Gene 12754 (Tetrahymena)

12754

Species: Tetrahymena
Alias: TTHERM_00402100, PreTt12754, 12754, 3713.m00098, 43.m00272, 408
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Aur

Sequence

Name Sequence Type Origin Length Description Download
12754.AA Protein None 2082 None Fasta, JSON
12754.kin_dom Protein Kinase Domain None 2050 None Fasta, JSON
12754.NA RNA None 6249 None Fasta, JSON

Protein domain

Protein domains of 12754.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 12754.AA Aur 1807-2058 52 3.3e-217 580.11 In-house 1-257 (257) Show / Hide 
Range on Protein: 1807-2058
Range on HMM: 1-257/257
Sequence Identity: 52% (134 aa)

FKIGKHLGTGKFSEVHMAQDLNTGLIVALKKIKKEVLIKYKSEDYLENEIKIQIFSNHPNILKLYGFYYDEEFVYLVQEYASHGELYQELKRQPNQRFDE
|.|||.|| |||..|..|.. .|. |.||| ..|| ..||. |..|..|||||  .|||||||.||...|....||..|||..||||.||..|||.||||
FEIGKPLGKGKFGNVYLARHKKTHFIFALKVMFKEQIKKYCMEHQLRREIKIQSHLNHPNILKMYGYFHDDQRIYLILEYAPGGELYKELQKQPNKRFDE

IKGAAYMRQICDAFTYLHRYHIIHRDIKPENILMS--FGVLKIADFGCSVYCP-DDRRETFCGTIDYISPEIVNGEAYGQSVDIWSLGILTFELLTGKSP
.. | ||.|||.|..|.|...||||||||||||..   |..||.|||.||.||  .|| |||||.||..||.|.|. ....||||.||.|..||..|..|
QRAAKYMYQICNALDYCHSKNIIHRDIKPENILLDQCNGNIKICDFGWSVHCPNNNRRMTFCGTLDYMPPEMVEGQMHDHKVDIWCLGVLCYELCHGCPP

FQY-ETKNEILVNIL-NMNINIPNYLSEEAKDFIKSLLVRDPSKRMTMDQVVNHKWI
|.. |...|.. .|. ...|..|...|.||||.|. .|..||..|||.||. ||.||
FESNENHDETYDRIKNKVDIQFPSHISKEAKDLISKILQHDPKQRMTLDQIMNHPWI
Kinase 12754.AA AGC 1807-2058 25 1.5e-105 273.32 In-house 1-395 (395) Show / Hide 
Range on Protein: 1807-2058
Range on HMM: 1-395/395
Sequence Identity: 25% (100 aa)

FKIGKHLGTGKFSEVHMAQDL------NTGLIVALKKIKKEV-LIKYK--SEDYLENE------------IKIQIFSN----------HPNILK-LYGFY
|.. |..|.| |..|. ...        || . |.|..||..  .. |   ...  .|             .|    |          ||.| | |.  .
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

YDEEF--VYLVQEYAS----------HGELYQELKRQ-PNQRFDEIKGAAYMRQ-------ICDAFTYLHR-YHIIHRD-IKPENILMSF-GVLKIADFG
 |..   .|.| ||..           .||.. |. .  ..||||     |. .       |. |. |||.  .||||| .||||||.   | .|..|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

CSVYCPD----------------------------------------------------DRRETFCG--TIDYISPEIVNGEAYGQSVDIWS--LGILTF
 .   ..                                                    ||  ||||  | .|..|||.    ||...|.||  ||.| .
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

ELLTGKSPFQYET----------KNEILVNIL------NMNINIP----------NYLSEEAKDFIKSLLVRDPSKRMT----------MDQVVNHKWI
|.|||..||. ..          ..|.  .|.      | .. .|           ..|.||||.|| ||..||.|| .           ... ||.| 
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 12754.AA S_TKc 1807-2058 34 1.1e-99 338.36 SMART 1-231 (231) Show / Hide 
Range on Protein: 1807-2058
Range on HMM: 1-231/231
Sequence Identity: 34% (92 aa)

FKIGKHLGTGKFSEVHMAQDLNTGLIVALKKIKKEVLIKYKSEDYLENEIKIQIFSNHPNILKLYGFYYDEEFVYLVQEYASH--GELYQELKRQPNQR-
..|....| | |..|. ... .|| |||.|.||          . ...||.|    .|||| |||....| ...|.| ||...  |.|.. .|... .. 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FDEIKGAAYMRQICDAFTYLHRYHIIHRDIKPENILMSFGVLKIADFGCSVYCPDDRRETFCGTIDYISPEIVNGEAYGQ-SVDIWSLGILTFELLT
   |.|   . ||.|||.|  |.|. .|||||.||||||..  ..||.||| .         ||||| .|..||..    ||  ..|.||.|.. .|.|.
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

GKSPFQYETKNEILVNILNMNINIPNYLSEEAKDFIKSLLVRDPSKRMTMDQVVN-------HKWI
|. ||.  . .... .|.          |.||||||. .|..||.||.|  .. .       | |.
GYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 12754.AA CAMK 1812-2058 23 8.8e-99 318.95 In-house 1-425 (425) Show / Hide 
Range on Protein: 1812-2058
Range on HMM: 1-425/425
Sequence Identity: 23% (100 aa)

HLGTGKFSEVHMAQDLNTG------------LIVALKKIKKEVLIK-------------------------YKSEDYLENEIKIQIFSN-------HPNI
 ||.| |..|. ... ||.              || | |.|. | .                          |... ...||.|    .       ||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LKLYGFYYD-------------------EEFVYLVQ---EYASHGEL----YQELKRQPN-------------QRFDEIKGAAYMRQICDAFTYLHRYHI
.||| .| |                   ....|.|    ||.| |||    .. ......              ||.|   . |.||||.|  |.|  .|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHRDIKPENILMS--F----------------GVLKIADFGCSVYCP-------------------------DDRRETFCGTIDYIS-PEIVNG------
.|||.||||||..  .                . .||.||| . ...                         ..  .|||||  |.. ||..||      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------EAYGQSVDIWSLGILTFELLTGKSPFQYE-------------TKNEILVNILNMNIN-IPNY-----------------------LSEEAKD
        . ||...|.||.|.... .|.|..||. .             . .|.. .|.. . . .| |                       .|.|.||
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

FIKSLLVRDPSKRMTMDQVVNHKWI
.|...|..||.|||| .|. ||.|.
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 12754.AA CAMKL 1807-2058 33 1.5e-90 289.21 In-house 1-297 (297) Show / Hide 
Range on Protein: 1807-2058
Range on HMM: 1-297/297
Sequence Identity: 33% (100 aa)

FKIGKHLGTGKFSEVHMAQD-LNTGLIVALKKIKKEVLI-KYKSEDY-----------LENEIKIQIFSN---HPNILKLYGFYYDEEF------VYLVQ
..||| ||.| |..| .|.. ..||  || | |.|. .  . ....            .. ||.|.   |   |||| |||  ....|.      .||| 
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EYASHGE--LYQELKRQPN--QRFDEIKGAAYMRQICDAFTYLHRYHIIHRDIKPENILMS-FG--VLKIADFGCSVY---C---PDDRRETFCGTIDYI
||.| ||  |.. ......  .|..|     | |||..|  |.|. .|.|||||||||| .  |  ..||.||| | .   |   |..  .||||.  | 
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

SPEIVNG--E-AYGQSVDIWSLGILTFELLTGKSPFQYETKN---------EILVNILNMNINIPNYLSEEAKDFIKSLLVRDPSKRMTMDQVVNHKWI
.|||..|  .  .|. |||||.|.. . ...|. ||  .| |         .  ....  ...|....| ...|.|...|...|.||.|..|..||.| 
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 12754.AA Pkinase 1807-2058 32 1.1e-88 305.77 Pfam 1-293 (293) Show / Hide 
Range on Protein: 1807-2058
Range on HMM: 1-293/293
Sequence Identity: 32% (97 aa)

FKIGKHLGTGKFSEVHMAQDLNTGLIVALKKIKKEVLIKYKSEDYLEN--EIKIQIFSNHPNILKLYGFYYDEEFVYLVQEYASHG----ELYQELKRQP
..||. .| | |..|  ... .|| |||.|.|||.  .| . . .. .  ||.|    |||||..||....|.  .|.|.||. .|    .|.  .... 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

NQRF--DEIKGAAYMRQICDAFTYLHRYHIIHRDIKPENILMS-FGVL----KIADFGCSV---YCPDDRRETFCGTIDYISPEIVN-GEAYGQSVDIWS
. .|  .|     ||.||. .  |.|.  |||||.||||||..  |..    ||.|||..    | ..    |||||..|..||... |. ||..||.||
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

LGILTFELLTGKSPFQYE------TKNEILVNILNMNINIPNYLS---------------------EEAKDFIKSLLVRDPSKRMTMDQVVNHKWI
.|.. .|.|.|. ||. .      ........|.   .  . . .                     ||.|||||..| .||.|| | .|...|.|.
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 12754.AA Ciliate-E2 1807-2058 27 9.2e-83 281.26 In-house 1-365 (365) Show / Hide 
Range on Protein: 1807-2058
Range on HMM: 1-365/365
Sequence Identity: 27% (103 aa)

FKIGKHLGTGKFSEVHMAQDLNTG-----------------------LIVALKKIKKEVLIKYKSEDYLENEIK----------IQIFSNHPNILKLYGF
.|. | .|.| |. |  ... ...                        |.|.| .||  ..  |.|... .||.          |. . |||||.|.| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YY--DEEFVYLVQEYASHGELYQELKRQPNQR---------FDEIKGAAYMRQICD---------------AFTYLHRYH-IIHRDIKPENILMSFGVLK
..  |.. .||| ||...|.|.. .| .. .|         |.| . . .|.||..               |. |||  . ||||||||||||.    .|
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----IK

IADFGCSVYCPDDRRET---------------------------------FCGTIDYISPEIVNGEA---------YGQSVDIWSLGILTFELLTGKSPF
|.||| | .. ||. ..                                 .|||  | .|||.||.          |. ..||||||.. .|.|.|| ||
IIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF

QYETKNEILVNILNMNINIP------------------NYLSEEAKDFIKS----LLVRDPSKRMT-MDQVVNHKWI
        . .|.. .|..|                  ...|.|.||.||     .|..||.||.| ..|. ||.|.
--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 12754.AA Ciliate-E2-Unclassified 1807-2058 26 3.2e-78 266.17 In-house 1-352 (352) Show / Hide 
Range on Protein: 1807-2058
Range on HMM: 1-352/352
Sequence Identity: 26% (94 aa)

FKIGKHLGTGKFSEVHMAQDLNTGLIV-----ALKKIKKEVLIK-YKSEDYLENEIKIQ----------------IFSNHPNILKLYGFYY--DEEFVYL
.||.| .|.| |..|...|. ...  .     . |.... .... .|  ... ... ..                |..|||...... ||.  |.. .|.
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

VQEYASHGELYQELKRQPN---------------QRFDEIKGA-----AYMRQICDAFTYLHRYH-IIHRDIKPENILMSFG----VLKIADFGCSV---
| ||. .|.| | .| ...               ..|.| . .      |..||.... |||. . ||||||||||||.. .     .||.||| |    
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

--------------YCPDDRRETFCGTIDYI----SPEIVNGEAYGQS----VDIWSLGILTFELLTGKSPFQYETKNE----------------ILVNI
              . ....  |||||. |.    .||.  |. |..|    .||||||.. .|.|.|. ||.......                .. ||
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

LNMNINIPN--------YLSEEAKDFIK----SLLVRDPSKRMTMDQVVNHKWI
.. ||..|.         .|.||||||.    ..|. .|.||.|..|. || |.
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 12754.AA MARK 1807-2058 37 3.4e-76 248.58 In-house 1-262 (262) Show / Hide 
Range on Protein: 1807-2058
Range on HMM: 1-262/262
Sequence Identity: 37% (99 aa)

FKIGKHLGTGKFSEVHMAQDLNTGLIVALKKIKKEVLIKYKSEDYLENEIKIQIFSNHPNILKLYGFYY--DEEF-VYLVQEYASHGELYQELKRQPNQR
.|..| .|.| ...|  |....||  ||.| ..|. | . ..   .. ||.|    .|||| ||.      .|.  .||. |||| ||||. .| .|| |
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR

FDEIKGAAYMRQICDAFTYLHRYHIIHRDIKPENILM-SFG--VLKIADFGCSVYC-PDDRRETFCGTIDYISPEIVNGEAYG-QSVDIWSLGILTFELL
  |    .. |||. |  |.|. .|.||||||||||. . |    ||.||| |. . |. . .|||||  | .|||.... |  . |||||||.. . ..
LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMV

TGKSPFQYET--KNEILVNILNMNINIPNYLSEEAKDFIKSLLVRDPSKRMTMDQVVNHKWI
.|. ||   |   .|.  .||. .  || ..| |....|..||. .|..|.|......|.|.
CGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase 12754.AA RSK 1809-2058 33 8.1e-74 251.55 In-house 1-278 (278) Show / Hide 
Range on Protein: 1809-2058
Range on HMM: 1-278/278
Sequence Identity: 33% (92 aa)

IGKH--LGTGKFSEVHMAQDLNTGLIVALKKIKKEVLIKY-KSEDYLENEIKIQIFSN-HPNILKLYGFYYDEEFVYLVQEYASHGELYQELKRQPN-QR
.     .| ||.. ..  .. .|| | | | .|| ....  |.  .   |..|   .. ||.| .|.  . .|. .||. || . |||.  |...     
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FDEIKGAAYMRQICDAFTYLHRYHIIHRDIKPENILMSF----GVLKIADFGCSVY-CPD--DRRETFCGTIDYISPEIVN----GEAYGQSVDIWSLGI
|.|   ..||..|  |  .||  .|||||.||||||       | .|. ||| . .  .|   .  |||.||.|. ||...    ........|.||||.
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LTFELLTGKSPFQY---ETKNEILVNILNMN--INIP--NYLSEEAKDFIKSLLVRDPSKRMT-----MDQVVNHKWI
| .|.|||..|||    ....||. .|.. .   ..|  .|||.||||.|. .| |||.|| .     .... .|.|.
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 12754.AA CAMK-Unique 1807-2058 24 1.3e-71 235.66 In-house 1-363 (363) Show / Hide 
Range on Protein: 1807-2058
Range on HMM: 1-363/363
Sequence Identity: 24% (88 aa)

FKIGKHLGTGKFSEVHMAQDLNTGLIVALKKIKK-EVL-IKYKS---------------EDYLENEIKIQIFSNHPNILKLYGF----YYDEE-------
 | .. .|.| |..|  ..|  || . | |..||  .  .|.|                .  |..|. | .. .||||.|||..    . |..       
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI

--------FVYLVQEYASHGELYQELKR------------------QPNQRFDE--IKGAAYMRQICDAFTYLHRYHIIHRDIKPENILMSFG-------
          |.|.||.  |.|.... .                  . ...| |     . .|...  |  |.|   |.|||.|.|||. .         
IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHH

----------VLKIADFGCSVYCPDDRRE----TFCGTIDYISP--------------EIVNGEAYGQSV----DIWSLGILTFELLTGKSPFQYETKN-
           .|..||| ...    . .    |.|||..|..|              |..|.  |.| .    |||||| .....|.|..||  |... 
RDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDR

-------EILVNILNMNI--------NIPNYLSEEAKDFIKSLLVRDPSKRMTMDQVVNHKWI
       ||. .|.  ..        ..| | |.|||||.| ....||..| .  .   | ||
DYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase 12754.AA STE 1807-2058 25 2.5e-70 239.97 In-house 1-359 (359) Show / Hide 
Range on Protein: 1807-2058
Range on HMM: 1-359/359
Sequence Identity: 25% (93 aa)

FKIGKHLGTGKFSEVHMAQDLN---------------TGLIVALKKIKKEVL--------------IKYKSEDYLENEIKIQIFSN--HPNILKLYGFYY
... . .| | | .|. | . .               || |.| |....|                .  . .. ...||||   .|  |||| | || |.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DE-------EFVYLVQEYASHGELYQELK------RQPN------QRFDEIKGAAYMRQICDA-FTYLHRYHIIHRDIKPENILMSFGVLKIADFGCSVY
.|       . .... || . | | . .|      .. |      .||.|   |.. |||. .   |||. ||||||||| |||.     |..|||..  
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----VKLCDFGVCGQ

CPDD------------------RRETFCGTIDYISPEIVNG------EAYGQSVDIWSLGILTFELLTGKSPFQYETKNEILVNILNMN-----------
  |.                  .| ||.||  . .||....        |. ..||||||..  |..||| |.  ..  . . .|....           
LTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCI

--INIPNYLS----------------------EEAKDFIKSLLVRDPSKRMTMDQVVN--HKWI
   ..|   .                      .| ||||.  |..||.|| | .|  .  |..|
VNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 12754.AA Pkinase_Tyr 1807-1951 33 6.5e-19 64.68 Pfam 1-156 (270) Show / Hide 
Range on Protein: 1807-1951
Range on HMM: 1-156/270
Sequence Identity: 33% (52 aa)

FKIGKHLGTGKFSEVHMAQDL----NTGLIVALKKIKKEVLIKY-KSEDYLENEIKIQIFS-NHPNILKLYGFYY-DEEF--VYLVQEYASHGELYQELK
 ..|| || | | ||...       ||.. || |..|     .  ..|| .. |.||     .||||..|||  . ..|   .|.| ||. || |.  |.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

RQ--PNQRFDEIKGAAYMRQICDAFTYLHRYHIIHRDIKPENILMS-FGVLKIADFG
..  ..|...      . .||...  ||.. ..||||.   |.| .  .| ||.|||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFG
Kinase 12754.AA TyrKc 1807-2058 23 4.7e-17 53.06 SMART 1-280 (280) Show / Hide 
Range on Protein: 1807-2058
Range on HMM: 1-280/280
Sequence Identity: 23% (70 aa)

FKIGKHLGTGKFSEVHMAQDLNTGLIVALKKIKKEVLIKYKSEDYLENEIKIQIFS--NHPNILKLYGFYYDE-------EFVYLVQEYASHGELYQELK
 . || || | | ||. ..     . || |..|..       .  . .|..|      .||||..|||   ..       | ...| ||..|| | . |.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

RQPNQRFDEIKGAAYMRQICDAFTYLHRYHIIHRDIKPENILMSFGV-LKIADFGCSVYCPDD----------R-----RETFCGTIDYISPEIVNGEAY
.  .. .   .   .. ||..   |||. ..||||.   |.| . .   ||.||| | .  ||          |      . .   |   .||  |   .
KHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

GQSVDIWSLGILTFELLT-GKSPFQYE----TKNEILVNILNMN--INIPNY--------LSEEAKDFIKSLLVRDPSKRMTMDQVVNHKWI
    |.|| |.. .|..| |..|   .     .|. ... .       .| .         ..|  . .|.   .||..| |. ..  |. .
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 12754.AA Pkinase_Tyr 1986-2005 40 0.041336 7.77 Pfam 196-217 (270) Show / Hide 
Range on Protein: 1986-2005
Range on HMM: 196-217/270
Sequence Identity: 40% (9 aa)

DIWSLGILTFELLT-GKSP-FQ
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DVWSFGVLMWEIFTYGEQPTYP