Gene 14332 (Tetrahymena)
14332
Group:
Other
Family:
Ciliate-D1
Sequence
Protein domains of 14332.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 14332.AA | TKL | 1119-1220 | 17 | 1.4e-15 | 52.6 | In-house | 224-364 (364) | Show / Hide |
Range on Protein: 1119-1220
Range on HMM: 224-364/364
Sequence Identity: 17% (25 aa)
SSVNNTTNQNGVNQNFYCAPELFKSDQKLN------------KPSTYSDIWSLGLLLYEILQG--ASLKIDNK--------KKIKKLQYEHFSKNFVG--
. .|..|. . . ..|||... ..... . |. .|..| |..|.||| . .... . . .. .... . .
Q-NNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPI
----------------MKNIIQKCLSKEPQQRPSCEEILSEL
||...|.| . .|..|||..|||..|
WQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
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| Kinase | 14332.AA | AGC | 1135-1218 | 22 | 4.4e-14 | 31.31 | In-house | 273-391 (395) | Show / Hide |
Range on Protein: 1135-1218 Range on HMM: 273-391/395 Sequence Identity: 22% (28 aa) YCAPELFKSDQKLNKPSTYSDIWS--LGLLLYEILQGASL-----------------KIDNKKKIKK---LQYEHFS----------KNF-VGMKNIIQK | ||| . . |.|| || |.|| | | . .. .| .. . . ..| ..| . |..|.| YMAPEIL--------YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKK CLSKEPQQRPSC----------EEILS .| |.| .|. | ||| . LLCKDPEKRLGCGGNDFGDKGAEEIKN |
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| Kinase | 14332.AA | PEK | 1134-1222 | 25 | 1.3e-12 | 39.5 | In-house | 554-655 (655) | Show / Hide |
Range on Protein: 1134-1222 Range on HMM: 554-655/655 Sequence Identity: 25% (27 aa) FYCAPELFKSDQKLNKPSTYS---DIWSLGLLLYEILQGASLKI-DNKKKIKKLQY------EHFS-KNFVG----MKNIIQKCLSKEPQQRPSCEEILS .|..||... .. | | |..|||... | ... . . | ...|. . |. |.| ...||..||. |||||| ..||. LYMSPEQLSGQ--HYQKSHYNHKVDMYSLGIIFFEMWYPFFTTMMERVKTLTDLRDESIQFPGDFPPKWFDNKYPKQADFIQWMLSHDPQQRPSAQQILQ ELLD .. HEFF |
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| Kinase | 14332.AA | Ciliate-E2 | 1135-1217 | 26 | 2.1e-10 | 31.91 | In-house | 253-360 (365) | Show / Hide |
Range on Protein: 1135-1217 Range on HMM: 253-360/365 Sequence Identity: 26% (29 aa) YCAPELFKSDQ-----KLNKPSTYSDIWSLGLLLYEILQGASLKIDNKKKIKKLQYE----------------HFSKNFVGMKNIIQK----CLSKEPQQ | ||| ... . | . .. .|||||| .||| | | ...| .|... . | .|..|.| .| |.|.. YMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF-QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEK RPS-CEEIL |.. |.|| RITGWEQIL |
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| Kinase | 14332.AA | TK | 1135-1220 | 17 | 2.2e-10 | 30.26 | In-house | 351-486 (486) | Show / Hide |
Range on Protein: 1135-1220
Range on HMM: 351-486/486
Sequence Identity: 17% (24 aa)
YCAPELFKSDQ-----KLNKPSTYSDIWSLGLLLYEILQ-G-ASLK--IDN------------KKKIKK------------------LQYEHFSKNF---
..||| ... . | .| .| ||.||.| |..||. | . ..| ..... | .| . .
WMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYR
--------VGMKNIIQKCLSKEPQQRPSCEEILSEL
. ..|.| ...|..||. ......|
MHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
|
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| S_TKc | 14332.AA | S_TKc | 910-1221 | 15 | 3.4e-10 | -27.39 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 910-1221
Range on HMM: 1-231/231
Sequence Identity: 15% (54 aa)
FDIKD---------VRKVSSLNDAETAFISEYKYQTYCLKQYLKLNDKKLNKIIANYHEQAVADNPQFTQTYAISVVAKGSDQKEKELYVLSELMYM---
..| . |.|. . . . .|. ... . |. .. . | . | . . ..||. |..
YEILRKIGKGAFGKVYKCRHKK----------TGRIVAIKIIK----EHIRREIQILKK----HHPNIVKLYDVFQD--------DHLYMVMEYCDGDLG
NLKNALDDKVF------KNESQQVEVCIQLVNALFNLHSKSIDEFKLFHGNLKPTNVLFDENLSLYLSD----VNLDPIGCPNVQNFKQSQSSSTSLTFP
.|. .... .| . .. |...|| .||. | | ||| |.|.|| . ..| |
DLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGI-----IHRDLKPENILLDE--HIKICDFGLARQL------------------------
IQNISQNINEKMMGLPQSSSSNLISSMNNSFSSVNNTTNQNGVNQNF-----YCAPELFKSDQKLNKPST-YSDIWSLGLLLYEILQGASLKIDNKKKIK
| |.|||.. . .. .|.||.| .||| | | . . ...
--------------------------------------------TTFCGTPWYMAPEVL-------GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMF
KLQYEHFSKNFVGMKNIIQKCLSKEPQQRPSCEEILS--------ELL
|. .|..|.||| |.|..||.. |.| . .
KKIG------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
|
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| Kinase | 14332.AA | CAMK | 1135-1218 | 18 | 3.5e-10 | 28.26 | In-house | 285-421 (425) | Show / Hide |
Range on Protein: 1135-1218
Range on HMM: 285-421/425
Sequence Identity: 18% (25 aa)
YCA-PELFKS----------DQKLNKPSTYSDIWSLGLLLYEILQGASLKIDN------------------KKKIKKLQY--EHFSKNFVG---------
|.| ||.... |.. . .|.||.| .|| | | . . ..||.| .| ... .
YMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWD
-------------MKNIIQKCLSKEPQQRPSCEEILS
|. |.|.| ..|..|...|..|.
DISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLN
|
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| Kinase | 14332.AA | Ciliate-A1 | 1135-1223 | 23 | 6.8e-10 | 29.81 | In-house | 185-301 (301) | Show / Hide |
Range on Protein: 1135-1223 Range on HMM: 185-301/301 Sequence Identity: 23% (27 aa) YCAPEL---FKSDQKL--NKPSTYSDIWSLGLLLYEILQ--------GASLKI--DNKKK------------IKKLQYEHFS-KNFVGMKNIIQKCLSKE |..||. . ||.. || . ||..|||. ... | .| | ||| .. . | . |.| | ...| YMSPEQYQMHYRDQMFIENKIYKQSDMYSLGCIICFLCYKEDSHPYVGTIVNIFGNNMQNDQSIHFCKSVNAIKKIIFPPMQEPRFEELQNLIFKMMQYE PQQRPSCEEILSELLDI |..| | ......| . PNNRCSLQQCIDCLYIF |
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| Kinase | 14332.AA | NEK | 1178-1222 | 34 | 2.5e-08 | 25.87 | In-house | 238-286 (286) | Show / Hide |
Range on Protein: 1178-1222 Range on HMM: 238-286/286 Sequence Identity: 34% (17 aa) KKIKKL-QYEHFSKN--F-VGMKNIIQKCLSKEPQQRPSCEEILSELLD .||.| ||. ... . ..|.|...| |.|.|||||..||. . MKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI |
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| Kinase | 14332.AA | TKL-Unique | 1196-1220 | 44 | 6.8e-08 | 24.11 | In-house | 266-290 (290) | Show / Hide |
Range on Protein: 1196-1220 Range on HMM: 266-290/290 Sequence Identity: 44% (11 aa) KNIIQKCLSKEPQQRPSCEEILSEL ...||.| .|.|||| .||...| RDLIQQCWHHDPSQRPSFDEIIHRL |
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| Kinase | 14332.AA | TK-Unique | 1195-1220 | 38 | 1.2e-07 | 22.56 | In-house | 269-294 (294) | Show / Hide |
Range on Protein: 1195-1220 Range on HMM: 269-294/294 Sequence Identity: 38% (10 aa) MKNIIQKCLSKEPQQRPSCEEILSEL | |... |...||..|||...|...| MYNLMKSCWQWEPEERPSFRQIKHRL |
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| Kinase | 14332.AA | Pkinase | 1134-1220 | 21 | 1.3e-07 | 28.03 | Pfam | 176-293 (293) | Show / Hide |
Range on Protein: 1134-1220 Range on HMM: 176-293/293 Sequence Identity: 21% (26 aa) FYCAPELFKSDQKLNKPSTYSDIWSLGLLLYEILQG-----AS----LKIDNKKKIKKLQYEHFSKNF------------------------VGMKNIIQ .|.|||. . . .. .. .|.||.|..||| | | . .| ...|.. . .. .. .| .| WYMAPEVIR---GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIK KCLSKEPQQRPSCEEILSE--L .|| | |..||..|.|| . WCLCKDPKKRPTAEQILQHPWF |
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| Kinase | 14332.AA | TK-Unique | 1135-1168 | 37 | 1.2e-05 | 15.6 | In-house | 202-234 (294) | Show / Hide |
Range on Protein: 1135-1168 Range on HMM: 202-234/294 Sequence Identity: 37% (13 aa) YCAPELFKSDQKLNKP-STYSDIWSLGLLLYEILQ ..||| .| . . .| ||.||.| |..||.. WMAPESLKCY--HGMYHTTKSDVWSFGVLMWEIFT |
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| Kinase | 14332.AA | TKL-Unique | 1116-1167 | 23 | 3.7e-05 | 14.33 | In-house | 161-222 (290) | Show / Hide |
Range on Protein: 1116-1167 Range on HMM: 161-222/290 Sequence Identity: 23% (15 aa) NSFSSVNNTTNQNGVNQN------------FYCAPELFKSDQKLNKPSTYSDIWSLGLLLYEIL ...| .|.. |.. .| . .. |||.... .. |. ||..| | |.||. FGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNF--CQYSEKSDVYSFGIVLWEIA |
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| TyrKc | 14332.AA | TyrKc | 943-1220 | 13 | 0.000966 | -162.13 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 943-1220
Range on HMM: 1-280/280
Sequence Identity: 13% (47 aa)
LKLNDK--------------------KLNKIIANYHEQAVADNPQFTQTY------AISVVAKGSDQKE-----KELYVLSELM-YMNLKNAL-DDKVFK
..|..| | | | ... . . . . .. ..|.. . |... |.| . .||. | . .
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKL
NESQQVEVCIQLVNALFNLHSKSIDEFKLFHGNLKPTNVLFDENLSLYLSDVNLDPIGCPNVQNFKQSQSSSTSLTFPIQNISQNINEKMMGLPQSSSSN
. .. .. |.| . |||| .. | | |.| .||.
CMKDLLSFCWQIACGMEYLHSK-----NCIHRDLAARNCLVGENH-------------------------------------------------------
LISSMNNSFSSV-----------NNT------TNQNGV----NQN-----FYCAPELFKSDQKLNKPSTYSDIWSLGLLLYEILQGASLKIDN-------
| . . . . . .||| . . .| .| ||.|| | ...||. .
----------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI----NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMS
----KKKIKKLQYEHFSKN---------FVGMKNIIQKCLSKEPQQRPSCEEILSEL
...|. . .| | .|...| .| .||. .|| ...
NQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
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| Kinase | 14332.AA | Pkinase_Tyr | 1195-1220 | 26 | 0.004856 | 10.92 | Pfam | 245-270 (270) | Show / Hide |
Range on Protein: 1195-1220 Range on HMM: 245-270/270 Sequence Identity: 26% (7 aa) MKNIIQKCLSKEPQQRPSCEEILSEL . .....| ..|..||. .||...| IYDLMKQCWHYDPEDRPTFSEIHEQL |
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| Kinase | 14332.AA | TKL | 1012-1060 | 20 | 0.005844 | 6.51 | In-house | 132-197 (364) | Show / Hide |
Range on Protein: 1012-1060 Range on HMM: 132-197/364 Sequence Identity: 20% (14 aa) SQQVEVCIQLVNALFNLHSKS---IDEFK--LFHGNLKPTNVLFDENLS--------------LYLSD .| . ... .. |||. | . | .||. |.| |||. . ..| HQRCRWALDIARGMNYLHSMNPKWCT--KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICD |
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| Kinase | 14332.AA | TKL-Unique | 1010-1063 | 26 | 0.00674 | 6.27 | In-house | 108-163 (290) | Show / Hide |
Range on Protein: 1010-1063 Range on HMM: 108-163/290 Sequence Identity: 26% (16 aa) NESQQVEVCIQLVNALFNLHSKS--IDEFKLFHGNLKPTNVLFDEN-----LSLYLSDVNL | .|.| |. . .. .||... | |..||..|.| |.| .. ..|..| NMQQRVKMAIDIAQGMYYLHHCEPPI-----IHRDLKSSNFLVDNNSNIAEWNIKICDFGL |
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| Kinase | 14332.AA | NEK | 1154-1166 | 76 | 0.009454 | 5.98 | In-house | 205-217 (286) | Show / Hide |
Range on Protein: 1154-1166 Range on HMM: 205-217/286 Sequence Identity: 76% (10 aa) SDIWSLGLLLYEI ||||||| .|||. SDIWSLGCVLYEM |
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| Kinase | 14332.AA | Ciliate-A1 | 1015-1049 | 31 | 0.009807 | 5.06 | In-house | 104-133 (301) | Show / Hide |
Range on Protein: 1015-1049 Range on HMM: 104-133/301 Sequence Identity: 31% (11 aa) VEVCIQLVNALFNLHSKSIDEFKLFHGNLKPTNVL .|.| |.. . .|.. | | ||| |.| YEICYQIIEGYADIHDHNI-----LHRDLKPQNIL |
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| Kinase | 14332.AA | Pkinase_Tyr | 1151-1167 | 52 | 0.043944 | 7.68 | Pfam | 192-208 (270) | Show / Hide |
Range on Protein: 1151-1167 Range on HMM: 192-208/270 Sequence Identity: 52% (9 aa) STYSDIWSLGLLLYEIL .| ||.|| | |..||. TTKSDVWSFGVLMWEIF |
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