Gene 6866 (Tetrahymena)

6866

Species: Tetrahymena
Alias: PreTt06866, 3715.m00011, 402, TTHERM_00497000, 6866, 62.m00150
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-A7

Sequence

Name Sequence Type Origin Length Description Download
6866.AA Protein None 313 None Fasta, JSON
6866.kin_dom Protein Kinase Domain None 300 None Fasta, JSON
6866.NA RNA None 942 None Fasta, JSON

Protein domain

Protein domains of 6866.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 6866.AA Ciliate-A7 1-312 35 3.8e-159 535.0 In-house 2-360 (360) Show / Hide 
Range on Protein: 1-312
Range on HMM: 2-360/360
Sequence Identity: 35% (129 aa)

MKLVIKRNKLSS-SCSKEIIGSSNASQIIREKKVALK-----------VLRGQNVDMLVHEYQVLSQLNHTNIIKLAS---DKPFKMLKGEEGKVGLKLE
||....    || ||..||..|||..||...||....           ....|...||..||..|....|..||.|..   |.................|
MKQIFE----SSNSCIFEIKNSSNQYQIVKVKKHHEHMMYNLEGREQCCHHCQECYMLKNEYNFLKKMDHPHIIMLFEQFNDYNMDEFWHHRNCCCILME

LGHIDLFHFLKQSQPA-RLNTP------------TVKSIFRQLAQALQYLHDEKQLAHNDIKLENILLFFIQNQQTEICPKLIDFGLASASKVQTST---
....|||....|..|. .|...            .....|||.||||.|||.||..||||||.|||..|...|||...|.||.|||.|.....|...   
QAECDLFQYFSQHYPHKNLHHNEKIENQCEYCVNQMRHCFRQIAQALHYLHNEKNIAHNDIKPENIFIFCNNNQQNQYCFKLADFGFAKKYQFQSHFEST

--------IYNNWCNRSPNNLPPEIIEQLNKCCDGTSSPALKSFDSFDDDEESEFDLSKCDVFQFGLTLFNALFLNNAFCWE---NGSSS-YENFINNTP
        .|.||..|......||||..|||||| ..|...|.|.|...|...|||..|||||.||...|..|| .|.||.|   ..... |......|.
LRQQIIEDQYKNWKYRCKQYFAPEIINCLNKCCD-KNSAKNKKFISQQIDNQCEFDEKKCDVFAFGVSFFQILFQQNPFCCEACHQNDPYKYKHYFQKTY

ENYWQQEKIQHMLNMLR---------VDSSQQEIEQVVDLFNLCFKYNPSERPSMKQILGHAWF
...||...||.|.|...         .|..||.|.|..||.| ....|||.|...||||.|.||
SKFWQWMQIQWMWNHFQKEIQDMIKNTDQQQQDIDQMKDLLNKMLCPNPSQRYCIKQILQHPWF
Kinase 6866.AA Ciliate-E2 90-312 17 9.3e-28 92.35 In-house 120-365 (365) Show / Hide 
Range on Protein: 90-312
Range on HMM: 120-365/365
Sequence Identity: 17% (53 aa)

DLFHFLKQS----------QPARLNTPTVKSIFRQLAQ---------------ALQYLHDEKQLAHNDIKLENILLFFIQNQQTEICPKLIDFGLAS-AS
|||...|..          .  ...   .| |..|..|               ||.||| ..   | |||.||||.           .|.|||||.  ..
DLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----------IKIIDFGLSKKYD

KVQTSTIY---NNWCNR-------------------------SPNNLPPEIIE------QLNKCCDGTSSPALKSFDSFDDDEESEFDLSKCDVFQFGLT
. .  ...   ..|.                           .|. ..|||..      |                      ....    |||.. .| .
DDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQ----------------------QKQKGYDYKCDIWSLGVI

LFNALFLNNAFCWENGSSSYENFINNTPENYWQQEKIQHMLNMLRVD----------------SSQQEIEQVVDLFNL----CFKYNPSERPS-MKQILG
|.  || .  |                         .|.. . .. .                | ..  ... ||..     .....|..|.. ..||| 
LYEMLFGKPPF------------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILN

HAWF
| ||
HPWF
Kinase 6866.AA CAMKL 89-160 33 1.2e-16 49.45 In-house 108-176 (297) Show / Hide 
Range on Protein: 89-160
Range on HMM: 108-176/297
Sequence Identity: 33% (25 aa)

IDLFHFLKQSQPAR--LNTPTVKSIFRQLAQALQYLHDEKQLAHNDIKLENILLFFIQNQQTEICPKLIDFGLA
.|||.....    |  .  .  . .|||.  |..|.|. .  .| |||.|||||   .|.      |.||||..
MDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHG-IVHRDIKPENILLDENGNN----NIKIIDFGFS
Kinase 6866.AA S_TKc 13-312 18 2.2e-16 61.69 SMART 1-231 (231) Show / Hide 
Range on Protein: 13-312
Range on HMM: 1-231/231
Sequence Identity: 18% (59 aa)

SCSKEIIGS------SNASQIIREKKVALKVLRGQNVDMLVHEYQVLSQLNHTNIIKLASDKPFKMLKGEEGKVGLKLELGHI---DLFHFLKQSQPAR-
    ..||.        .  .   ..||.|...    ...  | |.|.. .| ||.||     . .     ... . .|.      |||...|. .. . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK-HHPNIVKL-----YDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LNTPTVKSIFRQLAQALQYLHDEKQLAHNDIKLENILLFFIQNQQTEICPKLIDFGLASASKVQTSTIYNNWCNRSPNNLPPEIIEQLNKCCDGTSS
   ..  .......|...||.|.|.  .  | |.| |||||          . |..|||||      |. .       .|. ..||..            
RFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--------HIKICDFGLARQL---TTFCG------TPWYMAPEVL------------

PALKSFDSFDDDEESEFDLSKCDVFQFGLTLFNALFLNNAFCWENGSSSYENFINNTPENYWQQEKIQHMLNMLRVDSSQQEIEQVVDLFNLCFKYNPSE
                ..  |||.  .| .|.  |     |.                        .| |.....        ... |. . |....|..
---------------GYGKCKCDWWSCGCILYEMLCGYPPFP-----------------------QMQMMFKKIG-------SPEAKDFIRKCLQKDPEK

RPSMKQILG-------HAWF
||.  ..|        | ||
RPTA-EALQDEWDIKCHPWF
Kinase 6866.AA CAMK 90-160 25 3.1e-13 38.3 In-house 150-243 (425) Show / Hide 
Range on Protein: 90-160
Range on HMM: 150-243/425
Sequence Identity: 25% (24 aa)

DLFHFLKQSQP-------------ARLNTPTVKSIFRQLAQALQYLHDEKQLAHNDIKLENILLFFIQNQQ----------TEIC-PKLIDFGLA
||| ....  .              |..   .. .|||...|..|.|. .  .| |.|.|||||    . .           . .  |.||||.|
DLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN-IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFA
Kinase 6866.AA Ciliate-C1 109-140 43 3.1e-12 27.53 In-house 132-162 (328) Show / Hide 
Range on Protein: 109-140
Range on HMM: 132-162/328
Sequence Identity: 43% (14 aa)

KSIFRQLAQALQYLHDEKQLAHNDIKLENILL
...|.|| ...||.| .   .| |.|.|||||
RYYFHQLINVIQYIH-QNNICHRDLKPENILL
Kinase 6866.AA TKL 90-231 18 6.6e-12 39.17 In-house 124-280 (364) Show / Hide 
Range on Protein: 90-231
Range on HMM: 124-280/364
Sequence Identity: 18% (34 aa)

DLFHFLKQSQPARLNTPTVKSIFRQLAQALQYLHDEK-------QLAHNDIKLENILLF-FIQ-------NQQTEICPKLIDFGLASASKVQTSTIY---
.|.|.|          .   .. .. |....||| ..       ...| |.| .|||..   .       | . ..|.|. ||||.   .  ..      
SLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMT

--------------NNWCNRSPNNLPPEIIEQL--NKCCDGTSSPALKSFDSFDDDEESE---FDLS-KCDVFQFGLTLF
              .. .  .|. ..||....   .... |               .| .   |. | ||||. ||. |.
TMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGI--------------DE-FCKGFEYSEKCDVYSFGIVLW
Kinase 6866.AA Ciliate-E2a 102-160 35 1.2e-11 30.54 In-house 95-156 (275) Show / Hide 
Range on Protein: 102-160
Range on HMM: 95-156/275
Sequence Identity: 35% (23 aa)

RLNTP--TVKSIFRQLA-QALQYLHDEKQLAHNDIKLENILLF--FIQN-QQTEICPKLIDFGLA
|...    ...| .||  |.|.|.|  .   | |.|.||||.     .. |...|.  .||||||
RFFEEIQEICDIMQQLLWQGLHYMH-QRNIMHRDLKPENILFKNCSKNSIQNSDIK--IIDFGLA
Kinase 6866.AA Ciliate-E2-Unclassified 108-161 35 1.4e-11 36.5 In-house 140-195 (352) Show / Hide 
Range on Protein: 108-161
Range on HMM: 140-195/352
Sequence Identity: 35% (21 aa)

VK-----SIFRQLAQALQYLHDEKQLAHNDIKLENILLFFIQNQQTEICPKLIDFGLAS
.|      .|.|. |.|.||| ..   | |||.||||.   ..     ..|.||||...
AKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK---NYYIKIIDFGISK
Kinase 6866.AA Pkinase 88-160 30 4.4e-10 36.74 Pfam 88-159 (293) Show / Hide 
Range on Protein: 88-160
Range on HMM: 88-159/293
Sequence Identity: 30% (23 aa)

HIDLFHFLKQSQPARL--NTPTVKSIFRQLAQALQYLHDEKQLAHNDIKLENILLFFIQNQQTEICPKLIDFGLA
..|||.... ..  ..     ..|....|....|.|.|. .   | |.|.||||.   .| ... | |..|||||
VMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILID--NNGHIDACVKICDFGLA
Kinase 6866.AA MARK 109-160 38 4.7e-09 25.93 In-house 107-153 (262) Show / Hide 
Range on Protein: 109-160
Range on HMM: 107-153/262
Sequence Identity: 38% (21 aa)

KSIFRQLAQALQYLHDEKQLAHNDIKLENILLFFIQNQQT--EICPKLIDFGLA
. ||||.  |..|.|.    .| |||.||||.     ...   |  |.||||..
RRIFRQIVSAVNYCHSKN-IVHRDIKPENILI----DENGNHNI--KIIDFGFS
Kinase 6866.AA Ciliate-E2-Unclassified 262-312 21 1.1e-08 26.3 In-house 292-352 (352) Show / Hide 
Range on Protein: 262-312
Range on HMM: 292-352/352
Sequence Identity: 21% (13 aa)

QQEKIQHMLNMLRVDSSQQ-----EIEQVV-----DLFNLCFKYNPSERPSMKQILGHAWF
.| . . . . . .... .      . . .     ||.  ..|.||..|....||| | ||
KQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 6866.AA Ciliate-C1 287-312 38 2.1e-08 17.36 In-house 303-328 (328) Show / Hide 
Range on Protein: 287-312
Range on HMM: 303-328/328
Sequence Identity: 38% (10 aa)

DLFNLCFKYNPSERPSMKQILGHAWF
|| |  . ||| .|..  .|. |.| 
DLINQMLAYNPQKRITLQEIKCHPWY
Kinase 6866.AA STE 106-161 35 7.1e-08 24.02 In-house 151-195 (359) Show / Hide 
Range on Protein: 106-161
Range on HMM: 151-195/359
Sequence Identity: 35% (20 aa)

PTVKSIFRQLAQA-LQYLHDEKQLAHNDIKLENILLFFIQNQQTEICPKLIDFGLAS
. .. | ||. .. |.|||. .   | |||  ||||            ||.|||...
SQIAYICRQILKGLLYYLHSHH-IIHRDIKPANILL-----------VKLCDFGVCG
Kinase 6866.AA STE 287-312 32 1.5e-07 22.84 In-house 332-359 (359) Show / Hide 
Range on Protein: 287-312
Range on HMM: 332-359/359
Sequence Identity: 32% (9 aa)

DLFNLCFKYNPSERPSMKQILG--HAWF
|  |.|....|..||. .| |   | ..
DFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 6866.AA CAMK 283-312 26 1.8e-07 19.36 In-house 396-425 (425) Show / Hide 
Range on Protein: 283-312
Range on HMM: 396-425/425
Sequence Identity: 26% (8 aa)

EQVVDLFNLCFKYNPSERPSMKQILGHAWF
... || . . ...|..|.. .|.| | |.
QECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 6866.AA TyrKc 4-312 18 3.2e-07 -105.94 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-312
Range on HMM: 1-280/280
Sequence Identity: 18% (63 aa)

VIKRNKLSSSCSKEIIGSSNASQIIREKKVALKVLR-GQNVDMLVHEYQVLSQL--NHTNIIKLASDKPFKMLKGEE-----GKVGLKLEL-GHIDLFHF
. .  || . .  |.             .|| |.|. .  . .. .| .....|  .| ||..|        .....     . . . .|.  | || ..
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGV----CTQQGRNFMYIEPLMIVMEYMPHGDLKDY

LKQSQPARLNTPTVKSIFRQLAQALQYLHDEKQLAHNDIKLENILLFFIQNQQTEICPKLIDFGLASASKVQ----TSTIYNNW----CNR--SPNN-LP
|. ..|  |....  |.  | |.  .|||.  .. | |.   |.|.   .      . |  ||||. . .       |. |       . .   |   ..
LRKHRPK-LCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENH------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMA

PEIIEQLNKCCDGTSSPALKSFDSFDDDEESEFDLSKCDVFQFGLTLFNALFLNNAFCWE---NGSSSYEN----FINNTPENYWQQEKIQHMLNMLRVD
|| |                         ...|  .| ||. || ..           ||   .| . |..    ...|       || |..  .  | .
PECI------------------------NYGKFT-TKSDVWSFGVCM-----------WEIFTYGQQPYPGMIQQMMSN-------QEVIEYVKQGYRMP

SSQQ--------EIEQVVDLFNLCFKYNPSERPSMKQILGHAWF
  .           . . ..   | ...|..||....|  |  |
QPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 6866.AA MARK 296-312 47 1e-06 18.09 In-house 246-262 (262) Show / Hide 
Range on Protein: 296-312
Range on HMM: 246-262/262
Sequence Identity: 47% (8 aa)

NPSERPSMKQILGHAWF
||.|||....|. | |.
NPEERPTIEEIMKHPWM
Kinase 6866.AA CAMKL 296-312 47 3e-06 15.8 In-house 281-297 (297) Show / Hide 
Range on Protein: 296-312
Range on HMM: 281-297/297
Sequence Identity: 47% (8 aa)

NPSERPSMKQILGHAWF
||..||...||. | |.
NPEKRPTIHQIMNHPWM
Kinase 6866.AA Ciliate-E2a 294-312 36 5e-06 13.64 In-house 257-275 (275) Show / Hide 
Range on Protein: 294-312
Range on HMM: 257-275/275
Sequence Identity: 36% (7 aa)

KYNPSERPSMKQILGHAWF
...|..|.. .|.| | ||
EKDPKKRITAQQALNHPWF
Kinase 6866.AA CAMK 29-64 15 2.7e-05 12.22 In-house 21-103 (425) Show / Hide 
Range on Protein: 29-64
Range on HMM: 21-103/425
Sequence Identity: 15% (13 aa)

RE---------KKVALKVLR-------------------------------GQNVDMLVHEYQVLSQ-------LNHTNIIKL
.|         .||| |..                                ... ... .|......       |.| |||||
KERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKL
Kinase 6866.AA Pkinase 292-312 47 3.5e-05 19.42 Pfam 273-293 (293) Show / Hide 
Range on Protein: 292-312
Range on HMM: 273-293/293
Sequence Identity: 47% (10 aa)

CFKYNPSERPSMKQILGHAWF
|....|..||. .||| | ||
CLCKDPKKRPTAEQILQHPWF
Kinase 6866.AA CAMKL 30-64 26 9e-05 10.99 In-house 25-80 (297) Show / Hide 
Range on Protein: 30-64
Range on HMM: 25-80/297
Sequence Identity: 26% (15 aa)

EKKVALKVLR--GQNVDMLVH----------------EYQVLSQLN---HTNIIKL
..||| |..   . . |  ..                |.| ...||   | |||||
GEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKL
Kinase 6866.AA TKL 283-310 28 0.000376 10.86 In-house 337-364 (364) Show / Hide 
Range on Protein: 283-310
Range on HMM: 337-364/364
Sequence Identity: 28% (8 aa)

EQVVDLFNLCFKYNPSERPSMKQILGHA
... .|   | ...|..|||...|| . 
PSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase 6866.AA MARK 30-64 31 0.000435 9.45 In-house 24-64 (262) Show / Hide 
Range on Protein: 30-64
Range on HMM: 24-64/262
Sequence Identity: 31% (13 aa)

EKKVALKVLR-----G-QNVDMLVHEYQVLSQLNHTNIIKL
..|||.|..        |.  ..  | .....|.| |||||
GRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKL
Kinase 6866.AA Pkinase 31-64 29 0.001246 13.92 Pfam 25-65 (293) Show / Hide 
Range on Protein: 31-64
Range on HMM: 25-65/293
Sequence Identity: 29% (12 aa)

KKVALKVLRGQNVDMLVH-------EYQVLSQLNHTNIIKL
|.||.|... .. .. ..       | |..  ||| ||..|
KIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRL
Kinase 6866.AA STE 31-63 14 0.007791 5.99 In-house 40-94 (359) Show / Hide 
Range on Protein: 31-63
Range on HMM: 40-94/359
Sequence Identity: 14% (8 aa)

KKVALKVLR--------------------GQNVDMLVHEYQVLSQLN--HTNIIK
. .| |...                     .... . .| ......|  | ||.|
EIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVK
Kinase 6866.AA Ciliate-E2 31-64 24 0.030868 3.46 In-house 48-97 (365) Show / Hide 
Range on Protein: 31-64
Range on HMM: 48-97/365
Sequence Identity: 24% (12 aa)

KKVALKVLRGQNVDMLVHEYQVL----------------SQLNHTNIIKL
|..|.|... ... ..  | ...                .|||| ||||.
KIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKM
Kinase 6866.AA TKL 29-64 15 0.270526 0.43 In-house 15-90 (364) Show / Hide 
Range on Protein: 29-64
Range on HMM: 15-90/364
Sequence Identity: 15% (12 aa)

RE----------KKVALKVLRGQNV------------------------------DMLVHEYQVLSQLNHTNIIKL
|           | || |... .|.                              . .. |  ..|.|.| ||...
RGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQF