Gene 24780 (Tetrahymena)

24780

Species: Tetrahymena
Alias: 77, PreTt24780, TTHERM_00384880, 24780, 41.m00187
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: CAMKK
Subfamily: CAMKK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
24780.AA Protein None 2113 None Fasta, JSON
24780.kin_dom Protein Kinase Domain None 282 None Fasta, JSON
24780.NA RNA None 6342 None Fasta, JSON

Protein domain

Protein domains of 24780.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 24780.AA CAMKK-Unclassified 1755-2036 31 9.3e-168 550.93 In-house 1-392 (392) Show / Hide 
Range on Protein: 1755-2036
Range on HMM: 1-392/392
Sequence Identity: 31% (126 aa)

YIILKNIGHGAFGKVKQVFDTNT-----KKHFAVKIINRDKLMKKKLDRNKSAFSLIEK--------EIAICKKMAHPNIVKLYEYIDDQDEAKIYM--I
|..|...|.|.|||||......|     .|.||.|.....||.|||...|..||....|        ||||.||..||||.||||.|||.|..||||  .
YEFLDKLGRGSFGKVKLATRRYTTDDGVQKQFAIKVFKKQKLKKKKFIYNDNAFTMKMKNRLHLVQQEIAIMKKLWHPNICKLYEVIDDPDNDKIYMGQV

MDLLKKGSINSKSYWKTEKG----------------KEYKETEKYN----------------------------MSEQKLKKYFRDFLLGLDYLHNFVN-
|.....|.|.|..|||....                | ......|.                            |.||.||||||....||.|.|||.. 
MEYCQMGQIMSWDYWKQDYQPNDGEIEYFFQTQTEYKPDQFCCQYYNQNGKLHNRQNQKICLFSNQILEMKPYKMHEQYLKKYFRQCCKGLQYMHNFNQA

-------------------VVHRDIKPDNLLIGDEDQ-----LKIADFGVSQMFEGEKDE-LNNDNGTKCYLAPEAFTSNGFNGRPLD------------
                   ..||||||.|.||..||.     .||||||.|...|.|... |.|..||.|..|||......|.....|            
CSYIIIYINEFDKIDHFQDIIHRDIKPQNILIDHEDNDKGEHFKIADFGISVIMEHEQQKKLKNNAGTYCFMAPEFWSKENFKYDYNDYSFLPGTFNPLR

---------------IWAAGVSLYEIFTGSRPFNGRTLEVLKKNYMQILQIIQKFRPNYPSNMSPEFVSMLQKCLNKDPKKRADVQALIVDDWV
               ||..||..|.....|.||....|..|..  ..|.|....|.|.|....|.||....||...|.||||.......|..|.
KTYRIERICFYKKADIWSLGVTFYCMVYHSLPFWHKNLQELFH--QMICQKEINFPPQYHPHCSHEFKDLIQKMCDKNPKKRITIDQMLVHPWF
Kinase 24780.AA CAMKK 1755-2036 32 1.6e-161 516.74 In-house 1-396 (396) Show / Hide 
Range on Protein: 1755-2036
Range on HMM: 1-396/396
Sequence Identity: 32% (128 aa)

YIILKNIGHGAFGKVKQVFDTNT-KKHFAVKIINR----DKLMKKKLDR-----------------NKSAFSLIEKEIAICKKMAHPNIVKLYEYIDDQD
| ..|.||.|.|||||....... .||.|.||.|.    .||.||.  .                 ....|.....||||.||. |||||||||.|||..
YELMKEIGQGQFGKVKLAYNEYDTQKHYAIKIFNKKYVFKKLKKKQQFYRDPPKRMTNMNQNGEMQMMNPFDCVYQEIAIMKKCNHPNIVKLYEVIDDPQ

EAKIYMI-MDLLKKGSINSKSYWKTEKGKE--YKETEKYN-----------MSEQK---------------------LKKYFRDFLLGLDYLHNFVN---
. ||||. |.....|.|... |||......  |..||.|.           ||||.                     ..|||||...||.||||...   
NDKIYMVQMEYCERGQIMWWPYWKQDYQPNWPYQYTELYSNRQYQNKDFSIMSEQQSISEFINQVVKQDQYFIHEDYAWKYFRDCIKGLEYLHNYQKACS

----------------VVHRDIKPDNLLIGDED---QLKIADFGVSQMFEGEKDELNN-----------DNGTKCYLAPEAFTS-NG-------------
                ..||||||.|.||..|.   ..||||||||..|||....| |           ..||....|||...  |.             
YIIIYINEFIIDHFQDIIHRDIKPQNILIDEEGCGEHVKIADFGVSHIFEGQDQTLSNCESCFQRELNKTAGTPAFMAPELCSKENQKENYNGYKYRFRF

-FNGRPLDIWAAGVSLYEIFTGSRPFNGRTLEVLKKNYMQILQIIQKFRPN---------YPSNMSPEFVSMLQKCLNKDPKKRADVQALIVDDWV
 ..|...||||.||.|| ...|..||....|. |..|||.|..  .||..|         |....|..........|.|.|.|| ......|..||
IYCGKAADIWALGVTLYCFVFGKCPFWHNNLMQLHHNYMKIKNDPIKFPENKEMLNNVSIYCPEISEDLKDLIKRMLEKNPTKRITIPQIKVHPWV
Kinase 24780.AA S_TKc 1755-2036 27 1e-73 252.13 SMART 1-231 (231) Show / Hide 
Range on Protein: 1755-2036
Range on HMM: 1-231/231
Sequence Identity: 27% (82 aa)

YIILKNIGHGAFGKVKQVFDTNTKKHFAVKIINRDKLMKKKLDRNKSAFSLIEKEIAICKKMAHPNIVKLYEYIDDQDEAKIYMIMDLLKK--GSINSKS
| ||. ||.||||||... ...|....|.|||.                  |..||.|.||  ||||||||....|    ..||.|...    |.  .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDY-

YWKTEKGKEYKETEK----YNMSEQKLKKYFRDFLLGLDYLHNFVNVVHRDIKPDNLLIGDEDQLKIADFGVSQMFEGEKDELNNDNGTKCYLAPEAFTS
          |.  .    . ..|   ..|..  ...|.|.|.  ...|||.||.|.|. .  ..||.|||..  .       .   ||  |.||| .  
---------IKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL--

NGFNGRPLDIWAAGVSLYEIFTGSRPFNGRTLEVLKKNYMQILQIIQKFRPNYPSNMSPEFVSMLQKCLNKDPKKRADVQALIV-------DDWV
 |..... |.|. |. ||| ..|  ||          ........|           |||. ....|||.|||.||  .  .         . |.
-GYGKCKCDWWSCGCILYEMLCGYPPFP---------QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 24780.AA CAMKL 1755-2036 27 9e-70 221.79 In-house 1-297 (297) Show / Hide 
Range on Protein: 1755-2036
Range on HMM: 1-297/297
Sequence Identity: 27% (88 aa)

YIILKNIGHGAFGKVKQVFD-TNTKKHFAVKIINRDKLMKKKLDRNKSAFSL---------IEKEIAICKKMA---HPNIVKLYEYIDDQDE----AKIY
|.|.| .|.|.|||||   .  .|... |.|||...|.   ..| ....  .         |..||.| |..    ||||.|||| |....      |||
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKI---WNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIY

MIMDLLKKGS------INSKSYWKTEKGKEYKETEKYNMSEQKLKKYFRDFLLGLDYLHNFVNVVHRDIKPDNLLIGDED--QLKIADFGVSQMFE-G--
..| .   |.      | .. . .              |.|   ..|||  . ...|.|.   .|||||||.|.|. . .  ..||.||| | |.. .  
LVMEYCSGGEMDLFDYIVKHGHRR------------GRMPEHEARRYFRQIVSAVNYCHSHG-IVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIF

-EKDELNNDNGTKCYLAPEAFTS--NGFNGRPLDIWAAGVSLYEIFTGSRPFNGRTL---EVLKKNYMQILQIIQKFRPNYPSNMSPEFVSMLQKCLNKD
 . . |.   |. .| ||| | .    ..|.. |||..|| || . .|  ||.. |.    .  . |.   .... ..|. .. .| .  ....| |...
GPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVN

PKKRADVQALIVDDWV
|.||. .. .  . |.
PEKRPTIHQIMNHPWM
Kinase 24780.AA CAMK 1760-2036 20 3.3e-67 215.37 In-house 1-425 (425) Show / Hide 
Range on Protein: 1760-2036
Range on HMM: 1-425/425
Sequence Identity: 20% (89 aa)

NIGHGAFGKVKQVFDTNTK------------KHFAVKIINRDKLMK-----------KKLDRNKS--------AFSLIEKEIAICKKMA-------HPNI
 .|.|.||||| ....||.            ...|.|||...|| .           ..  ..|.            ...||.|.||.        ||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKLYEYIDDQD-----------------EAKIYMIM---DLLKKG----SINSKSYWKTEKGKEYKETEKYN---------MSEQKLKKYFRDFLLGLDY
.||||...| .                 . ..||.|   ..   |     . ..   .. .| |                 ..|.  ..|||  . ...|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEF------DQFDIVERGRFTEREARRYFRQICSAVHY

LHNFVNVVHRDIKPDNLLIGDED-----------------QLKIADFGVSQMFEG-----------------------EKDELNNDNGTKCYLA-PEAFT
.|.   .||||.||.|.|. | .                 ..||.||| ...|..                       | . ..   || .| | || . 
CHSHN-IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLN

S-------------NGFNGRPLDIWAAGVSLYEIFTGSRPFNGRTLEVLKK------NYMQILQIIQKFRPN-YPSNMSP--------------------
.             .   |.. |.|..|| ||   .|  ||.| . .   .      |. .... |.| . . .|. .||                    
GKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHF

---EFVSMLQKCLNKDPKKRADVQALIVDDWV
   |  ....|.|..||.||. ..    . |.
VSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 24780.AA Pkinase 1755-2036 27 1.2e-60 212.6 Pfam 1-293 (293) Show / Hide 
Range on Protein: 1755-2036
Range on HMM: 1-293/293
Sequence Identity: 27% (86 aa)

YIILKNIGHGAFGKVKQVFDTNTKKHFAVKIINRDKLMKKKLDRNKSAFSLIEKEIAICKKMAHPNIVKLYEYIDDQDEAKIYMIMDLLKKG----SIN-
| |.. || |.||.|..  . .| | .|||||....  ..|. ..  .      ||.| |.. |||||.||..  |  . .|||.|... .|    .   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL-----SEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFD

---SKSYWKTEKGKEYKETEKYNM--SEQKLKKYFRDFLLGLDYLHNFVNVVHRDIKPDNLLIGDEDQL----KIADFGVSQMF-EGEKDELNNDNGTKC
                   .. ..  ||. .|.|..  | ||.|.|.  ...|||.||.|.|| .....    ||.|||..  | .  .  ..   ||  
YIST--------------WRHGCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPW

YLAPEAFTSNGFNGRPLDIWAAGVSLYEIFTGSRPFNGR----TLEVLKKNYMQILQIIQKFRPNYPSNMS-----------------PEFVSMLQKCLN
|.|||   ..   |.. |.|..|. ||| ..|  || |.    .    .. . .|.. . .|   .....|                 .|. . . .||.
YMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLC

KDPKKRADVQALIVDDWV
||||||   . .  ..|.
KDPKKRPTAEQILQHPWF
Kinase 24780.AA STE 1755-2036 22 4.2e-55 189.37 In-house 1-359 (359) Show / Hide 
Range on Protein: 1755-2036
Range on HMM: 1-359/359
Sequence Identity: 22% (85 aa)

YIILKNIGHGAFGKVKQVFDTN---------------TKKHFAVKIIN--RDKLMKKK-------LDRNKSAFSLIEKEIAICKKMA--HPNIVKLYEYI
. ... ||.||||.| .  . .               |.. .|.|..|  ... .. .        ..|.. .  |.||| |.||.   |||||| | . 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

D-----DQDEAKIYMIMDLLKKGSIN--SKSYWKTEKG-----KEYKETEKYNMSEQKLKKYFRDFLLG-LDYLHNFVNVVHRDIKPDNLLIGDEDQLKI
      .... .....| ..  ||.    |..... |.     .      .  ..|. .... |. | | |.|||.   ..||||||.| |.      |.
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQ----H-QHRFPESQIAYICRQILKGLLYYLHSHH-IIHRDIKPANILL-----VKL

ADFGVSQMFEGEKD----------------ELNNDNGTKCYLAPEAFTSNGFN-----GRPLDIWAAGVSLYEIFTGSRPF-NGRTLEVL-KKNYM----
.||||.  .. . .                . | . ||  . |||  . || .     ..  |||  |  . |  ||  |. ..  ....  .. .    
CDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQ

----QILQIIQKFRPNYPS-------------------NMSPEFVSMLQKCLNKDPKKRADVQALIV--DDWV
    |. .|...  |  |.                   ..||||   ..|||.|||.||.... |.     ..
QQFEQL-CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 24780.AA Ciliate-E2 1755-2036 22 5.3e-54 183.77 In-house 1-365 (365) Show / Hide 
Range on Protein: 1755-2036
Range on HMM: 1-365/365
Sequence Identity: 22% (87 aa)

YIILKNIGHGAFGKVKQVFDTNTKKHFAVKIINRDK------------LMKKKLDRNKSAFSLIEKEIAICKKMA----------------HPNIVKLYE
|...| || |.||.|... . ...| || |||. .|             .. .   .|.    |..|| |....                 ||||.|.||
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

YIDDQDEAKIYMIMDLLKKGSINSKSYWK-TEKGKEYKETEKYNMSEQKLKKYFRDFLL---------------GLDYLHNFVNVVHRDIKPDNLLIGDE
.  ..|. .||..|.... |.  .  . . . ...| .. .  ...|.. |....  |                .| |||.  |..||||||.|.|.   
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEK-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---

DQLKIADFGVSQ------------MFEGEKDELNNDN--------------------GTKCYLAPEAFTSNGFNG--------RPLDIWAAGVSLYEIFT
  .||.||| |.               ... . .||.                    ||  |.||| . . . ..           |||..|| |||  .
--IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF

GSRPFNGRTLEVLKKNYMQILQIIQKFRPNYP------------------SNMSPEFVSMLQK----CLNKDPKKRAD-VQALIVDDWV
| .||               .|.|..   ..|                   . |.|   ...|    .|.|||.|| .  . ..   | 
GKPPF---------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 24780.AA ULK 1755-2036 27 2.3e-53 183.62 In-house 1-329 (329) Show / Hide 
Range on Protein: 1755-2036
Range on HMM: 1-329/329
Sequence Identity: 27% (91 aa)

YIILKNIGHGAFGKVKQVFDTNTK----KHFAVKIINRDKLMKKKLDRN-KSAFSLIEKEIAICKKMA--------HPNIVKLYEYIDDQDEAKIYMIMD
|.. . .|.|.|||| . .. .||    . .|.|.| ..|. .|. ... . .  |...|| | ||.         ||||||||..  ....  ||.||.
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

LLKKGSINSKSYWKTEKGKEYKETE-KYNMSEQKLKKYFRDFLLGLDYLHNFVNVVHRDIKPDNLLIGDED------------QLKIADFGVSQMFE-G-
.   |    ..| |. |..  .. | | . |||. ...|...| |. .||   |..||||||.| || . .            .||||||| ..... . 
YCNGGDL--EQYIKKNKKLPEDT-EEKKRLSEQEAIQFFKQILNGFKELHK-HNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDN

-EKDELNNDN------GTKCYLAPEAFTSNG----FNGRPLDIWAAGVSLYEIFTGSRPFNGRTLEVLK-KNYMQILQI-------IQKFRPNYP-----
 |.. .          ||  | ||. . ..|    ..    |||  |. .||. .|  ||..   . .. ..... ...       |.|. ...|     
MEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGND

SNMSPEFVSMLQKCLNKDPKKRADVQALIVDDWV
 . |||. . ....| .|.|.| . . |.   |.
PQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 24780.AA ULK 1755-2036 28 1.5e-51 177.57 In-house 1-324 (324) Show / Hide 
Range on Protein: 1755-2036
Range on HMM: 1-324/324
Sequence Identity: 28% (93 aa)

YIILKNIGHGAFG-KVKQVFDTNT---KKHFAVKIINRDKLMKKKLDRN-KSAFSLIEKEIAICKKMA---HPN--IVKLYEYIDDQDEAKIYMIMDLLK
|.. . .|.|.|| || . .. .|   ....|.|.|...|. |||.... . .  |...|| | ||.    |||  |||||..  ....  ||.||..  
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

KGSINSKSYWKTEKG-KEYKETEKYNMSEQKLKKYFRDFLLGLDYLHNFVNVVHRDIKPDNLLIGDED------------QLKIADFGVSQMFEGEKDEL
 |    ..| |. |. .| .  || . |||. ...|.... |. .||.  |..||||||.|.|| . .            .||||||| ..... .  | 
GGDL--EQYIKKNKKLPE-T-EEKKRLSEQEAIQFFKQICNGFKELHK-HNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQ

NND----N-----GTKCYLAPEAFTSNG----FNGRPLDIWAAGVSLYEIFTGSRPFNGRTLEVLKKNYMQILQI--------IQKFRPNYP-----SNM
.      |     ||  | ||. . ..|    ..    |||  |. .||. .|. ||...  . .... .| |.         |..   ..|      . 
QMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLY-IQKLINNGKEQQIYIKNQPIQFPKPPKDPKI

SPEFVSMLQKCLNKDPKKRADVQALIVDDWV
|||. . ....| .|.|.| . . ..   |.
SPECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase 24780.AA Meta 1870-2036 38 3.9e-42 119.46 In-house 120-287 (287) Show / Hide 
Range on Protein: 1870-2036
Range on HMM: 120-287/287
Sequence Identity: 38% (67 aa)

MSEQKLKKYFRDFLLGLDYLHNFVNVVHRDIKPDNLLIGDEDQLKIADFGVSQMFEGEKDELNN--DNGTKCYLAPEAFT--SNG-FNGRPLDIWAAGVS
.||..  .|||| ..|| |||    ..|||||| |||..|. . ||||||||  |||    | |    ||   .|||| .  .|  . || ||.|| ||.
LSEDQAWSYFRDIVCGLEYLH-YQKIIHRDIKPSNLLLNDDGHVKIADFGVSNEFEGDDAFLCNGSTAGTPAFMAPEACSEEQNHFYCGRALDVWAMGVT

LYEIFTGSRPFNGRTLEVLKKNY-MQILQIIQKFRPNYPS--NMSPEFVSMLQKCLNKDPKKRADVQALIVDDWV
||    |  ||      . | || | . . |    . .|     | .  ..  . | |.|..|  .  . .. ||
LYCFVFGQCPF------IDKTNYIMCLHDKIKNHPVMFPEQPEISEDLKDCIKRMLDKNPEHRIMIPEIKTHPWV
Kinase 24780.AA MARK 1876-2036 31 2.2e-32 103.29 In-house 107-262 (262) Show / Hide 
Range on Protein: 1876-2036
Range on HMM: 107-262/262
Sequence Identity: 31% (52 aa)

KKYFRDFLLGLDYLHNFVNVVHRDIKPDNLLIGDED--QLKIADFGVSQMF-EGEKDELNNDNGTKCYLAPEAFTSNGFNGRPLDIWAAGVSLYEIFTGS
...||  . .. |.|.   .|||||||.|.|| ..   . ||.||| |  . .|.|  ||   ||. | ||| | .   .|.. |||. || || . .|.
RRIFRQIVSAVNYCHSKN-IVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQK--LNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMVCGY

RPFNGRTLEVLKKN--YMQILQIIQKFRPNYPSNMSPEFVSMLQKCLNKDPKKRADVQALIVDDWV
 ||         ..  | .. . |.. .. .|...|.|  ...|. |. .|..|.... .  . |.
FPFD-------GDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase 24780.AA Meta 1755-1848 31 2.2e-29 82.0 In-house 1-111 (287) Show / Hide 
Range on Protein: 1755-1848
Range on HMM: 1-111/287
Sequence Identity: 31% (35 aa)

YIILKNIGHGAFGKVKQVFDTNTKKHFAVKIINRDKLMKKK--LDR---------------NKSAFSLIEKEIAICKKMAHPNIVKLYEYIDDQDEAKIY
|     || |..|.||     ....| | || .  ||.|.     |                .... .. .|||| ||. |||.|||.| .||  |  .|
YRLMEEIGKGSYGVVKLAYNEEDHHHYAMKILSKKKLLKQYGFMRRPPPRGNKPNQGGCIQPRNPLDRVYQEIAILKKLDHPNVVKLVEVLDDPNEDYLY

MIMDLLKKGSI
|......||..
MVFEYVEKGPV
Kinase 24780.AA MARK 1755-1847 37 8.8e-26 81.4 In-house 1-88 (262) Show / Hide 
Range on Protein: 1755-1847
Range on HMM: 1-88/262
Sequence Identity: 37% (36 aa)

YIILKNIGHGAFGKVKQVFDTNTKKHFAVKIINRDKLMKKKLDRNK-SAFSLIEKEIAICKKMAHPNIVKLYEYIDDQDEAK--IYMIMDLLKKGS
| .|| ||||...||| . ...|....|.||... ||       |.  ... .. ||.| ||. ||||.||...|. ||. .  ||.||..  .|.
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKL-------NDPQWMKNVMREIEIMKKLDHPNIIKLFHVIE-QDTEQHQIYLIMEYASGGE
Kinase 24780.AA TyrKc 1755-2035 24 1.2e-15 30.55 SMART 1-280 (280) Show / Hide 
Range on Protein: 1755-2035
Range on HMM: 1-280/280
Sequence Identity: 24% (75 aa)

YIILKNIGHGAFGKVKQVFDTNTKKHFAVKIINRDKLMKKKLDRNKSAFSLIEKEIAICKKM--AHPNIVKLYEYIDDQDE-----AKIYMIMDLLKKGS
   .| .|.||||.| .   .      ||| .. |.               . .|. | .|    |||||.|| .. .| .       ....| . ..|.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGD

INSKSYWKTEKGKEYKETEKYNMSEQKLKKYFRDFLLGLDYLHNFVNVVHRDIKPDNLLIGDEDQLKIADFGVSQMFEGE------KDELNNDN--GTK-
   |.| .  ..|          . ..| ..  .   | .|||   |..|||.   | |.|.. . ||.||| |   . .      ||        |.| 
L--KDYLRKHRPK---------LCMKDLLSFCWQIACGMEYLHS-KNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKT

-C---YLAPEAFTSNGFNGRPLDIWAAGVSLYEIFT-GSRPFNGRTLEVLKKNYMQILQIIQKFRPNYPSN--------MSPEFVSMLQKCLNKDPKKRA
      .|||..  . |.    |.|. || ..|||| |  |  | ...  ..|.  | .. | .|.  | |        ...|  .. ..| . ||..| 
MLPIRWMAPECINYGKFTTKS-DVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRP

DVQALIVDDW
  ... ....
TFSEI-HECF
Kinase 24780.AA Pkinase_Tyr 1957-2024 30 0.000104 16.58 Pfam 196-260 (270) Show / Hide 
Range on Protein: 1957-2024
Range on HMM: 196-260/270
Sequence Identity: 30% (21 aa)

DIWAAGVSLYEIFT-GSRPFNGRTLEVLKKNYMQILQI-IQKFRPNYPSNMSPEFVSMLQKCLNKDPKKR
|.|. || ..|||| |  |    | . . .|.  . .|  .  |   | | ..|  .....| ..||..|
DVWSFGVLMWEIFTYGEQP----TYPGM-SNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDR
Kinase 24780.AA Pkinase_Tyr 1755-1847 31 0.000151 16.02 Pfam 1-93 (270) Show / Hide 
Range on Protein: 1755-1847
Range on HMM: 1-93/270
Sequence Identity: 31% (31 aa)

YIILKNIGHGAFGKVKQVFDT----NTKKHFAVKIINRDKLMKKKLDRNKSAFSLIEKEIAICKKM-AHPNIVKLYEYIDDQDEA-KIYMIMDLLKKGS
 ...| .|.||||.|..   .    ||| . |||.. ... |.. .           .|..| |..  |||||.||  . ||.|  .||..| . ..|.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQN-----CREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGD
Kinase 24780.AA Pkinase_Tyr 1885-1921 37 0.034171 8.05 Pfam 123-158 (270) Show / Hide 
Range on Protein: 1885-1921
Range on HMM: 123-158/270
Sequence Identity: 37% (14 aa)

GLDYLHNFVNVVHRDIKPDNLLIGDEDQLKIADFGVS
|..||..  | .|||.   | |.... . ||.||| .
GMEYLES-KNCIHRDLAARNCLVTENNVVKICDFGLA