18266

Species: Tetrahymena
Alias: 3742.m00017, PreTt18266, TTHERM_00755890, 1072, 123.m00085, 18266
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-A4

Sequence

Name Sequence Type Origin Length Description Download
18266.AA Protein None 914 None Fasta, JSON
18266.kin_dom Protein Kinase Domain None 145 None Fasta, JSON
18266.NA RNA None 2745 None Fasta, JSON

Protein domain

Protein domains of 18266.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 18266.AA Ciliate-A4 470-585 51 5.1e-78 254.06 In-house 140-255 (284) Show / Hide
Range on Protein: 470-585
Range on HMM: 140-255/284
Sequence Identity: 51% (60 aa)

PIAVKKLKTIEEFARELYLMETLQSIYMPQLFFYDETQKKLFMEMGLCSLEDLKKYSEQTDFCLTDQQTFSILNQLLVAIELFIDQKAFHSDIKPSNIVI
|.|.||.||.|||.||||.|.|.|..|||.||.||..|..||||||||||.|||..|||...|..|..|.|||..|..|||.....||............
PVACKKIKTQEEFIRELYIMQTVQCEYMPKLFYYDIDQQILFMEMGLCSLYDLKQDSEQNNYCFSDEFTYSILINLIQAIESMLSNKAYNQQEQKHQPLF

RSKLNESNKIQLQLMI
.|.....||||||.|.
HSDIKPQNKIQLQIML

Kinase 18266.AA Ciliate-E2-Unclassified 445-597 17 1e-15 51.02 In-house 1-200 (352) Show / Hide
Range on Protein: 445-597
Range on HMM: 1-200/352
Sequence Identity: 17% (35 aa)

FRYITSIGEGSFGTVDLYEFTPLKFPIAVKKLKTIEEFARELY------------------------------LMETLQSIYMPQLFFYDETQKKLFMEM
.. |  ||.|.||.| . .    |.  | | .| | .... ..                              ..  .....   .|........... |
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

GLCSLEDLKKYSEQTDF----------------CLTDQQTF-----SILNQLLVAIELFIDQK-AFHSDIKPSNIVIRSKLNESNKIQLQLMIIDYGGAS
 .|   ||..| ..  .                ..|.||.       .. |.|...|  . ..   | ||||.||.. .. .      ... |||.| ..
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK-----NYYIKIIDFGISK

FDIED
. ...
KYQQN

Kinase 18266.AA Ciliate-A4 445-466 77 1.5e-14 43.59 In-house 36-57 (284) Show / Hide
Range on Protein: 445-466
Range on HMM: 36-57/284
Sequence Identity: 77% (17 aa)

FRYITSIGEGSFGTVDLYEFTP
|.|.||||||||||||||.|..
FYYYTSIGEGSFGTVDLYFFEI

Kinase 18266.AA Ciliate-E2 445-609 15 1.4e-13 43.02 In-house 1-256 (365) Show / Hide
Range on Protein: 445-609
Range on HMM: 1-256/365
Sequence Identity: 15% (42 aa)

FRYITSIGEGSFG-----TVDLY--------------------EFTPLKFPIAVKKLKTIEEFARELYLM----------------ETLQSIYMPQLF--
.  |  ||.|.||     .|..                     ...  .. . ..| . ||.. .|...|                |.|.. .  ...  
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FYDETQKKLFMEMGLCSLEDLKKYSEQTDFC----------LTDQQTFSILNQLLV---------------AIELFIDQK-AFHSDIKPSNIVIRSKLNE
|.......... | .|.  ||..| .. . .          .|...   |  |.|                |.|    ..  .| ||||.||..      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

SNKIQLQLMIIDYGGASFDIEDYW-----------------------------------IYYTPAFVCP
       . ||| | . .  .|.                                    |..|| ...|
-------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAP

Kinase 18266.AA S_TKc 445-741 12 4.5e-09 -43.79 SMART 1-231 (231) Show / Hide
Range on Protein: 445-741
Range on HMM: 1-231/231
Sequence Identity: 12% (42 aa)

FRYITSIGEGSFGTVDLYEFTPLKFPIAVKKLKTIEEFARELYLMETLQSIYMPQLFFYDETQKKLFMEMGLCSL--EDLKKYSEQTDF-----CLTDQQ
.. .  ||.|.||.| .   .  .   |.|..|  | . ||. ...  .  .  .|. . .. ..|.| | .|.    ||..| ..         ..  .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-H

TFSILNQLLVAIELFIDQKAFHSDIKPSNIVIRSKLNESNKIQLQLMIIDYGGASFDIEDYWIYYTPAFVCPKLWEKLLSSDSC----------------
. ... |.. |.|   ...  | |.||.|| . .          ...|.| | | .    . .  || .. | .      . ..                
ARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----------HIKICDFGLARQL---TTFCGTPWYMAPEVL-----GYGKCKCDWWSCGCILYEML

-----FSKDISKEKSAYIQELDSIEENYEQECDTNNIEKSKLENSTNLGEIDRRQSMENSLTLKTNNSNDKSTLASKTSQNFPSYQQQDSIQMLTDQKQP
     |.     .  . .. .                                                                          . |. 
CGYPPFP-----QMQMMFKKIG-----------------------------------------------------------------------SPEAKDF

ISRVFNDN----LSSYQKSQNF--DKKSKIF
|.. .. .    ..  .  |.    |.   |
IRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase 18266.AA Ciliate-C4 540-589 34 6.7e-07 17.77 In-house 144-194 (361) Show / Hide
Range on Protein: 540-589
Range on HMM: 144-194/361
Sequence Identity: 34% (18 aa)

SILNQLLVAIELFIDQKAFHSDIKPSNIVIRSK--LNESNKIQLQLMIIDYG
..  ..  |. .  ..|  |.||||.||.. .|   . || || |. .||.|
KFIQHICHALWHLHQNKWVHCDIKPENILVKYKSDFGGSNNIQ-QVKLIDFG

Kinase 18266.AA STE 445-581 15 7e-06 16.81 In-house 1-188 (359) Show / Hide
Range on Protein: 445-581
Range on HMM: 1-188/359
Sequence Identity: 15% (30 aa)

FRYITSIGEGSFG-TVDLYEFT-----PLKFP---------IAVKKLK----------------------TIEEFARELYLMETLQ--SIYMPQLF--FY
.. |  ||.|.|| ..  .        . ..          .|.|...                       .... .|. .|  ..  . .  . .  ..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DE-------TQKKLFMEMGLC-SLEDLKKYSEQTDFCLT----------DQQTFSILNQLLVA-IELFIDQKAFHSDIKPSNIVIRSKLNESNKIQL
.|       ..  ..||     ||.|. |    . . |.           .|   |. |.| .  ..  ...  | ||||.|| .         . |
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL---------VKL

Kinase 18266.AA urch 451-474 45 7e-06 18.74 In-house 1-24 (217) Show / Hide
Range on Protein: 451-474
Range on HMM: 1-24/217
Sequence Identity: 45% (11 aa)

IGEGSFGTVDLYEFTPLKFPIAVK
|| |..|.| ||.... | |.|.|
IGRGTYGRVHLYRHRQTKQPVAIK

Kinase 18266.AA Ciliate-E3 502-569 29 8e-06 14.54 In-house 71-136 (202) Show / Hide
Range on Protein: 502-569
Range on HMM: 71-136/202
Sequence Identity: 29% (20 aa)

FYDETQKKLFMEMGLCSLEDLKKYSEQTDFCLTDQQTFSILNQLLVAIELFIDQKAFHSDIKPSNIVI
.||.  | .|  . .||  ||. |    .  .| . .  |  |..  .     ..  ||||||.|| .
YYDQQNKMIFIVQEYCSNGDLYHYIK--QQNKTQNIIYDICIQIIQGMIAIHEKNIIHSDIKPDNILV

Kinase 18266.AA Ciliate-A4 586-597 75 1.1e-05 14.2 In-house 273-284 (284) Show / Hide
Range on Protein: 586-597
Range on HMM: 273-284/284
Sequence Identity: 75% (9 aa)

IDYGGASFDIED
||.|||||..||
IDFGGASFQLED

Kinase 18266.AA SGK 445-459 53 1.6e-05 12.47 In-house 1-15 (283) Show / Hide
Range on Protein: 445-459
Range on HMM: 1-15/283
Sequence Identity: 53% (8 aa)

FRYITSIGEGSFGTV
|.... ||.|||| |
FDFLKVIGKGSFGKV

Kinase 18266.AA MELK 445-574 24 2.8e-05 13.63 In-house 1-135 (254) Show / Hide
Range on Protein: 445-574
Range on HMM: 1-135/254
Sequence Identity: 24% (33 aa)

FRYITSIGEGSFGTVDLYEFTPLKFPIAVKKL------KTIEEFARELYLMETLQSIYMPQLFFYDETQKKLFMEMGLCSLEDLKKYSEQTDFCLTDQQT
.     || | |. | |         .|.| .      . .     |.  .  |.   . ||. | ||..|.|| |  |.  ..  |  . |  | ...|
YEVHDEIGTGGFAKVKLACHILTNQMVAIKIMDKNQLGHDLPRVKTEMDALKNLRHQHICQLYHYIETEDKIFMVMEYCPGGEMFDYIIRQD-RLEEEET

FSILNQLLVAIELFIDQKAFHSDIKPSNIVIRSKLN
  .. |.. ||     |   | |.|| |...  ...
RHFFRQIVSAIAYVHSQGYAHRDLKPENLLFDEDHH

Kinase 18266.AA AGC 445-459 53 3.8e-05 7.68 In-house 1-15 (395) Show / Hide
Range on Protein: 445-459
Range on HMM: 1-15/395
Sequence Identity: 53% (8 aa)

FRYITSIGEGSFGTV
|. .. ||.||||.|
FEFLKVIGKGSFGKV

Kinase 18266.AA TyrKc 445-637 13 0.000144 -148.76 SMART 1-280 (280) Show / Hide
Range on Protein: 445-637
Range on HMM: 1-280/280
Sequence Identity: 13% (40 aa)

FRYITSIGEGSFGTVDLYEFTPLKFPIAVKKLK--TIEEFARELYLMETL--QSIYMPQLFFYDETQ-------KKLFMEMGLCSLEDLKKYSEQTD-FC
 . .  .||| ||.| . . .    . |||.||  ..|.| ||. .|  |  .     .|. .  .|       . |.. | .... |||.|   .    
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK-

LTDQQTFSILNQLLVAIELFIDQKAFHSDIKPSNIVIRSKL-----------NESNK--------IQL-----QLM------------------------
|. ..  |.  |     |   ...  | |.   |. . ...           .  ..                .                          
LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDV

--------------IIDYGG------ASFDIEDYWIYY---TPAFV--------CPKLWEKLLSSDSCFSKDISK--EKSAYIQEL
                 | |        ...  |        .           ||.   .. .  .|   | ..    |. ....
WSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMK--QCWHEDPEDRPTFSEIHECF