19451

Species: Tetrahymena
Alias: 203, 3814.m00967, TTHERM_01265030, 19451, PreTt19451, 300.m00014
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-A7

Sequence

Name Sequence Type Origin Length Description Download
19451.NA RNA None 2097 None Fasta, JSON
19451.AA Protein None 698 None Fasta, JSON
19451.kin_dom Protein Kinase Domain None 321 None Fasta, JSON

Protein domain

Protein domains of 19451.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 19451.AA Ciliate-A7 354-674 33 8.10000000001e-151 507.34 In-house 1-360 (360) Show / Hide
Range on Protein: 354-674
Range on HMM: 1-360/360
Sequence Identity: 33% (125 aa)

VIKEVIKPNNLSESDFKKEGGQYQLLLNEFMVSKMI-------------PKHKNILKPYYFEEYNEGACLVMPFAAFGDADMLSKWQHNNFKNIQMYSSE
..|......|......|....|||..........|.             ...... ..|.|..........|.|..|.|..| ..|.|.|...|.|...|
RMKQIFESSNSCIFEIKNSSNQYQIVKVKKHHEHMMYNLEGREQCCHHCQECYMLKNEYNFLKKMDHPHIIMLFEQFNDYNMDEFWHHRNCCCILMEQAE

LHKLRCSSQSYEYQQPHIQEKIENQCEYLEKLIKEEIIQKQLGTCVNVIRVLAKQIGEALYLLHNKYDIAHNDIKPDNLYISEFNIKQNKYNFKLADFGY
.......||.|.....|..|||||||||                |||..|....||..||..|||...||||||||.|..|...|..||.|.|||||||.
CDLFQYFSQHYPHKNLHHNEKIENQCEY----------------CVNQMRHCFRQIAQALHYLHNEKNIAHNDIKPENIFIFCNNNQQNQYCFKLADFGF

AKKGQFQSHKES----------FEFFNRKNKRFFSPELLYLVDG--------------QLEANQTIVDQKKCDVYALGLSLYEILVGG--FFPFKDDLND
|||.|||||.||          ........|..|.||.......              | ..||...|.|||||.|.|.|...||...  |.......||
AKKYQFQSHFESTLRQQIIEDQYKNWKYRCKQYFAPEIINCLNKCCDKNSAKNKKFISQQIDNQCEFDEKKCDVFAFGVSFFQILFQQNPFCCEACHQND

PL-YIKYLNKTIS---IKDLMQWFYQYFS------------KVTSADQMIDLLSHMMDPNPSTRYSITQVLQHPWL
|. |..|..||.|   ... .||....|.            .....|||.|||..|..||||.||.|.|.|||||.
PYKYKHYFQKTYSKFWQWMQIQWMWNHFQKEIQDMIKNTDQQQQDIDQMKDLLNKMLCPNPSQRYCIKQILQHPWF

Kinase 19451.AA Ciliate-E2-Unclassified 487-674 23 5e-22 73.2 In-house 138-352 (352) Show / Hide
Range on Protein: 487-674
Range on HMM: 138-352/352
Sequence Identity: 23% (54 aa)

NVIR-----VLAKQIGEAL-YLLHNKYDIAHNDIKPDNLYISEFNIKQNKYNFKLADFGYAKKGQFQSHKESFE-------------FFNRKNKRFF---
. ..      ...|| ..| || |.. .| | ||||.|. ... .    .|. |..||| .|| | .. .. ..               .  . ..    
QQAKYKKAKFYFAQILQGLEYLHHKN-NIIHRDIKPENILFDNNGK---NYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQY

-SPELLYL-VDGQLEANQTIVDQKKCDVYALGLSLYEILVGGFFPFKDDLNDPLYIKYLNKTIS---IKDLMQWFYQ---YFSK-------VTSADQMID
 .||.|     ..  |       .|||...||  |||.| |  .||.|   .  ..   ...     .| | |...|   .|.|        .. .. .|
TAPEVLQGQNYDHSKA-------YKCDIWSLGVILYEMLFGY-YPFYDNNCEQHQQLITQWI-NNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKD

LLS----HMMDPNPSTRYSITQVLQHPWL
...     |.. ||. |... |.|.|||.
FINDLLQKMLKKNPNKRITFEQILNHPWF

Kinase 19451.AA Ciliate-E2 487-674 19 1.4e-19 63.88 In-house 145-365 (365) Show / Hide
Range on Protein: 487-674
Range on HMM: 145-365/365
Sequence Identity: 19% (50 aa)

NVIRVLAKQIGE---------------ALYLLHNKYDIAHNDIKPDNLYISEFNIKQNKYNFKLADFGYAKKGQFQSHKES-----FEFFNRK-------
. |. . ||| .               ||  ||.|  | | ||||.|. .            |..|||..|| . .. ...      .. . |       
KEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTP

-----------------NKRFFSPELLYLVD--GQLEANQTIVDQKKCDVYALGLSLYEILVGGFFPFKDDLNDPLYIKYLNKTISIKDLMQWFYQYF--
                 .  . .|| |   .  .|   ..     .|||...||  ||| | |  .||                . ..   .. .. .  
GYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQ---QKQKGYDYKCDIWSLGVILYEMLFG-KPPF----------------QQQIKQCKIDFPCPEW

------------SKVTSADQMIDLLSH----MMDPNPSTRYS-ITQVLQHPWL
            |.    ....||..     |.. .|. |.. . |.|.|||.
QKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF

Kinase 19451.AA CAMK1 649-674 42 2e-14 38.26 In-house 251-276 (276) Show / Hide
Range on Protein: 649-674
Range on HMM: 251-276/276
Sequence Identity: 42% (11 aa)

DLLSHMMDPNPSTRYSITQVLQHPWL
|...||....|. ||...|.|.|||.
DFIKHMLEVDPKKRYTCEQCLNHPWI

Kinase 19451.AA WEE 489-600 21 7.1e-14 43.0 In-house 113-229 (297) Show / Hide
Range on Protein: 489-600
Range on HMM: 113-229/297
Sequence Identity: 21% (28 aa)

IRVLAKQIGEALYLLHNKYDIAHNDIKPDNLYISEFN----------------IKQNKYNFKLADFGYAKKGQ-----FQSHKESFEFFNRKNKRFFSPE
|. .  .| ..|  .|.. .. |.||||.|..||.                  . .|  ..|..||| ...       ...  |.       . |. .||
IWQILVDICQGLHHIHSNCGMVHMDIKPENIFISKKMNCNQIVNNDQQNNNDWW-FN-MMCKIGDFGHVTDMNSNNNNPHQEQEG-------DSRYMAPE

LLYLVDGQLEANQTIVDQKKCDVYALGLSLYEI
.|         . . .. .| |...||. .||.
ILQG-------YYHYTHLYKADIFSLGITIYEL

Kinase 19451.AA S_TKc 367-674 15 7.7e-14 26.02 SMART 1-231 (231) Show / Hide
Range on Protein: 367-674
Range on HMM: 1-231/231
Sequence Identity: 15% (53 aa)

SDFKKEGGQ---------YQLLLNEFMVSKMIPKHKNILKPYYFEEYNEGACLVMPFAAFGDADMLSKWQHNNFKNIQMYSSELHKLRCSSQSYEYQQPH
 .. .. |.         .    .. .  |.|.                         .    ..|.| .| |   ...| .  .               
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------------------EHIRREIQILKK-HHPNI--VKLYDVFQD---------------

IQEKIENQCEYLEKLIK-----EEIIQKQLG------TCVNVIRVLAKQIGEALYLLHNKYDIAHNDIKPDNLYISEFNIKQNKYNFKLADFGYAKKGQF
     .. .  .| .        ..|.|. .          ..| ...|| .||  .|..  | | |.||.|. ..|        . |..||| |..   
-----DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--------HIKICDFGLARQL--

QSHKESFEFFNRKNKRFF------SPELLYLVDGQLEANQTIVDQKKCDVYALGLSLYEILVGGFFPFKDDLNDPLYIKYLNKTISIKDLMQWFYQYFSK
              . |       .||.|              . .|||....|  ||| |. |  ||    .. . .| .                   
--------------TTFCGTPWYMAPEVL------------GYGKCKCDWWSCGCILYEMLC-GYPPFP---QMQMMFKKIG------------------

VTSADQMIDLLSHMMDPNPSTRYSITQVLQ-------HPWL
    ....|....... .|. |... ..||       |||.
---SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase 19451.AA CAMK 586-674 21 2.3e-12 35.45 In-house 313-425 (425) Show / Hide
Range on Protein: 586-674
Range on HMM: 313-425/425
Sequence Identity: 21% (25 aa)

KKCDVYALGLSLYEILVGGFFPFKDDLNDPLY--------IKYLNKTISIKDLM-QWFY----------QYFSKVTSA------DQMIDLLSHMMDPNPS
.|||. ..|  || |.. |..|| .| ..  .        .. | . |   .    ..|          .. ....        .. .||...|. ..|.
PKCDMWSCGVILY-IMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPE

TRYSITQVLQHPWL
 |..|.|.|.|||.
KRMTIEQCLNHPWM

Kinase 19451.AA ULK 586-674 25 2.4e-12 39.51 In-house 235-329 (329) Show / Hide
Range on Protein: 586-674
Range on HMM: 235-329/329
Sequence Identity: 25% (25 aa)

KKCDVYALGLSLYEILVGGFFPFKDDLNDPLYIKYLNKTIS--------IKDLMQWFYQYFSKVTSADQMIDLLSHMMDPNPSTRYSITQVLQHPWL
.|||.. ||  .||.|.|   ||.   . ..|.....| |         ||.    |... ....  ....||.. |.  ... | |......|||.
YKCDIWSLGCIFYEMLYGK-PPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF

Kinase 19451.AA Pkinase 586-674 19 4.6e-11 40.21 Pfam 191-293 (293) Show / Hide
Range on Protein: 586-674
Range on HMM: 191-293/293
Sequence Identity: 19% (21 aa)

KKCDVYALGLSLYEILVGGFFPFKDD----LNDPLYIKYLNKTISIKDLMQWFY---QYFSKVTS----------ADQMIDLLSHMMDPNPSTRYSITQV
.|.|....|. ||| |  | .||...      .  . .. ..   . .   .      ||. ..            . ..|... . ...|. |....|.
PKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQI

LQHPWL
|||||.
LQHPWF

Kinase 19451.AA ULK 586-674 27 1.9e-10 33.34 In-house 231-324 (324) Show / Hide
Range on Protein: 586-674
Range on HMM: 231-324/324
Sequence Identity: 27% (26 aa)

KKCDVYALGLSLYEILVGGFFPFKDDLNDPL--YIKYLNK----TISIKDLMQWFYQYFSKVTSADQMIDLLSHMMDPNPSTRYSITQVLQHPWL
.|||.. ||  .||.| |   .|..  ||     .| .|.     | ||.    |. . . .   ....||.. |.  ... | |......|||.
YKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF

Kinase 19451.AA DCAMKL 649-674 50 1.2e-09 25.59 In-house 254-279 (279) Show / Hide
Range on Protein: 649-674
Range on HMM: 254-279/279
Sequence Identity: 50% (13 aa)

DLLSHMMDPNPSTRYSITQVLQHPWL
|| |||.  .|  ||.  |..|||| 
DLISHMLQVDPEKRYTAEQIMQHPWV

Kinase 19451.AA Ciliate-E9 487-539 33 2.5e-09 25.57 In-house 111-157 (298) Show / Hide
Range on Protein: 487-539
Range on HMM: 111-157/298
Sequence Identity: 33% (18 aa)

NVIRVLAKQIGEALYLLHNKYDIAHNDIKPDNLYISEFNIKQNKYNFKLADFG
||... .||. ..   .|..  | | |.||.|. | .      .|| |. |||
NVAKYYFKQLIDSIEYMHQYQNICHRDLKPENMLIDK------NYNMKICDFG

Kinase 19451.AA ULK 487-543 32 1e-06 19.11 In-house 130-191 (329) Show / Hide
Range on Protein: 487-543
Range on HMM: 130-191/329
Sequence Identity: 32% (21 aa)

NVIRVLAKQIGEALYLLHNKYDIAHNDIKPDNLYISEFNIK-------QNKYNFKLADFGYAKK
. ..   ||| ...  || .  | | ||||.|  |.. ..|       . .. .|.|||| ||.
QEAIQFFKQILNGFKELHKH-NIIHRDIKPQNILIHNGQPKTDSKKVHP-NGVLKIADFGFAKH

Kinase 19451.AA CAMK 490-543 29 1e-06 16.69 In-house 182-245 (425) Show / Hide
Range on Protein: 490-543
Range on HMM: 182-245/425
Sequence Identity: 29% (19 aa)

RVLAKQIGEALYLLHNKYDIAHNDIKPDNLYISEFNIKQNK-----------YNFKLADFGYAKK
| . .|| .|.  .|..  |.| |.||.|. ... |  ...           .| |..||| |.|
RRYFRQICSAVHYCHSHN-IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANK

Kinase 19451.AA DCAMKL 495-542 37 1e-06 16.09 In-house 123-167 (279) Show / Hide
Range on Protein: 495-542
Range on HMM: 123-167/279
Sequence Identity: 37% (18 aa)

QIGEALYLLHNKYDIAHNDIKPDNLYISEFNIKQNKYNFKLADFGYAK
....||. || .  | | |||| || . .   .  .   ||.||| |.
CLCKALKYLHEM-NIVHRDIKPENLLVCKHEDG--EKSLKLCDFGLAC

Kinase 19451.AA Ciliate-E9 648-674 37 4e-06 15.33 In-house 272-298 (298) Show / Hide
Range on Protein: 648-674
Range on HMM: 272-298/298
Sequence Identity: 37% (10 aa)

IDLLSHMMDPNPSTRYSITQVLQHPWL
||..  | .  |  | || ..  |||.
IDMMNWMLQQDPQNRISIQEIRMHPWM

Kinase 19451.AA Pkinase 487-553 28 7e-06 21.83 Pfam 108-171 (293) Show / Hide
Range on Protein: 487-553
Range on HMM: 108-171/293
Sequence Identity: 28% (20 aa)

NVIRVLAKQIGEALYLLHNKYDIAHNDIKPDNLYIS-EFNIKQNKYNFKLADFGYAKK--GQFQSHKESF
....  ..|| ..|. .|.   | | |.||.|. |. . .|.     .|..||| ||.     .|   .|
WECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDA---CVKICDFGLAKQFDY-NNS-MTTF

Kinase 19451.AA WEE 649-674 46 1e-05 15.2 In-house 272-297 (297) Show / Hide
Range on Protein: 649-674
Range on HMM: 272-297/297
Sequence Identity: 46% (12 aa)

DLLSHMMDPNPSTRYSITQVLQHPWL
.|.  ||.|.|. | .. | |||| |
QLIKWMMHPDPEQRPTCQQLLQHPVL

Kinase 19451.AA ULK 487-543 32 1.9e-05 15.33 In-house 126-187 (324) Show / Hide
Range on Protein: 487-543
Range on HMM: 126-187/324
Sequence Identity: 32% (21 aa)

NVIRVLAKQIGEALYLLHNKYDIAHNDIKPDNLYISEFNIK-------QNKYNFKLADFGYAKK
. ..   ||| ...  ||..  | | ||||.|. |.. ..|       . .. .|.|||| ||.
QEAIQFFKQICNGFKELHKH-NIIHRDIKPQNILIHNGQPKTDSKKVHP-NGVLKIADFGFAKH

TyrKc 19451.AA TyrKc 342-674 13 0.000374 -155.47 SMART 1-280 (280) Show / Hide
Range on Protein: 342-674
Range on HMM: 1-280/280
Sequence Identity: 13% (53 aa)

ITNN---------------LTNNLQKSVIKEVIKPNNLSESDFKKEGGQYQLLLNEFMVSKMI-PKHKNILKPYYFEEYN-------EGACLVMPFAAFG
|| .               ..       |.  .|  . .           . ...|  . ... ..|.||.. |             |  ..|| ... |
ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHG

D-ADMLSKWQHNNFKNIQMYSSELHKLRCSSQSYEYQQPHIQEKIENQCEYLEKLIKEEIIQKQLGTCVNVIRVLAKQIGEALYLLHNKYDIAHNDIKPD
|  | | | ...                                                       |.      . || .    || |  . | |.   
DLKDYLRKHRPK------------------------------------------------------LCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAAR

NLYISEFNIKQNKYNFKLADFGYAKKGQFQ-SHKESFEFFNRK---NKRF------FSPELLYLVDGQLEANQTIVDQ---KKCDVYALGLSLYEILVGG
|  ..| .        | .||| ....    .. || .    |   ....       .|| .              .     | ||.. |  ..||.  |
NCLVGENH------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-------------NYGKFTTKSDVWSFGVCMWEIFTYG

FFPFKDD----LNDPLYIKYLNKTISIKDLMQWFYQY-----FSKVTSADQMIDLLSHMMDPNPSTRYSITQVLQHPWL
  |  ..    ...   |.|.      .  .    ..     |  |.  | | .. .   . .|. | . ...  |  .
QQPYPGMIQQMMSNQEVIEYV-----KQGYRMPQPPNDYPMSF--VCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF

Kinase 19451.AA CAMK1 494-543 38 0.080649 1.0 In-house 115-162 (276) Show / Hide
Range on Protein: 494-543
Range on HMM: 115-162/276
Sequence Identity: 38% (21 aa)

KQIGEALYLLHNKYDIAHNDIKPDN-LYISE-FN--IK-QNKYNFKLADFGYAKK
||| .|.. .| | .|.| |.|| | || .. ..  ||        .|||| .|.
KQILSAVEYMHSK-GIVHRDLKPENLLYYDKDEDSKIKRS------IADFGLSKI

Kinase 19451.AA DCAMKL 587-609 47 0.101912 0.5 In-house 199-220 (279) Show / Hide
Range on Protein: 587-609
Range on HMM: 199-220/279
Sequence Identity: 47% (11 aa)

KCDVYALGLSLYEILVGGFFPFK
|.|. |.|  || .|. || ||.
KVDIWAAGVILYILLC-GFPPFR

Kinase 19451.AA Pkinase 368-415 20 0.931009 3.76 Pfam 35-82 (293) Show / Hide
Range on Protein: 368-415
Range on HMM: 35-82/293
Sequence Identity: 20% (10 aa)

DFKKEGGQYQLLL-NEFMVSKMIPKHKNILKPYYFEEYNEGACLVMPFA
. .|.. ...... .|  . |.. .|.||.. |.. |..   ..||...
RHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYC