Gene 14732 (Tetrahymena)

14732

Species: Tetrahymena
Alias: 14732, 345.m00014, TTHERM_01358410, 1023, PreTt14732
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-D1

Sequence

Name Sequence Type Origin Length Description Download
14732.AA Protein None 1605 None Fasta, JSON
14732.kin_dom Protein Kinase Domain None 240 None Fasta, JSON
14732.NA RNA None 4818 None Fasta, JSON

Protein domain

Protein domains of 14732.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
ABC_membrane 14732.AA ABC_membrane 210-325 16 1e-06 26.4 Pfam 170-288 (288) Show / Hide 
Range on Protein: 210-325
Range on HMM: 170-288/288
Sequence Identity: 16% (20 aa)

QRWIGKMASRHTSKRIQKSDERIKLINEILEGIRIVKIYGWEEAIKMIIEKIRSEEIRELIRACVLQYIDKSISISSVLLSAALTFMIIYYQ---GSYEL
|....|. .. . |. .. ... ....|.|..|| ||...|||.    ..|.. . ..  |...... .  ... . ...| |. | .. |     . ..
QYYFMKWMRQLQRKEMKAYAKAGSHAEESLSNIRTVKAFCWEEYFCERYDKALDDMRKAWIKKAFWNGWFFGFMQMIMYCSYAIIFWFGGYLVSVIMGQM

NSAKIFSTIEMLSYLRTNL
.. ..|...  .....  |
SVGQVFAFMSYMNQFQMPL
ABC_tran 14732.AA ABC_tran 450-569 21 1.1e-23 73.25 Pfam 1-142 (142) Show / Hide 
Range on Protein: 450-569
Range on HMM: 1-142/142
Sequence Identity: 21% (32 aa)

TSFLQCFLEEIP-YF-EGIFQIK----KQNKNQKELS-----FAYVEQEPYIF---SSTVRENILFGAEY----------------NEQWYSQVVKSCCL
.. | ... ...    ||  ..      .  ......      .|| |.| .|   . ||||||..|. .                 .... .. . ..|
STLLKMICGLYQIPTAEGQIWWDPGRDITDMPHRDRQHWRKHIGYVFQDPHLFYDPHMTVRENIFYGMPDHKDWFWRRLWGMSECEMDDRIEKWLERVGL

ITDLEQFQNGDSTVIGERGVNLSGGQKARICFARAIYRNADLYLLDDPLS
  .. .|        .||. .|||||. |.| |||. .......|| | .
PHFIWRF--------NERPHTLSGGQQQRVCIARALMCKPKVLILDEPTN
AAA 14732.AA AAA 435-615 14 4.3e-09 37.46 SMART 1-92 (92) Show / Hide 
Range on Protein: 435-615
Range on HMM: 1-92/92
Sequence Identity: 14% (27 aa)

FGDHVAVVGKIGSGKTSFLQCFLEEIPYFEGIFQIKKQNKNQKELSFAYVEQEPYIFSSTVRENILFGAEYNEQWYSQVVKSCCLITDLEQFQNGDSTVI
 | |...||  |.||| ...... ...   |.. |  .                                                              
PGEHILIVGPPGCGKTTLARAIARYLQP--GVIYIDCD--------------------------------------------------------------

GERGVNLSGGQKARICFARAIYRNADLYLLDDPLSAVDSKVAFELVKNCILGLLKDKTIILVTH--QIHFTK--YCDKIIMLGEE
        |||..|. |||| .   |....|.. |. |                  .|.|..||  . . ..   ...|...  .
--------GGQRIRQAFARARK---DVLFIDEITSMLD------------------VTVICTTHDPDPMALRHRFDRRIYIRRPD
Miro 14732.AA Miro 438-454 47 0.000864 15.74 Pfam 1-17 (140) Show / Hide 
Range on Protein: 438-454
Range on HMM: 1-17/140
Sequence Identity: 47% (8 aa)

HVAVVGKIGSGKTSFLQ
.|.|.|. |.||.||..
KVVVCGDKGCGKSSFIH
ABC_membrane 14732.AA ABC_membrane 726-992 11 0.00116 15.53 Pfam 1-288 (288) Show / Hide 
Range on Protein: 726-992
Range on HMM: 1-288/288
Sequence Identity: 11% (34 aa)

YITLILFILSECAFTTF------NRGLGF---FDQTSSD--SKGNLFGFLIG----FAFLYLILNATKFVVLST--GISLGNK---NLHNSMFKSLIRAP
.. ....|.  .|.  .      .| ..|    . .. |   ..||.  ...    . ..|..  .. . .. .  .. .| .    .. .||.......
LFIGFFCIIIVGATNPVAFPIFFGRWIDFWFPWNDGNDDHDHWWNLWSMAFLSMAFMFAIYVFQCCFLWGYFYCYAMEHMGMRIRKRMFRRMFRHIMHWF

ILFFDKTHSGNLMNKFSNDVSLLDNNLHFASNDSLDIFCNFFNLMITCIVFNPYTVIPGFFELVLLFFFLLYCKDIINQTRQLDLSHKTPVFQHFQSTVQ
  |||....|..|....||.. ... . ..  . .  ...|. ..|   .....  .  .. ....... .|   ...| ... ...  ....|.. .. 
MSFFDNNPTGEIMSRMTNDTENIRDGIGDKIFMWFQPVMTFVCGFIMMFYYGWKLTLIILIIMPIYILVQYYFMKWMRQLQRKEMKAYAKAGSHAEESLS

GSIAIKVYQQNDAFLKKMQILANNSVTANQSFWMASRFFGSFTQIFAILCSTVGVFLILSLP--NNDPTKQAQSLTYFMLIVDAIQWCL
.   .| .   ..|... .   ..   |      ....|..|.| .. ..  ...| . .    . .   . .....||...  .|. |
NIRTVKAFCWEEYFCERYDKALDDMRKAWIKKAFWNGWFFGFMQMIMYCSY-AIIFWFGGYLVSVIMGQMSVGQVFAFMSYMNQFQMPL
ABC_tran 14732.AA ABC_tran 1107-1228 25 6.1e-24 74.04 Pfam 6-142 (142) Show / Hide 
Range on Protein: 1107-1228
Range on HMM: 6-142/142
Sequence Identity: 25% (37 aa)

TLFRLTE-PE-EGSIIKI---DGIDTSQLGLHTLRQRISIIPQIPFVF---QGTIRRNLDPFNQY----------------RDDQIWESLKMVELDYYVK
.. .|.. |. ||.|      |. | ..  ....|..|. ..| |..|   . |.| |.. . ..                .||.|.. |..| |.  ..
MICGLYQIPTAEGQIWWDPGRDITDMPHRDRQHWRKHIGYVFQDPHLFYDPHMTVRENIFYGMPDHKDWFWRRLWGMSECEMDDRIEKWLERVGLPHFIW

NNCLQGLYTDMSIASSVFSVGQKQLICLARALLKKNKILVLDEATA
..             . .| ||.| .|.||||..| |.|.|||.|.
RF---------NERPHTLSGGQQQRVCIARALMCKPKVLILDEPTN
AAA 14732.AA AAA 1069-1275 12 9e-07 29.75 SMART 1-92 (92) Show / Hide 
Range on Protein: 1069-1275
Range on HMM: 1-92/92
Sequence Identity: 12% (26 aa)

PGQKIGCVGRTGAGKSSVL-QVIQFISKDFIDNLNIYKQTLFRLTEPEEGSIIKIDGIDTSQLGLHTLRQRISIIPQIPFVFQGTIRRNLDPFNQYRDDQ
||..|. ||..|.||. .. ...... .                      ..| ||.                                           
PGEHILIVGPPGCGKTTLARAIARYLQP----------------------GVIYIDCD------------------------------------------

IWESLKMVELDYYVKNNCLQGLYTDMSIASSVFSVGQKQLICLARALLKKNKILVLDEATANVDMETDNLIQKTIRSKFNDSTVLTIAH---RLNTIADY
                                    . | | .|.|...| ..|..||.|.  |                  ||. ..|   ......  
------------------------------------GGQRIRQAFARARK-DVLFIDEITSMLD-----------------VTVICTTHDPDPMALRHRF

DKIIVMNEGVL
|..|.. . ..
DRRIYI-RRPD
Miro 14732.AA Miro 1072-1088 41 0.638746 5.5 Pfam 1-17 (140) Show / Hide 
Range on Protein: 1072-1088
Range on HMM: 1-17/140
Sequence Identity: 41% (7 aa)

KIGCVGRTGAGKSSVLQ
|.. .| .|.|||| ..
KVVVCGDKGCGKSSFIH
Kinase 14732.AA Ciliate-A7 1359-1600 22 3.1e-36 126.72 In-house 52-360 (360) Show / Hide 
Range on Protein: 1359-1600
Range on HMM: 52-360/360
Sequence Identity: 22% (69 aa)

CFNLINEYQVSSQLSHPNIVQPQC--------ANFKYDGGCSVLFPQAECDAFSYLL----NGVLDIS------------VVKLYFKSMILTLNYLHNQQ
| .| |||.. ....||.|....          .  ....|  |..||||| | |.     ...|...            ... .|...   |.||||  
CYMLKNEYNFLKKMDHPHIIMLFEQFNDYNMDEFWHHRNCCCILMEQAECDLFQYFSQHYPHKNLHHNEKIENQCEYCVNQMRHCFRQIAQALHYLHNEK

LFAHNDFKLENVLVFKTEN--ENEMFQLTDFGYSYYLGNKHNNCR--------NYSKYWTTRNTIFLSPTNCQSIQF---------------KQFRNLRE
 .||||.|.||...|. .|      |.|.|||... ....  . .        .  | |. |.. ...|   . .                   ...  .
NIAHNDIKPENIFIFCNNNQQNQYCFKLADFGFAKKYQFQSHFESTLRQQIIEDQYKNWKYRCKQYFAPEIINCLNKCCDKNSAKNKKFISQQIDNQCEF

KE--GDMFGLGCTLFMILFRKYPFGSNLPTLNEKLKVCEDIQKFGYQYFLQ---FQTAFNIYE--------------NDWVILIDLIIQLLVIDDSCRAT
.|  .| |..| ..| |||   || ..  ..|. .|  . .....|..| |   .|.  |...               |  ...||.. .|  ..| | .
DEKKCDVFAFGVSFFQILFQQNPFCCEACHQNDPYK-YKHYFQKTYSKFWQWMQIQWMWNHFQKEIQDMIKNTDQQQQDIDQMKDLLNKMLCPNPSQRYC

SLQLMNHPWV
..|.  ||| 
IKQILQHPWF
Kinase 14732.AA Ciliate-E2 1419-1600 19 1.5e-20 67.27 In-house 165-365 (365) Show / Hide 
Range on Protein: 1419-1600
Range on HMM: 165-365/365
Sequence Identity: 19% (46 aa)

YFKSMILTLNYLHNQQLFAHNDFKLENVLVFKTENENEMFQLTDFGYSYYLGNKHNNCR--NYSKYWTTRN-------TIF-------LSPTNCQSIQFK
|. ..|| |.|||..    | | |.||.|.           ..|||.| .. ....|..  . .| ..  .       ...       .  | | .  ..
YIACIILALEYLHSKNNIIHRDIKPENILF---------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYM

QFRNLRE-------------KEGDMFGLGCTLFMILFRKYPFGSNLPTLNEKLKVCEDIQKFGYQYFLQFQTAFN----------------IYENDWVIL
   .|.              .. |.. ||..|.. || |.||                     .|  .| .  |.                ....     
APEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF---------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQEC

IDLIIQ----LLVIDDSCRAT-SLQLMNHPWV
.||| .    .|. | . | |   |..|||| 
KDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
S_TKc 14732.AA S_TKc 1311-1600 15 5e-15 43.47 SMART 1-231 (231) Show / Hide 
Range on Protein: 1311-1600
Range on HMM: 1-231/231
Sequence Identity: 15% (49 aa)

NTQREVVERGQYVILSKCKHVDIFRKPIDCVIKESLHSEDEPKCCTKFCFNLINEYQVSSQLSHPNIVQPQCANFKYDGGCSVLFPQAEC---DAFSYLL
 .  ... .| .    ||.|..       . ||.                ....| |. ..  |||||.   .     .   . .  ..    | |.|. 
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK-------------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIK

NGV-------LDISVVKLYFKSMILTLNYLHNQQLFAHNDFKLENVLVFKTENENEMFQLTDFGYSYYLGNKHNNCRNYSKYWTTRNTIFLSPTNCQSIQ
.         ..  ... |.. ... |.|.|..  . | | | ||.|. .         ..||| .  |                        | | .  
KRGRHGLRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE------HIKICDFGLARQL-----------------------TTFCGTPW

FK---QFRNLREKEGDMFGLGCTLFMILFRKYPFGSNLPTLNEKLKVCEDIQKFGYQYFLQFQTAFNIYENDWVILIDLIIQLLVIDDSCRATSLQLMN-
.     .     .. |.  .||.|.  | .. ||     .... .|..                           ..|.| ..|. | . | |  .... 
YMAPEVL-GYGKCKCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG-----------------------SPEAKDFIRKCLQKDPEKRPTA-EALQD

------HPWV
      |||.
EWDIKCHPWF
Kinase 14732.AA Ciliate-E2-Unclassified 1416-1600 21 1.5e-09 29.28 In-house 140-352 (352) Show / Hide 
Range on Protein: 1416-1600
Range on HMM: 140-352/352
Sequence Identity: 21% (48 aa)

VK-----LYFKSMILTLNYLHNQQLFAHNDFKLENVLVFKTENENEMFQLTDFGYSYYLGNKHNNCRNYSKYWTTRNTIF---LSPTNCQSIQFK-----
.|      ||.  .. |.||| .. . | | |.||.|. .  . |    ..||| |.....  |.  . ..   ..  |.   .. |.|......     
AKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK-NYYIKIIDFGISKKYQQNNNCD-TNQQ---QKMQIWKQQMMWTFCGTPNYMPQYTA

--QFRN-LRE----KEGDMFGLGCTLFMILFRKYPFGSNLPTLNEKLKVCEDIQKF------GYQYFLQFQTAFNIYEN-----DWV-ILIDLII----Q
   ...   .    .. |...||. |. .|| .|||..|  . ...|.    .. .       || ..| .. |. ...     .|    .|.|     .
PEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLIT--QWI-NNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQK

LLVIDDSCRATSLQLMNHPWV
.|. . . | |  |..|||| 
MLKKNPNKRITFEQILNHPWF
Kinase 14732.AA Pkinase 1361-1464 24 2.4e-09 34.11 Pfam 44-157 (293) Show / Hide 
Range on Protein: 1361-1464
Range on HMM: 44-157/293
Sequence Identity: 24% (28 aa)

NLIN--EYQVSSQLSHPNIVQPQCANFKYDGGCSVLFPQAEC-----DAFSYLL---NGVL--DISVVKLYFKSMILTLNYLHNQQLFAHNDFKLENVLV
....  | |.   |.|||||.  .. | ... . . .. .|.     | |.|.    .|..  .  ..| |.. ..  |.|.|. . . | | |.||.|.
THRRLSEIQIMKRLNHPNIVRLYDW-FEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILI

FKTENENEMFQLTDFG
 .. . .... ..|||
DNNGHIDACVKICDFG
Kinase 14732.AA DCAMKL 1575-1600 50 1.5e-08 22.15 In-house 254-279 (279) Show / Hide 
Range on Protein: 1575-1600
Range on HMM: 254-279/279
Sequence Identity: 50% (13 aa)

DLIIQLLVIDDSCRATSLQLMNHPWV
||| ..|. |   | |. | | ||||
DLISHMLQVDPEKRYTAEQIMQHPWV
Kinase 14732.AA Ciliate-E9 1415-1466 38 4.1e-08 21.61 In-house 112-159 (298) Show / Hide 
Range on Protein: 1415-1466
Range on HMM: 112-159/298
Sequence Identity: 38% (20 aa)

VVKLYFKSMILTLNYLHNQQLFAHNDFKLENVLVFKTENENEMFQLTDFGYS
|.| ||| .|.  .|.|..|   | | |.||.|.    ..|    . ||| |
VAKYYFKQLIDSIEYMHQYQNICHRDLKPENMLI----DKNYNMKICDFGMS
Kinase 14732.AA CAMK 1574-1600 44 7.7e-08 20.58 In-house 399-425 (425) Show / Hide 
Range on Protein: 1574-1600
Range on HMM: 399-425/425
Sequence Identity: 44% (12 aa)

IDLIIQLLVIDDSCRATSLQLMNHPWV
.||| ..|. | . |.|  | .||||.
KDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 14732.AA MAPKAPK 1575-1600 53 5.5e-07 17.19 In-house 267-292 (292) Show / Hide 
Range on Protein: 1575-1600
Range on HMM: 267-292/292
Sequence Identity: 53% (14 aa)

DLIIQLLVIDDSCRATSLQLMNHPWV
||| .||. | . | |  |.|||||.
DLIRKLLRRDPTQRLTIEQVMNHPWI
Kinase 14732.AA Pkinase 1513-1600 19 1e-06 24.55 Pfam 194-293 (293) Show / Hide 
Range on Protein: 1513-1600
Range on HMM: 194-293/293
Sequence Identity: 19% (21 aa)

DMFGLGCTLFMILFRKYPFGSNL----PTLNEKLKVCEDIQ---KFGYQYFLQFQTAFNIYE-----------NDWVILIDLIIQLLVIDDSCRATSLQL
||...||.|.  |... ||  .     . .... ..|.. .   .| ...     . | ..             .   ..|.|  .|  | ..| |  |.
DMWSCGCILYEMLCGRPPFP-GHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRHWHFHWTFHNWSEE---CKDFIKWCLCKDPKKRPTAEQI

MNHPWV
..|||.
LQHPWF
Kinase 14732.AA MARK 1575-1600 38 2e-06 17.51 In-house 237-262 (262) Show / Hide 
Range on Protein: 1575-1600
Range on HMM: 237-262/262
Sequence Identity: 38% (10 aa)

DLIIQLLVIDDSCRATSLQLMNHPWV
.|| .||... . |.|  ..|.|||.
NLIQRLLTVNPEERPTIEEIMKHPWM
Kinase 14732.AA CAMK-Unique 1427-1473 25 1.1e-05 14.47 In-house 170-227 (363) Show / Hide 
Range on Protein: 1427-1473
Range on HMM: 170-227/363
Sequence Identity: 25% (15 aa)

LNYLHNQQLFAHNDFKLENVLVFKTENE------------NEMFQLTDFGYSYYLGNKH
..|.|.|.   | | ||||..| . ...            | .  |.||| . .. ...
VAYMHSQDIV-HRDLKLENIMVCYSFKDNNHHRDFPYDWSNWHIKLCDFGLCCHYNHNK
Kinase 14732.AA CAMK 1403-1475 17 1.3e-05 13.26 In-house 152-252 (425) Show / Hide 
Range on Protein: 1403-1475
Range on HMM: 152-252/425
Sequence Identity: 17% (18 aa)

FSYLLN----------------GVLDISVVKLYFKSMILTLNYLHNQQLFAHNDFKLENVLVFKTENENE-------------MFQLTDFGYSYYLGNKH
|.|.                  | .. . .. ||. ..  ..|.|..   .| | |.||.|. . .....                ..||| . ..  ..
FDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN-IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGE

NN
||
NN
Kinase 14732.AA Ciliate-E9 1513-1533 47 1.8e-05 13.03 In-house 207-227 (298) Show / Hide 
Range on Protein: 1513-1533
Range on HMM: 207-227/298
Sequence Identity: 47% (10 aa)

DMFGLGCTLFMILFRKYPFGS
|.| .|| |||...  |||..
DIFSAGCILFMMVMNQYPFFH
Kinase 14732.AA CAMK-Unique 1573-1600 21 4.5e-05 12.48 In-house 336-363 (363) Show / Hide 
Range on Protein: 1573-1600
Range on HMM: 336-363/363
Sequence Identity: 21% (6 aa)

LIDLIIQLLVIDDSCRATSLQLMNHPWV
..|........| . | .. .|  |.|.
AKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase 14732.AA MAPKAPK 1427-1465 38 5.1e-05 12.71 In-house 117-153 (268) Show / Hide 
Range on Protein: 1427-1465
Range on HMM: 117-153/268
Sequence Identity: 38% (15 aa)

LNYLHNQQLFAHNDFKLENVLVFKTENENEMFQLTDFGY
. ..|     || | |.|| | .|....| .  |||||.
VQHCHSMNI-AHRDLKPENLL-YKDTQPNCVLKLTDFGF
Kinase 14732.AA MAPKAPK 1575-1600 50 0.000213 10.59 In-house 243-268 (268) Show / Hide 
Range on Protein: 1575-1600
Range on HMM: 243-268/268
Sequence Identity: 50% (13 aa)

DLIIQLLVIDDSCRATSLQLMNHPWV
||| .|| .| . | |  ..|||||.
DLIRKLLRTDPTERLTIEEFMNHPWI
Kinase 14732.AA MAPKAPK 1427-1464 39 0.000918 7.03 In-house 116-151 (292) Show / Hide 
Range on Protein: 1427-1464
Range on HMM: 116-151/292
Sequence Identity: 39% (15 aa)

LNYLHNQQLFAHNDFKLENVLVFKTENENEMFQLTDFG
. .||.    || | |.||.| ... |.|    |.|||
VDFLHSMNI-AHRDLKPENIL-CTDTNHNCPVKLCDFG
Kinase 14732.AA DCAMKL 1427-1464 44 0.004607 4.76 In-house 128-164 (279) Show / Hide 
Range on Protein: 1427-1464
Range on HMM: 128-164/279
Sequence Identity: 44% (17 aa)

LNYLHNQQLFAHNDFKLENVLVFKTENENEMFQLTDFG
|.|||      | | |.|| || | |       | |||
LKYLHEMNI-VHRDIKPENLLVCKHEDGEKSLKLCDFG
Kinase 14732.AA MARK 1417-1448 31 0.006986 5.45 In-house 107-137 (262) Show / Hide 
Range on Protein: 1417-1448
Range on HMM: 107-137/262
Sequence Identity: 31% (10 aa)

KLYFKSMILTLNYLHNQQLFAHNDFKLENVLV
. .|. ..  .||.|..   .| | |.||.|.
RRIFRQIVSAVNYCHSKN-IVHRDIKPENILI
Kinase 14732.AA CAMK 1513-1546 22 0.030518 2.22 In-house 316-363 (425) Show / Hide 
Range on Protein: 1513-1546
Range on HMM: 316-363/425
Sequence Identity: 22% (11 aa)

DMFGLGCTLFMILFRKYPFGS--------------NLPTLNEKLKVCE
||  .|. |.. |  ..|| .              |.. | || . ..
DMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGK