Gene 26118 (Tetrahymena)

26118

Species: Tetrahymena
Alias: 3695.m00013, 35.m00179, 571, TTHERM_00343380, 26118, PreTt26118
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Aur

Sequence

Name Sequence Type Origin Length Description Download
26118.AA Protein None 1319 None Fasta, JSON
26118.kin_dom Protein Kinase Domain None 256 None Fasta, JSON
26118.NA RNA None 3960 None Fasta, JSON

Protein domain

Protein domains of 26118.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 26118.AA Aur 1053-1308 45 5.1e-196 523.04 In-house 1-257 (257) Show / Hide 
Range on Protein: 1053-1308
Range on HMM: 1-257/257
Sequence Identity: 45% (117 aa)

FEFIKLLGQGVFGQVHMVRDKKTKGIFALKLIDKQMIKEKEMETQLQRELNIHSQYSNHENVLECLGYFEDEKYYYLLLEYASDGTCASLIENLPLRRLT
||. |.||.| ||.|...|.|||. |||||...|..||...|| ||.|| .|.|.. ||.|.|.. |||.|....||.||||..|.. ... ..|..|..
FEIGKPLGKGKFGNVYLARHKKTHFIFALKVMFKEQIKKYCMEHQLRREIKIQSHL-NHPNILKMYGYFHDDQRIYLILEYAPGGELYKELQKQPNKRFD

EQQSCNIVKQILESVNYLHKNKIIHRDLKLENVLIS--NGKVKLCDFGCATFCDNPPYQRRRSFCGTLDYVSPEMIQDQIYDKEIDIWAIGVITFELCSG
||.......|| . ..|.|...|||||.| ||.|..  ||..|.||||....|.|  ..||. |||||||..|||...| .|...|||..||...|||.|
EQRAAKYMYQICNALDYCHSKNIIHRDIKPENILLDQCNGNIKICDFGWSVHCPN--NNRRMTFCGTLDYMPPEMVEGQMHDHKVDIWCLGVLCYELCHG

FAPFTQ-FNDQQTYSAIQ-NVKHAWPKCFSEELKDFIQKIFVVDPTQRATASQLLYHDWI
..||.. .|...||..|. .|.. .|...|.|.||.|.||...|| || |  | ..|.||
CPPFESNENHDETYDRIKNKVDIQFPSHISKEAKDLISKILQHDPKQRMTLDQIMNHPWI
Kinase 26118.AA S_TKc 1053-1308 30 2.8e-95 323.78 SMART 1-231 (231) Show / Hide 
Range on Protein: 1053-1308
Range on HMM: 1-231/231
Sequence Identity: 30% (81 aa)

FEFIKLLGQGVFGQVHMVRDKKTKGIFALKLIDKQMIKEKEMETQLQRELNIHSQYSNHENVLECLGYFEDEKYYYLLLEYASD--GTCASLIENLPLRR
.|.....|.| ||.|. .|.|||. |.|.| |.           ...||..|...  .|.|.  ....|.| ...|. .||..   |.  ..|.. . ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----LTEQQSCNIVKQILESVNYLHKNKIIHRDLKLENVLISNGKVKLCDFGCATFCDNPPYQRRRSFCGTLDYVSPEMIQDQIYDK-EIDIWAIGVITF
    ..| . . ...||.. ..|.|...||||||| ||.|...  .|.|||| |..         ..||||..|..||..    |.| ..|.|..|.| .
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

ELCSGFAPFTQFNDQQTYSAIQNVKHAWPKCFSEELKDFIQKIFVVDPTQRATASQLLY-------HDWI
|...|  ||   ..|...  |           |.|.||||.|....||..| || ..|        | |.
EMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 26118.AA AGC 1053-1308 22 6.2e-95 245.22 In-house 1-395 (395) Show / Hide 
Range on Protein: 1053-1308
Range on HMM: 1-395/395
Sequence Identity: 22% (90 aa)

FEFIKLLGQGVFGQVHMVRDK------KTKGIFALKLIDKQM-IKEKE--METQLQRE------------LNIHSQYSN---------HENVLE-CLGYF
|||.|..|.| ||.|. ||.|       |. ..|.| ..|.  |..|.  |. . ..|             || .....         | ..       |
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

EDEKY--YYLLLEYAS--------DGTCASLIENL---PLRRLTEQQSCNIVKQ-------ILESVNYLHK-NKIIHRD-LKLENVLISN-GKVKLCDFG
.|...   |...||..         | | ... .      .|..|.... .  .       |.  . |||. ..||||| ||.||.|. . | .||.|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

CATFCDNPP---------------------------------YQRRR----------------SFCG--TLDYVSPEMIQDQIYDKEIDIWA--IGVITF
 ..   | .                                  || .                .|||  | .|..||..    |.|. |.|.   |.. .
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

ELCSGFAPFTQFNDQ----------QTYSAIQ------NVKHAWP----------KCFSEELKDFIQKIFVVDPTQRAT----------ASQLLYHDWI
|. .|  ||.  |.|          ...  |.      | |  .|          . ||.|.||.|.| ...||..| .          |...  | | 
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 26118.AA CAMK 1058-1308 21 3.4e-93 300.62 In-house 1-425 (425) Show / Hide 
Range on Protein: 1058-1308
Range on HMM: 1-425/425
Sequence Identity: 21% (92 aa)

LLGQGVFGQVHMVRDKKTKGI------------FALKLIDKQMIKEKE-------------------------METQLQRELNIHSQYS------NHENV
 ||.| ||.|. ...|.|.|             .| | |||. .|.|.                         .. ...||..|... .      .|.|.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LECLGYFED-------------------EKYYYLLL---EYASDG----TCASLIENLPL-------------RRLTEQQSCNIVKQILESVNYLHKNKI
. .. ..||                   .|..|. .   ||.| |     . . |   .              .|.||.. . ...||.. |.|.|...|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHRDLKLENVLI-SN-----------------GKVKLCDFGCATFCDN----------------------PPYQRRRSFCGTLDYVS-PEMIQDQI----
.|||||.||.|. .|                 ...|..||| |...|                        . |  . ||||. |.. ||... .     
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

----------YDKEIDIWAIGVITFELCSGFAPFTQF-------------NDQQTYSAIQNVKHA-WPKCFSE-----------------------ELKD
          |....|.|..|||.. . .|. ||                ||....  |.. |    |. ||.                       | ||
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

FIQKIFVVDPTQRATASQLLYHDWI
.|.|. .|||..|.|..| | | |.
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 26118.AA CAMKL 1053-1308 27 6.6e-83 264.4 In-house 1-297 (297) Show / Hide 
Range on Protein: 1053-1308
Range on HMM: 1-297/297
Sequence Identity: 27% (82 aa)

FEFIKLLGQGVFGQVHMVRD-KKTKGIFALKLIDKQMIKEKEMETQ------------LQRELNIHSQYS--NHENVLECLGYFEDEKY------YYLLL
....| ||.| ||.| . .. . |.   | | |||. |....  ..            ..|| .|... .   |.|.   .  .|....      .|| .
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EYASDGT--CASLIENLPLRR--LTEQQSCNIVKQILESVNYLHKNKIIHRDLKLENVLIS-NG--KVKLCDFGCATFCD---NPPYQRRRSFCGTLDYV
||.| |       |.. . ||  ..| . . . .||.. |||.|...|.|||.|.||.|.. ||  ..|..||| .....   ..| |  . |||.. | 
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

SPEMIQD-QI-YD-KEIDIWAIGVITFELCSGFAPFTQFN-------DQQTYSAIQNVKHAWPKCF---SEELKDFIQKIFVVDPTQRATASQLLYHDWI
.||..|. .  || ...|||..||| . .  |  || . .       .. ..  ....   .|  .   | ...|.|.|. .|.|..|.|. |.. | | 
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 26118.AA Pkinase 1053-1308 30 3.3e-82 284.23 Pfam 1-293 (293) Show / Hide 
Range on Protein: 1053-1308
Range on HMM: 1-293/293
Sequence Identity: 30% (91 aa)

FEFIKLLGQGVFGQVHMVRDKKTKGIFALKLIDKQMIKEKEMETQLQ-RELNIHSQYSNHENVLECLGYFEDEKYYYLLLEYASDG----TCASLIE---
..... .|.| ||.|   ..|.|  |.|.| |.|. .|... .| .  .|. |.    ||.|.......|||....|. .||.  |      ...|.   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

NLPLRRLTEQQSCNIVKQILESVNYLHKNKIIHRDLKLENVLIS-NGKV----KLCDFGCATFCDNPPYQRRRSFCGTLDYVSPEMIQ-DQIYDKEIDIW
. ..  ..|.. .....|||. ..|.|...|||||||.||.||. || .    |.||||.| . |. ...   .||||..|..|| |. .| |....|.|
HGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

AIGVITFELCSGFAPFTQF------NDQQTYSAIQN--VKHAWPKCFS-------------------EELKDFIQKIFVVDPTQRATASQLLYHDWI
..|.| .|...|  || .       ...| .  |    ..  ||.  |                   ||.|||| ... .||..| || |.| |.|.
SCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 26118.AA Ciliate-E2 1053-1308 24 1.1e-79 271.08 In-house 1-365 (365) Show / Hide 
Range on Protein: 1053-1308
Range on HMM: 1-365/365
Sequence Identity: 24% (93 aa)

FEFIKLLGQGVFGQVHMVRDKKTKG-----------------------IFALKLIDKQMIKEKEMETQLQRELNIHS----------QYSNHENVLECLG
..|||..||| ||.|  ....|..                        |.|.| . |..|.....| .. ||.|.            .  || |....  
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINC-FYKKINEKNILEQLNHPNIIKMYE

YFE--DEKYYYLLLEYASDGTCASLIENLPLRR---------LTEQQSCNIVKQILE---------------SVNYLHKNK-IIHRDLKLENVLISNGKV
.|.  |....|| .||.. |.  ..|.| .. |         .||.. ..| ||||.                ..|||... |||||.|.||.|.    .
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----I

KLCDFGCATFCDNPPYQRR------------------------------RSFCGTLDYVSPEMIQ---------DQIYDKEIDIWAIGVITFELCSGFAP
|..||| ....|.. ..|.                              ...|||. |..||...          . ||...|||..||| .|...|  |
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FTQFNDQQTYSAIQNVKHAWP------------------KCFSEELKDFIQK----IFVVDPTQRAT-ASQLLYHDWI
|        .  |.. |   |                  |  |.| ||.|.|    ....|| .| | ..|.| | |.
F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 26118.AA Ciliate-E2-Unclassified 1053-1308 25 4.9e-76 258.91 In-house 1-352 (352) Show / Hide 
Range on Protein: 1053-1308
Range on HMM: 1-352/352
Sequence Identity: 25% (91 aa)

FEFIKLLGQGVFGQVHMVRDKKTKGIFALKLIDKQMIKE-KEMET-----QLQRELNIHS---------------QYSNHENVLECLGYFEDEKYYYLLL
...|| .||| ||.|.....||.| ..|.| . |..|.  | ...     . . |.|...               . ..|.... .. .|.|... |. .
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

EYASDGTCASLIENLPL---------------RRLTEQQSC-----NIVKQILESVNYLHKNK-IIHRDLKLENVLISNG----KVKLCDFGCATFCDNP
||. .|.    |.. .                ...||||..     .. .|||.  .|||... |||||.|.||.|..|.    ..|..||| . . ...
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

--------------PYQRRRSFCGTLDYV----SPEMIQDQIYD----KEIDIWAIGVITFELCSGFAPFTQFNDQQ----------------TYSAIQN
              ..|.  .||||. |     .||..| | ||    ...|||. ||| .|.. |  || . |. |                 |. |..
NNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQ

----VKHAWP----KCFSEELKDFIQ----KIFVVDPTQRATASQLLYHDWI
    ......    |  |.| ||||.    |.....| .| |..|.| | |.
KNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 26118.AA STE 1053-1308 24 8.9e-72 244.77 In-house 1-359 (359) Show / Hide 
Range on Protein: 1053-1308
Range on HMM: 1-359/359
Sequence Identity: 24% (88 aa)

FEFIKLLGQGVFGQVHMVRDKK---------------TKGIFALKLID----KQMIKE-----------KEMETQLQRELNIHSQYSN-HENVLECLGYF
.|.|. .|.| ||.|.  ...|               |. |.| | ..    .... |           .| . |...|..|...... |.|. ...|..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

EDE-------KYYYLLLEYASDGTCASLIEN--LPLRRLT----------EQQSCNIVKQILES-VNYLHKNKIIHRDLKLENVLISNGKVKLCDFGCAT
..|        . .. .|| . |.. ..|..   ....|.          |.| . |..|||.   .|||...|||||.|  |.|.    |||||||...
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----VKLCDFGVCG

FCDN--------------PPYQ-RRRSFCGTLDYVSPEMIQDQI------YDKEIDIWAIGVITFELCSGFAPFTQ-FNDQQTYSAIQNVKHAW------
  ..                 | .| .|.||  . .||.|| .       ||   ||| .|    |.. |  |.    . .  . ...| . ..      
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---------PKC-------------------FSEELKDFIQKIFVVDPTQRATASQLLY--HDWI
         |                     .|.|.||||.| .. || .|.||||||   | .|
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 26118.AA MARK 1053-1308 31 4.3e-71 231.66 In-house 1-262 (262) Show / Hide 
Range on Protein: 1053-1308
Range on HMM: 1-262/262
Sequence Identity: 31% (85 aa)

FEFIKLLGQGVFGQVHMVRDKKTKGIFALKLIDKQMIKE-KEMETQLQRELNIHSQYSNHENVLECLGYFE--DEKY-YYLLLEYASDGTCASLIENLPL
....| .|.| ...|  ...|.|.  .|.| ..|. . . ..|.  ..||..|...  .|.|. ... ..|  .|.   || .|||| |   . |.. | 
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKN-VMREIEIMKKL-DHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPN

RRLTEQQSCNIVKQILESVNYLHKNKIIHRDLKLENVLI-SNG--KVKLCDFGCATFCDNPPYQRRRSFCGTLDYVSPEMIQDQIYD-KEIDIWAIGVIT
.||.|     | .||.. |||.|.. |.|||.|.||.|| .||  ..|..||| .. .  || |.  .||||. | .||... . || ...|||. ||. 
GRLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICI--PPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVL

FELCSGFAPFTQFN--DQQTYSAIQNVKHAWPKCFSEELKDFIQKIFVVDPTQRATASQLLYHDWI
. . .|  ||   .  . . |  |.. |   |   | |....||....|.| .|.|..... | |.
YFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase 26118.AA CAMK-Unique 1053-1308 23 2.3e-69 228.06 In-house 1-363 (363) Show / Hide 
Range on Protein: 1053-1308
Range on HMM: 1-363/363
Sequence Identity: 23% (86 aa)

FEFIKLLGQGVFGQVHMVRDKKTKGIFALKLIDKQMIKEKEMETQ-----------------LQRELNIHSQYSNHENVLECLGY----FEDEK------
 ......|.| || |  . |..|. ..| |.. ||  ..| . .|                 | ||..|  .  .|.| .. ...    |.|.|      
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIW-KMVDHPNIIKLYDWNNPIFCDRKYPLCDL

---------YYYLLLEYASDGTCASLIENL------------------PLRRLTE--QQSCNIVKQILESVNYLHKNKIIHRDLKLENVLISNG------
         |.|...||. .|.  ..|  .                    ....|   ..|.|. ..|. |.|.|...|.||||||||.....       
IIKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNH

-----------KVKLCDFGCATFCDNPPYQR-RRSFCGTLDYVSP--------------EMIQDQIYDKEI----DIWAIGVITFELCSGFAPFTQFNDQ
           ..|||||| ..  ..        ..|||..|..|              |.|  | ||       |||..|||.... .|  ||.  .. 
HRDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECED

--------QTYSAIQNVKH------AWPKC--FSEELKDFIQKIFVVDPTQRATASQLLYHDWI
         ....|   .       .|      |.|.|||... ..||| .| .|..|| |.||
RDYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase 26118.AA ULK 1053-1308 28 7.3e-64 218.49 In-house 1-329 (329) Show / Hide 
Range on Protein: 1053-1308
Range on HMM: 1-329/329
Sequence Identity: 28% (93 aa)

FEFIKLLGQGVFGQVHMVRDKKTK----GIFALKLIDKQ-MIKEKEMET------QLQRELNIHSQYS---NHEN----VLECLGYFEDE--KYYYLLLE
.. .. ||.| ||.|.  |.||||     ..| | |||| |.... . .      .|..|  |  .     .|.|    . . . .||.   ...|. .|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YASDGTCASLIENLPL--------RRLTEQQSCNIVKQILESVNYLHKNKIIHRDLKLENVLISNGK-------------VKLCDFGCATFCDNP--PYQ
|  .|.  ..|..           .||.||.  .. ||||.   .|||..|||||.|..|.||.||.             .|..||| | ..||.    |
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

RRRSFC------GTLDYVSPEMIQDQ-----IYDKEIDIWAIGVITFELCSGFAPF--TQFNDQQTYSAIQNVKH-------------AWPKC-----FS
   ..       ||  | .|. .|.|      ||.. ||| .|.| .|.  |  ||    ||||. .  .....               .||      .|
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

EELKDFIQKIFVVDPTQRATASQLLYHDWI
.|.||.|.. ...|...| .  .|. | |.
PECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 26118.AA TyrKc 1053-1308 20 5.4e-16 35.87 SMART 1-280 (280) Show / Hide 
Range on Protein: 1053-1308
Range on HMM: 1-280/280
Sequence Identity: 20% (59 aa)

FEFIKLLGQGVFGQVHMVRDKKTKGIFALKLID---KQMIKEKEMETQLQRELNIHSQY-SNHENVLECLGYFEDE-------KYYYLLLEYASDGTCAS
 ...| || | ||.|.  . |          |.   | . ...  .  . ||..| ...  .|.|.. ..|.  ..       . .....||.. | . .
ITLGKKLGEGAFGEVYKGTWK----------IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

LIENLPLRRLTEQQSCNIVKQILESVNYLHKNKIIHRDLKLENVLISNGK-VKLCDFGCATFCDNP-------PYQR-----RRSFCGTLDYVSPEMIQD
 . .   . |. .. ...  || .  .|||....|||||   |.|..... || .||| . . ..         | |      . .   .   .|| |..
YLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY

QIYDKEIDIWAIGVITFELCS-GFAPFTQ-----FNDQQTYSAIQNV--KHAWPK-------CFSEELKDFIQKIFVVDPTQRATASQLLYHDWI
 ..  . |.|. ||  .|... |  |         ..|. .  ...       |        | ..|. . ...    || .| | |..  |. .
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 26118.AA Pkinase_Tyr 1053-1198 28 8.2e-13 44.01 Pfam 1-156 (270) Show / Hide 
Range on Protein: 1053-1198
Range on HMM: 1-156/270
Sequence Identity: 28% (45 aa)

FEFIKLLGQGVFGQVHMVRDK----KTKGIFALKLIDKQMIKEKE-METQLQRELNIHSQYSNHENVLECLGYFE-DEKY--YYLLLEYASDGTCASLIE
 .|.| ||.| ||.|.. . |    .||   | | . |.   ... .   . ||..| .|. .|.|.. ..|    ...   .|. .||.  |   .   
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

NL--PLRRLTEQQSCNIVKQILESVNYLHKNKIIHRDLKLENVLIS-NGKVKLCDFG
.   . ..|| .. ...  || .  .||. ...|||||   |.|.. |..|| ||||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFG