Gene 5908 (Tetrahymena)

5908

Species: Tetrahymena
Alias: 209.m00045, 3760.m00234, 278, PreTt05908, 5908, TTHERM_01044590
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CK1
Family: CK1
Subfamily: CK1-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
5908.AA Protein None 530 None Fasta, JSON
5908.kin_dom Protein Kinase Domain None 217 None Fasta, JSON
5908.NA RNA None 1593 None Fasta, JSON

Protein domain

Protein domains of 5908.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 5908.AA CK1-Unclassified 34-276 47 2.4e-168 500.9 In-house 1-244 (244) Show / Hide 
Range on Protein: 34-276
Range on HMM: 1-244/244
Sequence Identity: 47% (121 aa)

YEILEKLDQGSFGYVFKARRQKDPNNKHINSQGDDLYAVKIEDNTSKNQDTLTKEAKILYDLKAEK-------GFTRMYYYIKNDK--INIMVTTLLDKS
|...||..|||||...|.          ||.| ....|.|.|...|| ...|..||||...|. ..       |...||.......  .||||..||..|
YRVIEKIGQGSFGEIYKC----------INMQTNEEVAIKLEKKNSK-HPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPS

LDKLFNICKKKFTLKTVLMIADQMLTRLQHFHSRGYVHRDIKPDNFMIG-RGVEKNQIFLIDFGLSKSYL--KKNGAHIDFSEKVGLVGTTRYTSVQSHL
|..|||.|..||.|||||||||||..|....|.....|||||||||..| .| ...|...||||||| |.  .|.| ||.. |. .|.||.||.|...||
LEDLFNMCNRKFSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHL

GMEQSRRDDLESLGYTLIFFLKGTLPWMNLKSRNKSEHQKLISQVKMKTPLLELC
|.|||||||||||||.||.||||.|||.|.|  || | .. |   || ||. .||
GIEQSRRDDLESLGYVLIYFLKGSLPWQNIKANNKKEKYEKIMEMKMSTPVEQLC
Kinase 5908.AA CK1 34-302 43 7.29999999999e-153 514.13 In-house 1-271 (271) Show / Hide 
Range on Protein: 34-302
Range on HMM: 1-271/271
Sequence Identity: 43% (121 aa)

YEILEKLDQGSFGYVFKARRQKDPNNKHINSQGDDLYAVKIEDNTSKNQDTLTKEAKILYDLKA------EKGFTRMYYYIKN--DKINIMVTTLLDKSL
|.. .|..|||||..... .  . ...      . ..|.|.|.|.||..  | .||||.. |.       ..|. .||.. ..   . ||||..|| .||
YRVGRKIGQGSFGDIYLGINM-TNGEE------N-HVAIKLEKNKSKHP-QLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSL

DKLFNICKKKFTLKTVLMIADQMLTRLQHFHSRGYVHRDIKPDNFMIGR-GVEKNQIFLIDFGLSKSYLK-KNGAHIDFSEKVGLVGTTRYTSVQSHLGM
..|||.|..||.|||||||||||..|....|.....|||||||||..|| | ...|...|||||.| |.. |.. || . |. .|.||.||.|...|||.
EDLFNFCNRKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGI

EQSRRDDLESLGYTLIFFLKGTLPWMNLKSRNKSEHQKLISQVKMKTPLLELCKD-LPVEFNKYMTYVKSLGFFDEPNYN
|||||||.||||| |..||.|.|||..||  .| .    |.  ||.||. .|||. .|.||. |..|...|.|...|.| 
EQSRRDDMESLGYVLMYFLRGSLPWQGLKANTKKQKYEKIMEKKMSTPVEQLCKGNFPNEFAMYLNYCRQLHFEEKPDYM
Kinase 5908.AA CK1 34-304 32 9.40000000001e-115 387.54 In-house 1-339 (339) Show / Hide 
Range on Protein: 34-304
Range on HMM: 1-339/339
Sequence Identity: 32% (112 aa)

YEILEKLDQGSFG-YVFKARRQKDPNNKHINSQGD-----DLYAVKIEDNTSKNQ-DTLTKEAKILYDLKAE-------------------KGFTRMYYY
... .|...|.||  ..|....     .|......     . ||.|.| ..|. |  .| .|....  |..                    ... .||.|
WKVVKKIGEGGFGYQIYKVQKE-----DHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWY

IKNDK--INIMVTTLLDKSLDKLFN---ICKKKFTLKTVLMIADQMLTRLQHFHSRGYVHRDIKPDNFMIGR------GVEKN--------QIFLIDFGL
 ....   |.|| ||| ..|..|..    |..||..||.||||.||| .|.. |..|..|||||||||..||      | . .        |...||||.
HGEEDDYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKH-HHEWNNEHRQVYMIDFGM

SK-SYLKKNG------------AHIDFSE---KVGLVG-TTRYTSVQSHLGMEQSRRDDLESLGYTLIFFLKGT--LPWMNLKSRNK-------SEHQKL
..  |..|.|             |. . |   |.|..| |.||.|. .|||.||.|||||.|..|.|| .||||  |||.|.|. .|        .... 
ARRKYRDKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEF

ISQVKMKTPLLELCKD-----LPVEFNKYMTYVKSLGFFDEPNYNYL
|.  ||.||.. ||.      .| || |.|.|..|| ..|.|.| ..
IDEKKMSTPFF-LCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase 5908.AA CK1-A 34-304 43 8.2e-87 294.72 In-house 1-261 (261) Show / Hide 
Range on Protein: 34-304
Range on HMM: 1-261/261
Sequence Identity: 43% (117 aa)

YEILEKLDQGSFGYVFKARRQKDPNNKHINSQGDDLYAVKIEDNTSKNQDTLTKEAKILYDLKAEKGFTRMYYYIKNDKINIMVTTLLDKSLDKLFNICK
| .. |.  |||| .. .          || .  .  |.|.| |  .    |  |||.   |.   |. .| .| ..   |.||  ||  ||. |||.||
YRLVRKIGSGSFGDIYLG----------INITNGEEVAIKMESNKARHPQ-LIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNFCK

KKFTLKTVLMIADQMLTRLQHFHSRGYVHRDIKPDNFMIGRGVEKNQIFLIDFGLSKSYL-KKNGAHIDFSEKVGLVGTTRYTSVQSHLGMEQSRRDDLE
..||.|||||.||||..|.   | ....|||||||||..| |   |..|||||||.| |  ..   || . |   |.|| || |.. |||.|||||||.|
RRFTMKTVLMLADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDME

SLGYTLIFFLKGTLPWMNLKSRNKSEHQKLISQVKMKTPLLELCKDLPVEFNKYMTYVKSLGFFDEPNYNYL
|.|| ...| .|.|||  .|  .|      ||  || ||. .|||  | ||  ||.|...|.| ..|.| ||
SMGYVMMYFNRGKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL
Kinase 5908.AA CK1-D 34-304 42 4.3e-81 275.73 In-house 1-261 (261) Show / Hide 
Range on Protein: 34-304
Range on HMM: 1-261/261
Sequence Identity: 42% (115 aa)

YEILEKLDQGSFGYVFKARRQKDPNNKHINSQGDDLYAVKIEDNTSKNQDTLTKEAKILYDLKAEKGFTRMYYYIKNDKINIMVTTLLDKSLDKLFNICK
| |  |.  |||| ..             | | ..  |.|.|   .|    |  |.|.   ..   |  .. .. ..   |.||  ||  ||. ||| |.
YRIGRKIGSGSFGDIYHGT----------NIQTNEEVAIKLECIKTKHPQ-LHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYCH

KKFTLKTVLMIADQMLTRLQHFHSRGYVHRDIKPDNFMIGRGVEKNQIFLIDFGLSKSYLKKN-GAHIDFSEKVGLVGTTRYTSVQSHLGMEQSRRDDLE
.|| ||||||.||||..|... |.| ..|||||||||..| |   | ...|||||.| |   .   || . |.  | || || |.  |.|.|||||||||
RKFSLKTVLMLADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLE

SLGYTLIFFLKGTLPWMNLKSRNKSEHQKLISQVKMKTPLLELCKDLPVEFNKYMTYVKSLGFFDEPNYNYL
|||| |..| .|.|||  ||  .| .    |.. ||.|.. .||| .| || .|| |...| | | |.| ||
SLGYVLMYFNRGSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL
Kinase 5908.AA CK1-G 105-304 46 3.5e-72 243.94 In-house 62-266 (266) Show / Hide 
Range on Protein: 105-304
Range on HMM: 62-266/266
Sequence Identity: 46% (95 aa)

YYYIKNDKINIMVTTLLDKSLDKLFNICKKKFTLKTVLMIADQMLTRLQHFHSRGYVHRDIKPDNFMIGRGVEKNQ--IFLIDFGLSKSYL-KKNGAHID
||.    | ||||  ||  ||  ||..|  ||..|||.|.| ||..|..  ||.  . ||.|||||.|||  .|.|  |..||||. | |   . . || 
YYFGQCGKYNIMVMDLLGPSLEDLFDWCDRKFSVKTVCMVAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHIP

FSEKVGLVGTTRYTSVQSHLGMEQSRRDDLESLGYTLIFFLKGTLPWMNLKSRNKSEHQKLISQVKMKTPLLELCKD--LPVEFNKYMTYVKSLGFFDEP
. |.  | || || |.  ||| |||||||.|.||   ..|| | |||  ||  |  |  . | . | ||.   ||.   .|..| .|. || .| ||..|
YREHKSLTGTARYMSINTHLGREQSRRDDMEALGHMFMYFLRGSLPWQGLKADNNKERYQKIGDTKRKTNIEDLCQNNAFPEQFATYLRYVRRLDFFECP

NYNYL
 |.||
DYDYL
Kinase 5908.AA Worm6 34-304 30 5.6e-62 212.21 In-house 1-279 (279) Show / Hide 
Range on Protein: 34-304
Range on HMM: 1-279/279
Sequence Identity: 30% (87 aa)

YEILEKLDQGSFGYVFKARRQKDPNNKHINSQGDDLYAVKIED--NTSKNQDTLTKEAKILYDLKAEK--GFTRMYYYIKNDK--INIMVTTLLDKSLDK
.....|. .|.|| |.|. . .| ..|         .|.| |    ..| |. |  |. .|  .| .|  .|...  . | |.   | .| ||. |.|  
WKVTKKIGEGGFGAVYKVEDKSDKKKK--------QFAMKCEKQMENMKRQM-LKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWD

LFNIC-KKKFTLKTVLMIADQMLTRLQHFHSRGYVHRDIKPDNFMIGR-----GVEKNQIFLIDFGLSK--SYLKKNGAHIDFS-EKVGLVGTTRYTSVQ
|   . ..||.. | | || |.| .... |. |..|||.|| || |||       |  .|...|||...   |. |..  .    ...| .||.|| ...
LRKNRPDRKFSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLA

SHLGMEQSRRDDLESLGYTLIFFLKGTLPWMNLKSRNKSE-HQKLISQVKMKTPLLELCKDLPV-EFNKYMTYVKSLGFFDEPNYNYL
.| |.||.|.||.||  | .. ...|.|||...| ..  | |.| .   . ..   .. .  |  |||. |.|. .. ..|.|.|...
CHKGQEQCRKDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI
Kinase 5908.AA TTBKL 34-308 28 4.1e-56 187.97 In-house 1-288 (288) Show / Hide 
Range on Protein: 34-308
Range on HMM: 1-288/288
Sequence Identity: 28% (87 aa)

YEILEKLDQGSFGYVFKARRQKDPNNKHINSQGDDLYAVKIEDNT-SKNQDTLTKEAKILYDLK--AEKGFTRMYYYIKNDKINIMVTTLLDKSLDKLFN
..| .....| || |....  ||..         | .|.|.| |. ...  .. .|...|. |     . | ..... |... | || ||. ..|..| .
WMIVKMIGEGGFGQVYHVWDMKDKK---------DCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRK

ICKKK--FTLKTVLMIADQMLTRLQHFHSRGYVHRDIKPDNFMIGRG---VEK-NQIFLIDFGLSKSYLKKNG-----------AHIDFSE---KVGLVG
  . |  |.  |.. |. | |  |.  |. |..|||.|| |...|      |.   ..|||||... |..|.|            .    .   |... |
MMPNKKRFSDGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRG

TTRYTSVQSHLGMEQSRRDDLESLGYTLIFFLKGTLPWMNLKSRNKSEHQKLISQVKMKTPLLELCKD------LPVEFNKYMTYVKSLGFFDEPNYNYL
||||.|.  |...||.| ||| |. |..| ...| ||| |.... .      | ..|... .  |.||      .| || | |....|| . |.|.| ..
TTRYCSPNMHDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMEDKME------IEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMI

KKLF
 ..|
YECF
Kinase 5908.AA TTBK 34-304 32 3.4e-42 146.48 In-house 1-257 (257) Show / Hide 
Range on Protein: 34-304
Range on HMM: 1-257/257
Sequence Identity: 32% (90 aa)

YEILEKLDQGSFGYVFKARRQKDPNNKHINSQGDDLYAVKIEDNTSKNQDTLTKEAKILYDLKAEKGFTRMYYYIKNDKINIMVTTLLDKSLDKL-FNIC
  .. |  .| || .. |   ||  |.|         |.|.|    . |  |  |  .|  |   .   | .    ||| | || .|. |.|  |  .  
WKVVKKIGGGGFGEIYEA---KDMINHH------EQVAIKVESAQQPKQ-VLKMEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQP

KKKFTLKTVLMIADQMLTRLQHFHSRGYVHRDIKPDNFMIGRGVEK-NQIFLIDFGLSKSYLKKNGAHIDFSEKVGLVGTTRYTSVQSHLGMEQSRRDDL
. .|.| | | .  |.|  ..  || |. |||||| || .||  .. ......||||   |.   |      |  |  || || |. .|.  |  |.|||
RGCFSLSTTLRLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTNACGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDL

ESLGYTLIFFLKGTLPWMNLKSRNKSEHQKLISQVKMKTPLLELCKDLPVEFNKYMTYVKSLGFFDEPNYNYL
 || | |. |..| |||  .| ...      . ..| |  .  | |..| ||  .|  .|||...| |.|  .
WSLFYMLVEFVQGQLPWRKIKDKDQ------VGEMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI
Kinase 5908.AA VRK 116-252 37 5.2e-30 93.62 In-house 106-244 (284) Show / Hide 
Range on Protein: 116-252
Range on HMM: 106-244/284
Sequence Identity: 37% (53 aa)

MVTTLLDKSLDKLFN-ICKKKFTLKTVLMIADQMLTRLQHFHSRGYVHRDIKPDNFMIGRGVEKNQIFLIDFGLSKSYLKKNGAHIDFSE--KVGLVGTT
||   .. .| |.    ....|. ||||  | .||  |.  |. .||| |||  | . |    ..| .|.|.||.  | . || | .. |  . .  || 
MVMPRFGRDLQKIYEDQNGHRFSMKTVLQLACRMLDVLEYLHENEYVHGDIKAANILLGFEKNPDQVYLVDYGLAYRY-CPNGKHRQYKEDPRRCHNGTC

RYTSVQSHLGMEQSRRDDLESLGYTLIFFLKGTLPWMNLK
 .||   |.|   ||| |||.||| ..  | |.||||...
EFTSMDAHKGCAPSRRSDLEILGYCMMMWLYGYLPWMDCL
Kinase 5908.AA Pkinase 34-258 21 3.3e-24 86.69 Pfam 1-225 (293) Show / Hide 
Range on Protein: 34-258
Range on HMM: 1-225/293
Sequence Identity: 21% (53 aa)

YEILEKLDQGSFGYVFKARRQKDPNNKHINSQGDDLYAVKIEDNTSKNQDTLTK-----EAKILYDLKAEKGFTRMYYYIKNDKINIMVTTLLDKSLDKL
|.|..|. .|||| |.|.......           ..|||| .  ... . .       |..|.  |. .    |.|..  ...   ||. .... |  .
YHIGRKIGSGSFGCVYKCHHKGTGK----------IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPN-IVRLYDWFEDKDHIYMVMEYCEGGLY-V

FNIC-------KKKF--TLKTVLMIADQMLTRLQHFHSRGYVHRDIKPDNFMIG-RGVEKNQIFLIDFGLSKSYLKKNGAHIDFSEKVGLVGTTRYTSVQ
.  .       ...|  . ... ... |.|  |.. ||.| .|||.||.|..|  .|. .  . ..||||.| .      .   |   ...|| .| .  
MDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-----Y-NNS-MTTFCGTPWYMAPE

SHL-GMEQSRRDDLESLGYTLIFFLKGTLPWMNL----KSRNKSE
 .. | . ... |  |.| .|. .| | .|. .     . ... .
VIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQ
Kinase 5908.AA S_TKc 34-326 17 3.8e-15 45.26 SMART 1-231 (231) Show / Hide 
Range on Protein: 34-326
Range on HMM: 1-231/231
Sequence Identity: 17% (54 aa)

YEILEKLDQGSFGYVFKARRQKDPNNKHINSQGDDLYAVKIEDNTSKNQDTLTKEAKILYDLKAEKGFTRMYYYIKNDKINIMVTTLLDK---SLDKLFN
||||.|. .|.|| |.|.|  |           . ..|.|| .      ... .| .||      .   ..|... . .   ||. ..|    .| ..  
YEILRKIGKGAFGKVYKCRHKK----------TGRIVAIKIIK------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIK

ICKKK-----FTLKTVLMIADQMLTRLQHFHSRGYVHRDIKPDNFMIGRGVEKNQIFLIDFGLSKSYLKKNGAHIDFSEKVGLVGTTRYTSVQSHLGMEQ
 ....     |.  ..  .. |..  |.. ||.| .|||.||.| .. .     .| ..||||.. .               ..||  | .         
KRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL-------------TTFCGTPWYMAPEVL---GY

SR-RDDLESLGYTLIFFLKGTLPWMNLKSRNKSEHQKLISQVKMKTPLLELCKDLPVEFNKYMTYVKSLGFFDEPNYNYLKKLFRTLFLKE-----NFQY
.. . |  |.| .|. .| |  |.          ..... .. .                                   .| . | .. |.         
GKCKCDWWSCGCILYEMLCGYPPFP---------QMQMMFKKIG--------------------------------SPEAKDFIRKCLQKDPEKRPTA-E

DDK-------FDWI
  .         |.
ALQDEWDIKCHPWF
Kinase 5908.AA TyrKc 34-283 14 2.7e-05 -136.98 SMART 1-280 (280) Show / Hide 
Range on Protein: 34-283
Range on HMM: 1-280/280
Sequence Identity: 14% (44 aa)

YEILEKLDQGSFGYVFKARRQKDPNNKHINSQGDDLYAVKIEDNTSKNQDTLTKEAKILYDL--KAEKGFTRMYYYIKND-------KINIMVTTLLDK-
 . ..||  | || |.|..                  |||   . .  .  . .||.|.  |  . .    |.| ..  .       .   .|. . .. 
ITLGKKLGEGAFGEVYKGTWK-------------IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIV-RLYGVCTQQGRNFMYIEPLMIVMEYMPHG

SLDKLFNICKKKFTLKTVLMIADQMLTRLQHFHSRGYVHRDIKPDNFMIGRGVEKNQIFLIDFGLSKSYLKK-----NGAHIDFSEKVGLV--GTTRYTS
.|..    ...|...|. | .. |     .. ||....|||.   | ..|..    ..   |||||.    .     ..  .. .|. |       | ..
DLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMA

VQSHLGMEQSRRDDLESL--G------------------YTLIFFLKGT-----LPWMNLKSRNKSEHQKLISQV-----------KMKTPLLELC----
              .|..  |                  .|.            ...  .  . |. .   . .            .| . . . |    
--------------PECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHED

-------KDLPVEF
       ...  .|
PEDRPTFSEIHECF