Gene 26895 (Tetrahymena)
26895
Group:
Other
Family:
Ciliate-A8
Sequence
Protein domains of 26895.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 26895.AA | Ciliate-A8 | 1112-1235 | 42 | 2.9e-64 | 219.82 | In-house | 18-151 (151) | Show / Hide |
Range on Protein: 1112-1235 Range on HMM: 18-151/151 Sequence Identity: 42% (57 aa) AYSQVLKENFAIKIIIYQHFEDEQLKKIKNEIYKYSNLIDKSNYNIQIYEQIEDPNQKFIGFVYDYFDC--------NLESILD--SNQFTFDQVVNLTK |||. .....|||||.|.........|...........|....|..||.|.|.|..|.||..|....|| ||.|||. .|.|||.|.|.||. AYSINHQCQVAIKIIKYMNQQNKINDKEFEKCIQAMQKIKNEKYILQIIECIQDKEQGFIAIVTEFCDCFDFYKKKENLASILENNLNKFTFEQIVALTY QLLECLSIFQEKNAIHCNIKPQNILFNKSECKFV |||.||..||||..|||.|||||||...|...|. QLLKCLLVFQEKGIIHCDIKPQNILYSWSKNQFI |
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| Kinase | 26895.AA | Ciliate-E1 | 1118-1282 | 25 | 4.4e-24 | 75.52 | In-house | 19-202 (202) | Show / Hide |
Range on Protein: 1118-1282 Range on HMM: 19-202/202 Sequence Identity: 25% (47 aa) KENFAIKIIIYQHF-EDEQLKKIKNEIYKYSNLIDKSNYNIQIYEQIEDPNQKFIGFVYDYFDCNLESILD--------------SNQFTFDQVVNLTKQ ... |.||| .. . ..... ....|.||. . . | | |||...|.. . ... .. .. .|.|. |. |||||.|......| YNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQCQQNQNQFTFQQKMQIIFQ LLECLSIFQEKNAIHCNIKPQNILFNKSECKFVIVDYGVSYLLEQILSQKTKSILGSNAAYQSPELL------DKQEPFDIKSDVF |.. |.... .| ||..|||||||.|.. ..|. | |.| .| | .. . |..... .|... ..|||.. LIDGLIELHQYNIIHRDIKPQNILINNQ-GNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINYKSDIY |
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| Kinase | 26895.AA | Ciliate-B2 | 1173-1285 | 26 | 9.5e-17 | 35.82 | In-house | 78-197 (197) | Show / Hide |
Range on Protein: 1173-1285 Range on HMM: 78-197/197 Sequence Identity: 26% (33 aa) FVYDYFDCNLESILD----SN-QFTFDQVVNLTKQLLECLSIFQEKNAIHCNIKPQNILFNKSECKFVIVDYGVSYLLEQILSQKTKSILGSNAAYQSPE .. . . | |.. |. .|. ... ||.. | | .| .| |||||||| ... ..| |.|.| . . . .| | .| ||| LIMEKCECSLKQELQKIQKQQKCFNNQKLYQMIFQLIDGLIQFRMYNILHLDIKPQNILFMQNG-NYVYCDFGISSIKK---DNQQIKIKGFTKKYASPE LLDKQ------EPFDIKSDVFSVG ... | .||..| | QMECDHNQTFVTNIDFQSDIYSMG |
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| S_TKc | 26895.AA | S_TKc | 1100-1354 | 16 | 4.5e-14 | 29.5 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 1100-1354 Range on HMM: 1-231/231 Sequence Identity: 16% (47 aa) FQLF-------ISNCMLIYAYSQVLKENFAIKIIIYQHFEDEQLKKIKNEIYKYSNLIDKSNYNIQIYEQIEDPNQKFIGFVYDYFDC---NLESILDSN ... . ... . . .. .||||| ..|..|| .. . . ...|. ..| ... .| .| | .| ...... YEILRKIGKGAFGKVYKCRHKK--TGRIVAIKIIK---------EHIRREIQILKK---HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKR Q-------FTFDQVVNLTKQLLECLSIFQEKNAIHCNIKPQNILFNKSECKFVIVDYGVSYLLEQILSQKTKSILGSNAAYQSPELLDKQEPFDI-KSDV . |. .. ...|... | ... ||. .||.|||... | | |.. .| ... |. | .||.| ... |.|. GRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL--------TTFCGT-PWYMAPEVL----GYGKCKCDW FSVGLIITEALLKRRLQGREHINLKLYSLERGMEEQQKKENELFLQQILFKMVNPDLNKRLIPSQLLD------CLKIF |.| |. | | . . .... . . . ... .. |. . | .||. ..| | | WSCGCILYEMLCGYPPFP--QMQMMFKKIG----------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 26895.AA | Ciliate-C5 | 1178-1298 | 30 | 1.4e-13 | 40.78 | In-house | 75-198 (260) | Show / Hide |
Range on Protein: 1178-1298 Range on HMM: 75-198/260 Sequence Identity: 30% (38 aa) FDCNLESILDS-----NQFTFDQVVNLTKQLLECLSIFQEKNAIHCNIKPQNILFNKSECKFVIVDYGVSYLLEQILSQKTKSILGSNAAYQSPELLDKQ . ||| |. | .|.. . |. . |..| || .||.|||.. | | . ||| | ... . || . | | ||. |. YSCNLKDIMQSFFDQKKTLPLNQIIGFAIQMSTVFEKIQQNNLIHSDVKPENILYDSQEKCFNLCDYGESKSFKD--GSKTYDLKGFTRKYAAPEITDDN EPFDIKSDVFSVGLIITEALLKRRLQ |.|| |.. .|.|. | | . |. GFFNIKYDIYGLGIILLELTLGKFLE |
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| Kinase | 26895.AA | TKL | 1216-1351 | 14 | 6.6e-13 | 42.81 | In-house | 162-364 (364) | Show / Hide |
Range on Protein: 1216-1351 Range on HMM: 162-364/364 Sequence Identity: 14% (30 aa) IHCNIKPQNILFNK-------------SECKFVIVDYGVSYLLEQILSQK-----------------TKSILGSNAAYQSPELLDKQ------------- ||...|..||| .. .... | |.| | ..| ... |.. . . .. .||.|..| IHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFC --EPFDIKSDVFSVGLIITEALLKRRLQGREHINLKLYS----LERGMEEQQKKENELF------------------LQQILFKMVNPDLNKRLIPSQLL .... |.||.| |... | | .| .. . . . .. | . .. .. . ... . ..| .||. ...| KGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEIL DCL . | KRL |
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| Kinase | 26895.AA | C8 | 1202-1288 | 27 | 2.5e-12 | 39.21 | In-house | 131-226 (226) | Show / Hide |
Range on Protein: 1202-1288 Range on HMM: 131-226/226 Sequence Identity: 27% (27 aa) QLLECLSIFQEKNAIHCNIKPQNILFNKSECKF---VIVDYGVSYLLEQILS-QKTKSI--LGSNAAYQSPELLDK----QEPFDIKSDVFSVGLII |...... . || .| |||.|.| .. . . | |.. ... | .| . .| . || || . | . |.||.|||||. QMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCG-TWAYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL |
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| Kinase | 26895.AA | STE | 1186-1288 | 23 | 1.4e-10 | 33.7 | In-house | 138-258 (359) | Show / Hide |
Range on Protein: 1186-1288 Range on HMM: 138-258/359 Sequence Identity: 23% (30 aa) LDSNQ-----FTFDQVVNLTKQLLEC-LSIFQEKNAIHCNIKPQNILFNKSECKFVIVDYGVSYLLEQILS---------------QKTKSILGSNAAYQ |..|. | .|. ..|.|. |. ... || |||.|||. ..| ||. |..... ||.... |. . LNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP--WM SPELLDK-----QEPFDIKSDVFSVGLII .|| ... . |.|.|. |.|. | APEVIQQNGQGRDKGYDTKCDIWSLGCTI |
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| Kinase | 26895.AA | STE-Unique | 1194-1288 | 19 | 2.1e-10 | 32.61 | In-house | 403-543 (616) | Show / Hide |
Range on Protein: 1194-1288 Range on HMM: 403-543/616 Sequence Identity: 19% (28 aa) DQVVNLTKQLLECLSIFQEKN--AIHCNIKPQNILFNKSE----CKFVIVDYGVSYLLEQI------------------LS------------------- ..| .|.|.|| | . || ..|| ||..... || .|.|.| . . . .. TEVIWYTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVKICDFGHATCCQPDHFEKDNNSKNSNTWININNNSSTNSTAQQTPMWDLNINN QKTKSILGSNAAYQSPELLDKQ----EPFDIKSDVFSVGLII |.. | . | .|| . .. |.| |.|..| | .. YTMKYCCG-TPCYMCPEVINCRNQINNPYDTKVDIWSLGCMC |
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| Kinase | 26895.AA | Ciliate-E2 | 1118-1349 | 18 | 6.5e-09 | 26.71 | In-house | 24-361 (365) | Show / Hide |
Range on Protein: 1118-1349
Range on HMM: 24-361/365
Sequence Identity: 18% (68 aa)
KENFAIKIIIYQH-------------------FEDEQLKKIKNEIYKYS---------N-----LIDKSNYNIQIYEQIEDPNQKFIGFVYDYFDC-NLE
...|||||| | .. |.. ||.||. . | ...... |..|| .. ... | .| .|.. .|.
QKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLF
SILDSN------------QFTFDQVVNLTKQLLE---------------CLSIFQEKN-AIHCNIKPQNILFNKSECKFVIVDYGVSY------------
... .| .|| .. ...||.|. .| .|| || .|||.|||| |.| | |
DYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------IKIIDFGLSKKYDDDNQNRTHK
----LLEQILS---------------QKTKSILGSNAAYQSPELLD--------KQEPFDIKSDVFSVGLIITEALLKRRLQGREHINLKLYSLERGMEE
.. . . . ...|.| .. |..|| | ||.. | |.|..|.| |. | | ... .
QQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICG-TPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF-----------------Q
QQKKENELFLQ--------------------------QILFK----MVNPDLNKRLI-PSQLLD
||.|.... .. ... | | . | .||. ..|.|.
QQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILN
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| Kinase | 26895.AA | NEK-Unclassified | 1202-1290 | 29 | 1.5e-08 | 24.11 | In-house | 105-189 (258) | Show / Hide |
Range on Protein: 1202-1290 Range on HMM: 105-189/258 Sequence Identity: 29% (26 aa) QLLECLSIFQEKNAIHCNIKPQNILFNKSECKFVIVDYGVSYLLEQILSQKTKSILGSNAAYQSPELLDKQEPFDIKSDVFSVGLIITE |. . . . || ||||| .. . |.|.| .. | . |. . ||| ...| |.. .||| | | || | QMIMAVQYIHQRKIIHRDLKPQNIFLTDDDT-VSMGDFGISRIMDHTR-DKARTCVGT-MCWMSPEVCQDQ-PYNNRSDVWSLGCIIYE |
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| Kinase | 26895.AA | Pkinase | 1119-1295 | 20 | 5.8e-08 | 29.25 | Pfam | 25-209 (293) | Show / Hide |
Range on Protein: 1119-1295 Range on HMM: 25-209/293 Sequence Identity: 20% (40 aa) ENFAIKIIIYQHFEDEQLKKIKN--EIYKYSNLIDKSNYNIQIYEQIEDPNQKFIGFVYDYFDC-----NLESILD---SNQF--TFDQVVNLTKQLLEC . .|.||| ..| ...... . ||. .| . . . ...|. || . | .| .| .. | ... .. | . ... . .|.|. KIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-N-HPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRG LSIFQEKNAIHCNIKPQNILFNKSECKF----VIVDYGVSYLLEQILSQKTKSILGSNAAYQSPELLDKQEPFDIKSDVFSVGLIITEALLKR | ... ||. .||.|||.. ... | | |.. ... . .. . . | .||.. .... . |.|..|.|.|. | |..| LEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGR |
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| LRR_RI | 26895.AA | LRR_RI | 1415-1442 | 32 | 0.001225 | 19.09 | SMART | 1-28 (28) | Show / Hide |
Range on Protein: 1415-1442 Range on HMM: 1-28/28 Sequence Identity: 32% (9 aa) NLTFLILDLQTNAIGIEGATHIGFSLKQ | . . |.|. | .|.||. .. .||. NCSLRELWLSNNKLGDEGCRQLCEGLKH |
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| LRR_RI | 26895.AA | LRR_RI | 1473-1502 | 26 | 0.043759 | 8.13 | SMART | 1-28 (28) | Show / Hide |
Range on Protein: 1473-1502 Range on HMM: 1-28/28 Sequence Identity: 26% (8 aa) LHQLQDLKLNFCDNKIGVQGAQWFASRLHD .. |. | |. .||.| |...... |.. NCSLRELWLS--NNKLGDEGCRQLCEGLKH |
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| LRR_RI | 26895.AA | LRR_RI | 1563-1592 | 20 | 0.156179 | 4.23 | SMART | 1-28 (28) | Show / Hide |
Range on Protein: 1563-1592 Range on HMM: 1-28/28 Sequence Identity: 20% (6 aa) LNKLVYLNINLCDNDIQDPGANSIGNCLEK . .| |... .|.. | |. . ..|. NCSLRELWLS--NNKLGDEGCRQLCEGLKH |
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| LRR_RI | 26895.AA | LRR_RI | 1533-1562 | 16 | 0.18325 | 3.74 | SMART | 1-28 (28) | Show / Hide |
Range on Protein: 1533-1562 Range on HMM: 1-28/28 Sequence Identity: 16% (5 aa) NTKIESLRLSLYQNNICQIGVNSIEQFIQK |.... .|.| .|... |. . . .. NCSLR--ELWLSNNKLGDEGCRQLCEGLKH |
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| LRR_RI | 26895.AA | LRR_RI | 1623-1652 | 40 | 0.179698 | 3.8 | SMART | 1-28 (28) | Show / Hide |
Range on Protein: 1623-1652 Range on HMM: 1-28/28 Sequence Identity: 40% (12 aa) CVNITELSVVLKNNKVGKEGAADLVSALGH .. ||. | |||.| ||.. | ..| | NCSLRELW--LSNNKLGDEGCRQLCEGLKH |
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| LRR_RI | 26895.AA | LRR_RI | 1595-1622 | 28 | 0.228015 | 3.07 | SMART | 1-28 (28) | Show / Hide |
Range on Protein: 1595-1622 Range on HMM: 1-28/28 Sequence Identity: 28% (8 aa) NLKRLYLNLNKNNIKKQGASNLFKGLQQ | . . |.|. |.. |. | .||.. NCSLRELWLSNNKLGDEGCRQLCEGLKH |
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