Gene 8814 (Tetrahymena)
8814
Group:
Other
Family:
Ciliate-B3
Sequence
Protein domains of 8814.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 8814.AA | Ciliate-B3 | 98-166 | 76 | 9.1e-44 | 151.72 | In-house | 1-69 (69) | Show / Hide |
Range on Protein: 98-166 Range on HMM: 1-69/69 Sequence Identity: 76% (53 aa) LALKLFKQVVEKIKILHEKNVCHCDIKLENILLDNQDQENYKVIIIDFGHYQRACKNCKSREICGTLSY .|||.|.|||||||||||||.||||||..|||...||.||||||||||||.||.|.||||..|||||.| FALKHFHQVVEKIKILHEKNICHCDIKVDNILVNQQDKENYKVIIIDFGHCQRKCQNCKSEMICGTLTY |
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| Kinase | 8814.AA | CAMK | 99-169 | 23 | 1e-15 | 46.44 | In-house | 181-289 (425) | Show / Hide |
Range on Protein: 99-169 Range on HMM: 181-289/425 Sequence Identity: 23% (26 aa) ALKLFKQVVEKIKILHEKNVCHCDIKLENILLDNQD-------------QENYKVIIIDFGHYQRACK------------------------NCKSREIC | ..|.|... .. .|..|..|.|.|.||||||. . ..|... ||||| .. . . | .. | ARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFC GTLSYNP-P ||..| . | GTPEYMAAP |
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| Kinase | 8814.AA | MARK | 98-169 | 40 | 1.2e-15 | 47.81 | In-house | 105-174 (262) | Show / Hide |
Range on Protein: 98-169 Range on HMM: 105-174/262 Sequence Identity: 40% (29 aa) LALKLFKQVVEKIKILHEKNVCHCDIKLENILLDNQDQENYKVIIIDFGHYQRACKNCKSREICGTLSYNPP .| ..|.|.|. .. .|.||..|.|||.||||.| . . | | ||||| . ..| . |||..| .| EARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIK--IIDFGFSICIPPGQKLNTFCGTPPYMAP |
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| Kinase | 8814.AA | Ciliate-E2-Unclassified | 99-169 | 30 | 1.1e-14 | 47.39 | In-house | 140-235 (352) | Show / Hide |
Range on Protein: 99-169 Range on HMM: 140-235/352 Sequence Identity: 30% (30 aa) AL-----KLFKQVVEKIKILHEKN-VCHCDIKLENILLDNQDQENYKVIIIDFGHYQRACKN----------------CKSREICGTLSYN----PP |. ..|.|... .. ||.|| ..| |||.||||.||. . ||.. ||||| . .| ... .|||..| .| AKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK-NYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAP |
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| Kinase | 8814.AA | Ciliate-E2 | 99-207 | 22 | 3e-14 | 45.31 | In-house | 147-291 (365) | Show / Hide |
Range on Protein: 99-207
Range on HMM: 147-291/365
Sequence Identity: 22% (36 aa)
ALKLFKQVVE---------------KIKILHEKN-VCHCDIKLENILLDNQDQENYKVIIIDFGHYQ------------RACKNCKSRE-----------
.....||... .. ||.|| ..| |||.||||. . ||||| . . ||...
IKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMD
----------ICGTLSYNPPKIIEDFE---QFLLSGKQIEEYSPQELDVYQLGMLLFHILF
||||. | .| |.. . | | ... . |.. ||..|. ||
QIIQQNMFNTICGTPGYMAPEILNGKKYDNQ------QKQKGYDYKCDIWSLGVILYEMLF
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| Kinase | 8814.AA | Ciliate-E9 | 103-207 | 30 | 6.2e-13 | 37.31 | In-house | 117-220 (298) | Show / Hide |
Range on Protein: 103-207 Range on HMM: 117-220/298 Sequence Identity: 30% (35 aa) FKQVVEKIKILHEKN-VCHCDIKLENILLDNQDQENYKVIIIDFGHYQRACKN---------CKSREICGTLSYNPPKIIEDFEQFLLSGKQIEEYSPQE |||... | .| . .|| |.|.||.|.| .|| |.||| . |.. | || |||| . .|. | .|. | FKQLIDSIEYMHQYQNICHRDLKPENMLID----KNYNMKICDFGMSAQCRNDKTQVIGNLQCQPKENHGTNQYNPPNNQQ--QQY-----QGIKYNGQK LDVYQLGMLLFHILF |.. .| .|| ... FDIFSAGCILFMMVM |
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| Kinase | 8814.AA | DAPK | 99-163 | 36 | 7.2e-13 | 31.47 | In-house | 105-169 (264) | Show / Hide |
Range on Protein: 99-163 Range on HMM: 105-169/264 Sequence Identity: 36% (24 aa) ALKLFKQVVEKIKILHEKNVCHCDIKLENILLDNQDQENYKVIIIDFGHYQRACKNCKSREICGT | .. ||. | .. || .|.|| |.| .||.| . .. .. ||||| . |. . |.| || ATRFMKQILEGVHYLHSRNICHLDLKPQNIMLTDRNIPQGDIKIIDFGLSRKICNGEEFRDIMGT |
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| Kinase | 8814.AA | MSK | 103-206 | 27 | 3.8e-12 | 37.37 | In-house | 107-204 (277) | Show / Hide |
Range on Protein: 103-206 Range on HMM: 107-204/277 Sequence Identity: 27% (29 aa) FKQVVEKIKILHEKNVCHCDIKLENILLDNQDQENYKVIIIDFG--HYQRACKNCKSREICGTLSYNPPKIIEDFEQFLLSGKQIEEYSPQELDVYQLGM . ..| .. .|.| . | |.|.||||.|... .| .| .|||| . . .. . |.|| | .| .... . .| ..|... |.. || MRELVMAVDHMHQKGIIHRDLKPENILFDDEE-DNGHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGY------AQDGGYDEA-CDWWSLGV LLFHIL .|. | ILYTML |
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| Kinase | 8814.AA | Ciliate-E8 | 105-148 | 43 | 1.1e-11 | 32.79 | In-house | 97-138 (138) | Show / Hide |
Range on Protein: 105-148 Range on HMM: 97-138/138 Sequence Identity: 43% (19 aa) QVVEKIKILHEKNVCHCDIKLENILLDNQDQENYKVIIIDFGHY |. . . .|| |. |||.||.|||. | . | ||||| QIMDAFCYLHNNNIIHCDFKLNNILVQRNDDTKIK--IIDFGFS |
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| Kinase | 8814.AA | CAMKL | 99-146 | 42 | 1.5e-11 | 32.98 | In-house | 129-174 (297) | Show / Hide |
Range on Protein: 99-146 Range on HMM: 129-174/297 Sequence Identity: 42% (21 aa) ALKLFKQVVEKIKILHEKNVCHCDIKLENILLD-NQDQENYKVIIIDFG | ..|.|.|. .. .|.....| |||.|||||| |... .. ||||| ARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN---NIKIIDFG |
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| Kinase | 8814.AA | Pkinase | 99-169 | 29 | 6.5e-10 | 36.14 | Pfam | 110-180 (293) | Show / Hide |
Range on Protein: 99-169 Range on HMM: 110-180/293 Sequence Identity: 29% (22 aa) ALKLFKQVVEKIKILHEKNVCHCDIKLENILLDNQDQENYKVIIIDFGH---YQRACKNCKSREICGTLSYNPP . . ..|... .. .|.....|.|.|.||||.||... . .| |.||| .. .| .|||. | .| CKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAP |
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| S_TKc | 8814.AA | S_TKc | 3-273 | 16 | 8.1e-10 | -32.95 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 3-273
Range on HMM: 1-231/231
Sequence Identity: 16% (50 aa)
EDKAEFYGGQARGEVFKCEARQ--NVYFRKIFEFENDYVREKQFYEKVLKNEIAKEQQSSFLELILFDDSKKELIFPFINS---QLVELVSNQKGI----
.. . | | |.|.|| . .. || .. || | .| . | . | .. ... ... | .. ....
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--EHIRREIQILKK-------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF
-KCRYLALKLFKQVVEKIKILHEKNVCHCDIKLENILLDNQDQENYKVIIIDFGHYQRACKNCKSREICGTLSYNPPKIIEDFEQFLLSGKQIEEYSPQE
| ....|... .. .|.....|.|.| ||||||. . |.||| . . .|||. | .| .. |.. .
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL------TTFCGTPWYMAPEVL--------------GYGKCK
LDVYQLG-----MLLFHILFYIRLTTGIKKVAQLKKRHLFKRAILSSYREAYKKELDLDEDIFDLIYKILSGEIK---DINQIQQ-------HDIY
|.. .| || .|. . . .||. ... |.| |.| . . . .. | |
CDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG--------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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