9756

Species: Tetrahymena
Alias: 24.m00187, 607, 3690.m00003, TTHERM_00266210, 9756, PreTt09756
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-A8

Sequence

Name Sequence Type Origin Length Description Download
9756.AA Protein None 676 None Fasta, JSON
9756.kin_dom Protein Kinase Domain None 197 None Fasta, JSON
9756.NA RNA None 2031 None Fasta, JSON

Protein domain

Protein domains of 9756.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 9756.AA Ciliate-A8 30-170 58 3.9e-91 309.06 In-house 1-151 (151) Show / Hide
Range on Protein: 30-170
Range on HMM: 1-151/151
Sequence Identity: 58% (89 aa)

YEYQKVLVKGDFSIIVMAYSYRLQQQVAIKIIQRLKQQNKAYLQEFYKEIQVIQVFENKKYALQIIETIQDKRQKFIGIVAEICQC--------NLATIL
|.|||||.|||||..|.|||...|.|||||||....||||.. .||.|.||..|...|.||.|||||.||||.|.||.||.|.|.|        |||.||
YKYQKVLEKGDFSYVVQAYSINHQCQVAIKIIKYMNQQNKINDKEFEKCIQAMQKIKNEKYILQIIECIQDKEQGFIAIVTEFCDCFDFYKKKENLASIL

D--LNTLSFEQVLALTYQLLHCLLLFQKYDTIHSDIKHESILYSKSKNQFK
.  ||...|||..|||||||.|||.||....||.|||...||||.|||||.
ENNLNKFTFEQIVALTYQLLKCLLVFQEKGIIHCDIKPQNILYSWSKNQFI

Kinase 9756.AA Ciliate-E1 36-218 26 4.6e-31 98.46 In-house 1-202 (202) Show / Hide
Range on Protein: 36-218
Range on HMM: 1-202/202
Sequence Identity: 26% (54 aa)

LVKGDFSIIVMAYSYRLQ-QQVAIKIIQRLKQQNKAYLQEFYKEIQ-VIQVFENKKYALQIIETIQDKRQKFIGIVAEICQCNLATILD-----------
. .|.|||.. |...  . .|||.|||..  ..|. ..|.  ||.. . . |....| .|||..|...  ... |. | |.|.|   |.           
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC

---LNTLSFEQVLALTYQLLHCLLLFQKYDTIHSDIKHESILYSKSKNQFKIANYGLSKIKSNPFYEKIQTFDDGKLCYRSPEVIN------GLKIQFNI
    | ..|.|......||.. |  .. |  ||.||| . ||.... ......  |.||.  |  .. .| ..  . .|..||..|        . . |.
QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GNYVYCDFGISKFLKNNQNQQCQ-YKGYTHYYYPPEQYNCPEQEHNKNQKINY

SVDIY
 .|||
KSDIY

Kinase 9756.AA S_TKc 30-291 17 6.3e-15 41.96 SMART 1-231 (231) Show / Hide
Range on Protein: 30-291
Range on HMM: 1-231/231
Sequence Identity: 17% (48 aa)

YEYQKVLVKGDFSIIVMAYSYRLQQQVAIKIIQRLKQQNKAYLQEFYKEIQVIQVFENKKYALQIIETIQDKRQKFIGIVAEICQC---NLATILDLNT-
||  ... || |.    ..  . ...||||||           . ...|||. .   . ..  ......||   ... .| | |     .| .... .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGR

------LSFEQVLALTYQLLHCLLLFQKYDTIHSDIKHESILYSKSKNQFKIANYGLSKIKSNPFYEKIQTFDDGKLCYRSPEVINGLKIQFNI-SVDIY
      ..  ..  ..||..  |    .   || |.| | || ..   . ||.  ||...          |   | . |..|||.     ...  ..|..
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL---------TTFCGTPWYMAPEVL-----GYGKCKCDWW

SIGLLLTEAFIQRKLTKAELDDLKEKDLLSVLQFLHNSEQIQFIQKILSKMVNPNQNQRLQPLNLIK-----NLNALY
|.| .| | .  . .   ... . .| .             .... ...|. . . ..|.    . .     ..    
SCGCILYEMLCGYPPFP-QMQMMFKKIG-----------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase 9756.AA Ciliate-B2 30-221 26 7.4e-15 31.28 In-house 1-197 (197) Show / Hide
Range on Protein: 30-221
Range on HMM: 1-197/197
Sequence Identity: 26% (54 aa)

YEYQKVLVKGDFSIIVMAY---SYRLQQQVAIKIIQRLKQQNKAYLQEFYKEIQVIQVFENKKYALQIIETIQDKRQKFIGIVAEICQCNLATILD---L
|   | . || . .|   |   | |  | .|.||    .. .|   .|. .||.....|| . .  ..|. || . .  . .. |.|.| |   |.   .
YYLCKYINKGGCGFICEGYKKHSIREYQDLAFKIYFNKQDCDK---EEIQHEIKIMKMFEYNINVVKYIDHIQINETIDV-LIMEKCECSLKQELQKIQK

NTLSFEQ--VLALTYQLLHCLLLFQKYDTIHSDIKHESILYSKSKNQFKIANYGLSKIKSNPFYEKIQTFDDGKLCYRSPEVINGL-----KIQFNISVD
    |..   . . .||.  |  |  |. .| ||| . || ... ....  ..| | ||..    ||  |      | ||| ..         . .   |
QQKCFNNQKLYQMIFQLIDGLIQFRMYNILHLDIKPQNILFMQN-GNYVYCDFGISSIKKDNQQIKIKGFT---KKYASPEQMECDHNQTFVTNIDFQSD

IYSIG
|||.|
IYSMG

Kinase 9756.AA Ciliate-E2 30-224 18 6.2e-11 33.75 In-house 1-286 (365) Show / Hide
Range on Protein: 30-224
Range on HMM: 1-286/365
Sequence Identity: 18% (55 aa)

YEYQKVLVKGDFSIIVMAYSYRLQQQVAIKIIQRL-----------------KQQNKAYLQEFYKEIQVIQVFE---------------NKKYALQIIET
|. .|.. .| |...  .  .. |.|.|||||...                 |...|  .... .||....  .               | .. ....|.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

IQDKRQKFIGIVAEICQC-NLATILDLNTLSF------------EQVLALTYQLLH---------------CLLLFQKYD-TIHSDIKHESILYSKSKNQ
 |.| .. | .| | ||  .|  ..  | ...            .... ...|.|                .|    .    || ||| | ||.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

FKIANYGLSKIKSNP---------FYEKIQTF---------------------DDGKLCYRSPEVINGLKIQ-------FNISVDIYSIGLLL
 ||.  ||||. ...          ..... .                       | . | .||..|| |..        . ..||.|.| .|
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL

Kinase 9756.AA Ciliate-E3 30-228 26 1.6e-10 29.33 In-house 1-202 (202) Show / Hide
Range on Protein: 30-228
Range on HMM: 1-202/202
Sequence Identity: 26% (54 aa)

YEYQKVLVKGDFSIIVMAYSYRLQQQVAIKIIQRLKQQN---KAYLQEFYKEIQVIQVFENKKYALQIIETIQDKRQKFIGIVAEICQC-NLATILDLNT
|  |. | .| |..   |..  . |.|||| |   .|||      .|.  .|.|  | . | .. ... . . |.  | | || | |   .| . .    
YTVQQILGCGQFGRVYKAFDFQNNQDVAIKAIICQNQQNEGVGEQFQKTQQEFQNCQQI-NSQNVVKCHDQYYDQQNKMIFIVQEYCSNGDLYHYIKQQN

LSFEQVLALTYQLLHCLLLFQKYDTIHSDIKHESILYSKSKNQF--KIANYGLSKIKSNPFYEK--IQTFDDGKLCYRSPEVINGLKIQFNISVDIYSIG
.. . .. .  |..  ..       |||||| . || .|..||   ||.  |.||  ..   .|  ..|...|   . ..  .|  . |.    |.||.|
KTQNIIYDICIQIIQGMIAIHEKNIIHSDIKPDNILVDKNNNQLIIKICDFGESKQLRK---NKGHTHTQYQGWTPFYAAPEQN-DQQQISKESDYYSVG

LLLTEAF
  . .  
AVFCQLC

Kinase 9756.AA C8 27-224 18 5.1e-10 31.07 In-house 1-226 (226) Show / Hide
Range on Protein: 27-224
Range on HMM: 1-226/226
Sequence Identity: 18% (42 aa)

KNKYEYQKVLVKGDFSIIVMAYSYRLQQQVAIKIIQRLKQQNKAYLQEFYKEIQVIQVFENKKYALQIIETIQDKRQKF----IG------------IVA
 |...|   | .| ..... |.  . ......|. .   .|..  ...  ||... |||.  .      .. ... ..|     .             | 
FNNFQY---LSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVM

E--ICQCNLATILDL-----NTLSFEQVLALTYQLLHCLLLFQKYDTIHSDIKHESILYSKSKNQF---KIANYGLSKI--KSNPFYEKIQTFDDGKLCY
|  .|. ||. . |        .| |. . .. |.. ..   .    .| ||| . .|   ..|.    |..  |..    |.   .. .. .  | . |
EMELCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAY

RSPEVING---LKIQFNISVDIYSIGLLL
  ||....      |..|  |..|.||.|
FAPEIEKKQDNQYKQYRIQSDLFSVGLVL

Kinase 9756.AA Ciliate-C5 69-299 23 6.3e-10 28.6 In-house 31-260 (260) Show / Hide
Range on Protein: 69-299
Range on HMM: 31-260/260
Sequence Identity: 23% (57 aa)

KAYLQEFYKEIQVIQVFENKKYALQIIETIQDKRQKFIGIVAEICQCNLATIL-----DLNTLSFEQVLALTYQLLHCLLLFQKYDTIHSDIKHESILYS
|. ..    | .....  .  |... || . ....     ..   .|||  |.     .  ||.  |.. .  |.       |. . ||||.| | ||| 
KPNFEKIKEEEKIMKLLKDTPYVFKSIEEFLNEKKSKYYQISKRYSCNLKDIMQSFFDQKKTLPLNQIIGFAIQMSTVFEKIQQNNLIHSDVKPENILYD

KSKNQFKIANYGLSKIKSNPFYEKIQTFDDGKLC--YRSPEVINGLKIQFNISVDIYSIGLLLTEAFIQRKLTKAELDDLKEKDLLSVLQFLHNSEQIQF
     |....|| ||     | .  .|.|       |  ||...     |||  ||| .|..| |  . . |   .   ... .|   .... . .  | 
SQEKCFNLCDYGESKS----FKDGSKTYDLKGFTRKYAAPEITDD-NGFFNIKYDIYGLGIILLELTLGKFLEDEDCTFIRNGKL---PNYISKNALYQD

IQKILSKMVNPNQNQRLQPLNLIKNLNALYNINEDCLR
| .|. ||..   ..|.. ..| |.|| |    |. . 
INQIIIKMLEKMPQNRIDSFELTKQLNELRLKLESQFI

Kinase 9756.AA TKL 151-226 20 7.4e-10 31.68 In-house 162-281 (364) Show / Hide
Range on Protein: 151-226
Range on HMM: 162-281/364
Sequence Identity: 20% (24 aa)

IHSDIKHESILYSKSKN-------------QFKIANYGLSKIKSNPF-----------------YEKIQTFDDGKLCYRSPEVINGL-------------
|| |.| . ||  .  .               ||. .|||. .|. .                 ..|      | ... .|||..|              
IHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFC

-KIQFNISVDIYSIGLLLTE
 . ... ..|.|| |..| |
KGFEYSEKCDVYSFGIVLWE

Kinase 9756.AA DYRK2 104-221 27 1.7e-09 26.74 In-house 74-189 (318) Show / Hide
Range on Protein: 104-221
Range on HMM: 74-189/318
Sequence Identity: 27% (34 aa)

KFIGIVAEICQCNLATILDLNTL---SFEQVLALTYQLLHCLLLFQKYDTIHSDIKHESI-LYSKSKNQFKIANYGLSKIKSN-PFYEKIQTFDDGKLCY
... |. |  . ||.  .  |     | . | . ....|.|| . .| . || | | | | |... ..  |..  |.|      ..|  ||.     . |
NHHCITFELLSMNLYEYIKKNHFQGFSLQLVRRFAHSILQCLRFLHKNNIIHCDLKPENILLKQWNRSGIKVIDFGSSCFEHQYRIYTYIQS-----RFY

RSPEVINGLKIQFNISVDIYSIG
|.||||  | .... ..|. | |
RAPEVI--LGGKYGMAIDMWSFG

Kinase 9756.AA ULK 30-224 20 5.7e-09 28.02 In-house 1-242 (324) Show / Hide
Range on Protein: 30-224
Range on HMM: 1-242/324
Sequence Identity: 20% (50 aa)

YEYQKVLVKGDFS-IIVMAYSYRL---QQQVAIKIIQRLKQQNKAYLQE-------FYKEIQVIQVFE--NKKY--ALQIIETIQDKRQKFIGIVAEICQ
|.  ..| || |      ..  .    .|.||.|.|.. |...| ..||       . .|||... .   . ..    . ..  ...  ..| |. | |.
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

C-NLATILDLN----------TLSFEQVLALTYQLLHCLLLFQKYDTIHSDIKHESILYSKSK-----------NQFKIANYGLSKIKSNP-FYEKI-QT
. .| ...  |          .|| ....   .|..  .   .|   || ||| . || .. .           ...|||  |..|.  |. . . . ||
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

FDD-----GKLCYRSPEVINGL--KIQFN-ISVDIYSIGLLL
.       |   | .|....|.  ..... . .||.|.| ..
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIF

Kinase 9756.AA DYRK2 30-67 39 5e-06 15.26 In-house 1-41 (318) Show / Hide
Range on Protein: 30-67
Range on HMM: 1-41/318
Sequence Identity: 39% (16 aa)

YEYQKVLVKGDFSIIVMAYSYRLQQQVAIKII---QRLKQQ
||  .|. || |   | .| . ..| ||||.|   .|. .|
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQ

Kinase 9756.AA TyrKc 30-287 14 8e-06 -128.79 SMART 1-280 (280) Show / Hide
Range on Protein: 30-287
Range on HMM: 1-280/280
Sequence Identity: 14% (44 aa)

YEYQKVLVKGDFSIIVMAYSYRLQQQVAIKIIQRLKQQNKAYLQEFYKEIQVIQVF-ENKKYALQIIETIQDKR------QKFIGIVAEICQCNLATILD
 .  |.|  | | ... .  .   .|||.| ..  .      ...|..|...   .  . .  ....  . ..       .    ..   .  .|   | 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

LNT--LSFEQVLALTYQL------LHCLLLFQKYDTIHSDIKHESILYSKSKNQFKIANYGLSKIKSNP-------FYEKIQTFDDGK--LCYR--SPEV
 .   |. .. |   .|       ||          || |.    .|... . . ||.  |||.   .         | . .. ..||  | .|  .||.
KHRPKLCMKDLLSFCWQIACGMEYLHSK------NCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPEC

INGLKIQFNISVDIYSIGLLLTEAFIQRKLTKAELDDLKE----KDLLSVLQFLHNSEQIQFIQK---------------ILSKMVNPNQNQRLQPLNLI
|   .  |..  |..| | .. | |     |  .     .    ..   |.... . .     .                | ..  . . ..|    ...
I--NYGKFTTKSDVWSFGVCMWEIF-----TYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIH

KNL
. .
ECF