Gene 5526 (Tetrahymena)

5526

Species: Tetrahymena
Alias: TTHERM_01661070, 44, 540.m00002, 5526, PreTt05526
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-C5

Sequence

Name Sequence Type Origin Length Description Download
5526.AA Protein None 642 None Fasta, JSON
5526.kin_dom Protein Kinase Domain None 242 None Fasta, JSON
5526.NA RNA None 1929 None Fasta, JSON

Protein domain

Protein domains of 5526.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 5526.AA Ciliate-C5 195-454 94 1.9e-198 659.22 In-house 1-260 (260) Show / Hide 
Range on Protein: 195-454
Range on HMM: 1-260/260
Sequence Identity: 94% (245 aa)

VYLTSYIAQGGYGCVFEAKYNGEIVAVKCSKPKFDKIKEEEKIMKLLKDTPYVFKSIEEFFNEKNSKYYQISKKYSCNLKDIMQSFFDQKKTLPLNQIVG
.||||||.|||.||||||||| ||||||||||.|.|||||||||||||||||||||||||.|||.||||||||.||||||||||||||||||||||||.|
IYLTSYISQGGFGCVFEAKYNEEIVAVKCSKPNFEKIKEEEKIMKLLKDTPYVFKSIEEFLNEKKSKYYQISKRYSCNLKDIMQSFFDQKKTLPLNQIIG

FAIQMSTVFEKIQQNNLIHSDIKPENILYDSQEKCFNLCDYGESKSFKDGSKTYNLKGFTRKYAAPEITDDNGLFNIKYDIYGLGIILLELTLGKFLEDG
|||||||||||||||||||||.||||||||||||||||||||||||||||||||.||||||||||||||||||.|||||||||||||||||||||||||.
FAIQMSTVFEKIQQNNLIHSDVKPENILYDSQEKCFNLCDYGESKSFKDGSKTYDLKGFTRKYAAPEITDDNGFFNIKYDIYGLGIILLELTLGKFLEDE

DCTFIRNGKLPNYISKNALYQDINQIIIKMLEKMPQNRIDSFGLTKQLNELRLKLESQFI
||||||||||||||||||||||||||||||||||||||||||.|||||||||||||||||
DCTFIRNGKLPNYISKNALYQDINQIIIKMLEKMPQNRIDSFELTKQLNELRLKLESQFI
Kinase 5526.AA Ciliate-E1 201-376 26 4.3e-30 95.28 In-house 1-202 (202) Show / Hide 
Range on Protein: 201-376
Range on HMM: 1-202/202
Sequence Identity: 26% (54 aa)

IAQGGYGCVFEA---KYN-----GEIVAVKC--SKPKFDKIKEEEK-IMKLLKDTPYVFKSIEEFFNEKNSKYYQISKKYSCNLKDIMQ---------SF
|..|... ||.|   ..|       |. ...  .. .|.....|.. ||| .|   |... |. .. ..|  ...|  ...|.||| .|         ..
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC

FDQKKTLPLNQIVGFAIQMSTVFEKIQQNNLIHSDIKPENILYDSQEKCFNLCDYGESKSFKDGSKT-YNLKGFTRKYAAPEIT-------DDNGLFNIK
  ... .   |..  ..|.   .. ..|.|.||.||||.|||...| . ...|| | || .|  ..  .. ||.| .|. ||         ..|   |.|
QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINYK

YDIY
.|||
SDIY
Kinase 5526.AA Ciliate-B2 196-379 28 1.1e-19 42.88 In-house 2-197 (197) Show / Hide 
Range on Protein: 196-379
Range on HMM: 2-197/197
Sequence Identity: 28% (58 aa)

YLTSYIAQGGYGCVFEAKYNGEI------VAVKCSKP----KFDKIKEEEKIMKLLKDTPYVFKSIEEFFNEKNSKYYQISKKYSCNLKDIMQSFFDQKK
||. ||..|| | ..|  |  ..      .|.|          . | .| ||||..    .| | |. .  ... .   |  |  | ||. .|    |.|
YLCKYINKGGCGFICEG-YKKHSIREYQDLAFKIYFNKQDCDKEEIQHEIKIMKMFEYNINVVKYIDHIQINETIDVL-IMEKCECSLKQELQKIQKQQK

TLPLNQIVGFAIQMSTVFEKIQQNNLIHSDIKPENILYDSQEKCFNLCDYGESKSFKDGSKTYNLKGFTRKYAAPEITDDN------GLFNIKYDIYGLG
  . . ..    |.     ..  .| .| ||||.|||  .|.  . .||.| | | |      . |||| ||| ||  ..          . . ||| .|
CFNNQKLYQMIFQLIDGLIQFRMYNILHLDIKPQNILF-MQNGNYVYCDFGIS-SIKKDNQQIKIKGFTKKYASPEQMECDHNQTFVTNIDFQSDIYSMG
Kinase 5526.AA CMGC 195-362 14 8.2e-18 54.25 In-house 1-296 (513) Show / Hide 
Range on Protein: 195-362
Range on HMM: 1-296/513
Sequence Identity: 14% (44 aa)

VYLTSYIAQGGYGCVFEAKY----------------NGEIVAVKCSKPKFDKIK---------------EEEKIMKLLK----------------DTPYV
    ..| .| || |....                 ..||||.|  | .|...                 | ||.| |.                . ...
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

FKSIEEFFNEKNS---------------KYYQISKKYSCNLKDIMQSFF------------------------DQKKTLPLNQIVGFAIQMSTVFE--KI
 | .. |  ...                . | .     ..|......                           ..| ... .|  .. |. .  .   .
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKYC

QQNN--LIHSDIKPENILYDSQEKCF-------------------NLCDYGESKSFKDG---------------------SKTYNLKGFTRKYAAPEI
 ...   || |.|||||| ... ...                    .|| | .... .                      ...|     || | ||||
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEI
Kinase 5526.AA Ciliate-E3 308-386 37 3.3e-16 47.32 In-house 121-202 (202) Show / Hide 
Range on Protein: 308-386
Range on HMM: 121-202/202
Sequence Identity: 37% (31 aa)

QNNLIHSDIKPENILYDSQEK--CFNLCDYGESKSFKDGS-KTYNL-KGFTRKYAAPEITDDNGLFNIKYDIYGLGIILLELT
. |.|||||||.||| |. .       || ||||  .     |  .  |.|  |||||. .|....    |.| .| ....| 
EKNIIHSDIKPDNILVDKNNNQLIIKICDFGESKQLRKNKGHTHTQYQGWTPFYAAPEQ-NDQQQISKESDYYSVGAVFCQLC
Kinase 5526.AA Pkinase 201-433 21 3.7e-16 58.23 Pfam 7-282 (293) Show / Hide 
Range on Protein: 201-433
Range on HMM: 7-282/293
Sequence Identity: 21% (62 aa)

IAQGGYGCVFEAKYNGE--IVAVKCSKPKFDKIKE--------EEKIMKLLKDTPYVFKSIEEFFNEKNSKYYQISKKYSCNLKDIMQSF----FDQKKT
| .|..|||....  |.  |||||. | . .| ..        | .||| | . |..   . ..| . ....| .     . |.  |  |     .....
IGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNI-VRLYDWFED-KDHIYMVMEYCEGGLY-VMDLFDYISTWRHGC

L--PLNQIVGFAIQMSTVFEKIQQNNLIHSDIKPENILYDSQEKC---FNLCDYGESKS--FKDGSKTYNLKGFTRKYAAPEITDDNGLFNIKYDIYGLG
.  . ...  .. |.    | . ... || |.||||||.|..  .   . .|| | .|      .| .. . | |. |.|||.  ..     | |....|
FYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCG-TPWYMAPEVIRGGQYYGPKVDMWSCG

IILLELTLGKFLEDGD--------CTFIRNGKLPNYISKNALY---------------------QDINQIIIKMLEKMPQNRI
.|| |. .|... .|.           |.. . | . .                          ..  ..| ..|.| |. |.
CILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRP
Kinase 5526.AA Ciliate-E2-Unclassified 197-390 20 6.7e-16 51.66 In-house 3-268 (352) Show / Hide 
Range on Protein: 197-390
Range on HMM: 3-268/352
Sequence Identity: 20% (56 aa)

LTSYIAQGGYGCVFEAKYNGE-------------IVAVKCSKPKFDKIKEEEKIMKLLK------------------DTPYVFKSIEEFFNEKNSKYYQI
.   | |||.|.|.... . .             |...|  . |   |. |.|.|. .|                  . |.. | ...| ...|   | .
IIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQN--IYIV

SKKY-SCNLKDIMQSF----------FDQKKT---LPLNQIV-----GFAIQMSTVFEKIQQNN-LIHSDIKPENILYDSQEK--CFNLCDYGESKSFKD
  .    .|.......          |...|.   .. .|..      .. |    .|.. ..|  || ||||||||.|.. |  .  ..|.| ||  ..
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

---------------GSKTYNLKGFTRKYA----APEITDDNGLFN---IKYDIYGLGIILLELTLGKF
                .. .. .  |  |     |||. . ..  .   .| ||..||.|| |.  |..
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYY
Kinase 5526.AA S_TKc 195-440 20 8.7e-16 54.58 SMART 1-220 (231) Show / Hide 
Range on Protein: 195-440
Range on HMM: 1-220/231
Sequence Identity: 20% (53 aa)

VYLTSYIAQGGYGCVFEAKYNG--EIVAVKCSKPKFDKIKEEEKIMKLLKDTPYVFKSIEEFFNEKNSKYYQISKKYSC---NLKDIMQSFFDQK--KTL
  .   | .|..|.|. .. ..  .|||.|. |   ..|. | .|.|   . |.. | .. | .   ...| .    .    .|.|....   ..  . .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

PLNQIVGFAIQMSTVFEKIQQNNLIHSDIKPENILYDSQEKCFNLCDYGESKSFKDGSKTYNLKGFTRKYAAPEITDDNGLFNI-KYDIYGLGIILLELT
|  ..  .. |.    | . ... || |.|||||| |.   .  .|| | .. .       .    |. | |||.      ..  | |.. .|.|| |. 
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEML

LGKFLEDGDCTFIRNGKLPNYISKNALYQDINQIIIKMLEKMPQNRIDSFGLTK
 |. . . .   . .  .          ..  ..| |.|.| |..|.    . .
CGYPPFP-QMQMMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQ
Kinase 5526.AA C8 195-382 22 2.1e-15 50.04 In-house 1-226 (226) Show / Hide 
Range on Protein: 195-382
Range on HMM: 1-226/226
Sequence Identity: 22% (51 aa)

VYLTSYIAQGGYGCVFEAKYNGE--IVAVKCSKPKFD-KIKEEEKIMKLLKDTPYVFKSIEEFFNEKNSKYYQISKK----YS-----------CNLKD-
.    |. .|.|| | .||   .   .. |  | . . .|...|.||| .. .| ||.  . . ||.. .| . ..      |           | ... 
FNNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYE-MPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEM

---------IMQSFFDQKKTLPLNQIVGFAIQMSTVFEKIQQNNLIHSDIKPENIL-YDSQEKC--FNLCDYGESKSFKDGSKTYNLKGF----TRKYAA
         . . . .... .. ..    ||||    . |.. | .| ||||.|.| . .|..     ||| |..   ..  . .  | .    | .| |
ELCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFA

PEITDD----NGLFNIKYDIYGLGIIL
|||  .    .  ..|. |.. .|..|
PEIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 5526.AA Ciliate-E2 195-434 18 1.2e-13 43.2 In-house 1-354 (365) Show / Hide 
Range on Protein: 195-434
Range on HMM: 1-354/365
Sequence Identity: 18% (70 aa)

VYLTSYIAQGGYGCVFEA-------------------------KYNGEIVAVKCSKPK-FDKIKEEEKIMKLLK---------------DTPYVFKSIEE
  .   | ||..|.|...                         |... |.|.|. |..    || |..||. ..               . |.. | .| 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FFNEKNSKYYQISKKYSC-NLKDIMQ---SFFDQK----KTLPLNQIVGFAIQMSTVF---------------EKIQQNN-LIHSDIKPENILYDSQEKC
| .......| .   ..  .|.|...    .....    | . ...|  .  |   .|               | . ..|  || ||||||||.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

FNLCDYGESKSFKDG---------SKTYNLKG-----------------------FTRKYAAPEITDDNGL--------FNIKYDIYGLGIILLELTLGK
  ..| | || ..|          .| |   .                        |  | ||||    .          . | ||. ||.|| |.  ||
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

FLEDGDCTFIRNGKLPNYISKNA--------------------------LYQDINQIIIK----MLEKMPQNRID
.                .. .                            . |.  ..| |    ||.| |..||.
PPF--------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT
Kinase 5526.AA TKL 310-389 20 1.2e-13 45.56 In-house 160-286 (364) Show / Hide 
Range on Protein: 310-389
Range on HMM: 160-286/364
Sequence Identity: 20% (26 aa)

NLIHSDIKPENILYDS-------------QEKCFNLCDYGESKSFK-------------------DGSKTYNLKGFTRKYAAPEITDDN-----------
..|| |.|..||| |.              . |  .||.| |....                   ...|| . .. |  . |||. ...           
PIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDE

----GLFNIKYDIYGLGIILLELTLGK
    . .. | |.|  ||.| |.  ..
FCKGFEYSEKCDVYSFGIVLWEILTRC
Kinase 5526.AA STE 196-247 18 9.7e-08 23.53 In-house 1-92 (359) Show / Hide 
Range on Protein: 196-247
Range on HMM: 1-92/359
Sequence Identity: 18% (17 aa)

YLT-SYIAQGGYGCVFEAKYN-----------------GEIVAVKCSK---------------------PKFDKIKEEEKIMKLLKD-TPYV
.   . | .|..| |. |...                 |||.|.|  .                      ....|..| |||| ...  |..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNI
Kinase 5526.AA STE 308-385 25 1.4e-07 22.97 In-house 170-261 (359) Show / Hide 
Range on Protein: 308-385
Range on HMM: 170-261/359
Sequence Identity: 25% (25 aa)

QNNLIHSDIKPENILYDSQEKCFNLCDYGESKSFKD-----------------GSKTYNLKGFTRKYAAPEITDD-----NGLFNIKYDIYGLGIILLEL
... || |||| |||         ||| | .... |                 ..|.. . |    . |||. .      ..  ..| ||. ||. ..|.
SHHIIHRDIKPANILL------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP--WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEM
Kinase 5526.AA TKL 201-242 19 1.5e-07 23.3 In-house 1-83 (364) Show / Hide 
Range on Protein: 201-242
Range on HMM: 1-83/364
Sequence Identity: 19% (16 aa)

IAQGGYGCVFEAKYNG----------EIVAVKCSKP-------------------------------KFDKIKEEEKIMKLLK
| .||.|.|. .|..|          . ||||  |                                 .....|| ..|. |.
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLR
Kinase 5526.AA TyrKc 195-442 16 1.6e-07 -100.83 SMART 1-280 (280) Show / Hide 
Range on Protein: 195-442
Range on HMM: 1-280/280
Sequence Identity: 16% (51 aa)

VYLTSYIAQGGYGCVFEAKYNGEIVAVKCSK--PKFDKIKEEEKIMKLL-KDTPYVFK----SIEEF-----------------------FNEKNSKYYQ
. |   .  | .| |...... . ||||. |       . .| .||. | .. | . .     ....                       .  |. .   
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK--

ISKKYSCNLKDIMQSFFDQKKTLPLNQIVGFAIQMSTVFEKIQQNNLIHSDIKPENILYDSQEKCFNLCDYGESKSFKDG------SKTY------NLKG
                      |.. . . |..| .   | . ..|.|| |.   |.|....  .   .| | |.  .|.      ...|      . |.
----------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKT

-FTRKYAAPEITDDNGLFNIKYDIYGLGIILLEL-TLGKFLEDGD--CTFIRNGKLPNYISKN-ALYQDIN--------------QIIIKMLEKMPQNRI
 .  .  |||   . | |..| |..  |. . |. |.|.    |.    .. |  . .|. .   . |  |              ||. .  .  | .| 
MLPIRWMAPECI-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRP

DSFGLTKQL
    . ...
TFSEIHECF