Gene 13181 (Tetrahymena)
13181
Group:
Other
Family:
Ciliate-A5
Sequence
Protein domains of 13181.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 13181.AA | Ciliate-A5 | 18-286 | 38 | 4.2e-144 | 485.03 | In-house | 3-275 (275) | Show / Hide |
Range on Protein: 18-286 Range on HMM: 3-275/275 Sequence Identity: 38% (104 aa) KHTKIFKVQHLQTGKIYALKEIEAKTLDKLNEYKEEAVQLSKVQNCNNVIKFHGYYFSETQYQTFRLGIITEFMDHNTNLEMIYRKRKKLGIQWKESELV . ||.|.||.|...|...|.|......|......|... ....|....|.||.....|...|........|..|.|...||..||.....|...|.||. GCMKIWKNQHQQEYYICKQKQIQDEDRQKHFQQYFEQRMQLQHPNIVKLIDFHTHKKEEFCSQFYKVNCYYEYHDNNLEQEMQMRKQCQKDIFYNEQELW TIMFSLISVCSLLQQKGICHRDIKPANIFIMENGEVKLIDFGESKDYFYDPEDESKNTYTMATIRGTPQYLSPILWKAHVVDG--NSRYVEHNIYKSDVF .||..|||||..|||..|||.||.|.||.....|.|||.|..||||.||.....|...|.........|||||..|....... |....|||.|||||| YIMDCLISVCMYLQQNNICHGDIRPQNICLTQDGQVKLMDMNESKDFFYQINWSSYKQYQHHMSTENKQYLSPMQWYQMMHRDEQNIQRPEHNWYKSDVF SSGLLIYQLAAIEEVTGFNN--KTPQTDGEQLIKQALIELEKKYSNQFVNIIALMLIFEESGRPSFVEIEQLF ..|............|.|.. .|.|....|||||.....|||||.||.|.|..||.|||..||.|..|.|.. CLGMICLEMCTMRDCTQFYYDYETFQIQNNQLIKQLIQMKEKKYSEQFINFIKQMLQFEENKRPDFHQIYQYL |
|||||||||
| Kinase | 13181.AA | STE | 7-190 | 21 | 2.6e-23 | 79.22 | In-house | 1-231 (359) | Show / Hide |
Range on Protein: 7-190 Range on HMM: 1-231/359 Sequence Identity: 21% (52 aa) FKKLDLLGSGKKHTKIFKVQHLQT--------------GKIYALKEIEAKTL-----------------DKLNEYKEEAVQLSKVQN-CNNVIKFHGYYF ..... .|.| | .. | .. |.|.| |... .. ........| ..| .. . |..|..|.|| WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF SET--QYQTFRLGIITEFMDHNTNLEMIYRKRKKLGIQWK----------ESELVTIMFSLISV-CSLLQQKGICHRDIKPANIFIMENGEVKLIDFGES | . . | |. |.|| . |. |...... | . . ||.. .| .... ..| ...| |||||||||.. |||.||| . KEGHNHKNDDELWICMEYMD-GGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVC KDYFY-----------DPEDESKNTYTMA----TIRGTPQYLSP . | . .||. |. ||| . .| GQLTDSMANIQSNNIID------CIETMQQKRNTFVGTP-WMAP |
|||||||||
| S_TKc | 13181.AA | S_TKc | 7-287 | 20 | 4.6e-23 | 83.87 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 7-287 Range on HMM: 1-231/231 Sequence Identity: 20% (59 aa) FKKLDLLGSGKKHTKIFKVQHLQTGKIYALKEIEAKTLDKLNEYKEEAVQLSKVQNCNNVIKFHGYYFSETQYQTFRLGIITEFMDHN-TNLEMIYRKRK ...|...|.| | .|..| ||.|.|.|.| . . | |.| .. |..|..... . .| ...|..|.. .| . .||. YEILRKIGKG-AFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK--HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRG K--LGIQWKESELVTIMFSLISVCSLLQQKGICHRDIKPANIFIMENGEVKLIDFGESKDYFYDPEDESKNTYTMATIRGTPQYLSPILWKAHVVDGNSR . |. . | . .| ... . ..||.|||.||.||.. | ..|..||| .. . |. ||| |..| . RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------------TTFCGTPWYMAPEVL---------- YVEHNIYKSDVFSSGLLIYQLAAIEEVTGFNNKTPQTDGEQLIKQALIELEKKYSNQFVNIIALMLIFEESGRPSFVEIEQ--------LFI .. |.|. | | ..| ... . . ....|. . | .. ..| .| .. . ||. |. | .. --GYGKCKCDWWSCGCILYEMLCGYPPFP--------QMQMMFKKIG-------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
|||||||||
| Kinase | 13181.AA | Ciliate-E2-Unclassified | 7-224 | 20 | 1.7e-22 | 74.83 | In-house | 1-263 (352) | Show / Hide |
Range on Protein: 7-224 Range on HMM: 1-263/352 Sequence Identity: 20% (55 aa) FKKLDLLGSGKKHTKIFKVQHLQTGKIYALKEIE-------AKTLDKLNEYKEEAVQLSKVQ----------------NCNNVIKFHGYYFSETQYQTFR .|.. .|.| . |..|.|| .....||.|.. . . | |.. |. .. . . |... .. . .| ... . YKIIKQIGQGG-FGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIY- LGIITEFMDHNTNLEMIYR------------KRKKLGIQWKESELV-----TIMFSLISVC-SLLQQKGICHRDIKPANIFIMENG---EVKLIDFGESK |..|...... ...| ...| . . | . . ... ... .| ....|.|||||| ||.. .|| ..|.|||| || --IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISK DYFYDPEDESKN---------TYTMATIRGTPQYL----SPILWKAHVVDGNSRYVEHNIYKSDVFSSGLLIYQL | ...... .| | |. |||.|. .| . . . |. . ||.|..| | ..|.. KYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA------YKCDIWSLGVILYEM |
|||||||||
| Kinase | 13181.AA | TKL | 13-286 | 14 | 4.2e-21 | 72.72 | In-house | 1-364 (364) | Show / Hide |
Range on Protein: 13-286
Range on HMM: 1-364/364
Sequence Identity: 14% (54 aa)
LGSGKKHTKIFKVQHLQ--------TGKIYALKEIE--------------------------AKTLDKLNEYKEEAVQLSKVQNCNNVIKFHGYYFSETQ
.||| ...| .. . ||| | | . .... .... .|| . . . .. |...| || .....
IGSGGFG-EVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPC
YQTFR--------LGIITEFMDHNT-NLEMIYRKRKKLGIQWKESELVTIMFSLISVCSLLQQ--------KGICHRDIKPANIFIMENGE---------
. |.|..|.... . .. . .. .. . . .. | . ..| |||.|..||.. ||..
GCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNP
-----VKLIDFGESKDYF--YDPEDESKNTY----------TMATIRGTPQYLSPILWKAHV----VDGNSRYVEHNI-------YKSDVFSSGLLIYQL
.|. ||| |.. . . .| .... | |..|||....| . . . |. . . |.||.| |.... .
NADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGI----DE-FCKGFEYSEKCDVYSFGIVLWEI
AAIEEVTGFNNKTPQTDG---EQLIKQALIEL-----------------EKKYSNQFVNIIALMLIFEESGRPSFVEIEQLF
.. ... .. |. . |. .... . .. .. ... . . |||| || . .
LTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
|
|||||||||
| Kinase | 13181.AA | Pkinase | 7-225 | 21 | 1.1e-20 | 74.27 | Pfam | 1-206 (293) | Show / Hide |
Range on Protein: 7-225 Range on HMM: 1-206/293 Sequence Identity: 21% (50 aa) FKKLDLLGSGKKHTKIFKVQHLQTGKIYALKEIEAKTLDKLNEYKE----EAVQLSKVQNCNNVIKFHGYYFSETQYQTFRLGIITEFMDHN----TNLE .... .||| . .| .| ||||.|.|.|. .. .. .. |. . .. |. |........ . . ...|.... . YHIGRKIGSG-SFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED----KDHIY-MVMEYCEGGLYVMDLFD MIY-RKRKKLGIQWKESELVTIMFSLISVCSLLQQKGICHRDIKPANIFIMENGEV----KLIDFGESKDYFYDPEDESKNTYTMATIRGTPQYLSPILW .| ...... . | |. .| ... . ..||.|||.||.||.| .||.. |..||| .| . | | |. ||| |..| . YISTWRHGCF-Y-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD------Y-NNS-MTTFCGTPWYMAPEVI KAHVVDGNSRYVEHNIYKSDVFSSGLLIYQLA . .. .|.|..| |...|... R---------GGQYYGPKVDMWSCGCILYEML |
|||||||||
| Kinase | 13181.AA | Ciliate-E4 | 94-157 | 35 | 3.3e-20 | 64.21 | In-house | 87-150 (150) | Show / Hide |
Range on Protein: 94-157 Range on HMM: 87-150/150 Sequence Identity: 35% (23 aa) NTNLEMIYRKRKKLGIQWKESELVTIMFSLISVCSLLQQKGICHRDIKPANIFIMENGEVKLID ...|. . .|. |. |||. .| |..|. . |||..| | |.|| |||. .. .||..| QKDLQQHIKQHKQQGQHFDESEIWQIAFCCINAMYYLQQVNITHGDLKPSNIFFDQYFMVKIAD |
|||||||||
| Kinase | 13181.AA | CAMK | 12-190 | 15 | 4.3e-20 | 60.79 | In-house | 1-289 (425) | Show / Hide |
Range on Protein: 12-190 Range on HMM: 1-289/425 Sequence Identity: 15% (44 aa) LLGSGKKHTKIFKVQHLQTG------------KIYALKEIEAKTLD----------------------------KLNEYKEEAVQLSKVQ------NCNN ||.| | ....| .|. . .| | |. | |. .. . . | ..|.| . | TLGRG-SFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPN VIKFHGYYFSETQ----YQTF-----------RLGIIT---EFMDHN----TNLEMIYRKRKKLG----------IQWKESELVTIMFSLISVCSLLQQK .||.. .| .... . . .. ... |... ...| ..... .|.| ... ..| . .. IIKLYEVYEDPHYFKNTND-YETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSH GICHRDIKPANIFIMEN-----------------GEVKLIDFGESKDYFYDPE----------------DESKNTYTMATIRGTPQYLS-P .|.|||.|| || . .| . .|.|||| .. .. . . .... . | | ||| | . | NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAP |
|||||||||
| Kinase | 13181.AA | Ciliate-E2 | 7-190 | 18 | 1.1e-19 | 64.22 | In-house | 1-256 (365) | Show / Hide |
Range on Protein: 7-190 Range on HMM: 1-256/365 Sequence Identity: 18% (49 aa) FKKLDLLGSGKKHTKIFKVQHLQTGKIY------------------ALKEIEAKTLDKLN-EYKEEAVQLSKVQN----------------CNNVIKFHG .|.. ..|.| . ...|... ...| . . |... |.. | . |... .. . | ..|.||.. YKFIKKIGQG-NFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE YYFSETQYQTFRLGIITEFMDHNTNLEMIYRKRKKLGIQWK------ESELVTIMFSLIS---------------VCSLLQQKG-ICHRDIKPANIFIME .. .... . ...|. .... .. |. ..|| . . . | | .|| ... | .|. |.|||||| ||.. CFQEKDDNNIY---LVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-- NGEVKLIDFGESK----------------DYFYDPEDESKNTY---------TMATIRGTPQYLSP .|.|||| || | . |.|. . . || ||| |..| ---IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAP |
|||||||||
| Kinase | 13181.AA | Ciliate-E2b | 130-190 | 40 | 1.9e-16 | 46.65 | In-house | 118-174 (272) | Show / Hide |
Range on Protein: 130-190 Range on HMM: 118-174/272 Sequence Identity: 40% (25 aa) LQQKGICHRDIKPANIFIMENGEVKLIDFGESKDYFYDPEDESKNTYTMATIRGTPQYLSP |....| .||||| || . ..| .||||.| .| ..|. .. |. ||.||| |. | LHNQNIIYRDIKPENIMVDHKGYMKLIDMGTAK-HMYKKNEQMTRTF---TIIGTPHYMAP |
|||||||||
| Kinase | 13181.AA | Ciliate-E2c | 129-190 | 46 | 8.6e-14 | 44.79 | In-house | 130-187 (310) | Show / Hide |
Range on Protein: 129-190 Range on HMM: 130-187/310 Sequence Identity: 46% (29 aa) LLQQKGICHRDIKPANIFIMENGEVKLIDFGESKDYFYDPEDESKNTYTMATIRGTPQYLSP | ..|.| ||||||.||.| ||..|. ||| || .|. .||. |. |||.| .| LHKEKNIFHRDIKPENILI-HNGMIKIADFGFSKICQ---DDNIQNTQGFNTCCGTPMYMAP |
|||||||||
| Kinase | 13181.AA | CDK | 130-159 | 45 | 2.2e-12 | 35.74 | In-house | 124-158 (284) | Show / Hide |
Range on Protein: 130-159 Range on HMM: 124-158/284 Sequence Identity: 45% (16 aa) LQQKGICHRDIKPANIFIMENGE-----VKLIDFG . ...| |||.||.|| |..||| .|. ||| CHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFG |
|||||||||
| Kinase | 13181.AA | TyrKc | 7-286 | 19 | 5.1e-07 | -109.11 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 7-286
Range on HMM: 1-280/280
Sequence Identity: 19% (60 aa)
FKKLDLLGSGKKHTKIFKVQHLQTGKIYALKEIEAKTLDKLNEYKEEAVQLSKV-QNCNNVIKFHGYYFSETQYQTF----RLGIITEFMDHNTNLEMIY
.... ||.| ...| . | | . . . . . .|| ..|. . |.....|. .. | | |..|.|.| .|
ITLGKKLGEG-AFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN--FMYIEPLMIVMEYMPH-GDLKDYL
RKRKKLGIQWKESELVTIMFSLISVCSLLQQKGICHRDIKPANIFIMENGEVKLIDFGESKDYFYD-PEDESKNTYTMATIRGTPQYLSPILWKAH-VVD
||... . ..|. ... . .. | .|.. |||. |. . ||. || ||| |.| | . ||| .|.... .. .. || | | .
RKHRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKE-HKGGKTMLPIRWMAPECI-
GNSRYVEHNIY--KSDVFSSGLLIYQLAAIEEVTGFNN----KTPQTDGEQLIKQALIELEKK--------YSNQFVNIIALMLIFEESGRPSFVEIEQL
.... ||||.| | ... . . . ...| |.. . . . . .|. .. . ||.| || ..
------NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHEC
F
|
F
|
|||||||||
| Kinase | 13181.AA | CDK | 7-39 | 34 | 0.000117 | 10.65 | In-house | 1-37 (284) | Show / Hide |
Range on Protein: 7-39 Range on HMM: 1-37/284 Sequence Identity: 34% (13 aa) FKKLDLLGSGKKHTKIFKVQHLQTG-----KIYALKEI ..||. .| | . . .| ...||| .|.|||.| YEKLEKIGEG-TYGVVYKARDKQTGRKKTGQIVALKKI |
|||||||||
| Kinase | 13181.AA | Ciliate-E2 | 210-282 | 19 | 0.288278 | 0.08 | In-house | 275-359 (365) | Show / Hide |
Range on Protein: 210-282 Range on HMM: 275-359/365 Sequence Identity: 19% (19 aa) YKSDVFSSGLLIYQLAAIEEVTGFNNKTPQTDGEQLIKQALIELE------------------KKYSNQFVNIIAL----MLIFEESGRPS-FVEI ||.|..| | ..|.. . .| ||| |.. || |.. ..| || ... |.. . .| YKCDIWSLGVILYEMLFGKPPF-----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQI |
|||||||||
| Kelch | 13181.AA | Kelch | 482-530 | 27 | 2.5e-10 | 41.53 | SMART | 1-55 (55) | Show / Hide |
Range on Protein: 482-530 Range on HMM: 1-55/55 Sequence Identity: 27% (15 aa) RVYTFGGYDSNL------KVQLSSCECYNIQAEKWQSIGDLIIPRSQSAGCRIND ..| .||.. | .. |.| |||. .||... .. ||. .. | .|. CIYVIGGWNGNHCCEPGEMQCLNSVECYDPETNKWRMCPPMPYPRCYHGVCVHNG |
|||||||||
| Kelch_1 | 13181.AA | Kelch_1 | 470-517 | 20 | 1.8e-07 | 30.52 | Pfam | 1-45 (45) | Show / Hide |
Range on Protein: 470-517 Range on HMM: 1-45/45 Sequence Identity: 20% (10 aa) IKNFFPAVYYSHRVYTFGGYDSNLKVQLSSCECYNIQAEKWQSIGDLI .. .... ..| .||.|. |.|.|||. .|. . .. PRCGHGVCVHNGKIYVIGGCDG---QYLNSVECYDPETNQWTRCPPMP |
|||||||||
| Kelch | 13181.AA | Kelch | 532-580 | 25 | 0.000556 | 17.11 | SMART | 1-55 (55) | Show / Hide |
Range on Protein: 532-580 Range on HMM: 1-55/55 Sequence Identity: 25% (14 aa) EILIFGGYNK-------EKGTLDSIERYLINENKFEVTNIKLPIPLRRFMVVRVSN | ..||.| |. .|.|.|.| .||... . ..| | .. |. . . CIYVIGGWNGNHCCEPGEMQCLNSVECYDPETNKWRMCP-PMPYPRCYHGVCVHNG |
|||||||||
| Kelch_1 | 13181.AA | Kelch_1 | 520-560 | 21 | 0.007699 | 13.95 | Pfam | 1-39 (45) | Show / Hide |
Range on Protein: 520-560 Range on HMM: 1-39/45 Sequence Identity: 21% (9 aa) RSQSAGCRINDNEILIFGGYNKEKGTLDSIERYLINENKFE . ..|. ...| ..||.. |.|.|.| .|. . PRCGHGVCVHNGKIYVIGGCDG--QYLNSVECYDPETNQWT |
|||||||||
| Kelch_1 | 13181.AA | Kelch_1 | 570-616 | 14 | 10.705448 | 2.68 | Pfam | 1-45 (45) | Show / Hide |
Range on Protein: 570-616 Range on HMM: 1-45/45 Sequence Identity: 14% (7 aa) LRRFMVVRVSNNNALILGGLTKFSKESQKVFKLEYDKKEIIELESLE |... | | |. . || . . .|... .... .. .. PRCGHGVCVHNGKIYVIGGCDG--QYLNSVECYDPETNQWTRCPPMP |
|||||||||