Gene 2963 (Tetrahymena)

2963

Species: Tetrahymena
Alias: 697, 2963, 3674.m00016, PreTt02963, TTHERM_00691250, 106.m00103
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-A7

Sequence

Name Sequence Type Origin Length Description Download
2963.AA Protein None 419 None Fasta, JSON
2963.kin_dom Protein Kinase Domain None 282 None Fasta, JSON
2963.NA RNA None 1260 None Fasta, JSON

Protein domain

Protein domains of 2963.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 2963.AA Ciliate-A7 137-418 30 7.4e-132 444.36 In-house 21-360 (360) Show / Hide 
Range on Protein: 137-418
Range on HMM: 21-360/360
Sequence Identity: 30% (102 aa)

PHPNIVQVYKVFENVD---------CFYSQSGINGKQKASNMIESSINSQTQDIEQQNNLSPQENEHPDSCCALLMEEAEMDLFDYVEKHYNLNRSKHIS
....||.|.|..|...         |...|.....|..................||.|.....|..|...||..|||.||.|||.|...||. ....|..
NQYQIVKVKKHHEHMMYNLEGREQCCHHCQECYMLKNEYNFLKKMDHPHIIMLFEQFNDYNMDEFWHHRNCCCILMEQAECDLFQYFSQHYPHKNLHHNE

-----------NLIHMYRQIAQGLDHIHS-FNYSHNDIKSENVLIFSNLK-----EAKITDFGLANDLNDYKGLTR---PQIIEKQVQQWEYRCLNHAAP
           ...|..|||||.|...|. .|..|||||.||..||.| .     ..|..|||.|........ ..   .||||.|...|.|||....||
KIENQCEYCVNQMRHCFRQIAQALHYLHNEKNIAHNDIKPENIFIFCNNNQQNQYCFKLADFGFAKKYQFQSHFESTLRQQIIEDQYKNWKYRCKQYFAP

EILNTLKT------------------RSQDFDEQKADVFAFGVSFFESVFGFRPFAQYALPSDPIYKHFANKQSFSRFWKTNAQIQAVLREIN-------
||.|.|..                  ....|||.|.||||||||||...|...||...| .....||.....|..........|||.......       
EIINCLNKCCDKNSAKNKKFISQQIDNQCEFDEKKCDVFAFGVSFFQILFQQNPFCCEACHQNDPYKYKHYFQKTYSKFWQWMQIQWMWNHFQKEIQDMI

----NGDVDIEKLFDIIYKTLNKNPKQRISSADLLIDPLF
    ....||....|...|.|..||.||......|..|.|
KNTDQQQQDIDQMKDLLNKMLCPNPSQRYCIKQILQHPWF
Kinase 2963.AA Ciliate-E2 208-418 20 7e-24 78.84 In-house 119-365 (365) Show / Hide 
Range on Protein: 208-418
Range on HMM: 119-365/365
Sequence Identity: 20% (60 aa)

MDLFDYVEKHYNLNRSK-------HISNLIHMYRQIAQ---------------GLDHIHSFN-YSHNDIKSENVLIFSNLKEAKITDFGLANDLND----
.||||| ....    ..        .   ... .||.|               .| ..|| |   | ||| ||.|.       ||.||||. ...|    
GDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------IKIIDFGLSKKYDDDNQN

---------------------YKGLTRPQIIEKQVQQWEYRCLNHAAPEILNTLKTR---SQDFDEQKADVFAFGVSFFESVFGFRPFAQYALPSDPIYK
                     | .    |||  ....  .  ..  ||||||  |      |     |.|....|| ..| .|| .||            
RTHKQQCKWYMFKNDTSRTPGYMD----QIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF------------

HFANKQSFSRFWKTNAQIQAVLREINNGDVDIEKLF-----------------------DIIYK----TLNKNPKQRIS-SADLLIDPLF
                     ...| ....|. . .                       |.| |     |.|.|..||.   ..|  | |
---------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 2963.AA Ciliate-E2-Unclassified 196-418 21 7.6e-21 69.05 In-house 93-352 (352) Show / Hide 
Range on Protein: 196-418
Range on HMM: 93-352/352
Sequence Identity: 21% (59 aa)

DSCCALLMEEAEM-DLFDYVEKH----------YNLNRSKHISNLIHMY--------RQIAQGLDHIHSFN-YSHNDIKSENVLIFSNLK--EAKITDFG
. .. . || .|  ||..| .|           .. .....|    ..         .|| |||...|. |   | ||| ||.|. .| |  . ||.|||
KQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFG

LAN---DLNDYKGLT--------RPQIIEKQVQQWEYRCLNHAAPEILNTLKTRSQDFDEQKADVFAFGVSFFESVFGFRPFAQYALPS-----------
..    . |...  .        ..|..  ...  .|     .|||.|   .   . .   |.|....|| ..| .|| .|| ..   .           
ISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMP-QYTAPEVLQGQNYDHSKA--YKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINN

----DPIYKHFANKQSFSRFWKTN--AQIQAVLREINNGDVDIEKLFDIIYKTLNKNPKQRISSADLLIDPLF
      . . ......|. |.. .   ...    .. |         |.. | |.|||..||.  ..|  |.|
AYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFIN---------DLLQKMLKKNPNKRITFEQILNHPWF
Pkinase 2963.AA Pkinase 128-344 21 2.9e-17 62.12 Pfam 50-212 (293) Show / Hide 
Range on Protein: 128-344
Range on HMM: 50-212/293
Sequence Identity: 21% (50 aa)

EWQLLENILPHPNIVQVYKVFENVDCFYSQSGINGKQKASNMIESSINSQTQDIEQQNNLSPQENEHPDSCCALLMEEAEM-----DLFDYVE-KHYNLN
| |.. ..  |||||. | .||.                                            .|... . || .|.     |||||.. . ..  
EIQIMKRL-NHPNIVRLYDWFED--------------------------------------------KDHIY-MVMEYCEGGLYVMDLFDYISTWRHGCF

--RSKHISNLIHMYRQIAQGLDHIHSFNYSHNDIKSENVLIFSNLKEA---KITDFGLANDLNDYKGLTRPQIIEKQVQQWEYRC-LNHAAPEILNTLKT
    ... . .   .||..||...|| .  | |.|.||.|| .|   .   ||.|||||  ..          . ...  . . . .. .|||...    
YFSEWECKFYM---YQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD----------Y-NNS-MTTFCGTPWYMAPEVIR----

RSQDFDEQKADVFAFGVSFFESVFGFRPF
 ..  . .|.|....|. ..| ..|  ||
-GGQYYGPKVDMWSCGCILYEMLCGRPPF
Kinase 2963.AA CAMKL 137-276 25 8.9e-17 49.92 In-house 72-177 (297) Show / Hide 
Range on Protein: 137-276
Range on HMM: 72-177/297
Sequence Identity: 25% (38 aa)

P-HPNIVQVYKVFENVDCFYSQSGINGKQKASNMIESSINSQTQDIEQQNNLSPQENEHPD---SCCALLMEEAE---MDLFDYVEKHYNLNRSKHISNL
. ||||.. | |.|. ..                                          |   ... | || ..   ||||||..|| . ... . .  
GKHPNIIKLYEVIETPEH------------------------------------------DIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEA

IHMYRQIAQGLDHIHSFNYSHNDIKSENVLIFSNLK-EAKITDFGLAN
 .. |||  .....|| .  | ||| ||.|. .| .  .||.|||..|
RRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSN
S_TKc 2963.AA S_TKc 8-418 16 2.2e-16 61.69 SMART 1-231 (231) Show / Hide 
Range on Protein: 8-418
Range on HMM: 1-231/231
Sequence Identity: 16% (68 aa)

FEPLDHCGCNSASKIFRIYSTQTRENVNLVMKTSQHSQDSTFLSHLYSPSSSHQPLQLQNQQIFESQGPHSVIKNNKNLRAKEANQKAITHQKSKTKIGN
.| |.. |  . .| .. . .    .    .|                                                                    
YEILRKIGKGAFGKVYKCRHKK--TGRIVAIKIIK-----------------------------------------------------------------

EMISSVDESHCNFHCYMIHKEWQLLENILPHPNIVQVYKVFENVDCFYSQSGINGKQKASNMIESSINSQTQDIEQQNNLSPQENEHPDSCCALLMEEAE
                .| .| |.|..   |||||. | ||..                                              ..  . || ..
---------------EHIRREIQILKK--HHPNIVKLYDVFQD----------------------------------------------DHLYMVMEYCD

M---DLFDYVEKHYN--LNRSKHISNLIHMYRQIAQGLDHIHSFNYSHNDIKSENVLIFSNLKEAKITDFGLANDLNDYKGLTRPQIIEKQVQQWEYRC-
    ||||| .|.    |..  .     .. .||...|...|| .  | |.| ||.|. .   . ||.|||||  |                      | 
GDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL-------------------TTFCG

-LNHAAPEILNTLKTRSQDFDEQKADVFAFGVSFFESVFGFRPFAQYALPSDPIYKHFANKQSFSRFWKTNAQIQAVLREINNGDVDIEKLFDIIYKTLN
 ..  |||.|         ..  |.|. ..|. ..| . |  ||       . ..|.                               . . |.| | |.
TPWYMAPEVL--------GYGKCKCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG----------------------------SPEAKDFIRKCLQ

KNPKQRISSADLLI-------DPLF
|.|..|..  ..|        .| |
KDPEKRPTA-EALQDEWDIKCHPWF
Kinase 2963.AA CMGC 201-275 22 7.2e-12 34.34 In-house 132-251 (513) Show / Hide 
Range on Protein: 201-275
Range on HMM: 132-251/513
Sequence Identity: 22% (27 aa)

LLMEEAEMDLFDYVEKHYNLNRS--KHISNLIH---------------MY------RQIAQGLD--HIHSFN--YSHNDIKSENVLIFSNLKE-------
| .|  ..||..| ... ....   ..  .  |               .       .|| .||.  ..|| .    | |.| ||.|| .| .        
LVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWK

------------AKITDFGLA
             || |||||
SEDWNPCQKNGRLKICDFGLA
Kinase 2963.AA CAMK 202-280 24 7.6e-12 33.72 In-house 141-248 (425) Show / Hide 
Range on Protein: 202-280
Range on HMM: 141-248/425
Sequence Identity: 24% (27 aa)

LMEEAEM--DLFDYVEKH------------YNLNRSKHISNLIHMYRQIAQGLDHIHSFNYSHNDIKSENVLIFSNL----------------KEAKITD
...  |.  |||||. .|               ..  . .   .. |||.......|| |  | |.| ||.|. .|                    ||.|
YCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIID

FGLANDLND
||.|| ...
FGFANKFDP
Kinase 2963.AA MAPKAPK 234-275 36 5.1e-10 26.75 In-house 110-153 (292) Show / Hide 
Range on Protein: 234-275
Range on HMM: 110-153/292
Sequence Identity: 36% (16 aa)

RQIAQGLDHIHSFNYSHNDIKSENVLIFSNLKEA--KITDFGLA
..|....|. || |  | |.| ||.|  .. . .  |..|||.|
KDICSAVDFLHSMNIAHRDLKPENILCTDTNHNCPVKLCDFGFA
Kinase 2963.AA STE 234-280 39 1.2e-09 30.4 In-house 158-199 (359) Show / Hide 
Range on Protein: 234-280
Range on HMM: 158-199/359
Sequence Identity: 39% (19 aa)

RQIAQG-LDHIHSFNYSHNDIKSENVLIFSNLKEAKITDFGLANDLND
||| .| |...|| .. | |||. |.|.      .|..|||..  |.|
RQILKGLLYYLHSHHIIHRDIKPANILL------VKLCDFGVCGQLTD
Kinase 2963.AA ULK 209-275 30 8.5e-09 26.92 In-house 106-189 (329) Show / Hide 
Range on Protein: 209-275
Range on HMM: 106-189/329
Sequence Identity: 30% (26 aa)

DLFDYVEKHYNLN----RSKHIS--NLIHMYRQIAQGLDHIHSFNYSHNDIKSENVLIFSNLKE-----------AKITDFGLA
||..| .|. .|.    . |..|    |.  .||..|. ..|. |. | ||| .|.||  .              .||.|||.|
DLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFA
Kinase 2963.AA ULK 209-275 31 1e-08 27.13 In-house 103-185 (324) Show / Hide 
Range on Protein: 209-275
Range on HMM: 103-185/324
Sequence Identity: 31% (26 aa)

DLFDYVEKHYNLN---RSKHIS--NLIHMYRQIAQGLDHIHSFNYSHNDIKSENVLIFSNLKE-----------AKITDFGLA
||..| .|. .|.   . | .|    |.  .||..|. ..|. |. | ||| .| ||  .              .||.|||.|
DLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFA
Kinase 2963.AA ULK 306-418 23 4.9e-08 24.24 In-house 219-329 (329) Show / Hide 
Range on Protein: 306-418
Range on HMM: 219-329/329
Sequence Identity: 23% (29 aa)

APEILNTL-KTRSQDFDEQKADVFAFGVSFFESVFGFRPFAQYALPSDP---IYKHFAN----KQSFSRFWKTNAQIQAVLREIN---NGDVDIEKLFDI
||.||. . .   ..... |.|.. .|. |.| ..|  ||  .   ..    |.| . |    .|          ||.    ...   |...  ... |.
APQILQGQGE--QKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQ----------QIKKQPLQFPKDGNDPQISPECKDL

IYKTLNKNPKQRISSADLLIDPLF
|.. | ...|.|||  .|.  |.|
IRRMLQYDEKDRISWEELFNHPWF
Kinase 2963.AA ULK 306-418 23 4e-07 21.38 In-house 215-324 (324) Show / Hide 
Range on Protein: 306-418
Range on HMM: 215-324/324
Sequence Identity: 23% (28 aa)

APEILNTL-KTRSQDFDEQKADVFAFGVSFFESVFGFRPFAQYALPSDP--IYKHFANK--QSFSRFWKTNAQIQAVLREINNGDVDIEKLFDIIYKTLN
||.||. . .   ..... |.|.. .|. |.| ..|  ||  .   ..   |.|.  |.  |    .   | .||  . .  ....  ... |.|.. | 
APQILQGQGE--QKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQ---QIYIKNQPIQFPKPP--KDPKISPECKDLIRRMLQ

KNPKQRISSADLLIDPLF
...|.|||  ...  |.|
YDEKDRISWEEIFNHPWF
TyrKc 2963.AA TyrKc 103-392 14 3e-06 -121.9 SMART 1-280 (280) Show / Hide 
Range on Protein: 103-392
Range on HMM: 1-280/280
Sequence Identity: 14% (50 aa)

TKIGNE---------------------MISSVDESHCNFHCYMIHKEWQLLENI-LPHPNIVQVYKVFENV----------------------DCFYSQS
 . | .                     |. .           ....| ... ..   |||||. | |                          . .   .
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

GINGKQKASNMIESSINSQTQDIEQQNNLSPQENEHPDSCCALLMEEAEMDLFDYVEKHYNLNRSKHISNLIHMYRQIAQGLDHIHSFNYSHNDIKSENV
. .                                                                 . |...  |||.| ...|| |. | |.   |.
RPK--------------------------------------------------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNC

LIFSNLKEAKITDFGLANDLNDY--KGLTRPQIIEKQV--QQWEYRCLNHAAPEILNTLKTRSQDFDEQKADVFAFGVSFFESV-FGFRPFAQYA---LP
|. .|.  .||.||||. |. |.  .|  . . . |.   .      .   ||| .|. |  .      | ||..|||  .|   .|  |    .   ..
LVGENH-TVKISDFGLSRDIYDDDQQG-ESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT------KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMS

SDPIYKHFANKQSFSRFWK--------TNAQIQAVLREINNGD-------VDIEKLF
 . ....  .     .             . .  . ..  . |        .| ..|
NQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 2963.AA Pkinase_Tyr 226-281 39 3e-06 21.81 Pfam 110-166 (270) Show / Hide 
Range on Protein: 226-281
Range on HMM: 110-166/270
Sequence Identity: 39% (23 aa)

ISNLIHMYRQIAQGLDHIHSFNYSHNDIKSENVLIFSNLKEAKITDFGLANDL--NDY
.. |..| .|||.|... .| |. | |.   |.|. .|.  .||.||||| |.   ||
MKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENN-VVKICDFGLARDIYNDDY
Kinase 2963.AA STE 389-418 31 3.5e-05 14.41 In-house 328-359 (359) Show / Hide 
Range on Protein: 389-418
Range on HMM: 328-359/359
Sequence Identity: 31% (10 aa)

EKLFDIIYKTLNKNPKQRISSADLLI--DPLF
... | | | |.|.|..| .. .||    | .
PEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 2963.AA CAMK 393-418 30 7.8e-05 10.73 In-house 400-425 (425) Show / Hide 
Range on Protein: 393-418
Range on HMM: 400-425/425
Sequence Identity: 30% (8 aa)

DIIYKTLNKNPKQRISSADLLIDPLF
| | | |...|..|.. .. | .| .
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 2963.AA Pkinase 389-418 36 0.000357 15.84 Pfam 264-293 (293) Show / Hide 
Range on Protein: 389-418
Range on HMM: 264-293/293
Sequence Identity: 36% (11 aa)

EKLFDIIYKTLNKNPKQRISSADLLIDPLF
| . |.|.. |.|.||.|.. ...| .| |
EECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 2963.AA MAPKAPK 138-155 54 0.000417 8.11 In-house 56-77 (292) Show / Hide 
Range on Protein: 138-155
Range on HMM: 56-77/292
Sequence Identity: 54% (12 aa)

HPNIVQVYKVFEN----VDCFY
||||||.  .|||    ..|||
HPNIVQIIDWFENMYQFDKCFY
Kinase 2963.AA CMGC 389-418 30 0.000624 7.78 In-house 484-513 (513) Show / Hide 
Range on Protein: 389-418
Range on HMM: 484-513/513
Sequence Identity: 30% (9 aa)

EKLFDIIYKTLNKNPKQRISSADLLIDPLF
....| . | |  .|..||. .. |  | |
PQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase 2963.AA CAMKL 393-418 30 0.002648 6.23 In-house 272-297 (297) Show / Hide 
Range on Protein: 393-418
Range on HMM: 272-297/297
Sequence Identity: 30% (8 aa)

DIIYKTLNKNPKQRISSADLLIDPLF
|.| | |..||..|..  ... .| .
DLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 2963.AA MAPKAPK 393-418 30 0.009174 3.88 In-house 267-292 (292) Show / Hide 
Range on Protein: 393-418
Range on HMM: 267-292/292
Sequence Identity: 30% (8 aa)

DIIYKTLNKNPKQRISSADLLIDPLF
|.| | |...|.||.. ....  |. 
DLIRKLLRRDPTQRLTIEQVMNHPWI
Kinase 2963.AA CAMK 138-155 21 0.013808 3.35 In-house 97-133 (425) Show / Hide 
Range on Protein: 138-155
Range on HMM: 97-133/425
Sequence Identity: 21% (8 aa)

HPNIVQVYKVFE------------NVDC--------FY
||||.. | |.|            . ..        .|
HPNIIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMY
Kinase 2963.AA ULK 135-155 35 0.119431 1.7 In-house 66-93 (324) Show / Hide 
Range on Protein: 135-155
Range on HMM: 66-93/324
Sequence Identity: 35% (10 aa)

ILP---HPN--IVQVYKVFENVDC--FY
.|    |||  ||. |..||. ..  .|
KLKELKHPNHHIVKLYDWFETSNHNNIY
Kinase 2963.AA ULK 138-155 45 0.149544 1.29 In-house 77-96 (329) Show / Hide 
Range on Protein: 138-155
Range on HMM: 77-96/329
Sequence Identity: 45% (9 aa)

HPNIVQVYKVFENV--DCFY
|||||. |..||.   ...|
HPNIVKLYDWFETSNHNNIY