Gene 12433 (Tetrahymena)

12433

Species: Tetrahymena
Alias: TTHERM_00222260, 845, 19.m00225, 12433, PreTt12433
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-A9

Sequence

Name Sequence Type Origin Length Description Download
12433.AA Protein None 877 None Fasta, JSON
12433.kin_dom Protein Kinase Domain None 357 None Fasta, JSON
12433.NA RNA None 2634 None Fasta, JSON

Protein domain

Protein domains of 12433.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 12433.AA Ciliate-A9 22-378 62 0.0 914.03 In-house 1-392 (392) Show / Hide 
Range on Protein: 22-378
Range on HMM: 1-392/392
Sequence Identity: 62% (245 aa)

FKPIKVIGQGAFGKVIQAIDNS--TNQEVAIKVINKKKMGEDCIEKVKQEARILEKLNHPNVVEFK---------------------KVCETDTKILIAM
|.|||.||.||||.|||..|..  ..||.|.|||.|.||..||||...|||.||....|||.|.||                     |.||.|..|.|.|
FEPIKIIGEGAFGCVIQCRDIQQEDKQEYAVKVIQKNKMKMDCIEFQDQEAKILQQHDHPNIVKFKNIKNINTQKETKQLNYIFQISKFCESDQNIHIVM

ELVRGGSLSQLMKERKSKNDWFKEKEVSQIMKSIMLGLVYIHGKNIVHRDLKPDRQINKCIQLFISSFIHLFINHHNYCKQQNKQTNKQTNEKINQVKIF
|....|.|.|||||||..|.||.|.|.|||||.||....|.|.|||.|||||||||||||||||||||||||||||||||||||||||||||||||||||
EYMKCGTLQQLMKERKKNNQWFNEQEISQIMKCIMSAVMYMHQKNICHRDLKPDRQINKCIQLFISSFIHLFINHHNYCKQQNKQTNKQTNEKINQVKIF

ILTENILINDVNDFTSIKIADFGLSS---------AFSLWTTNGLTEQCGTLLYMAPEFFASRVYSKKVKHAVSMKSRKRLIYLFLQLIILFLNSLKSQN
||||||||.|.||.|..||||||||.         .|..||......|||||.|||||||....||..|.||||||||||||||||||||||||||||||
ILTENILIGDKNDLTQVKIADFGLSKSFVKSQRVQYFTQWTYHSMYQQCGTLIYMAPEFFINKQYSQPVDHAVSMKSRKRLIYLFLQLIILFLNSLKSQN

QFILYRQFKQQIDIWSCGITMHNLLDFGNHPFYEP--KADDADTFKQKLS-NPKWKIPAHFSNLAKNLLSKLSLINPTERYSAIQALQHPFI
|||||||||||.|.|||||.|..||..|.|||..|  |.||.|.||.|.. ||.|......||.|||...|...|||..||.|.|.|.||.|
QFILYRQFKQQVDMWSCGIIMYMLLCMGKHPFWCPYEKNDDEDYFKMKIQCNPQWEFWDNCSNNAKNFIQKMTNINPSNRYNAFQCLKHPWI
Kinase 12433.AA S_TKc 22-378 23 7.4e-63 216.06 SMART 1-231 (231) Show / Hide 
Range on Protein: 22-378
Range on HMM: 1-231/231
Sequence Identity: 23% (85 aa)

FKPIKVIGQGAFGKVIQAIDNSTNQEVAIKVINKKKMGEDCIEKVKQEARILEKLNHPNVVEFKKVCETDTKILIAMELVRG--GSLSQLMKERKS--KN
.. ...||.|||||| ......|...||||.|.         |....| .||.| .|||.| .. |... ... . ||.. |  |.| ...|.|..  ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

DWFKEKEVSQIMKSIMLGLVYIHGKNIVHRDLKPDRQINKCIQLFISSFIHLFINHHNYCKQQNKQTNKQTNEKINQVKIFILTENILINDVNDFTSIKI
 .| | ..  .|. | ..| |.| ..|.||||||.   |    .....                                                 |||
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPE---N----ILLDE------------------------------------------------HIKI

ADFGLSSAFSLWTTNGLTEQCGTLLYMAPEFFASRVYSKKVKHAVSMKSRKRLIYLFLQLIILFLNSLKSQNQFILYRQFKQ-QIDIWSCGITMHNLLDF
.||||.  .        | .|||. ||||| .                                              ..    .|.||||...  .|  
CDFGLARQL--------TTFCGTPWYMAPEVL----------------------------------------------GYGKCKCDWWSCGCILYEMLC-

GNHPFYEPKADDADTFKQKLSNPKWKIPAHFSNLAKNLLSKLSLINPTERYSAIQALQ-------HPFI
|  ||.    ... .||. .           |  ||....|.   .|..|..| .|||       ||..
GYPPFP----QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 12433.AA MARK 22-258 29 9e-50 160.96 In-house 1-187 (262) Show / Hide 
Range on Protein: 22-258
Range on HMM: 1-187/262
Sequence Identity: 29% (73 aa)

FKPIKVIGQGAFGKVIQAIDNSTNQEVAIKVINKKKMGE-DCIEKVKQEARILEKLNHPNVVEFKKVCE--TDTK-ILIAMELVRGGSLSQLMKER--KS
.| .|.||.|...||  |..  |...||||...|.|. .   ...|. |..|. ||.|||.... .| |  | .. | . ||.. ||.| . .|..    
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR

KNDWFKEKEVSQIMKSIMLGLVYIHGKNIVHRDLKPDRQINKCIQLFISSFIHLFINHHNYCKQQNKQTNKQTNEKINQVKIFILTENILINDVN--DFT
     .|.|  .| . |  .. | | |||||||.||                                                  ||||| . .  .  
----LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKP--------------------------------------------------ENILIDENGNHN--

SIKIADFGLSSAFSLWTTNGLTEQCGTLLYMAPEFFASRVYS-KKV
 |||.|||.|  .   .   |.. |||. ||||| | .. |  .||
-IKIIDFGFSICIPPGQK--LNTFCGTPPYMAPEIFLKKPYDGPKV
Kinase 12433.AA CAMK 27-152 23 2.6e-45 143.5 In-house 1-208 (425) Show / Hide 
Range on Protein: 27-152
Range on HMM: 1-208/425
Sequence Identity: 23% (50 aa)

VIGQGAFGKVIQAIDNSTN------------QEVAIKVINKKKMGED--------------------------CIEKVKQEARILEK-------LNHPNV
..|.|.||||  .|. .|.            |.||||.|.|||. ..                            ..|..| .|. |       |.|||.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VEFKKVCE------------TDTK--------ILIAM---ELVRGG----SLSQLMKERKS----------KNDW--FKEKEVSQIMKSIMLGLVYIHGK
. .  | |            | .|        . . |   |.. ||     | .  .|...            ..  |.|.|...... |  .. |.| .
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCHSH

NIVHRDLKPD
|||||||||.
NIVHRDLKPE
Kinase 12433.AA CAMKL 22-152 30 2.8e-45 142.37 In-house 1-156 (297) Show / Hide 
Range on Protein: 22-152
Range on HMM: 1-156/297
Sequence Identity: 30% (47 aa)

FKPIKVIGQGAFGKVIQAID-NSTNQEVAIKVINKKKMGEDCIEK-------------VKQEARILEKLN---HPNVVEFKKVCETDTK------ILIAM
.. .|..|.|.||||  |..   |...||||.|.|||. .|.. |             ...|..|...||   |||.. .  | ||...      | . |
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

ELVRGGS--LSQLMKERKSKNDWFKEKEVSQIMKSIMLGLVYIHGKNIVHRDLKPD
|.. ||.  | .  .... ... ..|.|  .. . |. .. |.| ..|||||.||.
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPE
Kinase 12433.AA CAMK1 22-151 34 4.5e-42 120.06 In-house 1-136 (276) Show / Hide 
Range on Protein: 22-151
Range on HMM: 1-136/276
Sequence Identity: 34% (48 aa)

FKPIKVIGQGAFGKVIQAIDNST---NQEVAIKVIN-KKKMGEDCI---EKVKQEARILEK---LNHPNVVEFKKVCETDTKILIAMELVRGGS-LSQLM
.. .|.|| |||..| .... .|   ....|||.|. || | ..     |....|  |. |   ..|||.. |. . |.|... . |||| ||  . . .
YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRIV

KERKSKNDWFKEKEVSQIMKSIMLGLVYIHGKNIVHRDLKP
.        . ||. . ||| |   . |.| |.||||||||
EKG-----NYTEKDARHIMKQILSAVEYMHSKGIVHRDLKP
Kinase 12433.AA Pkinase 22-152 30 2.9e-41 147.0 Pfam 1-137 (293) Show / Hide 
Range on Protein: 22-152
Range on HMM: 1-137/293
Sequence Identity: 30% (43 aa)

FKPIKVIGQGAFGKVIQAIDNSTNQEVAIKVINKKKMGEDCIEKVKQ--EARILEKLNHPNVVEFKKVCETDTKILIAMELVRGG----SLSQLMKERKS
.. ...||.|.||.| .... .|...||.|.|.|..  ... .      |..|. .|||||.|... ..|....| . ||...||    .|. ...   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--W

KNDWF--KEKEVSQIMKSIMLGLVYIHGKNIVHRDLKPD
.. .|   |.|.  .|. |  || |.| ..|.||||||.
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPE
Kinase 12433.AA Ciliate-E2a 22-152 36 1.3e-39 114.28 In-house 1-131 (275) Show / Hide 
Range on Protein: 22-152
Range on HMM: 1-131/275
Sequence Identity: 36% (49 aa)

FKPIKVIGQGAFGKVIQAIDNSTNQEVAIKVINKKKMGEDC--IEKVKQEARILEKLNHPNVVEFKKVCETDTKILIAMELVRGGSLSQLMKERKSKNDW
.| ||.||.|.||.|  |    |... |.|...| || ..    |....|  |. .|.|||.  .  | |... . . ||.. ||.| . .|. |.    
YKFIKKIGKGNFGSVYLAQHKQTGKQFAMKKFIK-KMYQQKKGKEYFMNEINIMRQLDHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKR----

FKEK--EVSQIMKSIM-LGLVYIHGKNIVHRDLKPD
|.|.  |...||. .   || |.| .||.||||||.
FFEEIQEICDIMQQLLWQGLHYMHQRNIMHRDLKPE
Kinase 12433.AA STE 22-152 24 2.8e-37 129.21 In-house 1-181 (359) Show / Hide 
Range on Protein: 22-152
Range on HMM: 1-181/359
Sequence Identity: 24% (44 aa)

FKPIKVIGQGAFGKVIQAIDN------STNQE---------VAIKVINKKKMG---------------EDCIEKVKQEARILEKLN--HPNVVEFKKVCE
.. |..||.||||.| .|...      .|...         .|||..|...                 .. ......| .|. |.|  |||.|..   ..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

TD-------TKILIAMELVRGGSLSQLMKERKSKND----------WFKEKEVSQIMKSIMLG-LVYIHGKNIVHRDLKPD
 .       ... |.||.. ||||....|.......          .|.|.... | ..|  | | |.| ..|.|||.||.
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPA
Kinase 12433.AA Ciliate-E2 22-152 29 1.7e-36 122.77 In-house 1-190 (365) Show / Hide 
Range on Protein: 22-152
Range on HMM: 1-190/365
Sequence Identity: 29% (56 aa)

FKPIKVIGQGAFGKVIQAIDNSTNQ------------------EVAIKVINKKKMGEDCIEKVKQEARIL----------------EKLNHPNVVEFKKV
.| ||.||||.||.| .. . ....                  .|.|| ...| | .. || .||| .|.                |.|||||..... .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

CE--TDTKILIAMELVRGGSLSQLMKERKSKND-------WFKEKEVSQIMKSIML---------------GLVYIHGKN-IVHRDLKPD
 .  .|..| . ||.. ||.| ...|..| | .        |.|||...||| |                 .| |.| || |.|||.||.
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPE
Kinase 12433.AA CAMK-Unique 22-152 20 7e-31 99.03 In-house 1-186 (363) Show / Hide 
Range on Protein: 22-152
Range on HMM: 1-186/363
Sequence Identity: 20% (39 aa)

FKPIKVIGQGAFGKVIQAIDNSTNQEVAIKVINKKKMG-EDCIE-----------------KVKQEARILEKLNHPNVVEFKKV----CETDT-------
 | ...||.|.||.|. ..| .|  . |.|...|.. | .  ..                 | | |..|. ...||| ...  .     ....       
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI

--------KILIAMELVRGGSLSQLMKER-KSK---------------NDWFKE--KEVSQIMKSIMLGLVYIHGKNIVHRDLKPD
        .. | ||.. || |.... .. . .               .  | |   ....|| ..   . | | ..|||||||..
IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLE
Kinase 12433.AA Ciliate-E2-Unclassified 22-152 27 5.6e-30 101.18 In-house 1-173 (352) Show / Hide 
Range on Protein: 22-152
Range on HMM: 1-173/352
Sequence Identity: 27% (48 aa)

FKPIKVIGQGAFGKVIQAIDNSTNQEVAIKVINKKKMGEDCIEKVK----QEARILEKLN-------------------HPNVVEFKKVCETDTKILIAM
.| ||.||||.|||| ........|  |.| ..|...  ... . |    .|. ......                   ||..| .  . ... .| | |
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

ELVRGGSLSQLMKERKS----KND---------WFKEKEVS-----QIMKSIMLGLVYIHGKN-IVHRDLKPD
|...||.|.| .|.||.    .||          | |....     .... | .|| |.| || |.|||.||.
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPE
Kinase 12433.AA Pkinase_Tyr 22-149 30 1.2e-24 84.1 Pfam 1-137 (270) Show / Hide 
Range on Protein: 22-149
Range on HMM: 1-137/270
Sequence Identity: 30% (42 aa)

FKPIKVIGQGAFGKVIQAIDN----STNQEVAIKVINKKKMGED-CIEKVKQEARILEKL-NHPNVVEFKKVCE-TDTK--ILIAMELVRGGSLSQLMKE
 . .|..|.||||.| ... .    .|...||.|... . | |. |.|.  .||.|. .| .|||.| .  ||   .    |.| ||.. .|.|    ..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

RKSKNDWFKEKEVSQIMKSIMLGLVYIHGKNIVHRDL
... .. .. |.  |.   |  |. | . ||..||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL
Kinase 12433.AA CAMK 299-378 21 1.7e-17 52.27 In-house 313-425 (425) Show / Hide 
Range on Protein: 299-378
Range on HMM: 313-425/425
Sequence Identity: 21% (24 aa)

QQIDIWSCGITMHNLLDFGNHPFYEP-----------KADDADTFKQKLSNPKWKIPAHFSN-----------------------LAKNLLSKLSLINPT
...|.||||. .  .|  |  |||..           ...| ..|.. ..   . .| .||.                        .|.|..|.   .|.
PKCDMWSCGVILYIML-CGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPE

ERYSAIQALQHPFI
.|... |.|.||..
KRMTIEQCLNHPWM
Kinase 12433.AA Ciliate-E2 300-378 22 1.3e-14 46.52 In-house 276-365 (365) Show / Hide 
Range on Protein: 300-378
Range on HMM: 276-365/365
Sequence Identity: 22% (23 aa)

QIDIWSCGITMHNLLDFGNHPFYEPKADDADTFKQKLSNPKWKIP------------------AHFSNLAKNLLSK----LSLINPTERYS-AIQALQHP
..||||.|.... .| ||..||            |.  . |...|                   . |. .|.|..|    .   .| .|.. . |.|.||
KCDIWSLGVILYEML-FGKPPF-----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHP

FI
..
WF
Kinase 12433.AA CAMK-Unique 299-378 26 4.2e-14 42.76 In-house 268-363 (363) Show / Hide 
Range on Protein: 299-378
Range on HMM: 268-363/363
Sequence Identity: 26% (26 aa)

QQI----DIWSCGITMHNLLDFGNHPFYEPKADD------ADTFKQ-------KLSNPKWKIPAHFSNLAKNLLSKLSLINPTERYSAIQALQHPFI
||     ||||.| .|. .| .|..||...  |.      . .|.        ......| .|   |. ||... ..  . |  | || ..|.|..|
QQCSPASDIWSLGVIMYYML-CGCPPFDCECEDRDYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase 12433.AA Ciliate-E2-Unclassified 300-378 25 8.4e-14 44.28 In-house 250-352 (352) Show / Hide 
Range on Protein: 300-378
Range on HMM: 250-352/352
Sequence Identity: 25% (27 aa)

QIDIWSCGITMHNLLDFGNHPFYEPK------------------ADDADTFKQKLSNPK-WK--IPAHFSNLAKNLLS----KLSLINPTERYSAIQALQ
..||||.|. .. .| ||..||| ..                      . .......|| ..  || | |. ||....    |.   || .|... |.|.
KCDIWSLGVILYEML-FGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILN

HPFI
||..
HPWF
Kinase 12433.AA CAMKL 299-378 23 2.4e-12 35.54 In-house 215-297 (297) Show / Hide 
Range on Protein: 299-378
Range on HMM: 215-297/297
Sequence Identity: 23% (20 aa)

QQIDIWSCGITMHNLLDFGNHPFYEP-----KADDADTFKQKLSNPKWKIPAHFSN-LAKNLLSKLSLINPTERYSAIQALQHPFI
...||||||... ... .|. || ..     ..|.  ... |      ..| ...   ...|..|.   ||..|... | ..||. 
PKVDIWSCGVILYAMV-CGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVSDCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 12433.AA Ciliate-E2a 347-378 37 4.2e-12 31.94 In-house 244-275 (275) Show / Hide 
Range on Protein: 347-378
Range on HMM: 244-275/275
Sequence Identity: 37% (12 aa)

FSNLAKNLLSKLSLINPTERYSAIQALQHPFI
.|. .|.|..|.   .| .|..|.|||.||. 
CSKECKDLMKKMLEKDPKKRITAQQALNHPWF
Kinase 12433.AA CAMKL 202-254 36 5.5e-12 34.38 In-house 156-212 (297) Show / Hide 
Range on Protein: 202-254
Range on HMM: 156-212/297
Sequence Identity: 36% (21 aa)

ENILINDVNDFTSIKIADFGLSSAFS---LWTTNGLTEQCGTLLYMAPEFFAS--RVY
||||. . ..   |||.|||.|  .     .. . |...||.. ||||| |..  . |
ENILLDENGNN-NIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGNNKPY
Kinase 12433.AA CAMK1 202-258 36 1e-11 30.24 In-house 137-197 (276) Show / Hide 
Range on Protein: 202-258
Range on HMM: 137-197/276
Sequence Identity: 36% (23 aa)

ENILINDVNDFTSIK--IADFGLSSAFSLWTTN-GLTEQCGTLLYMAPEFFAS---RVYSKKV
||.|  |  .   ||  |||||||  |.    .  .. .|||. |.||| ..      |.|..
ENLLYYDKDEDSKIKRSIADFGLSKIFD--HDENLMKTACGTPGYVAPEVLECKKDKPYDKAC
Kinase 12433.AA TyrKc 22-281 15 1.1e-11 -33.84 SMART 1-280 (280) Show / Hide 
Range on Protein: 22-281
Range on HMM: 1-280/280
Sequence Identity: 15% (56 aa)

FKPIKVIGQGAFGKVIQAIDNSTNQEVAIKVINKKKMGEDCIEKVKQEARILEKL--NHPNVVEFKKVCETD-------TKILIAMELVRGGSLSQLMKE
 . .|..| ||||.| ... .   ..||.|.... .     .|   .||||. ||  .|||.| .  || ..         ..| ||.. .|.| .  ..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

RKSKNDWFKEKEVSQIMKSIMLGLVYIHGKNIVHRDL-------KPDRQINKCIQLFISSFIHLFINHHNYCKQQNKQTNKQTNEKINQVKIFILTENIL
.. |   .. |.  ...  |  |  |.| ||..||||       . ..                                                    
HRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----------------------------------------------------

INDVNDFTSIKIADFGLSSAF----------SLWTTNG--LTEQCGTLLYMAPEFFASR---------------------------------VYSKKVKH
         .||.||||| .           .  .. .   .     .  |||| .  .                                 .  . | .
--------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIE

AVSMKSRKRLIYL------------------------------FLQLIILF
 |    | .                                  | ... .|
YVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 12433.AA Pkinase 202-258 42 1.5e-11 41.88 Pfam 137-193 (293) Show / Hide 
Range on Protein: 202-258
Range on HMM: 137-193/293
Sequence Identity: 42% (25 aa)

ENILINDVNDF-TSIKIADFGLSSAFSLWTTNGLTEQCGTLLYMAPEFFA-SRVYSKKV
|||||.. ..  ...||.||||.  |. .  |..|  |||. |||||    .. |..||
ENILIDNNGHIDACVKICDFGLAKQFD-Y-NNSMTTFCGTPWYMAPEVIRGGQYYGPKV
Kinase 12433.AA CAMK 202-258 25 3.1e-11 31.74 In-house 208-315 (425) Show / Hide 
Range on Protein: 202-258
Range on HMM: 208-315/425
Sequence Identity: 25% (27 aa)

ENILINDVNDFTS--------------IKIADFGLSSAFSL------------------WTTN----GLTEQCGTLLYMA-PEFFAS-------------
||||..| || ..              |||.|||..  |                    |||      ....|||. ||| || . .             
ENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEE

-RVYSKKV
 . |..|.
KPYYGPKC
Kinase 12433.AA CAMK1 348-378 34 3.6e-11 28.65 In-house 245-276 (276) Show / Hide 
Range on Protein: 348-378
Range on HMM: 245-276/276
Sequence Identity: 34% (11 aa)

SNL-AKNLLSKLSLINPTERYSAIQALQHPFI
|.  ||......   .|..||.. |.|.||.|
SDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase 12433.AA Ciliate-E2 202-258 22 2.6e-10 31.56 In-house 190-277 (365) Show / Hide 
Range on Protein: 202-258
Range on HMM: 190-277/365
Sequence Identity: 22% (22 aa)

ENILINDVNDFTSIKIADFGLSSAFS-------------LWTTNG------------------LTEQCGTLLYMAPEFFASRV---------YSKKV
||||.        |||.|||||  ..             ...  .                     .|||. ||||| . .           |..|.
ENILF--------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKC
Kinase 12433.AA CAMK-Unique 202-258 22 8.2e-10 28.37 In-house 186-270 (363) Show / Hide 
Range on Protein: 202-258
Range on HMM: 186-270/363
Sequence Identity: 22% (19 aa)

ENILINDV-ND------------FTSIKIADFGLSSAFSLWTTNG-LTEQCGTLLYMAP--------------EFFASRVYSKKV
|||...   .|            .. ||..||||.  ..    .  . . |||..||||              |  . . |. ..
ENIMVCYSFKDNNHHRDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQC
Kinase 12433.AA STE 302-378 21 2e-09 29.59 In-house 250-359 (359) Show / Hide 
Range on Protein: 302-378
Range on HMM: 250-359/359
Sequence Identity: 21% (24 aa)

DIWSCGITMHNLLDFGNHPF---YEPKADDADTFKQKLSN----------PKWKIP-------------------AHFSNLAKNLLSKLSLINPTERYSA
|||| |.|.  ... |..|.   . ..|  . .|... ..          |  ..|                    ..|   |. ..|   ..| .| .|
DIWSLGCTIIEMAT-GKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTA

IQALQ--HPFI
 | |.  ||||
SQLLKSEHPFI
Kinase 12433.AA Ciliate-E2a 202-258 31 5.7e-09 22.58 In-house 131-197 (275) Show / Hide 
Range on Protein: 202-258
Range on HMM: 131-197/275
Sequence Identity: 31% (21 aa)

ENILIN--DVNDF--TSIKIADFGLSSAFSLWTTNGLTEQCGTLLYMAPEFFASRV------YSKKV
||||..  . |.   . |||.||||.  ..    . .  .|||  |.||| ....       |..|.
ENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQKCGTPGYVAPEVLNNKEVLKHKQYDTKC
Kinase 12433.AA MARK 301-378 30 7.6e-09 25.22 In-house 187-262 (262) Show / Hide 
Range on Protein: 301-378
Range on HMM: 187-262/262
Sequence Identity: 30% (24 aa)

IDIWSCGITMHNLLDFGNHPFYEPKADD--ADTFKQKLSNPKWKIPAHFSNLAKNLLSKLSLINPTERYSAIQALQHPFI
.||||.|. .  ..  |. ||    .|.    . ..|  ..| .|| | |  ..||...|  .|| || .. . ..||..
VDIWSLGVVLYFMV-CGYFPFD---GDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase 12433.AA Pkinase 301-378 19 8.3e-09 32.22 Pfam 193-293 (293) Show / Hide 
Range on Protein: 301-378
Range on HMM: 193-293/293
Sequence Identity: 19% (20 aa)

IDIWSCGITMHNLLDFGNHPFYEP----KADDADTFKQKLSNPKWKIPAHFS---------------------NLAKNLLSKLSLINPTERYSAIQALQH
.|.||||.... .| .|. ||..     . .| .   ..   |... .   .                       .| .....   .|..|..| |.|||
VDMWSCGCILYEML-CGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQH

PFI
|..
PWF
Kinase 12433.AA Ciliate-E2-Unclassified 202-258 27 5.9e-08 23.71 In-house 173-251 (352) Show / Hide 
Range on Protein: 202-258
Range on HMM: 173-251/352
Sequence Identity: 27% (22 aa)

ENILINDVNDFTSIKIADFGLSS--------------AFSLWTTNGLTEQCGTLLYM----APEFFASRVYS----KKV
||||... .    |||.|||.|.               .. |  . .. .|||. ||    ||| . .  |.    .|.
ENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKC
Kinase 12433.AA STE 203-247 23 7e-06 17.0 In-house 182-232 (359) Show / Hide 
Range on Protein: 203-247
Range on HMM: 182-232/359
Sequence Identity: 23% (14 aa)

NILINDVNDFTSIKIADFGLSSAFSL--------------WTTN-GLTEQCGTLLYMAPE
|||.        .|..|||... ..                |.    .  .||  .||||
NILL--------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPE
Kinase 12433.AA Ciliate-E2a 299-328 33 0.000293 8.47 In-house 195-223 (275) Show / Hide 
Range on Protein: 299-328
Range on HMM: 195-223/275
Sequence Identity: 33% (10 aa)

QQIDIWSCGITMHNLLDFGNHPFYEPKADD
.. |.||||. .. || .|  ||.  ....
TKCDMWSCGVIFYILL-CGKPPFKGKTYNE
Kinase 12433.AA Pkinase_Tyr 203-223 38 0.403149 4.42 Pfam 141-158 (270) Show / Hide 
Range on Protein: 203-223
Range on HMM: 141-158/270
Sequence Identity: 38% (8 aa)

NILINDVNDFTSIKIADFGLS
|.|...  ..  .||.||||.
NCLVTE--NN-VVKICDFGLA