Gene 18047 (Tetrahymena)
18047
Group:
Other
Family:
Ciliate-C5
Sequence
Protein domains of 18047.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 18047.AA | Ciliate-C5 | 52-312 | 81 | 2.6e-180 | 598.56 | In-house | 1-260 (260) | Show / Hide |
Range on Protein: 52-312 Range on HMM: 1-260/260 Sequence Identity: 81% (214 aa) IYLTSYISQGSFGCVFEAKQNKEIVAVKCSKVDLEKIKEEEKILKLLKEAPYAFKPIKECINEQNSRYYQFSKRYQCSLKDIMKSFFDQKKTLSLNQIIG ||||||||||.||||||||.|.|||||||||...|||||||||.||||..||.|| |.|..||..|.|||.||||.|.|||||.|||||||||.|||||| IYLTSYISQGGFGCVFEAKYNEEIVAVKCSKPNFEKIKEEEKIMKLLKDTPYVFKSIEEFLNEKKSKYYQISKRYSCNLKDIMQSFFDQKKTLPLNQIIG LAIQMSSVFEIIQQNNLIHSDVKPDNILYDSQEKCFNLCDYGESKSFKDGSKTYDLKGHTPKYAAPEITDTKNGSFNIKYDIYGLGVILLELTLGKFLEY .|||||.|||.|||||||||||||.|||||||||||||||||||||||||||||||||.|.|||||||||. ||.|||||||||||.|||||||||||| FAIQMSTVFEKIQQNNLIHSDVKPENILYDSQEKCFNLCDYGESKSFKDGSKTYDLKGFTRKYAAPEITDD-NGFFNIKYDIYGLGIILLELTLGKFLED KDCKSIRNGELQKYISKNVLYQDINYIIVKMLDQISQNRIDSFELTKQLNELRLKLENQFI .|| ||||.| .||||| |||||| ||.|||... |||||||||||||||||||||.||| EDCTFIRNGKLPNYISKNALYQDINQIIIKMLEKMPQNRIDSFELTKQLNELRLKLESQFI |
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| Kinase | 18047.AA | Ciliate-E1 | 58-234 | 26 | 3.3e-28 | 89.06 | In-house | 1-202 (202) | Show / Hide |
Range on Protein: 58-234 Range on HMM: 1-202/202 Sequence Identity: 26% (55 aa) ISQGSFGCVFEAKQNKE--------IVAVKC--SKVDLEKIKEEEK-ILKLLKEAPYAFKPIKECINEQNSRYYQFSKRYQCSLKDIMK---------SF |..|||. ||.|||.. |. ... ..........|.. |.| .|. | .. |. . .|| ... ..||||| .. .. IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC FDQKKTLSLNQIIGLAIQMSSVFEIIQQNNLIHSDVKPDNILYDSQEKCFNLCDYGESKSFKDGSKT-YDLKGHTPKYAAPEITD------TKNGSFNIK ... .. |.. ...|. .....|.|.||.| ||.|||...| . ...|| | || .| .. .. ||.| .|. || || |.| QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINYK YDIY .||| SDIY |
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| Kinase | 18047.AA | Ciliate-E3 | 140-244 | 34 | 7.3e-18 | 52.54 | In-house | 96-202 (202) | Show / Hide |
Range on Protein: 140-244 Range on HMM: 96-202/202 Sequence Identity: 34% (38 aa) QKKTLSLNQIIGLAIQMSSVFEIIQQNNLIHSDVKPDNILYDSQEK--CFNLCDYGESKSFKDGS---KTYDLKGHTPKYAAPEITDTKNGSFNIKYDIY .. ...| |. ..||. .| . |.|||| |||||| |. . || |||| . |.. | || |||||. | . |. |.| KQQNKTQNIIYDICIQIIQGMIAIHEKNIIHSDIKPDNILVDKNNNQLIIKICDFGESKQLRKNKGHTHTQY-QGWTPFYAAPEQNDQQQISKES--DYY GLGVILLELT .|.....| SVGAVFCQLC |
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| Kinase | 18047.AA | C8 | 56-240 | 22 | 1.4e-16 | 54.14 | In-house | 5-226 (226) | Show / Hide |
Range on Protein: 56-240
Range on HMM: 5-226/226
Sequence Identity: 22% (50 aa)
SYISQGSFGCVFEAKQNKE--IVAVKCSKVDLE-KIKEEEKILKLLKEAPYAFKPIKECINEQNSRYYQFSKR----YQ-----------CSLKD-----
|.|.|..| | .|| |. .. | |. . .|...|.| | ... | |. . .||.. | .... . |....
QYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEM-PQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEMELCE
-IMKSFFDQKKTLSLN----QIIGLAIQMSSVFEIIQQNNLIHSDVKPDNIL-YDSQEKC--FNLCDYGESKSFKDGSKTYDLKGH----TPKYAAPEIT
.| ..|.... . . .|||| . |.. | .| |.||.|.| . .|.. ||| |.. .. . . | . | .| ||||
QNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAPEIE
DT---KNGSFNIKYDIYGLGVIL
.. ..|. |.. .|..|
KKQDNQYKQYRIQSDLFSVGLVL
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| Kinase | 18047.AA | Ciliate-B2 | 53-237 | 26 | 4.7e-15 | 31.76 | In-house | 2-197 (197) | Show / Hide |
Range on Protein: 53-237 Range on HMM: 2-197/197 Sequence Identity: 26% (53 aa) YLTSYISQGSFGCVFEAK-----QNKEIVAVKCSKV----DLEKIKEEEKILKLLKEAPYAFKPIKECINEQNSRYYQFSKRYQCSLKDIMKSFFDQKKT ||. || .| .| ..| . .. .|.| . | | | .| ||.|.. . | | . | ... . .||||. .. |.| YLCKYINKGGCGFICEGYKKHSIREYQDLAFKIYFNKQDCDKEEIQHEIKIMKMFEYNINVVKYI-DHIQINETIDVLIMEKCECSLKQELQKIQKQQKC LSLNQIIGLAIQMSSVFEIIQQNNLIHSDVKPDNILYDSQEKCFNLCDYGESKSFKDGSKTYDLKGHTPKYAAPEITDTK-----NGSFNIKYDIYGLG . .. . |. . .| .| |.||.||| .|. . .||.| | | | ||.| ||| || . . . ||| .| FNNQKLYQMIFQLIDGLIQFRMYNILHLDIKPQNILF-MQNGNYVYCDFGIS-SIKKDNQQIKIKGFTKKYASPEQMECDHNQTFVTNIDFQSDIYSMG |
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| Kinase | 18047.AA | S_TKc | 52-298 | 21 | 3e-14 | 31.99 | SMART | 1-220 (231) | Show / Hide |
Range on Protein: 52-298 Range on HMM: 1-220/231 Sequence Identity: 21% (55 aa) IYLTSYISQGSFGCVFEAKQNK--EIVAVKCSKVDLEKIKEEEKILKLLKEAPYAFKPIKECINEQNSRYYQFSKRYQ--CSLKDIMKSFFDQK--KTLS . | .|.||.|. .. .| .|||.|. | |.|. | .||| ..... . .. | . . .|.|..|. .. . .. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK---HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP LNQIIGLAIQMSSVFEIIQQNNLIHSDVKPDNILYDSQEKCFNLCDYGESKSFKDGSKTYDLKGHTPKYAAPEITDTKNGSFNI-KYDIYGLGVILLELT .. .. |. . | . ... || |.||.||| |. . .|| | .. . . || | |||. ... | |.. .|.|| |. E-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL-------TTFCGTPWYMAPEVL-----GYGKCKCDWWSCGCILYEML LGKFLEYKDCKSIRNGELQKYISKNVLYQDINYIIVKMLDQISQNRIDSFELTK |. . . ..|. . | . .. .| |.|. ..|. |. . CGYPPFP---------QMQMMFKKIG-SPEAKDFIRKCLQKDPEKRPTA-EALQ |
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| Kinase | 18047.AA | Ciliate-E2-Unclassified | 52-248 | 20 | 4.2e-14 | 45.32 | In-house | 1-268 (352) | Show / Hide |
Range on Protein: 52-248
Range on HMM: 1-268/352
Sequence Identity: 20% (55 aa)
IYLTSYISQGSFGCVFEAKQNKE-------------IVAVKCSKVDLEKIKEEEKILKLLKEAPYAFK-------------------PIKECINEQNSRY
. | ||.||.|......|. |...| . |. |.|... .|. | .. .| . .. |
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKK--YHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIY
YQFSKRYQCSLKDIMKSF----------FDQKKT---LSLNQII-----GLAIQMSSVF-EIIQQNNLIHSDVKPDNILYDSQEK--CFNLCDYGESKSF
. . .|....|.. |...|. .. .|.. .. | . . ....|| || | ||.|||.|.. | . ..|.| ||
IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKY
KD---------------GSKTYDLKGHTPKYA----APEITDTKNGSFN--IKYDIYGLGVILLELTLGKF
.. .. .. . || | |||. . .| . .| ||..||||| |. |..
QQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYY
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| Kinase | 18047.AA | Ciliate-E2 | 129-248 | 22 | 9.9e-14 | 43.5 | In-house | 120-294 (365) | Show / Hide |
Range on Protein: 129-248
Range on HMM: 120-294/365
Sequence Identity: 22% (41 aa)
SLKDIMK---SFFDQK----KTLSLNQIIGLAIQMSSVF---------------EIIQQNN-LIHSDVKPDNILYDSQEKCFNLCDYGESKSFKDGSK--
.|.|..| ..... | .....|. . | ..| | . ..| || | ||.|||. ..| | || ..| ..
DLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------IKIIDFGLSKKYDDDNQNR
------TYDLKGH------------------------TPKYAAPEITDTKNGS-------FNIKYDIYGLGVILLELTLGKF
. . || | |||| |. . . | ||. ||||| |. ||.
THKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP
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| Kinase | 18047.AA | TKL | 146-247 | 18 | 5.9e-13 | 42.99 | In-house | 131-286 (364) | Show / Hide |
Range on Protein: 146-247 Range on HMM: 131-286/364 Sequence Identity: 18% (29 aa) LNQIIGLAIQMSSVFEIIQQNN--------LIHSDVKPDNILYDS-------------QEKCFNLCDYGESKSFK-------------------DGSKTY ..|.. .|..... . ..| .|| | |..||| |. . | .||.| |.... ...|| WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTT DLKGHTPKYAAPEITDTK--------------NGSFNIKYDIYGLGVILLELTLGK .. || . |||. . . ..... | |.| |..| |. .. MTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRC |
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| Kinase | 18047.AA | Ciliate-E2b | 160-247 | 30 | 9e-13 | 35.3 | In-house | 115-207 (272) | Show / Hide |
Range on Protein: 160-247 Range on HMM: 115-207/272 Sequence Identity: 30% (29 aa) FEIIQQNNLIHSDVKPDNILYDSQEKCFNLCDYGESKSFKDGSK----TYDLKGHTPKYAAPEITD---TKNGSFNIKYDIYGLGVILLELTLGK .| ...| |. |.|| ||. |.. . | | | .| ... . |. . | || | |||| . ..| ||. .|..| |. |. LEYLHNQNIIYRDIKPENIMVDHKGYMK-LIDMGTAKHMYKKNEQMTRTFTIIG-TPHYMAPEIIQSLQPGGKGYTYKVDIWSVGICLYEFMCGY |
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| Kinase | 18047.AA | ULK | 141-247 | 29 | 1.8e-10 | 32.86 | In-house | 124-253 (329) | Show / Hide |
Range on Protein: 141-247 Range on HMM: 124-253/329 Sequence Identity: 29% (39 aa) KKTLSLNQIIGLAIQMSSVFEIIQQNNLIHSDVKPDNILYDS-QEK----------CFNLCDYGESKSFKDG------SKTYD----LKGHTPKYAAPEI ||.|| ...| .| . | ....| || | ||.||| . |.| .. ..| | .|.. .. .|. |.| || | ||.| KKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCG-TPLYMAPQI TDTK--NGSFN-IKYDIYGLGVILLELTLGK . . .. | ||. ||.|. |. || LQGQGEQKPYYDYKCDIWSLGCIFYEMLYGK |
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| Kinase | 18047.AA | Pkinase | 166-249 | 31 | 1.7e-09 | 34.64 | Pfam | 127-211 (293) | Show / Hide |
Range on Protein: 166-249 Range on HMM: 127-211/293 Sequence Identity: 31% (28 aa) NNLIHSDVKPDNILYDSQEKC---FNLCDYGESKS--FKDGSKTYDLKGHTPKYAAPEITDTK-NGSFNIKYDIYGLGVILLELTLGKFL .. || |.||.|||.|.. . . .|| | .| .| .... | || |.|||. . . | |....|.|| |. .|... MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCG-TPWYMAPEV--IRGGQYYGPKVDMWSCGCILYEMLCGRPP |
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| Kinase | 18047.AA | TyrKc | 52-300 | 16 | 2.4e-07 | -103.81 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 52-300 Range on HMM: 1-280/280 Sequence Identity: 16% (50 aa) IYLTSYISQGSFGCVFEAKQNKEIVAVKCSKVDLEKIKEEEKILKLLKEAPYAFKPI-KECINEQNSRYYQFSK-------RYQC---------SLKDIM | | . | || |.... . . ||||. | | . ...|| . . .. | . . .. . .||| ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA--------REDFMREA-RIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL KSFFDQKKTLSLNQIIGLAIQMSSVFEIIQQNNLIHSDVKPDNILYDSQEKCFNLCDYGESKSFKDG------SKTYDLKG--HTP-----KYAAPEITD .. .. |.. . . ..| .. | . ..|.|| | |.|.... . .| | |. .|. ...|. |. .. . ||| RKHRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI- TKNGSFNIKYDIYGLGVILLEL-TLGKFLEY------KDCKSIRNGELQKYISKNVLY----------QDINYIIVKMLDQISQNRIDSFELTKQL . | |..| |.. || . |. |.|. . .. . ... | | . . ... |. . . .| |. ... -NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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| Kinase | 18047.AA | ULK | 52-99 | 27 | 1e-06 | 19.37 | In-house | 1-68 (329) | Show / Hide |
Range on Protein: 52-99 Range on HMM: 1-68/329 Sequence Identity: 27% (19 aa) IYLTSYISQGSFGCVFEA--KQNK----EIVAVKCSK---VDLEK-----------IKEEEKILKLLK ..| . .|||| |... |..| |.||.| . .. .| | ||.| || YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLK |
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| Kinase | 18047.AA | TKL | 58-99 | 16 | 3.1e-05 | 14.84 | In-house | 1-83 (364) | Show / Hide |
Range on Protein: 58-99 Range on HMM: 1-83/364 Sequence Identity: 16% (14 aa) ISQGSFGCVFEAKQNK----------EIVAVKCSKV-------------------------------DLEKIKEEEKILKLLK | .|.||.|. .| . . |||| |. ....|| .... |. IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLR |
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| Kinase | 18047.AA | Ciliate-E2 | 52-100 | 19 | 0.000316 | 10.39 | In-house | 1-88 (365) | Show / Hide |
Range on Protein: 52-100 Range on HMM: 1-88/365 Sequence Identity: 19% (17 aa) IYLTSYISQGSFGCVFEA-------------------------KQNKEIVAVKCS-KVDLEKIKEEEKILK-------------LLKE . . | ||.||.|... |... |.|.|. | ..| || |..|.. .|.. YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQ |
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| Kinase | 18047.AA | Pkinase | 60-99 | 36 | 0.000613 | 15.01 | Pfam | 9-58 (293) | Show / Hide |
Range on Protein: 60-99 Range on HMM: 9-58/293 Sequence Identity: 36% (18 aa) QGSFGCVFEAKQNKE--IVAVKCSKVDLEKIKE--------EEKILKLLK .||||||.... .. |||||. |.. || .. | .|.| |. SGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN |
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| Kinase | 18047.AA | Ciliate-E3 | 52-79 | 33 | 0.003013 | 6.32 | In-house | 1-30 (202) | Show / Hide |
Range on Protein: 52-79 Range on HMM: 1-30/202 Sequence Identity: 33% (10 aa) IYLTSYISQGSFGCVFEA--KQNKEIVAVK . . .|.|| |. | ||. .|| | YTVQQILGCGQFGRVYKAFDFQNNQDVAIK |
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