25400

Species: Tetrahymena
Alias: 25400, 809, 22.m00345, TTHERM_00257140, PreTt25400
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CK1
Family: CK1
Subfamily: CK1-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
25400.AA Protein None 289 None Fasta, JSON
25400.kin_dom Protein Kinase Domain None 127 None Fasta, JSON
25400.NA RNA None 870 None Fasta, JSON

Protein domain

Protein domains of 25400.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 25400.AA CK1-Unclassified 21-189 57 3.9e-118 350.23 In-house 67-244 (244) Show / Hide
Range on Protein: 21-189
Range on HMM: 67-244/244
Sequence Identity: 57% (102 aa)

VYCFCTQ--GDQNIMVMDLLGPSLEELLDFCNRRFSLKTILMLAEQMIQTIEYIHYNNFICRNINPGNFLIG-SGNLLNQIFITGLGYSKRYFQ--RDGT
.|.....  || |||||||||||||.|. .|||.|||||.||.|.|||| |||.|..|||.| | | |||.| .|.  .|..|  .|.||||..  ..|.
MYWCGQEEQGDYNIMVMDLLGPSLEDLFNMCNRKFSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGK

HIPYREDKSLVGTPRYVSLNMHIGIEPSRRDDLISLFYCLIYFLKGSLPWQGLKIGRRNEMFVK----KLNTPIQELC
||||||.|.|.|| || |.|.|.||| |||||| || |.||||||||||||..|   . | . |    |..||...||
HIPYRENKNLTGTARYASINAHLGIEQSRRDDLESLGYVLIYFLKGSLPWQNIKANNKKEKYEKIMEMKMSTPVEQLC

Kinase 25400.AA CK1 21-215 56 5.3e-115 388.35 In-house 68-271 (271) Show / Hide
Range on Protein: 21-215
Range on HMM: 68-271/271
Sequence Identity: 56% (116 aa)

VYCFCTQ--GDQNIMVMDLLGPSLEELLDFCNRRFSLKTILMLAEQMIQTIEYIHYNNFICRNINPGNFLIGS-GNLLNQIFITGLGYSKRYFQ-RDGTH
.|.....  || |||||||||||||.|..||||.|||||.||.|.|||| |||.|..|||.| | | |||.|  |.  .|..|   | .||| . ....|
MYWCGQEEQGDYNIMVMDLLGPSLEDLFNFCNRKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQH

IPYREDKSLVGTPRYVSLNMHIGIEPSRRDDLISLFYCLIYFLKGSLPWQGLKIGRRNEMFVK----KLNTPIQELCLG-FPNEFIEYYNYVGKLSFEEK
|||||.|.|.|| || |.|.|.||| |||||. || |.|.|||.|||||||||   . . . |    |..||...|| | |||||..| ||. .|.||||
IPYRENKNLTGTARYASINTHLGIEQSRRDDMESLGYVLMYFLRGSLPWQGLKANTKKQKYEKIMEKKMSTPVEQLCKGNFPNEFAMYLNYCRQLHFEEK

PDYS
||| 
PDYM

Kinase 25400.AA CK1-D 24-217 55 1.8e-85 290.25 In-house 63-261 (261) Show / Hide
Range on Protein: 24-217
Range on HMM: 63-261/261
Sequence Identity: 55% (110 aa)

FCTQGDQNIMVMDLLGPSLEELLDFCNRRFSLKTILMLAEQMIQTIEYIHYNNFICRNINPGNFLIGSGNLLNQIFITGLGYSKRYFQRD-GTHIPYRED
.  .|| |.|||||||||||.|  .|.|.|||||.||||.|||. ||||| .||| | | | |||.| |   | ..|   | .|||       ||||||.
CGQEGDYNVMVMDLLGPSLEDLFNYCHRKFSLKTVLMLADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYREN

KSLVGTPRYVSLNMHIGIEPSRRDDLISLFYCLIYFLKGSLPWQGLKIGRRNEMF----VKKLNTPIQELCLGFPNEFIEYYNYVGKLSFEEKPDYSYC
|.| || || |.| | ||| |||||| || | |.|| .|||||||||   . . .     ||..|.|..|| |.|.|| .| ||. .| |..||||.| 
KNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYFNRGSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL

Kinase 25400.AA CK1 16-217 35 2.5e-83 283.12 In-house 89-339 (339) Show / Hide
Range on Protein: 16-217
Range on HMM: 89-339/339
Sequence Identity: 35% (89 aa)

HINFLVYCFCTQGDQNIMVMDLLGPSLEELLD---FCNRRFSLKTILMLAEQMIQTIEYIHYNNFICRNINPGNFLIGS------GNLLN--------QI
|.  ..|......  |.|||.||||.||.|..   .|||.||.||.||.|.||.. .||.| ..|| |.| |.||..|       |.  .        |.
HPCMYWYHGEEDDYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKH-HHEWNNEHRQV

FITGLGYSK-RYFQRDGT------------HIPYRE---DKSLVG-TPRYVSLNMHIGIEPSRRDDLISLFYCLIYFLKGS--LPWQGLK---------I
..   | .. .|  .||.            |.|.||    |...| |.||.|.|.| |.|..||||| |.||.||..|||.  ||||..|         .
YMIDFGMARRKYRDKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQV

GRRNEMF--VKKLNTPIQELCLG-----FPNEFIEYYNYVGKLSFEEKPDYSYC
..  . |   ||..||.  || .     .| || ....|. .|.....||| . 
EKMKYEFIDEKKMSTPFF-LCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI

Kinase 25400.AA CK1-A 29-217 55 3.3e-81 276.12 In-house 68-261 (261) Show / Hide
Range on Protein: 29-217
Range on HMM: 68-261/261
Sequence Identity: 55% (107 aa)

DQNIMVMDLLGPSLEELLDFCNRRFSLKTILMLAEQMIQTIEYIHYNNFICRNINPGNFLIGSGNLLNQIFITGLGYSKRYF-QRDGTHIPYREDKSLVG
| |.|||||||||||.|  ||.|||..||.||||.|||  |||.|  ||| | | | |||.| |   |..|.   | .|.|  .|  .|||||||| |.|
DYNVMVMDLLGPSLEDLFNFCKRRFTMKTVLMLADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTG

TPRYVSLNMHIGIEPSRRDDLISLFYCLIYFLKGSLPWQGLKIGRRNEMFV----KKLNTPIQELCLGFPNEFIEYYNYVGKLSFEEKPDYSYC
| || |.| |.||| |||||. |. |...|| .|.|||||.|   .   .     ||. |||..|| ||| ||  | ||. .| |||.||| | 
TARYASINAHLGIEQSRRDDMESMGYVMMYFNRGKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL

Kinase 25400.AA CK1-G 21-217 50 2.8e-77 261.49 In-house 61-266 (266) Show / Hide
Range on Protein: 21-217
Range on HMM: 61-266/266
Sequence Identity: 50% (103 aa)

VYCFCTQGDQNIMVMDLLGPSLEELLDFCNRRFSLKTILMLAEQMIQTIEYIHYNNFICRNINPGNFLIG--SGNLLNQIFITGLGYSKRYFQRD-GTHI
|| |   |  ||||||||||||| | |.|.|.||.||..|.| |||. .||.|  . | | . | |||||  | .  . |.|   |  | |   . . ||
VYYFGQCGKYNIMVMDLLGPSLEDLFDWCDRKFSVKTVCMVAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHI

PYREDKSLVGTPRYVSLNMHIGIEPSRRDDLISLFYCLIYFLKGSLPWQGLKIGRRNEMFVK----KLNTPIQELCLG--FPNEFIEYYNYVGKLSFEEK
|||| ||| || || | | |.| | |||||. .|    .||| |||||||||     | . |    | .|.|. || .  || .|  |  || .|.|.|.
PYREHKSLTGTARYMSINTHLGREQSRRDDMEALGHMFMYFLRGSLPWQGLKADNNKERYQKIGDTKRKTNIEDLCQNNAFPEQFATYLRYVRRLDFFEC

PDYSYC
||| | 
PDYDYL

Kinase 25400.AA Worm6 33-217 29 5.3e-33 115.79 In-house 80-279 (279) Show / Hide
Range on Protein: 33-217
Range on HMM: 80-279/279
Sequence Identity: 29% (59 aa)

MVMDLLGPSLEELLDFC-NRRFSLKTILMLAEQMIQTIEYIHYNNFICRNINPGNFLIGS-----GNLLNQIFITGLGYSK--RYFQRDGTHIPYR-EDK
.|| |.|..|..|  .. .|.||. | | .|.|... ||  | . ||.|.. |||| ||       | . .|..   | ..  .|  .... .. | .. 
IVMTLVGKNLWDLRKNRPDRKFSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTAC

SLVGTPRYVSLNMHIGIEPSRRDDLISLFYCLIYFLKGSLPWQGLKIGRRNE-MFVKKLNTP---IQELCLG-FPN-EFIEYYNYVGKLSFEEKPDYSYC
  .||.|| .|. | |.| .|.||. | || .. ...| |||...|   . |  . .. ..    . .. .| .|  || .   |. ..|....||| ..
GFRGTVRYAPLACHKGQEQCRKDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI





Kinase 25400.AA TTBK 31-217 34 1.6e-24 83.61 In-house 71-257 (257) Show / Hide
Range on Protein: 31-217
Range on HMM: 71-257/257
Sequence Identity: 34% (66 aa)

NIMVMDLLGPSLEEL-LDFCNRRFSLKTILMLAEQMIQTIEYIHYNNFICRNINPGNFLIG-SGNLLNQIFITGLGYSKRYFQRDGTHIPYREDKSLVGT
| |||.|.| .| .|        ||| | | |  |..| || ||   |  | | | || .|      .....   |   .|    |   | ||     ||
NYMVMQLQGKNLADLRRKQPRGCFSLSTTLRLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTNACGEVRPPREVAGFRGT

PRYVSLNMHIGIEPSRRDDLISLFYCLIYFLKGSLPWQGLKIGRRNEMFVKKLNTPIQELCLGFPNEFIEYYNYVGKLSFEEKPDYSYC
 || | | |   |  |.||| |||| |. |..| |||  .|      .  .| ....  |    | ||  . . .  | .|..|||   
VRYASINAHRNREMGRHDDLWSLFYMLVEFVQGQLPWRKIKDKDQVGEMKEKYDHRM--LLKHCPHEFHQFMDHIKSLNYEDRPDYQLI

Kinase 25400.AA TTBKL 106-221 26 3.7e-23 75.1 In-house 156-288 (288) Show / Hide
Range on Protein: 106-221
Range on HMM: 156-288/288
Sequence Identity: 26% (36 aa)

SKRYFQRDG-----------THIPYRE---DKSLVGTPRYVSLNMHIGIEPSRRDDLISLFYCLIYFLKGSLPWQGLKIGRRNEMFVKKLNTPIQELCLG
...|.  ||           .. . |.     .. ||.||.|.||| . | .| ||| |..| .|....| |||....   . |.  .|.|.  . |. .
ARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNMHDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMED--KMEIEHMKKNMKDEDLFKD

------FPNEFIEYYNYVGKLSFEEKPDYSYCQSLF
      .| || . . ..  |.. . |||.. . .|
MPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF

Kinase 25400.AA VRK 33-165 37 4.5e-21 64.63 In-house 106-240 (284) Show / Hide
Range on Protein: 33-165
Range on HMM: 106-240/284
Sequence Identity: 37% (51 aa)

MVMDLLGPSLEELLD-FCNRRFSLKTILMLAEQMIQTIEYIHYNNFICRNINPGNFLIGS-GNLLNQIFITGLGYSKRYFQRDGTHIPYREDKSLV--GT
|||. .| .|. ...  .. ||| || | || .|.   ||.| |.    .|   | | |  .|  .| .  . | . || . .| | .| ||.     ||
MVMPRFGRDLQKIYEDQNGHRFSMKTVLQLACRMLDVLEYLHENEYVHGDIKAANILLGFEKN-PDQVYLVDYGLAYRY-CPNGKHRQYKEDPRRCHNGT

PRYVSLNMHIGIEPSRRDDLISLFYCLIYFLKGSLPW
. . |.  | |  |||| || .| ||... | |.|||
CEFTSMDAHKGCAPSRRSDLEILGYCMMMWLYGYLPW

Kinase 25400.AA TTBKL 31-90 33 2.1e-08 24.57 In-house 75-136 (288) Show / Hide
Range on Protein: 31-90
Range on HMM: 75-136/288
Sequence Identity: 33% (21 aa)

NIMVMDLLGPSLEELL-DFCNRR-FSLKTILMLAEQMIQTIEYIHYNNFICRNINPGNFLIG
| ||| |.||.|  |  . .|.. ||  |.. .. | .  . ..| . || | . |.|. .|
NFMVMTLCGPNLQDLRKMMPNKKRFSDGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWG

S_TKc 25400.AA S_TKc 7-239 14 6.4e-08 -60.73 SMART 11-231 (231) Show / Hide
Range on Protein: 7-239
Range on HMM: 11-231/231
Sequence Identity: 14% (41 aa)

NFCISMIRIHIN-----------------------------FLVYCFCTQGDQNIMVMDLLGP---SLEELLDFCNRR-----FSLKTILMLAEQMIQTI
 |   .  .|..                              | ..| .  |   |||....    .| .... ..|.     |.  ..  .. |... .
AFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCAL

EYIHYNNFICRNINPGNFLIGSGNLLNQIFITGLGYSKRYFQRDGTHIPYREDKSLVGTPRYVSLNMHIGIEPSR-RDDLISLFYCLIYFLKGSLPWQGL
||.| ...| | . | | |. .     .| |.  | ....             ....||| |..  .      .. . |  |.  .|. .| |  |..  
EYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL-------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--

KIGRRNEMFVKKLNTPIQELCLGFPNEFIEYYNYVGKLSFEEKPDYSYCQSLFRQCFQK-----MGYEKDSN-------FDWI
     ..|| | .                                 . . .. |.|.||     ..  .  .         |.
---QMQMMFKKIG--------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase 25400.AA Pkinase 22-78 21 6.8e-05 18.38 Pfam 66-130 (293) Show / Hide
Range on Protein: 22-78
Range on HMM: 66-130/293
Sequence Identity: 21% (14 aa)

YCFCTQGDQNIMVMDLLGPSLEELLDFC-------NRRF--SLKTILMLAEQMIQTIEYIHYNNFI
|.... .|   |||....  |. ..| .       ...|  | ... . . |... .||.| ...|
YDWFEDKDHIYMVMEYCEGGLY-VMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGII