9865

Species: Tetrahymena
Alias: 602, PreTt09865, TTHERM_00268310, 3690.m00110, 9865, 24.m00296
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-A7

Sequence

Name Sequence Type Origin Length Description Download
9865.AA Protein None 313 None Fasta, JSON
9865.kin_dom Protein Kinase Domain None 261 None Fasta, JSON
9865.NA RNA None 942 None Fasta, JSON

Protein domain

Protein domains of 9865.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 9865.AA Ciliate-A7 43-300 37 1.5e-139 469.87 In-house 54-360 (360) Show / Hide
Range on Protein: 43-300
Range on HMM: 54-360/360
Sequence Identity: 37% (116 aa)

DLKREYTILKNLQHENIISVGEYFEDLALDNFKDHSEVRGFTMELAQCDLLTYLKSNHPN-PLHPV------------KARQIFSGIAKAVQYLHS-KNF
.||.||..||...|..||...|.|.|...|.|..|.......||.|.|||..|.....|. .||..            ..|..|..||.|..|||. ||.
MLKNEYNFLKKMDHPHIIMLFEQFNDYNMDEFWHHRNCCCILMEQAECDLFQYFSQHYPHKNLHHNEKIENQCEYCVNQMRHCFRQIAQALHYLHNEKNI

AHNDIKLENVLIFENGE------AKLSDFGFACN--TSSPF-----------QAEQWRYRAPSFLAPEMIKYLSK---KPSAASK-----DSNNQSTFDL
||||||.||..||.|..      .||.|||||..  ..|.|           |...|.||.....|||.|..|.|   |.||..|     ...||..||.
AHNDIKPENIFIFCNNNQQNQYCFKLADFGFAKKYQFQSHFESTLRQQIIEDQYKNWKYRCKQYFAPEIINCLNKCCDKNSAKNKKFISQQIDNQCEFDE

TKTDSFAFGVCMFESLFFVLPFHSERAFENDTY-YSYIVLKNYEGFWEIPFIKRLTNIYQR--F-----FDSSEVRFAQLKDLLNKLLTRNPSERLSFNE
.|.|.|||||..|..||...||..|....||.| |.... |.|..||....|....|..|.  .     .|.......|.||||||.|..|||.|.....
KKCDVFAFGVSFFQILFQQNPFCCEACHQNDPYKYKHYFQKTYSKFWQWMQIQWMWNHFQKEIQDMIKNTDQQQQDIDQMKDLLNKMLCPNPSQRYCIKQ

ILTHPWF
||.||||
ILQHPWF

Kinase 9865.AA CAMK 21-300 17 1.5e-40 127.87 In-house 29-425 (425) Show / Hide
Range on Protein: 21-300
Range on HMM: 29-425/425
Sequence Identity: 17% (73 aa)

TEENIEYALKI-----QTSSH----------------------QLAKEQDLKREYTILKNLQ-------HENIISVGEYFED------------------
|. . ..| ||      ....                      .  ... ..||. |.|.||       |.|||.  |..||                  
TN-GQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYETSKQVFT

------LALDNFKDHSEVRGFTMELAQC-----DLLTYLKSNHP-------------NPLHPVKARQIFSGIAKAVQYLHSKNFAHNDIKLENVLIFEN-
      . .             ||...      ||. |.... .               ..   ||..|  |. ||.|.||.| .| |.|.||.|. .| 
KDKHMYMVME-----------IMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNN

----------------GEAKLSDFGFA--CNTSS-------PFQAEQWRYR----------------APSFLA-PEMIKYLSKKPSAASKDSNNQSTFDL
                .  |..|||||  .. ..       . ..|    .                 |.. | ||.... .....  .  .... . . 
DDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQ-NA-TDEEKPYYG

TKTDSFAFGVCMFESLFFVLPFHSE---RAFENDTYYSYIVLKNYEGFW---EIPFIKRLTNIYQRFFDSSEVRF----------------------AQL
 |.|  . || ..  |   .|| ..   . .| |           |  |   ... ...     .  |.....                        .. 
PKCDMWSCGVILYIMLCGYPPFYGDCDNEICE-D-----------E--WIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQEC

KDLLNKLLTRNPSERLSFNEILTHPWF
|||..|.|...|..|..  ..| |||.
KDLIRKMLQVDPEKRMTIEQCLNHPWM

S_TKc 9865.AA S_TKc 2-300 20 1.7e-38 135.11 SMART 1-231 (231) Show / Hide
Range on Protein: 2-300
Range on HMM: 1-231/231
Sequence Identity: 20% (64 aa)

IYQAEHIDQTHSSTVMRIQTEE-NIEYALKIQTSSHQLAKEQDLKREYTILKNLQHENIISVGEYFEDLALDNFKDHSEVRGFTMELAQC---DLLTYLK
    ..| .   ..|.. .  . . ..|.||          ....||  |||. .|.||.   ..|.|          .   . ||..     ||..|.|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD----------DHLYMVMEYCDGDLGDLFDYIK

SNHPNP----LHPVKARQIFSGIAKAVQYLHSKNFAHNDIKLENVLIFENGEAKLSDFGFACNTSSPFQAEQWRYRA-PSFLAPEMIKYLSKKPSAASKD
.. ...    ...  || ..  |..|..|.||... | |.| ||.|. |  . |..|||.|.            .   | ..|||..             
KRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL-------------

SNNQSTFDLTKTDSFAFGVCMFESLFFVLPFHSERAFENDTYYSYIVLKNYEGFWEIPFIKRLTNIYQRFFDSSEVRFAQLKDLLNKLLTRNPSERLSFN
      ..  | |  ..|....| |    ||.     . .. .  |.                                ..||...|.|...|..|..  
-----GYGKCKCDWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG------------------------------SPEAKDFIRKCLQKDPEKRPTA-

EILT-------HPWF
|.|.       ||||
EALQDEWDIKCHPWF

Kinase 9865.AA Ciliate-E2 17-300 19 2.2e-37 125.9 In-house 36-365 (365) Show / Hide
Range on Protein: 17-300
Range on HMM: 36-365/365
Sequence Identity: 19% (76 aa)

MRIQT-----EENIEYALKIQTSS--HQLAKEQDLKREYT----------ILKNLQHENIISVGEYFEDLALDNFKDHSEVRGFTMELAQC-DLLTYLKS
. ...       . .||.||.  .   |. .|... ||            ||..|.| |||   |.|..   .|.        . ||..|  ||. |.|.
Q-QRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIY-------LVMEYCQGGDLFDYIKN

N----------HPNPLHPVKARQIFSGIAK---------------AVQYLHSKN-FAHNDIKLENVLIFENGEAKLSDFGFA-------CNTSSPFQAEQ
|            ...   ....|.  |..               |..||||||   | |||.||.|.      |..|||..       .|..  .|  .
NKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTH-KQQCK

WRYR-------------------------APSFLAPEMIKYLS---KKPSAASKDSNNQSTFDLTKTDSFAFGVCMFESLFFVLPFHSERAFENDTYYSY
|                             | ..|||.... .              ....   .| | ...||...| ||  .||              
WYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQ----------QKQKGYDYKCDIWSLGVILYEMLFGKPPF--------------

IVLKNYEGFWEIPFIKRLTNIYQRFFD--------------SSEVRFAQLKDLLNK----LLTRNPSERLS-FNEILTHPWF
             ... . . .. ..               | .    . |||..|    .| ..|..|.. ...|| ||||
-------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF

Kinase 9865.AA Ciliate-E2-Unclassified 91-300 23 5.1e-34 115.41 In-house 107-352 (352) Show / Hide
Range on Protein: 91-300
Range on HMM: 107-352/352
Sequence Identity: 23% (62 aa)

DLLTYLKSNHP---------------NPLHPVKAR-----QIFSGIAKAVQYLHSKN-FAHNDIKLENVLIFENG---EAKLSDFGFACNTSSP------
||. |.|...                . .   .|.     ..|  | .. .|||.|| . | |||.||.|. .||   . |..|||.. .  ..      
DLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTN

---------FQAEQWRYRAPSFL----APEMIKYLSKKPSAASKDSNNQSTFDLTKTDSFAFGVCMFESLFFVLPFHSERAFENDT-------------Y
         .|  . .   |...    |||...      |.|             | | ...||...| ||  .|| ..   ....             .
QQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA------------YKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQL

YSYIVLKNYEGFWEIP--FIKRLTNIYQRFFDSSEVRFAQLKDLLNKLLTRNPSERLSFNEILTHPWF
|. |  ||.. ... .  . |.. . .. |            ||| |.|  ||..|..|..|| ||||
YQNIKQKNIQFPKFPWQQIPKHWSPEAKDFIN----------DLLQKMLKKNPNKRITFEQILNHPWF

Kinase 9865.AA CAMKL 36-154 28 4.1e-27 83.45 In-house 53-176 (297) Show / Hide
Range on Protein: 36-154
Range on HMM: 53-176/297
Sequence Identity: 28% (40 aa)

HQLAKEQDLKREYTILKNLQ---HENIISVGEYFEDLALDNFKDHSEVRGFT---------MELAQCD---LLTYLKSNHP--NPLHPVKARQIFSGIAK
| ....  ..||. |.| |.   |.|||.  | .|.                         ||...     |. |....     ....  ||..|  |  
H-ESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEH------------DIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVS

AVQYLHSKNFAHNDIKLENVLIFENG--EAKLSDFGFA
||.|.||.. .| |||.||.|. |||   .|..||||.
AVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFS

Kinase 9865.AA Pkinase 23-226 23 2.8e-23 83.4 Pfam 23-215 (293) Show / Hide
Range on Protein: 23-226
Range on HMM: 23-215/293
Sequence Identity: 23% (51 aa)

ENIEYALKIQTSSHQLAKEQDLKR---EYTILKNLQHENIISVGEYFEDLALDNFKDHSEVRGFTMELAQC-----DLLTYLK-SNHPNPL--HPVKARQ
.....|.||   .|.  ...  .|   |  |.|.|.|.||.   ..|||        ....  . ||....     || .|.. ..| ...   .  .. 
TGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--------KDHIY-MVMEYCEGGLYVMDLFDYISTWRH-GCFYFSEWECKF

IFSGIAKAVQYLHSKNFAHNDIKLENVLIFENGEA----KLSDFGFACNTSSPFQAEQWRYRA-PSFLAPEMIKYLSKKPSAASKDSNNQSTFDLTKTDS
..  |.....|.||... | |.|.||.|| .||.     |..|||.|.  .   .   . .   | ..||| |.                .. . .| | 
YMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR---------------GGQYYGPKVDM

FAFGVCMFESLFFVLPFHSE
...|. ..| |.  .|| ..
WSCGCILYEMLCGRPPFPGH

Kinase 9865.AA TSSK 83-155 39 1.1e-22 71.29 In-house 94-171 (289) Show / Hide
Range on Protein: 83-155
Range on HMM: 94-171/289
Sequence Identity: 39% (31 aa)

FTMELAQC-DLLTYLKSN----HPNPLHPVKARQIFSGIAKAVQYLHSKNFAHNDIKLENVLIFENGEAKLSDFGFAC
..||.|.  ||| | . .      ..|| ..||. |. ...||.|.||.| .| |.|.||.| ....  ||.|||||.
MVMEYAEHGDLLEYIQRRTQERCCGALHEEQARKWFRQMVSAVKYCHSHNVVHRDLKCENILLDKHWNIKLTDFGFAR

Kinase 9865.AA CMGC 20-160 18 1.2e-18 57.08 In-house 34-257 (513) Show / Hide
Range on Protein: 20-160
Range on HMM: 34-257/513
Sequence Identity: 18% (42 aa)

QTEENIEYALKIQTSSHQLAKEQD-----------LKREYTILKNLQ-----------------HENIISVGEYFEDLA--LDNFKDHSE------VRGF
..| | ..|.|.  . .    ..              ||  |||.|.                 |.||..  ..| .     ....| ..         .
HHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYL

TMELAQCDLLTYLKSNH-------PNPLHPVK------------ARQIF------SGIAKAVQ--YLHSKN--FAHNDIKLENVLIFENGEA--------
 .|. ..||. |.|.|.       |.|| . .             . ..        | ...   |.||..  . | |.| ||.|| .|.|         
VFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKS

------------KLSDFGFACNTSSP
            |. |||.|. ....
EDWNPCQKNGRLKICDFGLARWYHPH

Kinase 9865.AA MARK 91-154 50 2.7e-18 56.58 In-house 88-153 (262) Show / Hide
Range on Protein: 91-154
Range on HMM: 88-153/262
Sequence Identity: 50% (33 aa)

DLLTYLKSNHPNPLHPVKARQIFSGIAKAVQYLHSKNFAHNDIKLENVLIFENG--EAKLSDFGFA
.|. |.|.    .||   ||.||. |  ||.|.|||| .| |||.||.|| |||   .|..||||.
ELYDYIKAHPNGRLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFS

Kinase 9865.AA ULK 85-154 33 8.9e-15 48.92 In-house 117-206 (324) Show / Hide
Range on Protein: 85-154
Range on HMM: 117-206/324
Sequence Identity: 33% (30 aa)

MELAQC-DLLTYLKSNHPNP-------LHPVKARQIFSGIAKAVQYLHSKNFAHNDIKLENVLIFEN------------GEAKLSDFGFA
||. .. || .|.| |.. |       |   .|.|.|  |. . ..||..|  | |||..| || ..            | .|..|||||
MEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFA

Kinase 9865.AA RSK 109-155 38 1.1e-13 46.78 In-house 106-155 (278) Show / Hide
Range on Protein: 109-155
Range on HMM: 106-155/278
Sequence Identity: 38% (19 aa)

ARQIFSGIAKAVQYLHSKNFAHNDIKLENVLIFE---NGEAKLSDFGFAC
|..... |..||..||.. . | |.|.||.|  .   .|. ||.||||..
ACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCK

Kinase 9865.AA CAMKL 272-300 37 1.1e-11 33.4 In-house 269-297 (297) Show / Hide
Range on Protein: 272-300
Range on HMM: 269-297/297
Sequence Identity: 37% (11 aa)

QLKDLLNKLLTRNPSERLSFNEILTHPWF
...||. |.|..||..| .  .|. |||.
DCRDLIRKMLQVNPEKRPTIHQIMNHPWM

Kinase 9865.AA RSK 274-300 46 1.6e-10 35.04 In-house 247-278 (278) Show / Hide
Range on Protein: 274-300
Range on HMM: 247-278/278
Sequence Identity: 46% (15 aa)

KDLLNKLLTRNPSERLS-----FNEILTHPWF
|||..|.|.|.|. ||.      .||. ||||
KDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF

Kinase 9865.AA MARK 271-300 43 3e-10 29.87 In-house 233-262 (262) Show / Hide
Range on Protein: 271-300
Range on HMM: 233-262/262
Sequence Identity: 43% (13 aa)

AQLKDLLNKLLTRNPSERLSFNEILTHPWF
.....|...||| ||.|| .  ||. |||.
KECRNLIQRLLTVNPEERPTIEEIMKHPWM

Kinase 9865.AA Pkinase 273-300 39 4.5e-10 36.71 Pfam 266-293 (293) Show / Hide
Range on Protein: 273-300
Range on HMM: 266-293/293
Sequence Identity: 39% (11 aa)

LKDLLNKLLTRNPSERLSFNEILTHPWF
.||.....|...|..|... .|| ||||
CKDFIKWCLCKDPKKRPTAEQILQHPWF

Kinase 9865.AA ULK 272-300 41 7.8e-10 31.14 In-house 296-324 (324) Show / Hide
Range on Protein: 272-300
Range on HMM: 296-324/324
Sequence Identity: 41% (12 aa)

QLKDLLNKLLTRNPSERLSFNEILTHPWF
..|||. ..|......| |. ||. ||||
ECKDLIRRMLQYDEKDRISWEEIFNHPWF

Kinase 9865.AA CMGC 272-300 41 2.5e-09 25.83 In-house 485-513 (513) Show / Hide
Range on Protein: 272-300
Range on HMM: 485-513/513
Sequence Identity: 41% (12 aa)

QLKDLLNKLLTRNPSERLSFNEILTHPWF
|. |||.|.|. .|..|..  ..| ||.|
QAIDLLKKMLQYDPDKRITAEQALQHPYF

TyrKc 9865.AA TyrKc 1-300 21 4.9e-09 -76.53 SMART 14-280 (280) Show / Hide
Range on Protein: 1-300
Range on HMM: 14-280/280
Sequence Identity: 21% (70 aa)

MIYQAEHIDQTHSSTVMRIQTEENIEYALKIQTSSHQLAKEQDLKREYTILKNL--QHENIISVGEYFEDLALDNF------KDHSEVRGFTMELAQC-D
 .|... .                |. | |   ...    ..|. ||  |...|  .|.||.     .   ... .      . .  |    ||..   |
EVYKGTWK----------------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVR----LYGVCTQQGRNFMYIEPLMIV----MEYMPHGD

LLTYLKSNHPNPLHPVKARQIFSGIAKAVQYLHSKNFAHNDIKLENVLIFENGEAKLSDFGFACNTSSP---FQAEQWRYRA----PSF-------LAPE
|. ||....|. | . .  ..   ||.  .||||||. | |.   |.|. ||. .| |||| . .  .      ...  ||.     .        .|||
LKDYLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG-ESKDYYRKKEHKGGKTMLPIRWMAPE

MIKYLSKKPSAASKDSNNQSTFDLTKTDSFAFGVCMFESLFFVLPFHSERA-----FENDTYYSYIVLKNYEGFWEI--PFIKRLTNIYQRFFDSSEVR-
 |               | ..|  ||.| ..|||||.|   | .             .|.  . |.   ..    .   | .          |    |. 
CI---------------NYGKFT-TKSDVWSFGVCMWE--IFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYP-MS---------F----VCC

FAQLKDLLNKLLTRNPSERLSFNEILTHPWF
 . . ..  .   ..|..| .|.||  |  |
PDEMYQIMKQCWHEDPEDRPTFSEI--HECF

Kinase 9865.AA Pkinase_Tyr 85-152 39 4.4e-08 27.99 Pfam 86-156 (270) Show / Hide
Range on Protein: 85-152
Range on HMM: 86-156/270
Sequence Identity: 39% (28 aa)

MELAQC-DLLTYLKSN--HPNPLHPVKARQIFSGIAKAVQYLHSKNFAHNDIKLENVLIFENGEAKLSDFG
||.... |||.||...   ..|| .    |.   |||. .||.|||. | |.   |.|. ||. .| .|||
MEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFG

Kinase 9865.AA TSSK 274-300 40 6.2e-07 18.78 In-house 263-289 (289) Show / Hide
Range on Protein: 274-300
Range on HMM: 263-289/289
Sequence Identity: 40% (11 aa)

KDLLNKLLTRNPSERLSFNEILTHPWF
|||. ..|. .|..|.. |||. |.| 
KDLIRHMLQPHPCNRPHINEICHHCWM

Kinase 9865.AA MARK 40-61 40 0.000659 8.85 In-house 42-63 (262) Show / Hide
Range on Protein: 40-61
Range on HMM: 42-63/262
Sequence Identity: 40% (9 aa)

KEQDLKREYTILKNLQHENIIS
. . ..||  |.| |.|.|||.
WMKNVMREIEIMKKLDHPNIIK

Kinase 9865.AA TSSK 46-67 47 0.054117 2.31 In-house 64-86 (289) Show / Hide
Range on Protein: 46-67
Range on HMM: 64-86/289
Sequence Identity: 47% (11 aa)

REYTILKN-LQHENIISVGEYFE
||  |... |.|.||| . | ||
REIQIMRKTLKHPNIIQFYEMFE

Kinase 9865.AA Pkinase_Tyr 29-61 35 0.158838 5.79 Pfam 36-68 (270) Show / Hide
Range on Protein: 29-61
Range on HMM: 36-68/270
Sequence Identity: 35% (12 aa)

LKIQTSSHQLAKEQDLKREYTILKNL-QHENIIS
|| .....|. . .|. ||  |.|.| .|.||..
LKEGAMHEQN-CREDFMREAKIMKQLGHHPNIVR

Kinase 9865.AA Pkinase_Tyr 202-215 57 5.090112 0.69 Pfam 193-206 (270) Show / Hide
Range on Protein: 202-215
Range on HMM: 193-206/270
Sequence Identity: 57% (8 aa)

TKTDSFAFGVCMFE
||.|  .|||.|.|
TKSDVWSFGVLMWE