Gene 16602 (Tetrahymena)

16602

Species: Tetrahymena
Alias: 340.m00014, 724, TTHERM_01350000, PreTt16602, 16602
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Aur

Sequence

Name Sequence Type Origin Length Description Download
16602.NA RNA None 7263 None Fasta, JSON
16602.AA Protein None 2420 None Fasta, JSON
16602.kin_dom Protein Kinase Domain None 213 None Fasta, JSON

Protein domain

Protein domains of 16602.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
REJ 16602.AA REJ 10-442 23 2.1e-126 431.06 Pfam 2-528 (528) Show / Hide 
Range on Protein: 10-442
Range on HMM: 2-528/528
Sequence Identity: 23% (124 aa)

YIET---C-ELGQITFFNEPVDLQLVSNQLQKQSL------SQYNQSSFQYDILPYSL-ASNQTFNMSLILNL-SSDSKISAIQNISVNIQITDLYLQII
...    | .. . |... .|. ....|..|....      ........|..| ||.| . |..||.....|. .||.......|..|..| ..|. .| 
HVDLYENCYSSAYTTHYEWWVFSVWDCNHWQTWYEPVYQHQAMVDTHRPQLTIPPYTLPYGNYCFNFTVSINMWPSDPPLETTDNTYVTVQPSPLVAVID

GGSSLNLGYQ--NKMVLNTDSRDYEIQDP-NQA------SNINFSWKCNSLSSN------------------DHIC-------YDYQNKQIQLQQGASSI
||||   |.|  ....... |..|.| || .        |.....|.|.. . |                  ||.|       ...|. ....... ||.
GGSSRTWGWQSSDDITMDG-SESYNI-DPTDVDSGDQDYSGWTYHWYCRRSNENFMLNDYMYYPLDEVEPNNDHGCWGRCPNNHNFQDNITWPWSWSSSF

AFPAKTFQPYTIIQFTVVGQKDS---RQSNFTTTCIFTELDIPPLNIFTA-THINGK---INLNDDLNFQINYGENVS---SDYLSYAGAILYDNNPVAA
 .||.|..... ..|... .|||   |.|..|. .|... . ||...    |. | |   .|....|..|.|. .|..   .....|  ...|..|....
TIPASTLKANMTYTFWLTVNKDSNSWRRSASTQQTIHIVQGNPPEVHIYCITNCNQKVYEVNPSSRLYLQANCSHNCDSCNNQWVTYRWSMYYQYNDMSW

IKFDYFQIRFRIWNYFQNIDPSKPTLQIRFSVYNP-------LYVMPS------LSTISIQI--NIPPQNCVLSINPQKG--IALETIFQIQLLSCTDED
............|....  . |...|.||..|..|       .||...      ....|...  | |||.. .|..|. |  .||||.|...   ..|||
LNNSFHWEQLTDWSSQTTTGRSGMYLVIRKGVLEPGVEYRFWVYVTDTSWQGGGYASYSFYTVMNHPPQGGTCSVTPDQGWVYALETKFTFTCQNWWDED

L---PLTYQFFY----YNNADDANQELISPWNILRRQIQDQTINNSIQTILPQG------NLVFMVQVMDSYLGVY-NTSSTIQVQAQNKSAD-------
    ||.|||||    .. ..|  ..  ..|..|....|.|.| ||.||.||.|      ....||||.|.| ... ... ||.|........       
QDCYPLWYQFFYVSFVHYTVQDRCRDESCEWFWLYYGSQQQSI-NSCQTYLPPGFENHDHQVTIMVQVCDCYGACTVQCNMTITVHPPTVTTSGKNVTQE

---EYYKLVNQQILQVQQSSNIQITNQLVT
    ...  |.   ..|.  ..| |.....
LHWMTMGTTNNLSKLLQHGDWQQATQYMNA
Kinase 16602.AA Aur 1105-1317 55 1.1e-181 484.4 In-house 1-214 (257) Show / Hide 
Range on Protein: 1105-1317
Range on HMM: 1-214/257
Sequence Identity: 55% (120 aa)

FELGPCLGKGKFSEVYLAREKLSGFIIALKIMQKNFLKEYGLEDQLRREILLQNGSDHPNILAIYGFFHDQNHIYLILEYAEQGDLYTLTRSFPEKRIPE
||.| .||||||..|||||.| ..||.|||.|.|. .|.|..|.|||||| .|. ..|||||  ||.|||...||||||||..|.||.. .. |.||..|
FEIGKPLGKGKFGNVYLARHKKTHFIFALKVMFKEQIKKYCMEHQLRREIKIQSHLNHPNILKMYGYFHDDQRIYLILEYAPGGELYKELQKQPNKRFDE

NLAAKYIKQTISALIFLHKNNVIHRDLKPENILLS--KGDVKLGDFGLAIENNNAIKEKRQTFCGTLDYISPEMFNRKGHDFRVDIWSIGVLCYELCSGQ
..||||..|...||...|..|.||||.|||||||.  .|..|..||| .....|  ...|.||||||||..||| ....||..||||..||||||||.|.
QRAAKYMYQICNALDYCHSKNIIHRDIKPENILLDQCNGNIKICDFGWSVHCPN--NNRRMTFCGTLDYMPPEMVEGQMHDHKVDIWCLGVLCYELCHGC

PPFES-ETYDETMRRV
||||| |..|||..|.
PPFESNENHDETYDRI
Kinase 16602.AA AGC 1105-1318 23 2.4e-89 230.45 In-house 1-328 (395) Show / Hide 
Range on Protein: 1105-1318
Range on HMM: 1-328/395
Sequence Identity: 23% (78 aa)

FELGPCLGKGKFSEVYLAREK------LSGFIIALKIMQKNF-LKEYG--LEDQLR--------------REILLQNGSD--------HPNILA-IYGFF
||.  ..||| |..|||.|.|       .| . |.|...|    ..     ...                |.|| .  ..        ||.|    .  |
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

HDQNH--IYLILEYAE--------QGDLYTLTRSF---PEKRIPENLAAKYIKQ-------TISALIFLHK-NNVIHRD-LKPENILLSK-GDVKLGDFG
.|..|  .|...||..         |.. .... .    |.| .|. |  |. .       ...|| .||. ...|||| |||||||| . | .|| |||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LAIENNNA-------------------------------------------------IKEKRQTFCG--TLDYISPEMFNRKGHDFRVDIWS--IGVLCY
|. |..|                                                   ... .||||  | .|..||..    ... .|.||   |.| |
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

ELCSGQPPFESET----------YDETMRRVC
|. .|.||| ...           .|.. ...
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIM
Kinase 16602.AA S_TKc 1105-1372 28 3.1e-79 270.47 SMART 1-231 (231) Show / Hide 
Range on Protein: 1105-1372
Range on HMM: 1-231/231
Sequence Identity: 28% (81 aa)

FELGPCLGKGKFSEVYLAREKLSGFIIALKIMQKNFLKEYGLEDQLRREILLQNGSDHPNILAIYGFFHDQNHIYLILEYAEQ--GDLYTLTRSFPEKR-
.|..  .||| |..||..|.| .| | |.||.           ...|||| .    .||||  .|..|.| .|.|...||...  |||... .. . .. 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---IPENLAAKYIKQTISALIFLHKNNVIHRDLKPENILLSKGDVKLGDFGLAIENNNAIKEKRQTFCGTLDYISPEMFNRKGHDF-RVDIWSIGVLCYE
   .||  |..|..|...|| ..|....||||||||||||..  .|..||||| .          |||||..|..||..   |... ..|.||.|.. ||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

LCSGQPPFESETYDETMRRVCSLVGYQGFESRLKEVVILNILYAVSIGLERLIFMKTALKINYI---NFGDAFI-------KQFL
...|.|||.  ..........                            | . |..  |. .        .|.         ...
MLCGYPPFP--QMQMMFKKIG--------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 16602.AA CAMK 1110-1319 21 3.8e-77 247.96 In-house 1-361 (425) Show / Hide 
Range on Protein: 1110-1319
Range on HMM: 1-361/425
Sequence Identity: 21% (77 aa)

CLGKGKFSEVYLAREKLSG------------FIIALKIMQKNFLKE-------------------------YGLEDQLRREILLQNGS-------DHPNI
 ||.| |..|.|...|...               | ||. |. ||.                            ....|||| . .         |||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LAIYGFFHD-------------------QNHIYLIL---EYAEQG----DLYTLTRSFPE-------------KRIPENLAAKYIKQTISALIFLHKNNV
. .| .. |                   ..|.|...   ||.. |    ||.   .. .              .|..|  |..|..| .||. ..|..|.
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHRDLKPENILLSK------------------GDVKLGDFGLAIENNNAI----------------------KEKRQTFCGTLDYIS-PEMFNR------
.|||||||||||..                  ...|. |||.|.. .                          .| .|||||. |.. ||..|.      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------KGHDFRVDIWSIGVLCYELCSGQPPFESE-------------TYDETMRRVCS
        ..... .|.||.||..| . .| |||...             .. |.......
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMK
Kinase 16602.AA Pkinase 1105-1318 32 1.3e-72 252.32 Pfam 1-228 (293) Show / Hide 
Range on Protein: 1105-1318
Range on HMM: 1-228/293
Sequence Identity: 32% (78 aa)

FELGPCLGKGKFSEVYLAREKLSGFIIALKIMQKNFLKEYGLEDQLRR--EILLQNGSDHPNILAIYGFFHDQNHIYLILEYAEQG----DLY----TLT
...| ..|.| |..||....| .| | |.||. |   .. . . ..||  || . .  .||||. .|..|.| .|||...||.| |    ||.    |  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--

RSFPEKRI--PENLAAKYIKQTISALIFLHKNNVIHRDLKPENILLS-KGDV----KLGDFGLA--IENNNAIKEKRQTFCGTLDYISPEMFN-RKGHDF
    ....  .|. . .|..|....| ..|....|||||||||||.. .|..    |..|||||  ..  .  ..  .|||||..|..||  . ..... 
--WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGP

RVDIWSIGVLCYELCSGQPPFESE----TYDETMRRVC
.||.||.|...||...|.||| ..    . .. | ..|
KVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMIC
Kinase 16602.AA CAMKL 1105-1310 32 2e-70 223.88 In-house 1-241 (297) Show / Hide 
Range on Protein: 1105-1310
Range on HMM: 1-241/297
Sequence Identity: 32% (79 aa)

FELGPCLGKGKFSEVYLARE-KLSGFIIALKIMQKNFLK-EYGLEDQ-----------LRREILLQNGSD---HPNILAIYGFFHDQNH------IYLIL
...|. |||| |..| ||.  .. |   | ||. |. .. .   ..            .|||| ..   .   ||||  .|  . ...|      |||..
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EYAEQGD--LYTLTRSFPEKR--IPENLAAKYIKQTISALIFLHKNNVIHRDLKPENILLS-KGD--VKLGDFGLAIE-NN--NAIKEKRQTFCGTLDYI
||.. |.  |.   .. ...|  .||. | .| .| .||. ..|.....|||.|||||||. .|.  .|. |||....  .  .   .|  ||||.. | 
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

SPEMFNR--KGHD-FRVDIWSIGVLCYELCSGQPPFESETY
.||.|..  | .| . |||||.||. | .  |. ||. .||
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTY
Kinase 16602.AA Ciliate-E2-Unclassified 1105-1312 23 3.8e-68 232.71 In-house 1-277 (352) Show / Hide 
Range on Protein: 1105-1312
Range on HMM: 1-277/352
Sequence Identity: 23% (66 aa)

FELGPCLGKGKFSEVYLAREKLSGFIIALKIMQKNFLKE-----YGLEDQLRREILLQNG----------------SDHPNILAIYGFFH--DQNHIYLI
.... ..|.| |..||....|  ... |.|.| |.  .      .   . .. .. ..|                 ..||... .. |..  |...||..
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

LEYAEQGDLYTLTRSFPE---------------KRIPENLAA-----KYIKQTISALIFLHKNN-VIHRDLKPENILLSKG----DVKLGDFGLAIENNN
.||.|.|||    ....                |...|. |.     .|..| ...| .||..| .||||.||||||....     .|. |||.......
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

A--------------IKEKRQTFCGTLDYI----SPEMFNRKGHD----FRVDIWSIGVLCYELCSGQPPFESETYDE
               .... .|||||. |.    .||.. ....|    . .|||| ||..||.. |..||.......
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQ
Kinase 16602.AA Ciliate-E2 1105-1305 26 1.6e-67 230.64 In-house 1-296 (365) Show / Hide 
Range on Protein: 1105-1305
Range on HMM: 1-296/365
Sequence Identity: 26% (79 aa)

FELGPCLGKGKFSEVYLAREKLSG-----------------------FIIALKIMQKNFLKEYGLEDQLRREIL----------LQNGSDHPNILAIYGF
...  ..|.| |. ||... .. .                       .|.|.|||.|| ...   |... |||           ..   .||||. .| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FH--DQNHIYLILEYAEQGDLYTLTRSFPEKR---------IPENLAAKYIKQTIS---------------ALIFLHKNN-VIHRDLKPENILLSKGDVK
|   |.|.|||..||...|||. . .... ||         . |. .....|| ..               || .||..| .||||.||||||.    .|
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----IK

LGDFGLAIENNNAIKEKR------------------------------QTFCGTLDYISPEMFNRKG---------HDFRVDIWSIGVLCYELCSGQPPF
. ||||. ....  ....                              .|.|||. | .||..|.|.         .|. .||||.||. ||...|.|||
IIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF
Kinase 16602.AA MARK 1105-1317 36 5.2e-64 208.18 In-house 1-220 (262) Show / Hide 
Range on Protein: 1105-1317
Range on HMM: 1-220/262
Sequence Identity: 36% (81 aa)

FELGPCLGKGKFSEVYLAREKLSGFIIALKIMQKNFLKEYGLEDQLRREILLQNGSDHPNILAIYGFFH--DQNH-IYLILEYAEQGDLYTLTRSFPEKR
.... ..|.| ...|.||. |..|   |.||..|. | .      ..||| .    |||||   .  .   . .| ||||.|||. |.||   ...|  |
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR

IPENLAAKYIKQTISALIFLHKNNVIHRDLKPENILL-SKG--DVKLGDFGLAIENNNAIKEKRQTFCGTLDYISPEMFNRKGHD-FRVDIWSIGVLCYE
..|..| .. .| .||. ..|..|..|||.||||||. ..|  ..|. |||..|.      .|  |||||. | .||.|..|  | . ||||| ||. | 
LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICI--PPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYF

LCSGQPPFESET--YDETMRRV
. .|. ||.  |  | | ....
MVCGYFPFDGDTQDYKELYKKI
Kinase 16602.AA STE 1105-1305 26 6.7e-63 215.28 In-house 1-268 (359) Show / Hide 
Range on Protein: 1105-1305
Range on HMM: 1-268/359
Sequence Identity: 26% (72 aa)

FELGPCLGKGKFSEVYLAREKL---------------SGFIIALKIMQ-----------KNFLKE-----YGLEDQLRREILLQNGSD--HPNILAIYGF
.|.  ..||| | .||.|. .                .|.|.| |.|             |   |        ..|. .|| . . ..  ||||   || 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQEN-Q-ELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGC

FHDQ-------NHIYLILEYAEQGDLYTLTR---SFPE---------KRIPENLAAKYIKQTISA-LIFLHKNNVIHRDLKPENILLSKGDVKLGDFGLA
. .        .......|| . | |  . .   . ..         .|.||.. |....|.. . | .||....||||.|| ||||    ||| |||..
YFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----VKLCDFGVC

IENNN---------------AIKEKRQTFCGTLDYISPEMFNR------KGHDFRVDIWSIGVLCYELCSGQPPF
   ..                ...||.||.||  . .||. ..      ||.|...||||.| .. |.. |.||.
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPW
Kinase 16602.AA CAMK-Unique 1105-1319 22 2.5e-60 197.79 In-house 1-315 (363) Show / Hide 
Range on Protein: 1105-1319
Range on HMM: 1-315/363
Sequence Identity: 22% (72 aa)

FELGPCLGKGKFSEVYLAREKLSGFIIALKIMQK-----NFLKE------------YGLEDQLRREILLQNGSDHPNILAIYGF----FHDQN-------
 ...  .|.| |..|| .  .  | . | |. .|     . .|.              .. .|.||. .    |||||. .|..    |.| .       
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI

--------HIYLILEYAEQGDLYTLTRS---FP---------------EKRIPE--NLAAKYIKQTISALIFLHKNNVIHRDLKPENILLSKG-------
        ..|...||.. |||. .  .   |                . .  |  .... .. .. ||. ..|.....|||||.|||....        
IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHH

----------DVKLGDFGLAIENNNAIKEK-RQTFCGTLDYISP--------------EMFNRKGHDFRV----DIWSIGVLCYELCSGQPPFESETYD-
          ..|| ||||. . |. ...   ||.|||..|..|              |. |. . |  .    ||||.||. |.. .| |||..|. | 
RDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDR

-------ETMRRVCS
       |. .. |.
DYENHDKEIFECICK
Kinase 16602.AA AktR 1105-1308 36 8e-57 195.1 In-house 1-208 (268) Show / Hide 
Range on Protein: 1105-1308
Range on HMM: 1-208/268
Sequence Identity: 36% (76 aa)

FELGPCLGKGKFSEVYLAREK-LSGFIIALKIMQKNFLKEYGLEDQLRRE-ILLQNGSDHPNILAIYGFFHDQNHIYLILEYAEQGDLYTLTRSFPEKRI
|..  |||||.|..|||...|  .. . |.|.  | ...|. .......|   ... ..|| |   . .| .......|.|| . |.|..  ..  .|..
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKK--KKKF

PENLAAKYIKQTISALIFLHKN-NVIHRDLKPENILLSK-GDVKLGDFGLAI-ENNNAIKEKRQTFCGTLDYISPEMFNR-KGHDFRVDIWSIGVLCYEL
 |. | .|. | . || .||.. |.| |||||||||| . | ||..||||.  .. ..  || ..||||  |..||| .. |||.. ||.|..|.. ||.
SEEQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEM

CSGQPPFESE
 .|.|||...
VTGCPPFYHK
Kinase 16602.AA TyrKc 1105-1339 21 4.2e-14 5.34 SMART 1-280 (280) Show / Hide 
Range on Protein: 1105-1339
Range on HMM: 1-280/280
Sequence Identity: 21% (62 aa)

FELGPCLGKGKFSEVYLAREKLSGFIIALKIMQKNFLKEYGLEDQLRREILLQNGS--DHPNILAIYGFFHDQ-------NHIYLILEYAEQGDLYTLTR
 .||  || | | |||... |      | | ....       .  ..||. .      .||||...||   .|         .....||.. |||    |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

SFPEKRIPENLAAKYIKQTISALIFLHKNNVIHRDLKPENILLSKGD-VKLGDFGLAIENNNA------IKEKRQTF--CGT----LDYISPEMFNRKGH
.  .| ..     ..  |  .   .||..|.|||||   |.|....  || .||||. .  .        . .|..   .|     .   .|| .| .  
KHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

DFRVDIWSIGVLCYELCS-GQPPFESETY-DETMRRVCSLVGYQGFESRLKE-------------------------------VVILNIL
 .  |.|| ||...|... ||.| . ..  . . ..|  .|   .   . ..                                 |  ..
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 16602.AA Pkinase_Tyr 1105-1251 28 7.1e-14 47.62 Pfam 1-158 (270) Show / Hide 
Range on Protein: 1105-1251
Range on HMM: 1-158/270
Sequence Identity: 28% (46 aa)

FELGPCLGKGKFSEVYLAREK----LSGFIIALKIMQKNFLKEYGLE----DQLRREILLQNGS-DHPNILAIYGFFH-DQNH--IYLILEYAEQGDLYT
 ..|  ||.| | |||... |      .   | |.. |.    .  |    . . ||. .     .||||.  ||    .. .  ||...||.. |||..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KE---GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLD

LTRS--FPEKRIPENLAAKYIKQTISALIFLHKNNVIHRDLKPENILLS-KGDVKLGDFGLA
  |.   ......     ..  |  ... .|. .| |||||   |.|.. .. || .|||||
YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase 16602.AA Pkinase_Tyr 1287-1306 40 0.14941 5.88 Pfam 196-217 (270) Show / Hide 
Range on Protein: 1287-1306
Range on HMM: 196-217/270
Sequence Identity: 40% (9 aa)

DIWSIGVLCYELCS-GQPP-FE
|.|| |||..|... |. | ..
DVWSFGVLMWEIFTYGEQPTYP