Gene 2942 (Tetrahymena)

2942

Species: Tetrahymena
Alias: 54, 476.m00004, 2942, PreTt02942, TTHERM_01574220
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-C5

Sequence

Name Sequence Type Origin Length Description Download
2942.AA Protein None 416 None Fasta, JSON
2942.kin_dom Protein Kinase Domain None 242 None Fasta, JSON
2942.NA RNA None 1251 None Fasta, JSON

Protein domain

Protein domains of 2942.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 2942.AA Ciliate-C5 69-328 92 3.1e-194 645.14 In-house 1-260 (260) Show / Hide 
Range on Protein: 69-328
Range on HMM: 1-260/260
Sequence Identity: 92% (241 aa)

IYLTSYISQGGNGCVFEAKYNEEIVAVKCSNPKFEKIKEEEKIMKLLKDTPYVFKSIEEFLNEKKTKYYQISKKYSCNLKDIMQSFFAEKKILPLNQIVG
|||||||||||.||||||||||||||||||.|.||||||||||||||||||||||||||||||||.|||||||.||||||||||||| .|| ||||||.|
IYLTSYISQGGFGCVFEAKYNEEIVAVKCSKPNFEKIKEEEKIMKLLKDTPYVFKSIEEFLNEKKSKYYQISKRYSCNLKDIMQSFFDQKKTLPLNQIIG

FAIQMSTVFEKIQQNNLIHSDIKPENILYDSQEKCFNLCDYGESKSFKDVSKTYNLKGFTRKYAAPEITEDNSFFNIKYDIYGLGIILLELTLGKFLEDG
|||||||||||||||||||||.||||||||||||||||||||||||||| ||||.||||||||||||||.||.||||||||||||||||||||||||||.
FAIQMSTVFEKIQQNNLIHSDVKPENILYDSQEKCFNLCDYGESKSFKDGSKTYDLKGFTRKYAAPEITDDNGFFNIKYDIYGLGIILLELTLGKFLEDE

DCAFIRNGKLPNYISKNALYQDINQIIIKMLEKTPQNRIDSFGLTKQLNELRLKLENQFI
||.||||||||||||||||||||||||||||||.||||||||.|||||||||||||.|||
DCTFIRNGKLPNYISKNALYQDINQIIIKMLEKMPQNRIDSFELTKQLNELRLKLESQFI
Kinase 2942.AA Ciliate-E1 75-250 28 1.7e-26 83.43 In-house 1-202 (202) Show / Hide 
Range on Protein: 75-250
Range on HMM: 1-202/202
Sequence Identity: 28% (59 aa)

ISQGGNGCVFEA---KYNEEIVAVKCSNPKFE--------KIKEEEKIMKLLKDTPYVFKSIEEFLNEKKTKYYQISKKYSCNLKDIMQ---------SF
|..|. . ||.|   ..|.. ||.|  | .|         .|||. |||| .|   |... |. .  ..   ...|  ...|.||| .|         ..
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC

FAEKKILPLNQIVGFAIQMSTVFEKIQQNNLIHSDIKPENILYDSQEKCFNLCDYGESKSFKDVSKT-YNLKGFTRKYAAPEIT-------EDNSFFNIK
  ... .   |..  ..|.   .. ..|.|.||.||||.|||...| . ...|| | || .|  ..  .. ||.| .|. ||         ..|   |.|
QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINYK

YDIY
.|||
SDIY
Kinase 2942.AA Ciliate-B2 70-253 29 3e-20 44.23 In-house 2-197 (197) Show / Hide 
Range on Protein: 70-253
Range on HMM: 2-197/197
Sequence Identity: 29% (59 aa)

YLTSYISQGGNGCVFEAKYNEEI------VAVKCSNP----KFEKIKEEEKIMKLLKDTPYVFKSIEEFLNEKKTKYYQISKKYSCNLKDIMQSFFAEKK
||. || .|| | ..|  |  ..      .|.|          | | .| ||||..    .| | |. .  ... .   |  |  | ||. .|    ..|
YLCKYINKGGCGFICEG-YKKHSIREYQDLAFKIYFNKQDCDKEEIQHEIKIMKMFEYNINVVKYIDHIQINETIDVL-IMEKCECSLKQELQKIQKQQK

ILPLNQIVGFAIQMSTVFEKIQQNNLIHSDIKPENILYDSQEKCFNLCDYGESKSFKDVSKTYNLKGFTRKYAAPEITEDN------SFFNIKYDIYGLG
  . . ..    |.     ..  .| .| ||||.|||  .|.  . .||.| | | |      . |||| ||| ||  |.       .  . . ||| .|
CFNNQKLYQMIFQLIDGLIQFRMYNILHLDIKPQNILF-MQNGNYVYCDFGIS-SIKKDNQQIKIKGFTKKYASPEQMECDHNQTFVTNIDFQSDIYSMG
Kinase 2942.AA Pkinase 77-307 21 2.5e-17 62.36 Pfam 9-282 (293) Show / Hide 
Range on Protein: 77-307
Range on HMM: 9-282/293
Sequence Identity: 21% (61 aa)

QGGNGCVFEAKYNEE--IVAVKCSNPKFEKIKE--------EEKIMKLLKDTPYVFKSIEEFLNEKKTKYYQISKKYSCNLKDIMQSF----FAEKKIL-
.|. |||....   .  |||||. . . || ..        | .||| | . |.. . .. | .  |...| .     . |.  |  |      ... . 
SGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--KDHIYMVMEYCEGGLY-VMDLFDYISTWRHGCFY

-PLNQIVGFAIQMSTVFEKIQQNNLIHSDIKPENILYDSQEKC---FNLCDYGESKSFKDVSKTYNLKGF--TRKYAAPEITEDNSFFNIKYDIYGLGII
 . ...  .. |.    | . ... || |.||||||.|..  .   . .|| | .| |.   .   ...|  |. |.|||.  ...    | |....|.|
FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCI

LLELTLGKFLEDGD--------CAFIRNGKLPNYISKNALY---------------------QDINQIIIKMLEKTPQNRI
| |. .|... .|.         . |.. . | . .                          ..  ..| ..|.| |. |.
LYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRP
Kinase 2942.AA Ciliate-E2-Unclassified 69-264 20 4.6e-17 55.74 In-house 1-268 (352) Show / Hide 
Range on Protein: 69-264
Range on HMM: 1-268/352
Sequence Identity: 20% (56 aa)

IYLTSYISQGGNGCVFEAKYNEE-------------IVAVKCSNPKFEKIKEEEKIMKLLK------------------DTPYVFKSIEEFLNEKKTKYY
  .   | |||.|.|.... ...             |...|  . |   |. |.|.|. .|                  . |.. | ...|  ..| . |
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCF--QDKQNIY

QISKKY-SCNLKDIMQSF-------------FAEKKILPLNQIV-----GFAIQMSTVFEKIQQNN-LIHSDIKPENILYDSQEK--CFNLCDYGESKSF
 .  .    .|.......               ..||.. .|..      .. |    .|.. ..|  || ||||||||.|.. |  .  ..|.| ||  
IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKY

KDV---------------SKTYNLKGFTRKYA----APEITEDNSFFN---IKYDIYGLGIILLELTLGKF
..                .. .. .  |  |     |||. . .   .   .| ||..||.|| |.  |..
QQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYY
Kinase 2942.AA S_TKc 69-314 20 1.5e-15 51.12 SMART 1-220 (231) Show / Hide 
Range on Protein: 69-314
Range on HMM: 1-220/231
Sequence Identity: 20% (53 aa)

IYLTSYISQGGNGCVFEAKYNE--EIVAVKCSNPKFEKIKEEEKIMKLLKDTPYVFKSIEEFLNEKKTKYYQISKKYSC---NLKDIMQSFFAEK--KIL
  .   | .|. |.|. .. ..  .|||.|. .   |.|. | .|.|   . |.. | .. | .   ...| .    .    .|.|....   ..  . .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

PLNQIVGFAIQMSTVFEKIQQNNLIHSDIKPENILYDSQEKCFNLCDYGESKSFKDVSKTYNLKGFTRKYAAPEITEDNSFFNI-KYDIYGLGIILLELT
|  ..  .. |.    | . ... || |.|||||| |.   .  .|| | .. .       .    |. | |||.      ..  | |.. .|.|| |. 
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEML

LGKFLEDGDCAFIRNGKLPNYISKNALYQDINQIIIKMLEKTPQNRIDSFGLTK
 |. . . . . . .  .          ..  ..| |.|.| |..|.    . .
CGYPPFP-QMQMMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQ
Kinase 2942.AA C8 73-256 22 1.6e-15 50.46 In-house 5-226 (226) Show / Hide 
Range on Protein: 73-256
Range on HMM: 5-226/226
Sequence Identity: 22% (50 aa)

SYISQGGNGCVFEAKYNEE--IVAVKCSNPKFE-KIKEEEKIMKLLKDTPYVFKSIEEFLNEKKTKYYQISKK----YS-----------CNLKD-----
 |.|.|. | | .||  ..   .. |    . . .|...|.||| .. .| ||.  . . ||....| . ..      |           | ...     
QYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYE-MPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEMELCE

-----IMQSFFAEKKILPLNQIVGFAIQMSTVFEKIQQNNLIHSDIKPENIL-YDSQEKC--FNLCDYGESKSFKDVSKTYNLKGF----TRKYAAPEIT
     . . .  ... .. ..    ||||    . |.. | .| ||||.|.| . .|..     ||| |..   ..  . .  | .    | .| |||| 
QNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAPEIE

ED----NSFFNIKYDIYGLGIIL
..    . ...|. |.. .|..|
KKQDNQYKQYRIQSDLFSVGLVL
Kinase 2942.AA Ciliate-E3 182-260 38 3.8e-15 43.95 In-house 121-202 (202) Show / Hide 
Range on Protein: 182-260
Range on HMM: 121-202/202
Sequence Identity: 38% (32 aa)

QNNLIHSDIKPENILYDSQEK--CFNLCDYGESKSF-KDV--SKTYNLKGFTRKYAAPEITEDNSFFNIKYDIYGLGIILLELT
. |.|||||||.||| |. .       || ||||   |.   . |.   |.|  |||||.  |.. .    |.| .| ....| 
EKNIIHSDIKPDNILVDKNNNQLIIKICDFGESKQLRKNKGHTHTQY-QGWTPFYAAPEQ-NDQQQISKESDYYSVGAVFCQLC
Kinase 2942.AA Ciliate-E2 69-308 18 2.8e-14 45.39 In-house 1-354 (365) Show / Hide 
Range on Protein: 69-308
Range on HMM: 1-354/365
Sequence Identity: 18% (69 aa)

IYLTSYISQGGNGCVFEA-------------------------KYNEEIVAVKCSNPK-FEKIKEEEKIMKLLK---------------DTPYVFKSIEE
. .   | ||. |.|...                         |..  |.|.|. ...  | || |..||. ..               . |.. | .| 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FLNEKKTKYYQISKKYSC-NLKDIMQSF-FAEKKILP------LNQIVGFAIQMSTVF---------------EKIQQNN-LIHSDIKPENILYDSQEKC
| .......| .   ..  .|.|.....   ......      ...|  .  |   .|               | . ..|  || ||||||||.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

FNLCDYGESKSFKDV---------SKTYNLKG-----------------------FTRKYAAPEITEDNSF--------FNIKYDIYGLGIILLELTLGK
  ..| | || ..|          .| |   .                        |  | |||| .  .          . | ||. ||.|| |.  ||
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

FLEDGDCAFIRNGKLPNYISKNA--------------------------LYQDINQIIIK----MLEKTPQNRID
.                .. .                            . |.  ..| |    ||.| |..||.
PPF--------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT
Kinase 2942.AA CMGC 69-236 14 6.4e-13 37.86 In-house 1-296 (513) Show / Hide 
Range on Protein: 69-236
Range on HMM: 1-296/513
Sequence Identity: 14% (42 aa)

IYLTSYISQGGNGCVFEAKY----------------NEEIVAVKCSNPKFEKIK---------------EEEKIMKLLK----------------DTPYV
    ..| .|  | |....                 ..||||.|    .|...                 | ||.| |.                . ...
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

FKSIEEFLNEK---------------KTKYYQISKKYSCNLKDIMQSFF------------------------AEKKILPLNQIVGFAIQMSTVFE--KI
 | .. |  ..                 . | .     ..|......                            .| ... .|  .. |. .  .   .
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKYC

QQNN--LIHSDIKPENILYDSQEKCF-------------------NLCDYGESKSFKDV---------------------SKTYNLKGFTRKYAAPEI
 ...   || |.|||||| ... ...                    .|| | .... .                      ...|     || | ||||
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEI
Kinase 2942.AA Ciliate-E2b 177-263 32 1.7e-12 34.42 In-house 115-207 (272) Show / Hide 
Range on Protein: 177-263
Range on HMM: 115-207/272
Sequence Identity: 32% (31 aa)

FEKIQQNNLIHSDIKPENILYDSQEKCFNLCDYGESKSFKDVSK----TYNLKGFTRKYAAPEITE----DNSFFNIKYDIYGLGIILLELTLGK
.|  ...| |. |||||||. |..  .  | | | .| ... .     |. . | |  | |||| .     .   ..| ||. .||.| |.  |.
LEYLHNQNIIYRDIKPENIMVDHKGYMK-LIDMGTAKHMYKKNEQMTRTFTIIG-TPHYMAPEIIQSLQPGGKGYTYKVDIWSVGICLYEFMCGY
Kinase 2942.AA TKL 184-263 20 2e-12 41.06 In-house 160-286 (364) Show / Hide 
Range on Protein: 184-263
Range on HMM: 160-286/364
Sequence Identity: 20% (26 aa)

NLIHSDIKPENILYDS-------------QEKCFNLCDYGESKSFK-------------------DVSKTYNLKGFTRKYAAPEITEDNSFFNIKY----
..|| |.|..||| |.              . |  .||.| |....                   . .|| . .. |  . |||. ... ... |.    
PIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDE

-----------DIYGLGIILLELTLGK
           |.|  ||.| |.  ..
FCKGFEYSEKCDVYSFGIVLWEILTRC
Kinase 2942.AA TyrKc 69-316 15 7.8e-07 -112.18 SMART 1-280 (280) Show / Hide 
Range on Protein: 69-316
Range on HMM: 1-280/280
Sequence Identity: 15% (48 aa)

IYLTSYISQGGNGCVFEAKYNEEIVAVKCSN--PKFEKIKEEEKIMKLL-KDTPYVFK----SIEE------------------------FLNEKKTKYY
| |   .  |  | |...... . ||||. .     | . .| .||. | .. | . .     ...                        .| ... |  
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK--

QISKKYSCNLKDIMQSFFAEKKILPLNQIVGFAIQMSTVFEKIQQNNLIHSDIKPENILYDSQEKC----FNLCDYGESK-----SFKDVSKTY--NLKG
                       |.. . . |..| .   | . ..|.|| |.   |.|....  .    | |. .....     | .  .|.   . |.
-----------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKT

-FTRKYAAPEITEDNSFFNIKYDIYGLGIILLEL-TLGKFLEDGD----------CAFIRNGKLPNYISKNA------LYQDINQIIIKMLEKTPQNRID
 .  .  |||   . . |..| |..  |. . |. |.|.    |.           .....|. .     .         ... ||. .  .  | .|  
MLPIRWMAPECI-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPT

SFGLTKQL
   . ...
FSEIHECF
Kinase 2942.AA TKL 75-116 16 6e-06 17.42 In-house 1-83 (364) Show / Hide 
Range on Protein: 75-116
Range on HMM: 1-83/364
Sequence Identity: 16% (14 aa)

ISQGGNGCVFEAKYNE----------EIVAVKCSNP-------------------------------KFEKIKEEEKIMKLLK
| .|| |.|. .|..           . ||||  .                                 .....|| ..|. |.
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLR