Gene 1609 (Tetrahymena)
1609
Group:
Other
Family:
Ciliate-A3
Sequence
Protein domains of 1609.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 1609.AA | Ciliate-A3 | 120-253 | 65 | 1.6e-68 | 232.09 | In-house | 101-237 (237) | Show / Hide |
Range on Protein: 120-253 Range on HMM: 101-237/237 Sequence Identity: 65% (90 aa) RDLKPQNILIQNDGKKIIAKISDQGLTKEVQCDLKSLIRTPNYMAPEILSAKKKGSVYDNKIDVWSFGLILYKMFTCKQIFKGDQKQILNSL--KKKLLI |||||.||||.|||.||||||||.||||||||||||..|||||||||||||||||||||.||||||||||||.|||||||||||||||.| | .. . RDLKPENILIHNDGEKIIAKISDYGLTKEVQCDLKSIVRTPNYMAPEILSAKKKGSVYDDKIDVWSFGLILYEMFTCKQIFKGDQKQIFNQLIHYNNKID KYGYIHGAYDVDQSIYKCIVLGDRKKQLEEQIDI-LI . . . || . . .|.. .|. .||. || QLLFQERFQDVSKLVIRCLQKDPKKRPDFKQIQTELI |
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| Kinase | 1609.AA | Ciliate-A3 | 16-101 | 61 | 3.1e-31 | 103.05 | In-house | 1-62 (237) | Show / Hide |
Range on Protein: 16-101 Range on HMM: 1-62/237 Sequence Identity: 61% (53 aa) NRNLQIQGGQASIYFAIDLKNYQQVVIKEYFKDSSFQVDYAVLKKIQDKYSENLEYLVKIYDQSSENEKMKFIVIEYCNQGDLYKY |.| ||||| .||||| |||||||||||||| ||||||||||.||||||||||||.|||| | NKNTIIQGGQ------------------------AFQVDYEVLKKIQDKYSENLENLVKIYDQSSEKEKMKFIVIEYCNEGDLYTY |
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| Kinase | 1609.AA | Ciliate-B1 | 120-206 | 41 | 1.3e-21 | 72.48 | In-house | 142-237 (290) | Show / Hide |
Range on Protein: 120-206 Range on HMM: 142-237/290 Sequence Identity: 41% (41 aa) RDLKPQNILIQND---------GKKIIAKISDQGLTKEVQC-DLKSLIRTPNYMAPEILS-AKKKGSVYDNKIDVWSFGLILYKMFTCKQIFK--GDQKQ ||||| |||| . .. | || | |. | | ...|.. |.||||||||. . ||.|.| ||||.|.| .| .| | |. | RDLKPENILIHKKNVPIYYNKQQNHYIFKITDFGISKMQQEYMMQSCVGTINYMAPEILNFNQQ----YDKKVDIWSFGCIMYEIITNEQLFCSLGNTQQ |
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| Kinase | 1609.AA | TKL | 120-201 | 23 | 3.1e-21 | 73.21 | In-house | 164-290 (364) | Show / Hide |
Range on Protein: 120-201 Range on HMM: 164-290/364 Sequence Identity: 23% (30 aa) RDLKPQNILIQNDGK-----------KIIAKISDQGLTKEVQCD---------------------LKSLIR-TPNYMAPEILSAKK------------KG ||||..|||. .... . .||.| || .... . .. .. ||..||||.| . || RDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKG SVYDNKIDVWSFGLILYKMFTCKQIFK . |. |.||.|||..|. ..|... .. FEYSEKCDVYSFGIVLWEILTRCRPYY |
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| Kinase | 1609.AA | Ciliate-E2a | 120-213 | 39 | 1.4e-20 | 57.28 | In-house | 126-230 (275) | Show / Hide |
Range on Protein: 120-213 Range on HMM: 126-230/275 Sequence Identity: 39% (41 aa) RDLKPQNILIQ-NDGKKI---IAKISDQGLTKEVQCD----LKSLIRTPNYMAPEILSAKK--KGSVYDNKIDVWSFGLILYKMFTCKQIFKG-DQKQIL |||||.|||. .. ..| ||.| || . .. | ... || |.|||.| | |. || | |.|| |.|.| . . |. ||| . ..|| RDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQKCGTPGYVAPEVLNNKEVLKHKQYDTKCDMWSCGVIFYILLCGKPPFKGKTYNEIL NSLKK . || QQNKK |
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| Kinase | 1609.AA | Ciliate-E2 | 120-209 | 32 | 9.8e-20 | 64.4 | In-house | 185-302 (365) | Show / Hide |
Range on Protein: 120-209 Range on HMM: 185-302/365 Sequence Identity: 32% (42 aa) RDLKPQNILIQNDGKKIIAKISDQGLTKEVQ-----------CDLKSLIR------------------------TPNYMAPEILSAKK-----KGSVYDN ||.||.|||. ||.| || |... | .. . ||.|||||||. || |. || RDIKPENILF--------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDY KIDVWSFGLILYKMFTCKQIFKGDQKQILN |.|.||.| ||| | . | | |.||.. KCDIWSLGVILYEMLFGKPPF---QQQIKQ |
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| Kinase | 1609.AA | ULK | 120-214 | 33 | 2.7e-18 | 60.53 | In-house | 154-274 (329) | Show / Hide |
Range on Protein: 120-214
Range on HMM: 154-274/329
Sequence Identity: 33% (41 aa)
RDLKPQNILIQNDGKK---------IIAKISDQGLTKEVQCD------LKSLI------RTPNYMAPEILSAK-KKGSVYDNKIDVWSFGLILYKMFTCK
||.||||||| |. | ...||.| |. | |..| ... || ||||.||. . .. || | |.||.| |.| | . |
RDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGK
-----QIFKGDQKQILNSLKKK
. | ...||...|...
PPFYAW-FNDQYLQIIQKLINN
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| Kinase | 1609.AA | Ciliate-E2-Unclassified | 120-195 | 35 | 3.4e-18 | 59.72 | In-house | 168-265 (352) | Show / Hide |
Range on Protein: 120-195 Range on HMM: 168-265/352 Sequence Identity: 35% (36 aa) RDLKPQNILIQNDGKKIIAKISDQGLTKEVQCD------------------LKSLIRTPNYM----APEILSAKKKGSVYDNK----IDVWSFGLILYKM ||.||.|||..|.||. ||.| |. |. | . ... . ||||| |||.| .| ||.. .|.||.| ||| | RDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVL----QGQNYDHSKAYKCDIWSLGVILYEM FT . LF |
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| Kinase | 1609.AA | ULK | 120-219 | 30 | 1.2e-17 | 59.26 | In-house | 150-279 (324) | Show / Hide |
Range on Protein: 120-219 Range on HMM: 150-279/324 Sequence Identity: 30% (40 aa) RDLKPQNILIQNDGKK---------IIAKISDQGLTKEVQ------CDLKSLI------RTPNYMAPEILSAK-KKGSVYDNKIDVWSFGLILYKMFTCK ||.||||||| |. | ...||.| |. | |. ...... || ||||.||. . .. || | |.||.| |.| | . | RDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGK QIFKGDQKQILN----SLKK-----KLLIKY |... .. .. .|.. ...||. YPFFSW-FNDQYLYIQKLINNGKEQQIYIKN |
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| Kinase | 1609.AA | MLK | 120-207 | 31 | 2.5e-17 | 56.77 | In-house | 151-243 (291) | Show / Hide |
Range on Protein: 120-207 Range on HMM: 151-243/291 Sequence Identity: 31% (30 aa) RDLKPQNILIQN---DGKKIIAKISDQGLTKEVQCD---LKSLIRTPNYMAPEILSAKKKGSVYDNKIDVWSFGLILYKMFTCKQIFKGDQKQI ||||..|||| . | .. ..||.| |. ..... | . |. .||||... ..... |. | ||||.|..|. |.|.. .|...... RDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAWMAPEVIQ-QFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPM |
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| Kinase | 1609.AA | Pkinase | 120-209 | 36 | 1.2e-15 | 56.41 | Pfam | 132-228 (293) | Show / Hide |
Range on Protein: 120-209 Range on HMM: 132-228/293 Sequence Identity: 36% (38 aa) RDLKPQNILIQNDGKK---IIAKISDQGL-----TKEVQCDLKSLIRTPNYMAPEILSAKKKGSVYDNKIDVWSFGLILYKMFTCKQIFKGD-------Q |||||.|||| |.| . ||.| || . . .... ||.|||||.. .|. |. |.|.||.|.||| |.. . .|.|. | RDLKPENILIDNNGHIDACV--KICDFGLAKQFDY-NNS--MTTFCGTPWYMAPEVIR---GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQ KQILN .|... MQMIC |
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| Kinase | 1609.AA | RSK | 120-195 | 36 | 1.7e-15 | 53.44 | In-house | 128-207 (278) | Show / Hide |
Range on Protein: 120-195 Range on HMM: 128-207/278 Sequence Identity: 36% (30 aa) RDLKPQNILIQNDGKK-IIAKISDQGLTKEVQCD----LKSLIRTPNYMAPEILS-AKKKGSVYDNKIDVWSFGLILYKMFT ||||| ||| .. |..| |. |. || ... . | .|||||.| |. ... .| |.||.| ..| |.| RDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRAN-QQGGHDKACDWWSLGVLMYEMLT |
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| Kinase | 1609.AA | S_TKc | 16-267 | 20 | 3.4e-14 | 31.34 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 16-267 Range on HMM: 1-231/231 Sequence Identity: 20% (59 aa) NRNLQI--QGGQASIYFAIDLKNYQQVVIKEYFKDSSFQVDYAVLKKIQDKYSENLEYLVKIYDQSSENEKMKFIVIEYCNQ--GDLYKYCNLNYQRHDD . |.. .|. .. | ... | ..| ||. ... ..||| . ...||.|| . . ..| |||.. |||..| . . . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--EHIRREIQILKK-------HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR --IKRIKPGD-------------------RDLKPQNILIQNDGKKIIAKISDQGLTKEVQCDLKSLIRTPNYMAPEILSAKKKGSVYDN-KIDVWSFGLI . |||||.|||. . ||.| || ... .... ||.|||||.| |. |.|.||.| | FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL----TTFCGTPWYMAPEVL-------GYGKCKCDWWSCGCI LYKMFTCKQIFKGDQKQILNSLKKKLLIKYGYIHGAYDVDQSIYKCIVLGDRKKQLEEQIDILIDLLEDNPQ-------MQ-------NNLV || |.. . | ....... .. .| .|.. .|. .|. .| . LYEMLCGYPPFP-QMQMMFKKIG--------------------------------SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF |
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| TyrKc | 1609.AA | TyrKc | 15-249 | 18 | 4.2e-07 | -107.81 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 15-249 Range on HMM: 1-280/280 Sequence Identity: 18% (57 aa) QNRNLQIQGGQ-ASIYFAIDLKNYQQVVIKEYFKDSSFQVDYAVLKKIQDKYSE-----NL----EYLVKIYDQSSENE------KMKFIVIEYCNQGDL . .. |. .| .. .|| .| .|. ..| ..| .| . .|..| .. . . .|| ||. ||| ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDL YKYCNLNYQRHDDIKRIKPGD----------------------RDLKPQNILIQNDGKKIIAKISDQGLTKEVQCD-----LKSLIRT-----PN----- .| | . |.. ... | ||| |.|. ... ..|||| ||.... | |. .|. . KDY--LRKHRPK----LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPI -YMAPEILSAKKKGSVYDNKIDVWSFGLILYKMFT-CKQIFKG------DQKQILNSLKKK-LLIKYGY------IHGAYDVDQSIYKCIVL--GDR--K |||| . . ... | |||||| .. .|| ..| | . ..... .|. . . . . .. | . .| || RWMAPECI----NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTF KQLEEQI ... |.. SEIHECF |
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| Kinase | 1609.AA | Ciliate-E2 | 22-107 | 19 | 0.000286 | 10.54 | In-house | 9-130 (365) | Show / Hide |
Range on Protein: 22-107 Range on HMM: 9-130/365 Sequence Identity: 19% (24 aa) QGGQASIYFAIDLKNYQQVVIK------------EYFKDSSFQVDYAVLKKIQDKYSENLEY-----------------------LVKIYDQSSE-NEKM ||...|.| . . |. .|. || |..| . . . . ..|. . .|. .. ..|.|. | ... QGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNN KFIVIEYCNQGDLYKYCNLNYQ ..| |||..|||..|.. |.. IYLVMEYCQGGDLFDYIKNNKK |
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| Kinase | 1609.AA | Ciliate-B1 | 57-107 | 27 | 0.000499 | 10.13 | In-house | 56-113 (290) | Show / Hide |
Range on Protein: 57-107 Range on HMM: 56-113/290 Sequence Identity: 27% (16 aa) VLKKIQDKYSEN--------LEYLVKIYDQSSENEKMKFIVIEYCNQGDLYKYCNLNYQ .......| .| .. . ||| ... ..|. |||.||||| | . ..| IIQCLIKKMNNNKISCQSSPCDHICNIYDVIQCQQQ-YYIIMEYCEQGDLYNYIYNCHQ |
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| Kinase | 1609.AA | ULK | 22-101 | 21 | 0.009918 | 5.46 | In-house | 9-110 (329) | Show / Hide |
Range on Protein: 22-101 Range on HMM: 9-110/329 Sequence Identity: 21% (22 aa) QGGQASIYFAIDLKN----YQQVVIKEYF---KDSSFQVDY------------AVLKKIQDK-YSEN-LEYLVKIYD-QSSENEKMKFIVIEYCNQGDLY .| . | ... |. ..|..| .. . . .. ..||. .. ..| .. || || . . |.. .|. ||||.||| KGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIMEYCNGGDLE KY .| QY |
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