKMSKRL--GTP-----YYIAPEVLDQN-
  . .. |   ... || .   | |..|..||||   | | ....     |. ||| ||. .         .  .|.   |.         |||... . 
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

YDEKCDVWSCGVILY-ILLCGYPPFGG-----RSEDEILKKVRLGKFKFEPED-----WDRISEEAKNLIKKMLTYDPKKRISAEQALNDA
. .| |||| || .. |.  | .|  |      | .|....|. |.    |..       . ..|  ...|.   .||..| . ..   . 
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 5812.AA Pkinase_Tyr 272-395 31 8.1e-21 71.13 Pfam 1-137 (270) Show / Hide 
Range on Protein: 272-395
Range on HMM: 1-137/270
Sequence Identity: 31% (43 aa)

YKIGEVLGEGAFGQVSKVVHK----STGMIRAMKTIKKSSIIKEE--EDRLFSEMNILKNL-DHPNILRLIELFQ-DNKN--YYLVTEYCSGGELFDKIK
 ..|..|||||||.| | . |    .|..  | |.. | .  .|.   . ...|..|.|.| .||||.||.     . .   .|.|.||. .| | |  .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

SM----THFTEKMAADYMKQILSAVVYCHQNNIVHRDL
.      ..| |.  ..  || ..  | ...|..||||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL
Kinase 5812.AA Pkinase_Tyr 439-483 30 4.503912 0.87 Pfam 182-230 (270) Show / Hide 
Range on Protein: 439-483
Range on HMM: 182-230/270
Sequence Identity: 30% (15 aa)

APEVLDQN-YDEKCDVWSCGVILYILLC-GYPP-FGGRSEDEILKKV-R
|||..  . . .| |||| || .. ..  |  | . | |  |..... .
APECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYE
EFh 5812.AA EFh 574-602 37 5.4e-08 33.79 SMART 1-29 (29) Show / Hide 
Range on Protein: 574-602
Range on HMM: 1-29/29
Sequence Identity: 37% (11 aa)

ELQKTFRSLDKNGDGTLSKEELIDGYTTV
|... || .||.|||....||..|. ...
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
Efhand 5812.AA efhand 574-602 34 3.9e-07 30.55 Pfam 1-29 (29) Show / Hide 
Range on Protein: 574-602
Range on HMM: 1-29/29
Sequence Identity: 34% (10 aa)

ELQKTFRSLDKNGDGTLSKEELIDGYTTV
||.. |. .||.|||....||........
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
EFh 5812.AA EFh 612-640 20 3e-06 27.84 SMART 1-29 (29) Show / Hide 
Range on Protein: 612-640
Range on HMM: 1-29/29
Sequence Identity: 20% (6 aa)

QVDRILDEVDINKSGKVDFTEFLMAASNK
..... ...| ...|..|| ||... ...
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
Efhand 5812.AA efhand 612-640 24 6e-06 26.13 Pfam 1-29 (29) Show / Hide 
Range on Protein: 612-640
Range on HMM: 1-29/29
Sequence Identity: 24% (7 aa)

QVDRILDEVDINKSGKVDFTEFLMAASNK
..... .|.| ...|..|| ||. . ...
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
EFh 5812.AA EFh 648-676 31 9e-07 29.74 SMART 1-29 (29) Show / Hide 
Range on Protein: 648-676
Range on HMM: 1-29/29
Sequence Identity: 31% (9 aa)

KVEQSFKIFDQDGNGNITKDELQYIMGDI
.... |..||.||.| |...|.. .|  .
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
Efhand 5812.AA efhand 648-676 34 2e-06 28.38 Pfam 1-29 (29) Show / Hide 
Range on Protein: 648-676
Range on HMM: 1-29/29
Sequence Identity: 34% (10 aa)

KVEQSFKIFDQDGNGNITKDELQYIMGDI
.... ||.||.||.| |...|.. .| ..
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
Efhand 5812.AA efhand 680-708 27 9e-06 25.55 Pfam 1-29 (29) Show / Hide 
Range on Protein: 680-708
Range on HMM: 1-29/29
Sequence Identity: 27% (8 aa)

FWKQILDECDTNKDGMISQTEFLDLLINK
 .|.. .| |...|| |.  ||.... ..
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
EFh 5812.AA EFh 680-708 27 4.1e-05 24.23 SMART 1-29 (29) Show / Hide 
Range on Protein: 680-708
Range on HMM: 1-29/29
Sequence Identity: 27% (8 aa)

FWKQILDECDTNKDGMISQTEFLDLLINK
 .|.. .. |...|| |.  ||.|.. ..
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL