Gene 3081 (Tetrahymena)
3081
Group:
Other
Family:
Ciliate-C5
Sequence
Protein domains of 3081.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 3081.AA | Ciliate-C5 | 69-329 | 86 | 2.5e-193 | 642.09 | In-house | 1-260 (260) | Show / Hide |
Range on Protein: 69-329 Range on HMM: 1-260/260 Sequence Identity: 86% (225 aa) IYLTSYISQGGFGCVFEAKYNEEIVAIKCSKTNFEKIEEEEKILKLLKDTPYVFKSIKGFTNQKNSRYYQISKRYSCNLKEIMKSFFEQRKTLPLNQIIG ||||||||||||||||||||||||||.||||.|||||.|||||.|||||||||||||..|.|.|.|.|||||||||||||.||.|||.|.|||||||||| IYLTSYISQGGFGCVFEAKYNEEIVAVKCSKPNFEKIKEEEKIMKLLKDTPYVFKSIEEFLNEKKSKYYQISKRYSCNLKDIMQSFFDQKKTLPLNQIIG FAIQMSTVFEKIEQNKLIHSDVKPENILYDSQEKCFYLCDYGESKQFKDGSKTYDLKGFAPKYAAPEITDTKNGTFNIKYDIYGLGVILLELTLGKFLED ||||||||||||.||.||||||||||||||||||||.||||||||.|||||||||||||..|||||||||. ||.|||||||||||.||||||||||||| FAIQMSTVFEKIQQNNLIHSDVKPENILYDSQEKCFNLCDYGESKSFKDGSKTYDLKGFTRKYAAPEITDD-NGFFNIKYDIYGLGIILLELTLGKFLED SDCSFIRNGQLPQYISKNGLYQDINQIIVKMLEKIPQNRISSFELTKKLNDLRLKLENEFI .||.|||||.||.||||| |||||||||.|||||.|||||.||||||.||.||||||..|| EDCTFIRNGKLPNYISKNALYQDINQIIIKMLEKMPQNRIDSFELTKQLNELRLKLESQFI |
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| Kinase | 3081.AA | Ciliate-E1 | 75-251 | 26 | 2e-27 | 86.52 | In-house | 1-202 (202) | Show / Hide |
Range on Protein: 75-251 Range on HMM: 1-202/202 Sequence Identity: 26% (54 aa) ISQGGFGCVFEA---KYNEEIVAIKCSKTNFE--------KIEEEEKILKLLKDTPYVFKSIKGFTNQKNSRYYQISKRYSCNLKEIMK---------SF |..|.|. ||.| ..|.. ||.| ...| .|.|. ||.| .| |... |. . ..| ...| ..|.||. .. .. IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC FEQRKTLPLNQIIGFAIQMSTVFEKIEQNKLIHSDVKPENILYDSQEKCFYLCDYGESKQFKDGSKT-YDLKGFAPKYAAPEITD------TKNGTFNIK .. . . |.. ..|. .. ..|...||.| ||.|||...| . . .|| | ||..| .. .. ||. .|. || || . |.| QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINYK YDIY .||| SDIY |
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| Kinase | 3081.AA | CMGC | 69-222 | 13 | 1.1e-17 | 53.77 | In-house | 1-282 (513) | Show / Hide |
Range on Protein: 69-222
Range on HMM: 1-282/513
Sequence Identity: 13% (39 aa)
IYLTSYISQGGFGCVFEAKY----------------NEEIVAIKCSKTNFEKIE---------------EEEKILKLLK----------------DTPYV
..| .| .| |.... ..|||||| | .|.... | |||| |. . ...
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI
FKSIKGFTNQKNS---------------RYYQISKRYSCNLKEIMKSFF------------------------EQRKTLPLNQIIGFAIQMSTVFE--KI
| . |. .. | . ..|....|. .. | ... .| .. |. . . .
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKYC
EQNK--LIHSDVKPENILYDSQEKCF-------------------YLCDYGESKQFKDG---------------------SKTY
... || | |||||| ... ... .|| | .... . ...|
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPY
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| Kinase | 3081.AA | Ciliate-E3 | 182-261 | 35 | 2.3e-16 | 47.79 | In-house | 121-202 (202) | Show / Hide |
Range on Protein: 182-261 Range on HMM: 121-202/202 Sequence Identity: 35% (30 aa) QNKLIHSDVKPENILYDSQEK--CFYLCDYGESKQFKDGS---KTYDLKGFAPKYAAPEITDTKNGTFNIKYDIYGLGVILLELT . ..|||| ||.||| |. . || ||||| . |.. |. | |||||. | .. . |.| .|.....| EKNIIHSDIKPDNILVDKNNNQLIIKICDFGESKQLRKNKGHTHTQY-QGWTPFYAAPEQND--QQQISKESDYYSVGAVFCQLC |
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| Kinase | 3081.AA | S_TKc | 69-322 | 23 | 6.6e-16 | 56.31 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 69-322 Range on HMM: 1-231/231 Sequence Identity: 23% (62 aa) IYLTSYISQGGFGCVFEAKYNE--EIVAIKCSKTNFEKIEEEEKILKLLKDTPYVFKSIKGFTNQKNSRYYQISKRYSC---NLKEIMKSFFEQR--KTL . | .|.||.|. .. .. .|||||. | |.|. | .||| . |.. | . | . ...| . . .|....|. .. . . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF PLNQIIGFAIQMSTVFEKIEQNKLIHSDVKPENILYDSQEKCFYLCDYGESKQFKDGSKTYDLKGFAPKYAAPEITDTKNGTFNI-KYDIYGLGVILLEL | .. .. |. | . ... || |.|||||| |. . .|| | ..|. . | | |||. .. | |.. .|.|| |. PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL-------TTFCGTPWYMAPEVL-----GYGKCKCDWWSCGCILYEM TLGKFLEDSDCSFIRNGQLPQYISKNGLYQDINQIIVKMLEKIPQNRISSFELTK----KLNDLRL |. . . |. . . | | .. ..| |.|.| |..|.. |. . .. . LCGYPPFP---------QMQMMFKKIG-SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 3081.AA | Pkinase | 77-317 | 20 | 6.6e-16 | 57.33 | Pfam | 9-293 (293) | Show / Hide |
Range on Protein: 77-317 Range on HMM: 9-293/293 Sequence Identity: 20% (60 aa) QGGFGCVFEAKYNEE--IVAIKCSKTNFEKIEE--------EEKILKLLKDTPYVFKSIKGFTNQKNSRYYQISKRYSCNLKEIMKSF----FEQRKTL- .|.||||.... . |||.|. | || .. | .|.| | . |.. . . |.. ....| . . |. | | ...... SGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--KDHIYMVMEYCEGGLY-VMDLFDYISTWRHGCFY -PLNQIIGFAIQMSTVFEKIEQNKLIHSDVKPENILYDSQEKC---FYLCDYGESKQFKDGSKTYDLKGFA--PKYAAPEITDTK-NGTFNIKYDIYGLG . .... .. |. | . ... || |.||||||.|.. . . .|| | .|||. . ...|. | |.|||. . . | |....| FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEV--IRGGQYYGPKVDMWSCG VILLELTLGKFLEDSD--------CSFIRNGQLPQYISKNGLY---------------------QDINQIIVKMLEKIPQNRISSFELTKK--L .|| |. .|... ... |.. |.. . .. ..| ..|.| |. |.. .. . . CILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | 3081.AA | Ciliate-B2 | 70-254 | 26 | 1e-14 | 30.93 | In-house | 2-197 (197) | Show / Hide |
Range on Protein: 70-254 Range on HMM: 2-197/197 Sequence Identity: 26% (53 aa) YLTSYISQGGFGCVFEAKYNEEI------VAIKCSKT----NFEKIEEEEKILKLLKDTPYVFKSIKGFTNQKNSRYYQISKRYSCNLKEIMKSFFEQRK ||. || .||.| ..| | .. .|.| . | |..| ||.|.. .| | | . ... | . | ||. .. |.| YLCKYINKGGCGFICEG-YKKHSIREYQDLAFKIYFNKQDCDKEEIQHEIKIMKMFEYNINVVKYIDHIQINETIDVL-IMEKCECSLKQELQKIQKQQK TLPLNQIIGFAIQMSTVFEKIEQNKLIHSDVKPENILYDSQEKCFYLCDYGESKQFKDGSKTYDLKGFAPKYAAPEITDTK-----NGTFNIKYDIYGLG . . .. |. .. . .| |.||.||| .|. . .||.| | || .. . ||| ||| || . . . ||| .| CFNNQKLYQMIFQLIDGLIQFRMYNILHLDIKPQNILF-MQNGNYVYCDFGISSIKKDNQQIK-IKGFTKKYASPEQMECDHNQTFVTNIDFQSDIYSMG |
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| Kinase | 3081.AA | Ciliate-E2 | 69-320 | 19 | 1.4e-14 | 46.49 | In-house | 1-365 (365) | Show / Hide |
Range on Protein: 69-320 Range on HMM: 1-365/365 Sequence Identity: 19% (72 aa) IYLTSYISQGGFGCVFEA-------------------------KYNEEIVAIKCSKTN-FEKIEEEEKILKLLK---------------DTPYVFKSIKG . . | ||.||.|... |.. |.|.|. | | | |. |..|.. .. . |.. | . YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC FTNQKNSRYYQISKRYSC-NLKEIMKSFFEQRKTLPL-------NQIIGFAIQMSTVF---------------EKIEQNK-LIHSDVKPENILYDSQEKC | ..... .| . .. .|....|.. .|. . ..|. . | .| | . ... || | ||||||. FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------ FYLCDYGESKQFKDGSK--------TYDLKGF------------------------APKYAAPEITDTKN------GT-FNIKYDIYGLGVILLELTLGK ..| | ||...| .. . . | | |||| |. .. . | ||. ||||| |. || IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK F---LEDSDCSFIRNGQLPQYI---------SKNGLYQDINQIIVK----MLEKIPQNRISSFELTKKLNDL . . .| . . . .| |.. . |. ..| | ||.| |..||...| .. . PPFQQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
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| Kinase | 3081.AA | Ciliate-E2-Unclassified | 69-265 | 18 | 1.7e-14 | 46.74 | In-house | 1-268 (352) | Show / Hide |
Range on Protein: 69-265 Range on HMM: 1-268/352 Sequence Identity: 18% (51 aa) IYLTSYISQGGFGCVFEAKYNEE---------IVAIKCS-------KTNFEKIEEEEKILK---------LLKD------TPYVFKSIKGFTNQKNSRYY . | |||||.|.... ... ....... . .. ...|....| .... |.. | . |....| | YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQN--IY QISKRY-SCNLKEIMKSF----------FEQRKT---LPLNQII-----GFAIQMSTVFEKIEQNK-LIHSDVKPENILYDSQEK--CFYLCDYGESKQF . .|....|.. |...|. .. .|.. .. | .|.. ... || | ||||||.|.. | . ..|.| ||. IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKY KD---------------GSKTYDLKGFAPKYA----APEITDT-KNG--TFNIKYDIYGLGVILLELTLGKF .. .. .. . | | |||. . ... .. .| ||..||||| |. |.. QQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA-YKCDIWSLGVILYEMLFGYY |
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| Kinase | 3081.AA | C8 | 73-257 | 22 | 2e-14 | 46.6 | In-house | 5-226 (226) | Show / Hide |
Range on Protein: 73-257
Range on HMM: 5-226/226
Sequence Identity: 22% (51 aa)
SYISQGGFGCVFEAKYNEE--IVAIKCSK-TNFEKIEEEEKILKLLKDTPYVFKSIKGFTNQKNSRYYQISKR----YS-----------CNLKE-----
|.|.|..| | .|| .. ...| | .| ..|...|.| | .. .| ||. . . |... | . .. | | ..|
QYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYE-MPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEMELCE
-IMKSFFEQRKTLPLN----QIIGFAIQMSTVFEKIEQNKLIHSDVKPENIL-YDSQEKC--FYLCDYGESKQFKDGSKTYDLKGF----APKYAAPEIT
.| ....|.. . . |||| . |.. . .| |.||.|.| . .|.. ||| |.. | .. . . | . .| ||||
QNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAPEIE
DT---KNGTFNIKYDIYGLGVIL
.. ..|. |.. .|..|
KKQDNQYKQYRIQSDLFSVGLVL
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| Kinase | 3081.AA | TKL | 184-264 | 19 | 2.2e-11 | 37.25 | In-house | 160-286 (364) | Show / Hide |
Range on Protein: 184-264 Range on HMM: 160-286/364 Sequence Identity: 19% (25 aa) KLIHSDVKPENILYDS-------------QEKCFYLCDYGESKQFK-------------------DGSKTYDLKGFAPKYAAPEITDTK----------- ..|| | |..||| |. . | .||.| |. .. ...|| .. | . |||. . . PIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDE ---NGTFNIKYDIYGLGVILLELTLGK ..... | |.| |..| |. .. FCKGFEYSEKCDVYSFGIVLWEILTRC |
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| Kinase | 3081.AA | STE | 180-329 | 19 | 1.7e-09 | 29.86 | In-house | 168-359 (359) | Show / Hide |
Range on Protein: 180-329 Range on HMM: 168-359/359 Sequence Identity: 19% (41 aa) IEQNKLIHSDVKPENILYDSQEKCFYLCDYGESKQFKD-----------------GSKTYDLKGFAPKYAAPEITDTKNGT----FNIKYDIYGLGVILL ..... || |.|| ||| ||| | ..|. | ..|.. . | . |||. . ... ..| ||. || .. LHSHHIIHRDIKPANILL------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP--WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTII ELTLGKFLE---DSD---CSFIRN--------------GQLPQYIS-----------------KNGLYQDINQIIVKMLEKIPQNRISSFELTKKLNDLR |. || ...| |. |. . . . .. .. | | |.| |..| .. .| | EMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKS----- LKLENEFI | .|| ---EHPFI |
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| Kinase | 3081.AA | TyrKc | 69-317 | 19 | 2.2e-08 | -87.18 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 69-317 Range on HMM: 1-280/280 Sequence Identity: 19% (56 aa) IYLTSYISQGGFGCVFEAKYNEEIVAIKCSK--TNFEKIEEEEKILKLL-KDTPYVFKSIKGFTNQ-------KNSRYYQISKRYSCNLKEIMKSFFEQR | | . | || |...... . ||.|. | . | . .| .|.. | .. | . . . | | . . .||. . . | ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH-GDLKDYLR---KHR KTLPLNQIIGFAIQMSTVFEKIEQNKLIHSDVKPENILYDSQEKCFYLCDYGESKQFKDG------SKTYD------LKG-FAPKYAAPEITDTKNGTFN ..|.. . . |..| . | ......|| | |.|.... . .| | |. .|. ...|. |. . . ||| . |.|. PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--NYGKFT IKYDIYGLGVILLEL-TLGKFLEDSD--CSFIRNGQLPQYISKN-GLYQDIN--------------QIIVKMLEKIPQNRISSFELTKKL .| |.. || . |. |.|. . .. | .. .|. . . | | ||. . . | .| . |. ... TKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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| Kinase | 3081.AA | TKL | 75-116 | 18 | 2.5e-08 | 26.1 | In-house | 1-83 (364) | Show / Hide |
Range on Protein: 75-116 Range on HMM: 1-83/364 Sequence Identity: 18% (15 aa) ISQGGFGCVFEAKYNE----------EIVAIKCSKT-------------------------------NFEKIEEEEKILKLLK | .||||.|. .|.. . ||.| |. .....||| .... |. IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLR |
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| Kinase | 3081.AA | STE | 70-121 | 18 | 1e-06 | 19.71 | In-house | 1-92 (359) | Show / Hide |
Range on Protein: 70-121 Range on HMM: 1-92/359 Sequence Identity: 18% (17 aa) YLT-SYISQGGFGCVFEAKYN-----------------EEIVAIKCSK---------------------TNFEKIEEEEKILKLLKD-TPYV . . | .|.|| |. |... ||.||| . .....|..| ||.| ... |.. WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNI |
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| Kinase | 3081.AA | Ciliate-E3 | 69-96 | 33 | 0.046222 | 2.57 | In-house | 1-30 (202) | Show / Hide |
Range on Protein: 69-96 Range on HMM: 1-30/202 Sequence Identity: 33% (10 aa) IYLTSYISQGGFGCVFEA--KYNEEIVAIK . . .|.|| |. | | .|||| YTVQQILGCGQFGRVYKAFDFQNNQDVAIK |
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