Gene 12052 (Tetrahymena)
12052
Group:
Other
Family:
Ciliate-D1
Sequence
Protein domains of 12052.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| TPR_1 | 12052.AA | TPR_1 | 49-71 | 34 | 0.002734 | 15.47 | Pfam | 5-27 (34) | Show / Hide |
Range on Protein: 49-71 Range on HMM: 5-27/34 Sequence Identity: 34% (8 aa) FQRGLCYMALKQNREAIQCFEKC ...|.||..... |||.|..|. YNLGNCYYKMGNYDEAIECYQKA |
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| TPR_2 | 12052.AA | TPR_2 | 45-71 | 29 | 0.003188 | 15.49 | Pfam | 1-27 (34) | Show / Hide |
Range on Protein: 45-71 Range on HMM: 1-27/34 Sequence Identity: 29% (8 aa) EFVNFQRGLCYMALKQNREAIQCFEKC . ...|.||..... |||...||. AEAWYNLGQCYYKQGDYDEAIEYYEKA |
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| TPR | 12052.AA | TPR | 45-78 | 23 | 0.044429 | 12.47 | SMART | 1-34 (34) | Show / Hide |
Range on Protein: 45-78 Range on HMM: 1-34/34 Sequence Identity: 23% (8 aa) EFVNFQRGLCYMALKQNREAIQCFEKCNSKQSKI . ...|.||..... |||.|..|. . . . AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN |
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| TPR_1 | 12052.AA | TPR_1 | 79-98 | 25 | 26.741024 | 1.54 | Pfam | 6-25 (34) | Show / Hide |
Range on Protein: 79-98 Range on HMM: 6-25/34 Sequence Identity: 25% (5 aa) NIGLMKIKLDKLEEAKTYFE |.|. |. ...|| ... NLGNCYYKMGNYDEAIECYQ |
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| TPR_2 | 12052.AA | TPR_2 | 74-102 | 24 | 43.386772 | 0.86 | Pfam | 1-29 (34) | Show / Hide |
Range on Protein: 74-102
Range on HMM: 1-29/34
Sequence Identity: 24% (7 aa)
KQSKINIGLMKIKLDKLEEAKTYFENLIR
|.|. .|. ...||. |.| ...
AEAWYNLGQCYYKQGDYDEAIEYYEKALK
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| TPR_1 | 12052.AA | TPR_1 | 145-178 | 35 | 3.9e-08 | 32.39 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 145-178 Range on HMM: 1-34/34 Sequence Identity: 35% (12 aa) FTAYHNLALCYSNMRDVEKALYFLDKSLSINPNF |. ||..|| .| . ..|. ...| |..|||. AEAWYNLGNCYYKMGNYDEAIECYQKALELNPNN |
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| TPR | 12052.AA | TPR | 145-178 | 35 | 1.9e-07 | 32.02 | SMART | 1-34 (34) | Show / Hide |
Range on Protein: 145-178 Range on HMM: 1-34/34 Sequence Identity: 35% (12 aa) FTAYHNLALCYSNMRDVEKALYFLDKSLSINPNF |. ||..|| .| | ..|. ...|.|...||. AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN |
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| TPR_2 | 12052.AA | TPR_2 | 145-178 | 32 | 1e-06 | 27.55 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 145-178 Range on HMM: 1-34/34 Sequence Identity: 32% (11 aa) FTAYHNLALCYSNMRDVEKALYFLDKSLSINPNF . |..||..|| ...| ..|. ...|.|...||. AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN |
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| Kinase | 12052.AA | Ciliate-E2 | 320-390 | 25 | 4.4e-10 | 30.78 | In-house | 115-203 (365) | Show / Hide |
Range on Protein: 320-390 Range on HMM: 115-203/365 Sequence Identity: 25% (25 aa) YYEEGSLSKYLQNNKLIK------------FQKQQIAFKIIK---------------GLQQLHSHS-INHLDLKIQNIVIQKSQSGEQINPIIIDFGAS |.. |.| .|..|||. . .. ..| .|.. .|. ||| | | |.| .||.. . ||||| | YCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----------IKIIDFGLS |
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| Kinase | 12052.AA | Ciliate-E1 | 325-434 | 29 | 1e-09 | 28.25 | In-house | 82-202 (202) | Show / Hide |
Range on Protein: 325-434 Range on HMM: 82-202/202 Sequence Identity: 29% (37 aa) SLSKYLQ-------------NNKLIKFQ-KQQIAFKIIKGLQQLHSHSINHLDLKIQNIVIQKSQSGEQINPIIIDFGASVVNLNPLNLIYAKKQENIAF || .||| |.. .|| | ||.| .|.||..||.. | |.|.| |||.| .. . ||| | . | | . .|.. . SLKDYLQNHNRLEYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYC-----DFGISKFLKNNQNQQCQYKGYTHYY Q-QIQFHTPSYRIPEDE--VDSRSDIF . . | .| . .... .. |||. YPPEQYNCPEQ-EHNKNQKINYKSDIY |
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| Kinase | 12052.AA | Ciliate-E2-Unclassified | 320-390 | 27 | 3.6e-08 | 24.45 | In-house | 102-194 (352) | Show / Hide |
Range on Protein: 320-390 Range on HMM: 102-194/352 Sequence Identity: 27% (26 aa) YYEEGSLSKYLQNNKL---------------IKFQKQQIA--------FKIIKGLQQLHSHS-INHLDLKIQNIVIQKSQSGEQINPIIIDFGAS | | |.|..|....| .|. ||.. |..||..||. | | |.| .||....... .. ||||| | YCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK--NYYIKIIDFGIS |
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| Kinase | 12052.AA | CAMK | 347-390 | 30 | 7.4e-08 | 20.64 | In-house | 188-243 (425) | Show / Hide |
Range on Protein: 347-390 Range on HMM: 188-243/425 Sequence Identity: 30% (17 aa) IIKGLQQLHSHSINHLDLKIQNIVIQKSQSGEQ------------INPIIIDFGAS |. ... .||| | |.||| || .... .... | ||||| . ICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFA |
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| S_TKc | 12052.AA | S_TKc | 234-521 | 13 | 9.1e-08 | -63.01 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 234-521
Range on HMM: 1-231/231
Sequence Identity: 13% (44 aa)
INQDDIIQQNIYSGVTVSKITINQNQYLKKEFKLVGQGELFSYIPQWLINELLIGSFCLGRYLNYNLFYDYYLDQYKNSYVTIYSNYYEE--GSLSKYLQ
..| . .. | . . . .. |. | . ...|. | . . | .||.. | ... . | . |.| .|..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------EHIRREIQILKK---HHPNIVKLYDVFQD----DHLYMVMEYCDGDLGDLFDYIK
NNK-------LIKFQKQQIAFKIIKGLQQLHSHSINHLDLKIQNIVIQKSQSGEQINPIIIDFGASVVNLNPLNLIYAKKQENIAFQQIQFHTPSYR---
... . . . .. |...|. .||| | | ||| .|| . . . |.||| . . . || |.
KRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------HIKICDFGLARQL------------------TTFCGTPWYMAPE
-IPEDEVDS-RSDIFNLGKIILEIYSNSGLGLLQDFQIDTSLLKKDEISNQLLRYIQEEIRNKNIIERPDIQLILYQFQKDYLFDLIYSCLI-DQS----
. . ..|. .| |. | .. | . . ... .... . . |.| || | .
VL---GYGKCKCDWWSCGCILYEMLC--GYPPFP---------QMQMMFKKIG--------------------------SPEAKDFIRKCLQKDPEKRPT
--LVD-------YQFF
. ..|
AEALQDEWDIKCHPWF
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| Kinase | 12052.AA | Ciliate-A1 | 322-375 | 35 | 1.4e-07 | 21.8 | In-house | 84-139 (301) | Show / Hide |
Range on Protein: 322-375 Range on HMM: 84-139/301 Sequence Identity: 35% (20 aa) EEGSLSKYLQNNK-LIKFQKQQIAFKIIKGLQQLHSHSINHLDLKIQNIVIQ-KSQ . | |. | .|. . | . . | .||.|. .|.| | |.||| |||.| . . QYGNLFNYCYQNDYMKKEEIYEICYQIIEGYADIHDHNILHRDLKPQNILIHFDDK |
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| Kinase | 12052.AA | DRAK | 346-390 | 42 | 6.7e-07 | 16.86 | In-house | 107-149 (259) | Show / Hide |
Range on Protein: 346-390 Range on HMM: 107-149/259 Sequence Identity: 42% (19 aa) KIIKGLQQLHSHSINHLDLKIQNIVIQKSQSGEQINPIIIDFGAS .| .|.. ||. .| ||||| ||| .. . | |.||| | QILEGVHYLHQRNIVHLDLKPQNILLTSEYPEDDIK--ICDFGMS |
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| Kinase | 12052.AA | TKL | 320-390 | 28 | 1e-06 | 20.24 | In-house | 119-201 (364) | Show / Hide |
Range on Protein: 320-390 Range on HMM: 119-201/364 Sequence Identity: 28% (25 aa) YYEEGSLSKYLQNNKLIKFQKQQIAFKIIKGLQQLHSHS--------INHLDLKIQNIVIQKS---------QSGEQINPIIIDFGAS |.. ||| ||. |. ..| | .|.. |||. | | ||| .|| . . ..... | ||| | YCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLS |
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| Kinase | 12052.AA | Ciliate-B2 | 342-374 | 42 | 2e-06 | 11.0 | In-house | 108-140 (197) | Show / Hide |
Range on Protein: 342-374 Range on HMM: 108-140/197 Sequence Identity: 42% (14 aa) QIAFKIIKGLQQLHSHSINHLDLKIQNIVIQKS |. | | || |... | |||.| ||| . .. QMIFQLIDGLIQFRMYNILHLDIKPQNILFMQN |
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| Kinase | 12052.AA | MLCK | 347-388 | 45 | 2e-06 | 12.16 | In-house | 106-144 (257) | Show / Hide |
Range on Protein: 347-388 Range on HMM: 106-144/257 Sequence Identity: 45% (19 aa) IIKGLQQLHSHSINHLDLKIQNIVIQKSQSGEQINPIIIDFG |. |.. .|.. | |||||..||..| .. . || ||||| ICEGVHHMHWQNIVHLDLKPENIMCQ-TRTSHQIK--IIDFG |
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| Kinase | 12052.AA | Ciliate-E8 | 347-390 | 36 | 3e-06 | 15.44 | In-house | 98-138 (138) | Show / Hide |
Range on Protein: 347-390 Range on HMM: 98-138/138 Sequence Identity: 36% (16 aa) IIKGLQQLHSHSINHLDLKIQNIVIQKSQSGEQINPIIIDFGAS |.. .. ||. | | |.| ||..|. . ||||| | IMDAFCYLHNNNIIHCDFKLNNILVQRN---DDTKIKIIDFGFS |
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| Kinase | 12052.AA | Pkinase | 320-371 | 29 | 0.000301 | 16.1 | Pfam | 81-141 (293) | Show / Hide |
Range on Protein: 320-371 Range on HMM: 81-141/293 Sequence Identity: 29% (18 aa) YYEEG----SLSKYLQ---NNKL--IKFQKQQIAFKIIKGLQQLHSHSINHLDLKIQNIVI | | | .|. |.. .... . . .. |..||. .||..| | ||| .|| | YCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILI |
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| Kinase | 12052.AA | Ciliate-B2 | 426-437 | 41 | 0.031908 | 0.91 | In-house | 186-197 (197) | Show / Hide |
Range on Protein: 426-437 Range on HMM: 186-197/197 Sequence Identity: 41% (5 aa) EVDSRSDIFNLG ..| .|||. .| NIDFQSDIYSMG |
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