Gene 15453 (Tetrahymena)

15453

Species: Tetrahymena
Alias: 52.m00231, 15453, PreTt15453, 3811.m00989, TTHERM_00449400, 233
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-C6

Sequence

Name Sequence Type Origin Length Description Download
15453.AA Protein None 431 None Fasta, JSON
15453.kin_dom Protein Kinase Domain None 271 None Fasta, JSON
15453.NA RNA None 1296 None Fasta, JSON

Protein domain

Protein domains of 15453.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 15453.AA Ciliate-C6 146-416 66 1.6e-201 675.74 In-house 1-306 (306) Show / Hide 
Range on Protein: 146-416
Range on HMM: 1-306/306
Sequence Identity: 66% (202 aa)

IDFRDSIGQGAFGQVYKVKNKYKDIIKNPDILQSMPDYYACKQIHMSQDG--ESQSSQIHHEIEVLEKLKKYDHVIKLQNYIIE-ERSTYIVLDLAESTL
|..|||.|.|.||||||.|||.|.||||.||||.||||||||||||.|..  |.|.|||.||||||||||||..|||.|||.|| .|.||||||||||||
INYRDSLGSGSFGQVYKCKNKHKQIIKNMDILQQMPDYYACKQIHMTQQMSFENQMSQIFHEIEVLEKLKKYENVIKMQNYFIEPNRQTYIVLDLAESTL

QEQINEKQAN------------------SEIYEESDIVKFLSQIGKTLAIIYVEERIAHRDIKPSNILIIDN--NYYLSDFGCAENLFDSEGTKNN-LVI
|..|..||||                  .| ..|..||.|..|||||||.||.|..|||||||||||||.|.  ||||||||||..||.||.|.|| ...
QDCIQMKQANVNNFYFKQEINIFSFNYKYEHFDENEIVQFCKQIGKTLADIYNECNIAHRDIKPSNILIMDDENNYYLSDFGCAQQLFQSEFTRNNDIHM

GTLKWMSPELKEKKK----------NEAIDYFKSDIFSLGMVLLYMLTLSDISSVNSDEFSKNQKLRIMRNSCKYVS-KEIILLVSKMLENNPDFRPDAP
||||||||||.|.||          |..|||||.|||||||.|||||||||||.||.|||.||||.|||.|.||..| ||||.|||||||.|||.|||..
GTLKWMSPELREMKKQYNQHQDDNSNQQIDYFKCDIFSLGMILLYMLTLSDISQVNCDEFMKNQKIRIMKNMCKDISYKEIIKLVSKMLETNPDHRPDMS

ILIQAI
||||.|
ILIQTI
Kinase 15453.AA S_TKc 146-416 22 1.4e-32 115.52 SMART 1-231 (231) Show / Hide 
Range on Protein: 146-416
Range on HMM: 1-231/231
Sequence Identity: 22% (64 aa)

IDFRDSIGQGAFGQVYKVKNKYKDIIKNPDILQSMPDYYACKQIHMSQDGESQSSQIHHEIEVLEKLKKYDHVIKLQNYIIEERSTYIVLDLAES---TL
 .. . ||.||||.|||...|                ..|.|.|.          .|  ||..|.|  . ....||  .. .  . |.|.....    .|
YEILRKIGKGAFGKVYKCRHKK------------TGRIVAIKIIK---------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDL

QEQINEKQANS--EIYEESDIVKFLSQIGKTLAIIYVEERIAHRDIKPSNILIIDNNYYLSDFGCAENLFDSEGTKNNLVIGTLKWMSPELKEKKKNEAI
 . | ... .     . | .. ... || . |. .    .| |||.||.|||. . .  ..||| |  |        . ..||. .|.||.         
FDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE-HIKICDFGLARQL--------TTFCGTPWYMAPEVL------GY

DYFKSDIFSLGMVLLYMLT----LSDISSVNSDEFSKNQKLRIMRNSCKYVSKEIILLVSKMLENNPDFRPDAPILIQ---------AI
...|.|. |.| .|  ||.     .             |  ..... .   |.| . ...|.|. .|. || |  . |          .
GKCKCDWWSCGCILYEMLCGYPPFP-------------QMQMMFKKIG---SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 15453.AA Pkinase 146-416 18 2.7e-27 97.61 Pfam 1-293 (293) Show / Hide 
Range on Protein: 146-416
Range on HMM: 1-293/293
Sequence Identity: 18% (58 aa)

IDFRDSIGQGAFGQVYKVKNKYKDIIKNPDILQSMPDYYACKQIHMSQDGESQSSQIHH--EIEVLEKLKKYDHVIKLQNYIIEERSTYIVLDLAES---
. .   ||.|.||.||| ..|   .             .|.|.|  . . ...  .  .  ||... .| . .....|  .  .... |.|....|    
YHIGRKIGSGSFGCVYKCHHKGTGK------------IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLY

--TLQEQINEKQANSEIY--EESDIVKFLSQIGKTLAIIYVEERIAHRDIKPSNILII-DNNY----YLSDFGCAENLFDSEGTKNNLVIGTLKWMSPEL
   | . |     ..  .  .| .. ... || . |. ..  ..| |||.||.||||  ...      ..|||.|. .    .. .. . ||. .|.||.
VMDLFDYIST--WRHGCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEV

KEKKKN-EAIDYFKSDIFSLGMVLLYMLT----LSDI----SSVNSDEFSKNQKLRIMRNSCKYVS--------------------KEIILLVSKMLENN
     .    .  |.|..|.| .| .||.     ..     . .. ..  .. . .. . .. . .                    .| . .....|. .
----IRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKD

PDFRPDAPILIQA--I
|  || |. . |   .
PKKRPTAEQILQHPWF
Kinase 15453.AA Ciliate-E2 146-409 20 1.5e-26 88.19 In-house 1-356 (365) Show / Hide 
Range on Protein: 146-409
Range on HMM: 1-356/365
Sequence Identity: 20% (77 aa)

IDFRDSIGQGAFG-----QVYKVKNKYKDIIKNPDILQSMP---DYYACKQIHMSQDGESQSSQIHHEIEVLEKLK-------------KYDH--VIKLQ
..|   ||||.||     .|.||....  .|.. ... . .   .... |.. | .  ..|  ||  || .. ...             . .|  .||. 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQ-QRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMY

NYII--EERSTYIVLDLAES-TLQE--QINEKQANSE-----IYEESDIVKFLSQIGKTL-------------AIIYVEER--IAHRDIKPSNILIIDNN
 . .   . . |.|.....  .|..  ..| |. |.|      . |  | ..  || .               |. |  ..  | ||||||.|||.    
ECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----

YYLSDFGCAENLFDS-------------------EGTKNNL-----------VIGTLKWMSPELKEKKK-----NEAIDYFKSDIFSLGMVLLYMLTL-S
  ..||| . .. |.                   ..|  ..           ..||.  |.||  ..||     ..    .|.||.|||..| .||.   
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

DISSVNSDEFSKNQKLRIMRN--------------SCKYVSKEIILLVSK----MLENNPDFRPD-A
        .  |..|...  .              | |..|.| . | .|    ||. .|. |.. .
PF-----QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGW
Kinase 15453.AA ULK 146-359 21 2.1e-21 71.53 In-house 1-251 (329) Show / Hide 
Range on Protein: 146-359
Range on HMM: 1-251/329
Sequence Identity: 21% (57 aa)

IDFRDSIGQGAFGQVYKVKNKYKDIIKNPDILQSMPDYYACKQIH---MSQDG-----ESQSSQIHHEIEVLEKLK-------KYDHVIKLQNYIIEE--
.  .. .|.|.||.||    | ...... |  .    ..|||.|    |.|.      . .  ..  ||... |||       .  ...||  .  .   
YCLNHCLGKGSFGKVY----KGRNKKTK-D-YVN--EKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNH

RSTYIVLDLAES-TLQEQINEKQA------NSEIYEESDIVKFLSQIGKTLAIIYVEERIAHRDIKPSNILIIDNNYY-------------LSDFGCAEN
  .||.... .  .|.. |....       .  . .|. ...|. ||   .  .. ...| ||||||.|||| ... .             ..||| |  
NNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELH-KHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKH

LFDS--EGTKNNLVI------GTLKWMSPELKEKK-KNEAIDYFKSDIFSLGMVLLYMLT
. ..  |   .          ||   |.|.. ... ...  . .|.||.|||... .||.
VDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLY
Kinase 15453.AA ULK 146-359 22 7.4e-21 70.78 In-house 1-247 (324) Show / Hide 
Range on Protein: 146-359
Range on HMM: 1-247/324
Sequence Identity: 22% (58 aa)

IDFRDSIGQGAFG-QVYKVKNKYKDIIKNPDILQSMPDYYACKQIHMSQDGESQSS--------QIHHEIEVLEKLK--KYDH--VIKLQNYIIEE--RS
.  .. .|.|.|| .||| .|| ..             |.|||.| ...  ....         ..  ||... |||  |  .  ..||  .  .     
YCLNHCLGKGSFGVKVYKGRNKKTNT---------QNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNN

TYIVLDLAES-TLQEQINEKQA-----NSEIYEESDIVKFLSQIGKTLAIIYVEERIAHRDIKPSNILIIDNNYY-------------LSDFGCAENLFD
.||.... .  .|.. |....      .  . .|. ...|. ||   .  .. .. | ||||||.|||| ... .             ..||| |  ...
IYIIMEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELH-KHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDN

--SEGTKNNLVI------GTLKWMSPELKEKK-KNEAIDYFKSDIFSLGMVLLYMLT
   | ...          ||   |.|.. ... ...  . .|.||.|||... .||.
NNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLY
Kinase 15453.AA CAMK 151-359 18 1.2e-19 59.32 In-house 1-329 (425) Show / Hide 
Range on Protein: 151-359
Range on HMM: 1-329/425
Sequence Identity: 18% (62 aa)

SIGQGAFGQVYKVKNK-YKDIIKNPDILQSMPDYYACKQIHMS--QD------------------------GESQSSQIHHEIEVLEKLKK------YDH
 .|.|.||.|.....|  .  ..   |.   .  .|.| |  .  .|                         ..   .. .|||.. ||..        .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTN-GQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPN

VIKLQNYIIE-------------------ERSTYIVL---DLAEST-----LQEQINEKQANSEI-----------YEESDIVKFLSQIGKTLAIIYVEE
.|||  ..                     ..  |.|.   ....       | . | |.  ..|            ..|..  ..  ||   .. .    
IIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

RIAHRDIKPSNILIIDN------------------NYYLSDFGCAENLFDSE----------------------GTKNNLVIGTLKWMS-PELKEKKK--
 |.|||.|| |||. ||                  |  ..||| |  ....|                      | | . . ||.  |. ||. ..|.  
-IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC

------NEAIDY--FKSDIFSLGMVLLYMLT
      .| ..|  .|.|. |.| .|  ||.
NMQNATDEEKPYYGPKCDMWSCGVILYIMLC
Kinase 15453.AA STE 278-359 33 6.6e-19 63.49 In-house 170-263 (359) Show / Hide 
Range on Protein: 278-359
Range on HMM: 170-263/359
Sequence Identity: 33% (33 aa)

EERIAHRDIKPSNILIIDNNYYLSDFGCAENLFD---------------SEGTKNNLVIGTLKWMSPELKEKKKNE-AIDY-FKSDIFSLGMVLLYMLT
. .| ||||||.|||.      |.|||.. .| |               . . |.| ..||  ||.||  .. ..    .| .|.|| ||| ... |.|
SHHIIHRDIKPANILL----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMAT
Kinase 15453.AA Ciliate-E2-Unclassified 146-359 20 1.4e-18 61.07 In-house 1-265 (352) Show / Hide 
Range on Protein: 146-359
Range on HMM: 1-265/352
Sequence Identity: 20% (57 aa)

IDFRDSIGQGAFGQVYKVKNKYKDIIKNPDILQSMPDYYACKQIHMS-QDGESQSSQIHHEIEVLEKLKKYDHVI-----------------KLQNYIIE
  .   ||||.||.|||...|     |.   .. |   |..|... . .  ...  .|  |.. ....|| .|.                  ..  . ..
YKIIKQIGQGGFGKVYKCQHK-----KQK-QYYAM--KYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFYCF

ERS--TYIVLDLAE-----STLQEQIN---------EKQANSEIYEESDIV-----KFLSQIGKTLAIIYVEERIAHRDIKPSNILIIDN----NYYLSD
.     |||....|       .... .         ... ...| .|  ..     ... || . |  .  .  | ||||||.|||. .|    .  ..|
QDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIID

FGCAENLFDS---EGTK------------NNLVIGTLKWM----SPELKEKKKNEAIDYFKSDIFSLGMVLLYMLT
|| . .. ..   . |.             . ..||.  |    .||. ......    .|.||.|||..| .||.
FGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLF
Kinase 15453.AA C8 281-354 38 3.8e-16 52.61 In-house 144-226 (226) Show / Hide 
Range on Protein: 281-354
Range on HMM: 144-226/226
Sequence Identity: 38% (32 aa)

IAHRDIKPSNIL-IIDNNYY----LSDFGCAENLFDSEG---TKNNLVIGTLKWMSPELKEKKKNEAIDY-FKSDIFSLGMVL
| ||||||.|.|   |.||     |.||| |  . ...    .|.   .||.... ||  .|..|.  .|  .||.||.|.||
IMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 15453.AA TKL 281-416 17 7.4e-15 49.94 In-house 161-364 (364) Show / Hide 
Range on Protein: 281-416
Range on HMM: 161-364/364
Sequence Identity: 17% (36 aa)

IAHRDIKPSNILIIDNN---------------YYLSDFGCAENLFDSEG------------------TKNNLVIGTLKWMSPEL--KEKKKNEA------
|.|||.|..|||. .|.                 ..||| . ... |..                  .... ..||. ||.||.  .. . .|.      
IIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEF

----IDYFKSDIFSLGMVLLYMLTLSDISSVNS-----------DEFSKNQ--KLRIMRN----------SCKYVSKEIILLVSKMLENNPDFRPDAPIL
        |.|..| |.||  .||     . .            ..|...   .||  .            |... .... |  .  . .|. || .  .
CKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEI

IQAI
.. .
LKRL
Kinase 15453.AA TyrKc 146-416 16 8e-12 -31.51 SMART 1-280 (280) Show / Hide 
Range on Protein: 146-416
Range on HMM: 1-280/280
Sequence Identity: 16% (50 aa)

IDFRDSIGQGAFGQVYKVKNKYKDIIKNPDILQSMPDYYACKQIHMSQDGESQSSQIHHEIEVLEKL-KKYDHVIKLQNYIIEE-------RSTYIVLDL
| . . .| ||||.||| . |                  | | .. .         ...|.... || .. .....|  .....          .||. .
ITLGKKLGEGAFGEVYKGTWK---------------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEY

AES-TLQEQINEKQANSEIYEESDIVKFLSQIGKTLAIIYVEERIAHRDIKPSNILIIDNN-YYLSDFGCAENLFDS------EGTKNN----LVI--GT
..   |.. . ... .      .| ..|  || .  . .  . .. |||.   |.|. .|.    |||| . .. |       . ..             
MPHGDLKDYLRKHRPK---LCMKDLLSFCWQIACGMEYL-HSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLP

LKWMSPELKEKKKNEAIDYFKSDIFSLGMVL--LYMLTLSDISS-----VNSDEFSKNQKLRIMRNSCKY--------VSKEIILLVSKMLENNPDFRPD
..||.||      |. .  .|||..| | ..  .. .  .  .      .. .|  .. | . ..   ..         ..|.  . ..  . .|. || 
IRWMAPECI----NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPT

APILIQAI
   ... .
FSEIHECF
Kinase 15453.AA STE20 278-351 36 1.2e-11 39.12 In-house 135-214 (288) Show / Hide 
Range on Protein: 278-351
Range on HMM: 135-214/288
Sequence Identity: 36% (29 aa)

EERIAHRDIKPSNILIIDN-NYYLSDFGCAENLFD----SEGTKNNLVIGTLKWMSPELKEKKKNEAIDY-FKSDIFSLG
...| |||||  |||. .. .  |.||| .  | .    ... | | ..||  ||.||. .. ..   .| .|.|| |||
SNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGPDKGYDYKCDIWSLG
Kinase 15453.AA STE 146-220 21 7e-10 31.19 In-house 1-94 (359) Show / Hide 
Range on Protein: 146-220
Range on HMM: 1-94/359
Sequence Identity: 21% (20 aa)

IDFRDSIGQGAFGQVYKVKNKYKDIIKNPDILQ----SMPDYYACKQIHMSQDG---------------ESQSSQIHHEIEVLEKLKK-YDHVIK
 .. . ||.||||.||| .|. ...|  .   .    .. ...| ||......                ...  || .||... |...  ....|
WEGIEKIGKGAFGTVYKAMNHKNCNIH-KTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVK
Kinase 15453.AA STE20 146-220 22 2e-06 19.83 In-house 1-68 (288) Show / Hide 
Range on Protein: 146-220
Range on HMM: 1-68/288
Sequence Identity: 22% (17 aa)

IDFRDSIGQGAFGQVYKVKNKYKDIIKNPDILQSMPDYYACKQIHMSQDGE--SQSSQIHHEIEVLEKLKKYDHVIK
 .. . ||||..|.|||. .|  . . |        . .| |.. .... .   .   |  || .. ..|   ...|
YELLEKIGQGSYGKVYKAYHKPTGEYCN--------QRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCK-HPNIVK
Kinase 15453.AA TKL 152-164 69 0.000383 10.83 In-house 1-13 (364) Show / Hide 
Range on Protein: 152-164
Range on HMM: 1-13/364
Sequence Identity: 69% (9 aa)

IGQGAFGQVYKVK
||.|.||.||| |
IGSGGFGEVYKGK
Kinase 15453.AA CAMK 386-409 37 0.120763 0.26 In-house 393-416 (425) Show / Hide 
Range on Protein: 386-409
Range on HMM: 393-416/425
Sequence Identity: 37% (9 aa)

YVSKEIILLVSKMLENNPDFRPDA
.||.| . |..|||. .|. |. .
FVSQECKDLIRKMLQVDPEKRMTI