Gene 15445 (Tetrahymena)

15445

Species: Tetrahymena
Alias: 15445, 3811.m00980, TTHERM_00449320, 52.m00223, PreTt15445, 241
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-C6

Sequence

Name Sequence Type Origin Length Description Download
15445.AA Protein None 422 None Fasta, JSON
15445.kin_dom Protein Kinase Domain None 269 None Fasta, JSON
15445.NA RNA None 1269 None Fasta, JSON

Protein domain

Protein domains of 15445.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 15445.AA Ciliate-C6 140-411 62 6.7e-200 670.38 In-house 1-306 (306) Show / Hide 
Range on Protein: 140-411
Range on HMM: 1-306/306
Sequence Identity: 62% (191 aa)

IDFRDSLGSGSYGDVYKVKNKHKEIIKNQEILSTMPDFYACKQICVTEQM--SDINSSVFHEIEVLEKLKKYDHVIKLQNYFVA-NRSTYLILDLAESTL
|..||||||||.|.|||.|||||.||||..||..|||.||||||..|.||  ....|..|||||||||||||..|||.||||.. ||.||..||||||||
INYRDSLGSGSFGQVYKCKNKHKQIIKNMDILQQMPDYYACKQIHMTQQMSFENQMSQIFHEIEVLEKLKKYENVIKMQNYFIEPNRQTYIVLDLAESTL

QEQINLKQAN------------------LEQFNQEEIVKFLVQIGKTLALIYSDEGIVHRDLKPSNILIREG--NYYLSDFGCAQELFQSEQIRNN-VAF
|..|. ||||                  .|.|...|||.|..|||||||.||....|.|||.|||||||...  |||||||||||.|||||..||| ...
QDCIQMKQANVNNFYFKQEINIFSFNYKYEHFDENEIVQFCKQIGKTLADIYNECNIAHRDIKPSNILIMDDENNYYLSDFGCAQQLFQSEFTRNNDIHM

GTLKWMSPELREMKR----------DQKINFFKSDVFSLGMILLYMLTLTDISQVNCDVIFKQAKIRLMKNMYKDTKYSQILLLVIRMIETNPDHRPDSS
||||||||||||||.          .|.|..||.|.|||||||||||||.||||||||...|..|||.||||.||..|..|..||..|.|||||||||.|
GTLKWMSPELREMKKQYNQHQDDNSNQQIDYFKCDIFSLGMILLYMLTLSDISQVNCDEFMKNQKIRIMKNMCKDISYKEIIKLVSKMLETNPDHRPDMS

ILIQTI
||||||
ILIQTI
Kinase 15445.AA Pkinase 140-353 25 5.2e-32 114.27 Pfam 1-207 (293) Show / Hide 
Range on Protein: 140-353
Range on HMM: 1-207/293
Sequence Identity: 25% (58 aa)

IDFRDSLGSGSYGDVYKVKNKHKEIIKNQEILSTMPDFYACKQICVTEQMSDINSSVFH--EIEVLEKLKKYDHVIKLQNYFVANRSTYLILDLAESTLQ
. .   .||||.| ||| ..|  ..             .|.|.|.. .. |. . . ..  ||... .| . .....|  .|  ... |......| .| 
YHIGRKIGSGSFGCVYKCHHKGTGK------------IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLY

EQINLK-------QANLEQFNQEEIVKFLVQIGKTLALIYSDEGIVHRDLKPSNILIR-EGNY----YLSDFGCAQEL-FQSEQIRNNVAFGTLKWMSPE
  . |.       . ..  |  .|. ... || . |. ..| .||.||||||.||||  .|.      ..|||.|  .   . .  ...  ||. .|.||
-VMDLFDYISTWRHGCFY-FSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS--MTTFCGTPWYMAPE

LREMKRDQKINFFKSDVFSLGMILLYMLT
.   . ...    |.|..|.| || .||.
V--IR-GGQYYGPKVDMWSCGCILYEMLC
Kinase 15445.AA S_TKc 140-409 21 2.7e-29 104.54 SMART 1-220 (231) Show / Hide 
Range on Protein: 140-409
Range on HMM: 1-220/231
Sequence Identity: 21% (61 aa)

IDFRDSLGSGSYGDVYKVKNKHKEIIKNQEILSTMPDFYACKQICVTEQMSDINSSVFHEIEVLEKLKKYDHVIKLQNYFVANRSTYLILDLAES---TL
 .. . .|.|..| |||...|.                .|.|.|           ..  ||..|.|  . ....||  .|.   . |.......    .|
YEILRKIGKGAFGKVYKCRHKK------------TGRIVAIKIIK---------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDL

QEQINLKQANL--EQFNQEEIVKFLVQIGKTLALIYSDEGIVHRDLKPSNILIREGNYYLSDFGCAQELFQSEQIRNNVAFGTLKWMSPELREMKRDQKI
 . |  .. .    .|.  .. ... || . |. . |  ||.||||||.|||. | .  ..||| | .|        .   ||. .|.||.       . 
FDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE-HIKICDFGLARQL--------TTFCGTPWYMAPEVL------GY

NFFKSDVFSLGMILLYMLT---LTDISQVNCDVIFKQAKIRLMKNMYKDTKYSQILLLVIRMIETNPDHRPDSSILIQ
...|.|. |.| ||  ||.   . .    . ...||. .             .. . .. .. . .|..||    . |
GKCKCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQ
Kinase 15445.AA Ciliate-E2 140-353 20 4e-24 79.69 In-house 1-291 (365) Show / Hide 
Range on Protein: 140-353
Range on HMM: 1-291/365
Sequence Identity: 20% (61 aa)

IDFRDSLGSGSYGDVYKVKNKHKE----IIKNQEILSTMPD---------FYACKQICVTEQMSDIN-SSVFHEIE----------VLEKLKKYDHVIKL
..|   .|.|..|.|||.|.. .     |....  ..  .          .|| |..   .  .  .  ... ||.          .||.|.  ...||.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQ-QRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLN-HPNIIKM

QNYFV--ANRSTYLILDLAES-TLQE-QINLKQANLEQ------FNQEEIVKFLVQIGK---------------TLALIYSDEGIVHRDLKPSNILIREG
  .|    . . ||......  .|..  .| |.  ...      |. .|| ..  || .                |  . |   |.|||.||.|||.   
YECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---

NYYLSDFGCAQ---------------ELFQSEQIRNNVAFG----------------TLKWMSPELREMKR-----DQKINFFKSDVFSLGMILLYMLT
   ..||| ..               ....  . .... .|                |.  |.||  ..|      .||   .|.|..|||.|| .||.
-IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF
Kinase 15445.AA STE 140-353 21 8.8e-24 80.92 In-house 1-263 (359) Show / Hide 
Range on Protein: 140-353
Range on HMM: 1-263/359
Sequence Identity: 21% (57 aa)

IDFRDSLGSGSYGDVYKVKNKHKEII-KNQEIL--STMPDFYACKQICVTEQMS---------------DINSSVFHEIEVLEKLKK-YDHVIKLQNYFV
 .. . .|.|..| ||| .|... .| |..|..   .. ...| ||. . .. .               ..  .. .||... |...  ....|   ...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

ANR-------STYLILDLAE-STLQEQIN---LKQANLE-------QFNQEEIVKFLVQIGKT-LALIYSDEGIVHRDLKPSNILIREGNYYLSDFGCAQ
 .        . .... . .  .| . |.    .. .|         |. ..| ....|| |  |... |   |.|||.||.|||.      |.|||.. 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH-IIHRDIKPANILL----VKLCDFGVCG

ELFQ---------------SEQIRNNVAFGTLKWMSPEL--REMKR-DQKINFFKSDVFSLGMILLYMLT
 | .               . | ..|   ||  ||.||   .. .  |.. . .|.|. |||  .. |.|
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYD-TKCDIWSLGCTIIEMAT
Kinase 15445.AA ULK 140-353 23 7.4e-23 77.97 In-house 1-247 (324) Show / Hide 
Range on Protein: 140-353
Range on HMM: 1-247/324
Sequence Identity: 23% (61 aa)

IDFRDSLGSGSYG-DVYKVKNKHKEIIKNQEILSTMPDFYACKQICVTEQMSDINS--------SVFHEIEVLEKLK--KYDH--VIKLQNYFVAN--RS
.  .. ||.||.|  ||| .|| ..             ..|||.|   ..  . |         .   ||... |||  |  .  ..||  .|       
YCLNHCLGKGSFGVKVYKGRNKKTNT---------QNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNN

TYLILDLAES-TLQEQINLKQA-----NLEQFNQEEIVKFLVQIGKTLALIYSDEGIVHRDLKPSNILIREGNYY-------------LSDFGCAQELFQ
.|.|... .  .|.. |. ..      .   ....|...|. ||   .  ... ..|.|||.||.|||| .|. .             ..||| |. .. 
IYIIMEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHK-HNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDN

--SEQIRNNVAF------GTLKWMSPELREMK-RDQKINFFKSDVFSLGMILLYMLT
   ||  .  .       ||   |.|.. . .   .. . .|.|..|||.|. .||.
NNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLY
Kinase 15445.AA ULK 140-353 23 1.6e-22 75.49 In-house 1-251 (329) Show / Hide 
Range on Protein: 140-353
Range on HMM: 1-251/329
Sequence Identity: 23% (61 aa)

IDFRDSLGSGSYGDVYKVKNKHKEIIKNQEILSTMPDFYACKQICVTEQMSDINS--------SVFHEIEVLEKLK-------KYDHVIKLQNYFVAN--
.  .. ||.||.| ||| .|| ..    . ..      .|||.|.  ..  . |         ..  ||... |||       .  ...||  .|     
YCLNHCLGKGSFGKVYKGRNKKTK-D-YVNEK------VACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNH

RSTYLILDLAES-TLQEQIN-LKQANLEQ-----FNQEEIVKFLVQIGKTLALIYSDEGIVHRDLKPSNILIREGNYY-------------LSDFGCAQE
  .|.|... .  .|.. |.  |  ....     ....|...|. ||   .  ... ..|.|||.||.|||| .|. .             ..||| |. 
NNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHK-HNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKH

LFQS--EQIRNNVAF------GTLKWMSPELREMK-RDQKINFFKSDVFSLGMILLYMLT
.  .  ||  .  .       ||   |.|.. . .   .. . .|.|..|||.|. .||.
VDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLY
Kinase 15445.AA Ciliate-E1 146-342 20 1.9e-21 66.87 In-house 1-202 (202) Show / Hide 
Range on Protein: 146-342
Range on HMM: 1-202/202
Sequence Identity: 20% (45 aa)

LGSGSYGDVYKVKNKHKEIIKNQEILSTMPDFYACKQICVTEQMSDINSSVFHEIEVLEKLKKYDHVIKLQNYFVANRS--TYLILDLAESTLQEQIN--
.|.||...|.| |...  ... ....          ..|  . . ....    ...... .||.. .|....|.    .  ...|... . .|.....  
IGNGSFSIVFKAKQQNNNYNQVAQKI---------INCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNH

-------LKQANLEQFNQEEIVKFLVQIGKTLALIYSDEGIVHRDLKPSNILI-REGNYYLSDFGCAQELFQSEQIRNNVAFGTLKWMSPELREM-----
       ..| |  ||.......  .|. . |. ...  .| |||.||.|||| ..||| ..|||... .....|. . . .| .. ..|.   .     
NRLEYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQ-YNIIHRDIKPQNILINNQGNYVYCDFGISK-FLKNNQNQQCQYKGYTHYYYPPEQYNCPEQE

-KRDQKINFFKSDVF
 ...|||| .|||..
HNKNQKIN-YKSDIY
Kinase 15445.AA CMGC 140-298 18 2.9e-18 55.74 In-house 1-249 (513) Show / Hide 
Range on Protein: 140-298
Range on HMM: 1-249/513
Sequence Identity: 18% (46 aa)

IDFRDSLGSGSYGDVYKVKNKHKEIIKNQEILSTM---PDFYACKQICVTEQMSD----------INSSVFHEIEVLEKLK---------------KYDH
 .  . .|.|.|| ||| ..|. .  | . .  ..     ..| | |   . . .          .... . ||. |..|.               | ..
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQ-AHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHN

-VIKLQNYFVANR-----------------STYLILDLAESTLQEQINLKQA-----NLEQFNQEE------------IVKFL------VQIGKTLA--L
 ..||...|. .                  . ||. .. . .| . |  .|      .   ... .            | .|.       || . |.   
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKY

IYSDEG-IVHRDLKPSNILIREGNY---------------------YLSDFG
. |  | |.||||||.|||| . .                       . |||
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFG
Kinase 15445.AA Ciliate-E2-Unclassified 140-353 18 2.8e-17 56.52 In-house 1-265 (352) Show / Hide 
Range on Protein: 140-353
Range on HMM: 1-265/352
Sequence Identity: 18% (49 aa)

IDFRDSLGSGSYGDVYKVKN-----------KHKEIIKN-QEILSTMPDFYACKQICVTEQMSDINSSVFHEIEVLEKLKKYDHVIKLQNYFVANRS--T
  .   .|.|..|.|||...           ..| .|.. . |..   ..  ....    .. ....    . .  . |.  .| ...  ... .     
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKK-YHQR-KY-NKIMQQILLNHPHPFIVKMFYCFQDKQNI

YLILDLAES-TLQEQINLKQA----------NLEQ---FNQEEIV-----KFLVQIGKTL-ALIYSDEGIVHRDLKPSNILIREG----NYYLSDFGCAQ
|......|  .|.. |. .            |..|   |  ....     ... || . |  |...  .|.|||.||.|||. ..    .  ..||| . 
YIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKN-NIIHRDIKPENILFDNNGKNYYIKIIDFGISK

ELFQSEQIRNNVA---------------FGTLKWM----SPELREMKRDQKINFFKSDVFSLGMILLYMLT
.. |..... .                  ||.  |    .||. . .   .  ..|.|..|||.|| .||.
KYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLF
Kinase 15445.AA TKL 274-348 22 1.8e-16 55.79 In-house 160-279 (364) Show / Hide 
Range on Protein: 274-348
Range on HMM: 160-279/364
Sequence Identity: 22% (27 aa)

GIVHRDLKPSNILIRE-GN--------------YYLSDFGCAQELFQSEQ------------------IRNNVAFGTLKWMSPELREMKRD---------
.|.|||||..|||. | ..                ..||| .....||..                   ...   ||. ||.||. ... .         
PIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDE

---QKINFFKSDVFSLGMIL
   ..  . |.||.| |..|
FCKGFEYSEKCDVYSFGIVL
Kinase 15445.AA TyrKc 140-411 15 7.4e-12 -30.99 SMART 1-280 (280) Show / Hide 
Range on Protein: 140-411
Range on HMM: 1-280/280
Sequence Identity: 15% (48 aa)

IDFRDSLGSGSYGDVYKVKNKHKEIIKNQEILSTMPDFYACKQICVTEQMSDINSSVFHEIEVLEKL-KKYDHVIKLQNYFVAN-------RSTYLILDL
| . . ||.| .| ||| . |                  | | .              .|.... || .. .....|  . .            .... .
ITLGKKLGEGAFGEVYKGTWK---------------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEY

AE-----STLQEQINLKQANLEQFNQEEIVKFLVQIGKTLALIYSDEGIVHRDLKPSNILIREGN-YYLSDFGCAQELFQS-------EQIRN----NVA
..     . |..  .        .. .. ..| .|| .  . . |  ...||||   |.|. |..    |||| . ..          . .|     .  
MPHGDLKDYLRKHRPK-------LCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGK

F-GTLKWMSPELREMKRDQKINFFKSDVFSLGMILLY-MLTLTDISQ-------VNCDVIFKQAKIRLMKNMYKD-------TKYSQILLLVIRMIETNP
.   ..||.||      . ..  .||||.| | .... ..|. .          .. . .... | . .    ..       .  . .  .  .  . .|
TMLPIRWMAPECI----NYGKFTTKSDVWSFG-VCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDP

DHRPDSSILIQTI
. ||  | ... .
EDRPTFSEIHECF
Kinase 15445.AA STE20 273-325 37 1.7e-09 31.13 In-house 136-193 (288) Show / Hide 
Range on Protein: 273-325
Range on HMM: 136-193/288
Sequence Identity: 37% (22 aa)

EGIVHRDLKPSNILIREG-NYYLSDFGCAQELFQ----SEQIRNNVAFGTLKWMSPEL
..|.|||.|  |||. |  .  |.||| .. | .    ..| . |   ||  ||.||.
NHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEV
Kinase 15445.AA STE20 140-214 22 1e-06 20.52 In-house 1-68 (288) Show / Hide 
Range on Protein: 140-214
Range on HMM: 1-68/288
Sequence Identity: 22% (17 aa)

IDFRDSLGSGSYGDVYKVKNKHKEIIKNQEILSTMPDFYACKQICVTEQMS--DINSSVFHEIEVLEKLKKYDHVIK
 .. . .|.||||.|||. .|.   . |        . .| |.. . ...   |   ... || .. ..|   ...|
YELLEKIGQGSYGKVYKAYHKPTGEYCN--------QRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCK-HPNIVK
Kinase 15445.AA TKL 146-158 61 0.001177 9.05 In-house 1-13 (364) Show / Hide 
Range on Protein: 146-158
Range on HMM: 1-13/364
Sequence Identity: 61% (8 aa)

LGSGSYGDVYKVK
.|||..| ||| |
IGSGGFGEVYKGK