14836

Species: Tetrahymena
Alias: TTHERM_01227810, 282.m00034, 763, PreTt14836, 14836
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-D1

Sequence

Name Sequence Type Origin Length Description Download
14836.AA Protein None 487 None Fasta, JSON
14836.kin_dom Protein Kinase Domain None 235 None Fasta, JSON
14836.NA RNA None 1464 None Fasta, JSON

Protein domain

Protein domains of 14836.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 14836.AA STE 88-321 23 3.1e-66 226.35 In-house 14-359 (359) Show / Hide
Range on Protein: 88-321
Range on HMM: 14-359/359
Sequence Identity: 23% (83 aa)

SIYRGMNK------QNAEI---------VALKEYNVIPA-----------------EDLQQIIQEISKESRVQ--DEFVSGLNDYFVSDG-------KLY
. |..||.      .. |.         .| |. |. .                  |..|||..||.  .. .   ...    .... .|       .|.
TVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELW

LISQYFSEGSVYDLIQNI--------------GPISEENICIIIKQALMG-LKYLHKNNRLHKNIKSSNIMLQSDGIVKLCDFSTSKKLTEILS------
..  | . ||. |.|..               ....|. |..|..| | | |.|||.... |  ||..||.|     |||||| ....||....      
ICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNN

---------QCRNYSY---WQSPETII------DQHFNEKSDIWSIGITAIEMAKGEPPYFNLPPKKAQFLTV----------------QEEPQIDS---
         | ||      | .|| |       |.. ..|.||||.|.|.|||| |.||.....| .| |..                 .. |.. .   
IIDCIETMQQKRNTFVGTPWMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLS

----------------SFSPQFQEFLKMCLEKNPEERASVGDLLL--SNFI
                ..|| |..|.. ||.|.|..|... .||     ||
QNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI

Kinase 14836.AA STE20 88-321 32 7.2e-63 215.17 In-house 14-288 (288) Show / Hide
Range on Protein: 88-321
Range on HMM: 14-288/288
Sequence Identity: 32% (90 aa)

SIYRGMNKQNAEI----VALKEYNVIPA----EDLQQIIQEISKESRVQDEFVSGLNDYFVSD----GKLYLISQYFSEGSVYDLIQ---NIG------P
..|.. .|.. |.    || |  |. ..    .... |..|||  .. . . .    . .. |     .|...  | . ||. |...   ..|      |
KVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMKHCMKCGKNHKGHP

ISEENICIIIKQALMGLKYLHKNNRLHKNIKSSNIMLQSDGIVKLCDFSTSKKLTE----ILSQCRNYS----YWQSPETIID-----QHFNEKSDIWSI
..|| |  | ...| ||.|||.|.. |  ||. ||.| .|| |||.||  . .||.      .. ||      || .|| |       .  ..|.|||| 
MNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGPDKGYDYKCDIWSL

GITAIEMAKGEPPYFNLPPKKAQFLTV--QEEPQIDSS-----FSPQFQEFLKMCLEKNPEERASVGDLLLSNFI
||||||||.||||||...| .| |..   |..|  ...     .||.|..|.. ||.|.||.|... .||   ||
GITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI

Kinase 14836.AA YSK 89-321 36 2.1e-61 183.49 In-house 15-257 (257) Show / Hide
Range on Protein: 89-321
Range on HMM: 15-257/257
Sequence Identity: 36% (89 aa)

IYRGMNKQNAEIVALKEYNVIPAED-LQQIIQEISKESRVQDEFVSGLNDYFVSDGKLYLISQYFSEGSVYDLIQN--IGPISEENICIIIKQALMGLKY
.| | ...  ..|| |  .   |||    | |||   |     ..      .  | ||  |  |   ||. ||.    .|.. |. | ||..  | ||.|
VYKGIDNRTQRVVAIKIIDLEHAEDEIEDIQQEIQFLSQCDSPYITKYYGSYLKDTKLWIIMEYCGGGSCLDLMKPKYVGQFDEKYIAIILREILKGLDY

LHKNNRLHKNIKSSNIMLQSDGIVKLCDFSTSKKLTEILSQCRNYS---YWQSPETIID--QHFNEKSDIWSIGITAIEMAKGEPPYFNLPPKKAQFLTV
||... .|  ||. |. |. .| ||||||  . ..|.            ||  || |       ..| ||||.||||.|||||||||  . | .. || .
LHSERKIHRDIKAANVLLSEHGDVKLCDFGVAGQITDTQIKRNTFVGTPYWMAPEVICQEVSYYDFKADIWSLGITAYEMAKGEPPYCDYHPMRVMFLIP

QEE-PQIDS-SFSPQFQEFLKMCLEKNPEERASVGDLLLSNFI
 .. |.    |.|  | ||  .||.|.||.| |  .|| . ||
KNNPPKLEGRSYSKMFKEFVECCLNKDPEQRPSAKELLKHKFI

Kinase 14836.AA S_TKc 75-321 21 2.7e-42 147.77 SMART 1-231 (231) Show / Hide
Range on Protein: 75-321
Range on HMM: 1-231/231
Sequence Identity: 21% (58 aa)

DILEKKTTQSMHSSIYRGMNKQNAEIVALKEYNVIPAEDLQQIIQEISKESRVQDEFVSGLNDYFVSDGKLYLISQYFSE--GSVYDLIQNIGP------
  . .|  .   .. |.. .|   .|||.|. .       ..|..||.  .. . ...  | |.|.. ..||..  | .   |...|.|.. |.      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

ISEENICIIIKQALMGLKYLHKNNRLHKNIKSSNIMLQSDGIVKLCDFSTSKKLTEILSQCRNY---SYWQSPETIIDQHFNE-KSDIWSIGITAIEMAK
..|  .. ...| . .|.|.|... .|  .| .||.| .   .|.|||  ...|       . .    .. .|| .   ...  |.|.||.|.. .||. 
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

GEPPYFNLPPKKAQFLTVQEEPQIDSSFSPQFQEFLKMCLEKNPEERASVGDLLL-------SNFI
|.||.      .. |  .          ||.. .|.. ||.|.||.| .. ..|          ..
GYPPFP---QMQMMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase 14836.AA STE-Unique 143-321 20 6.9e-42 145.47 In-house 367-616 (616) Show / Hide
Range on Protein: 143-321
Range on HMM: 367-616/616
Sequence Identity: 20% (50 aa)

GKLYLISQYFSEGSVYDLIQNIGP---------ISEENICIIIKQALMGLKYLHKNN--RLHKNIKSSNIMLQSDG-----IVKLCDFSTSKKLTEI---
. ....  | . |.. ..|.. |.         . |. .  ...|.| || |||      .| ..|..||.. .||      ||.||| ........   
NWVWIFMEYCEHGTLQQIIKRCGCPGNPNNLQLFPETEVIWYTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVKICDFGHATCCQPDHFE

--------------------------------------LSQCRNYSYWQSPETIIDQ-----HFNEKSDIWSIGITAIEMAKGEPPYFNLPPKKA--QFL
                                      .  |...  . .||.|  .     ... |.||||.|.. ..|. | ||. .. . .|  . .
KDNNSKNSNTWININNNSSTNSTAQQTPMWDLNINNYTMKYCCGTPCYMCPEVINCRNQINNPYDTKVDIWSLGCMCFHMCCGCPPWHQRYHMQAYIEMC

TVQEEPQI-------DSSFSPQFQEFLKMCLEKNPEERASVGDLLLSNFI
  .  ..         ....|..|.|.  |||.||  |.|. .|| . . 
IHIHCQPPQCPIENIPPKCQPEQQQFIEKCLERNPHHRPSAHQLLHHFWL

Kinase 14836.AA KHS 74-321 31 2.5e-41 136.66 In-house 1-258 (258) Show / Hide
Range on Protein: 74-321
Range on HMM: 1-258/258
Sequence Identity: 31% (81 aa)

YDILEKKTTQSMHSSIYRGMNKQNAEIVALKEYNVIPAEDLQQIIQEISKESRVQDEFVSGLNDYFVSDGKLYLISQYFSEGSVYDLIQNIGPISEENIC
|..| ..        .|.  ..|  |..|.|   . | .|.. | |||      .   . .    ...  ||...  |   ||. |. .  ||.||  | 
YELL-QRVGSGTYGDVYKARDIQSDELAAVKVIKMEPGDDFAVIQQEIMMMKDCRHPNIVAYFGSYLRRDKLWICMEYCGGGSLQDIYHVTGPLSELQIA

IIIKQALMGLKYLHKNNRLHKNIKSSNIMLQSDGIVKLCDFSTSKKLTEILSQCRNY---SYWQSPETIIDQH---FNEKSDIWSIGITAIEMAKGEPPY
 . ...| ||.||| . ..|. ||  ||.|...| ||| ||  | ..|  ... . .    ||  ||    ..   .|.  |||..||||||.|   || 
YVCRETLQGLHYLHSMGKMHRDIKGANILLTDQGDVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIWAVGITAIELAELQPPM

FNLPPKKAQFLTVQEE---PQID--SSFSPQFQEFLKMCLEKNPEERASVGDLLLSNFI
|.| | .| ||  . .   |..   . .|..| .|.||.| |||  | .   ||  .|.
FDLHPMRALFLMTKSNFQPPKLKDKHKWSQTFHHFVKMALTKNPKKRPTAEKLLQHPFV

Kinase 14836.AA SLK 89-321 29 2.5e-40 133.71 In-house 15-259 (259) Show / Hide
Range on Protein: 89-321
Range on HMM: 15-259/259
Sequence Identity: 29% (72 aa)

IYRGMNKQNAEIVALKEYNVIPAEDLQQIIQEISKESRVQDEFVSGLNDYFVSDGKLYLISQYFSEGSVYDLIQNIG-PISEENICIIIKQALMGLKYLH
.|.  .|..  . | |  ..   |.|.  . ||   | ..   . .| . .  |.||...  .   | |  .. ... |. |. | .. |. . .|..||
VYKAQHKEQKVFAAAKMIEIKDEEELEDYMVEIDILSECKHPNIVKLYEAYYYDNKLWMMIEFCDGGAVDNIMVELEHPLTEDQIQYVCKHMCEALNWLH

KNNRLHKNIKSSNIMLQSDGIVKLCDFSTSKKLTEILSQCRNY---SYWQSP-----ETIIDQHFNEKSDIWSIGITAIEMAKGEPPYFNLPPKKAQFLT
.|. .|...|  ||..  || |.| ||  | |... . .   .    ||  |     ||. || .  |.||||.||| ||||..|||. .. | .  .  
SNKVIHRDLKAGNILMTMDGDVRLADFGVSAKNKHTMQKRDTFIGTPYWMAPEVVMCETFKDQPYDYKADIWSLGITLIEMAQMEPPHHEMNPMRVLLKI

VQEEP---QIDSSFSPQFQEFLKMCLEKNPEERASVGDLLLSNFI
 . ||   .  | .| .|..||| ||.|.|. | .  .|.  ...
QKSEPPTLEQPSHWSKEFKDFLKKCLVKDPQNRWTTAQLMQHQWV

Kinase 14836.AA MEKK15 155-321 35 4e-38 132.98 In-house 86-264 (264) Show / Hide
Range on Protein: 155-321
Range on HMM: 86-264/264
Sequence Identity: 35% (64 aa)

GSVYDLIQNIGPISEENICIIIKQALMGLKYLHKNNRLHKNIKSSNIMLQSDGIVKLCDFSTSKKLTEI-LSQCR--------NYSYWQSPETIIDQHFN
||.  .|   ||. |   |   || | | .||| |. .|. ||  |.|| . ||.|| ||   |.|.   ... .           ||  || | .  . 
GSISSIINRFGPLDEMVFCKYTKQILQGVQYLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCAKRLCWQGINRTHSDMLKSMRGTPYWMAPEVIMETGYG

EKSDIWSIGITAIEMAKGEPPYFNLPPKKAQFLTVQE---EPQIDSSFSPQFQEFLKMCLEKNPEERASVGDLLLSNFI
 |||||||| |  ||| . ||. ....  | |    .    ||.   || . ..| .||| .  .||..  .||   ||
RKSDIWSIGCTVFEMATRKPPWADMDRMAAMFYIGAHRDPMPQLPVKFSEDARMFVRMCLTRDQHERPTASQLLKHPFI

Kinase 14836.AA PAKL 155-275 42 2.7e-30 106.98 In-house 82-207 (256) Show / Hide
Range on Protein: 155-275
Range on HMM: 82-207/256
Sequence Identity: 42% (54 aa)

GSVYDLIQNIG-PISEENICIIIKQALMGLKYLHKNNRLHKNIKSSNIMLQSDGIVKLCDFSTSKKLTEILS-QCRNYS---YWQSPETIIDQHFNEKSD
||. |... ..    |. | .|..|.| || |||  |  |  ||. || |  |..||. ||  | .|   .. |   .    ||  || |  |  | | |
GSINDMMESCCKTLNEKQISVILQQTLKGLHYLHSKNIIHRDIKAANILLNEDCQVKIADFGVSQQLQDEYDGQANQMIGTPYWMAPEIINKQNYNNKCD

IWSIGITAIEMAKGEPPYFNLPPKKA
||| |||||||| |.||   .|| .|
IWSLGITAIEMADGFPPHYDMPPMRA

Kinase 14836.AA Pkinase 87-321 21 5.2e-30 107.19 Pfam 13-293 (293) Show / Hide
Range on Protein: 87-321
Range on HMM: 13-293/293
Sequence Identity: 21% (61 aa)

SSIYRGMNKQNAEIVALKEYNVIPAEDLQQIIQ----EISKESRVQDEFVSGLNDYFVSDGKLYLISQYFSEG----SVYDLIQ--NIGPI--SEENICI
.. |....| . .|||.|. ..  ... ....     ||.   |.. ...  | |.| .....|..  |   |    . .|.|.  . |..  ||. .. 
GCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKF

IIKQALMGLKYLHKNNRLHKNIKSSNIMLQSDGIV----KLCDFSTSKKL-TEILSQCRNY---SYWQSPETII-DQHFNEKSDIWSIGITAIEMAKGEP
...| | ||.|.|... .|  .|..||.. ..| .    |.|||  .|.. .   | .  .   ... .|| |  .|.   |.|.||.|.. .||. |.|
YMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRP

PYFNL---PPKKAQFLTVQEEPQIDSSFS-------------------------PQFQEFLKMCLEKNPEERASVGDLLLSNFI
|. .    ..   |   ...  . . .|.                         . ...|.| ||.|.|..| .  ..| . ..
PFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF

Kinase 14836.AA PAKA 232-321 44 5.9e-30 102.35 In-house 168-260 (260) Show / Hide
Range on Protein: 232-321
Range on HMM: 168-260/260
Sequence Identity: 44% (41 aa)

YWQSPETIIDQHFNEKSDIWSIGITAIEMAKGEPPYFNLPPKKAQFLTVQE-EPQIDS--SFSPQFQEFLKMCLEKNPEERASVGDLLLSNFI
|| .|| |  .  .|| ||||.|| ||||. ||||| | || .| .|  ..  | | .  ..|..|..||. ||......|||. .||   |.
YWMAPEVIRRKQYDEKVDIWSLGIMAIEMIEGEPPYLNEPPLRAMYLIATNGKPDIKDPDKWSQEFCDFLDKCLCVDVDRRASAQELLHHPFL

Kinase 14836.AA MST 232-321 44 2.4e-29 90.35 In-house 162-254 (254) Show / Hide
Range on Protein: 232-321
Range on HMM: 162-254/254
Sequence Identity: 44% (41 aa)

YWQSPETIIDQHFNEKSDIWSIGITAIEMAKGEPPYFNLPPKKAQFLTVQEEPQI---DSSFSPQFQEFLKMCLEKNPEERASVGDLLLSNFI
|| .|| |  .  . | |||| |||||||| |.|||... |  | |.  |  |.     . .|..|  |.. || ||||.|..  .||   ||
YWMAPEVIQEIKYDCKADIWSLGITAIEMAEGMPPYSDIHPMRAMFMIPQKPPPTFKDPEQWSQEFNDFVCKCLQKNPEQRWTAEQLLQHPFI

Kinase 14836.AA MST 88-214 33 7.3e-18 53.29 In-house 14-141 (254) Show / Hide
Range on Protein: 88-214
Range on HMM: 14-141/254
Sequence Identity: 33% (44 aa)

SIYRGMNKQNAEIVALKEYNVIPAEDLQQIIQEISKESRVQDEFVSGLNDYFV--SDGKLYLISQYFSEGSVYDLIQNIG-PISEENICIIIKQALMGLK
| |.  .||. .||| |  .|   ||||.|| |||  .  . ... .. . .    .  . ..  |   ||| |..  .. . .|. |  | ...| ||.
SVYKAIHKQTGKIVAIKMVPV--NEDLQEIIKEISIMQQCKSKYIVKYYGSYFDAKNNHCWIVMEYCGMGSVCDIMKITQRTLNEQQIACILYDTLQGLQ

YLHKNNRLHKNIKSSNIMLQSDGIVKLCDF
|||.| . |  ||. || |  .|  || ||
YLHDNKKIHRDIKAGNILLNHEGECKLADF

Kinase 14836.AA PAKA 138-214 34 3.5e-17 56.93 In-house 67-147 (260) Show / Hide
Range on Protein: 138-214
Range on HMM: 67-147/260
Sequence Identity: 34% (28 aa)

YFVSDGKLYLISQYFSEGSVYDLIQNIG-----PISEENICIIIKQALMGLKYLHKNNRLHKNIKSSNIMLQSDGIVKLCDF
| | | .|...  | . |.  |.|..       ...|. |  .... | ||...|...| |  ||| || | .|| ||. ||
YLV-DDELWVVMEYMEGGCLTDVITQCCNIQCNYMDEGQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILLGMDGSVKITDF

Kinase 14836.AA TyrKc 75-320 18 1.2e-12 -18.25 SMART 1-280 (280) Show / Hide
Range on Protein: 75-320
Range on HMM: 1-280/280
Sequence Identity: 18% (53 aa)

DILEKKTTQSMHSSIYRGMNKQNAEIVALKEYNVIPAEDLQQIIQEISKESRV--QDEFVSGLNDYFVSD-------GKLYLISQYFSEGSVYDLIQNIG
  |.||        .|.|. |   . || |  .      .. ...|..  ...  . . .  |  . ...       . |...  | . |.  | ... .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

P-ISEENICIIIKQALMGLKYLHKNNRLHKNIKSSNIMLQSDGIVKLCDFSTSKKLT---------EILSQ----CRNY-S--YWQSPETIIDQHFNEKS
| .. .  . .  |.  |  |||..|  |  .   |... ....|| .||  |....         .  ..    ....     | .||.| .  |..||
PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKS

DIWSIGITAIEMA-KGEPPYFN-----LPPKKAQFLTVQE--EPQIDS-------SFSPQFQEFLKMCLEKNPEERASVGDLLLSNF
|.|| |..  |.   |..|| .     .... .  .  |    || ..         ..   .  |.| . .||.| .  ..  . |
DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF

Kinase 14836.AA PAKL 290-321 50 1.3e-08 28.47 In-house 225-256 (256) Show / Hide
Range on Protein: 290-321
Range on HMM: 225-256/256
Sequence Identity: 50% (16 aa)

FSPQFQEFLKMCLEKNPEERASVGDLLLSNFI
.|| |  ||  |. | ||.|.|. |||   ||
WSPCFNDFLAQCCVKDPEKRWSPIDLLCHPFI

Kinase 14836.AA Pkinase_Tyr 233-272 38 0.000223 15.45 Pfam 180-221 (270) Show / Hide
Range on Protein: 233-272
Range on HMM: 180-221/270
Sequence Identity: 38% (16 aa)

WQSPETIIDQHFNEKSDIWSIGITAIEMAK-GEPP-YFNLPP
| .|| | .  |..|||.|| |..  |.   || | | ....
WMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSN

Kinase 14836.AA Pkinase_Tyr 181-214 32 0.102101 6.44 Pfam 122-155 (270) Show / Hide
Range on Protein: 181-214
Range on HMM: 122-155/270
Sequence Identity: 32% (11 aa)

MGLKYLHKNNRLHKNIKSSNIMLQSDGIVKLCDF
.|. ||. .|  |  .   |... ....|| |||
KGMEYLESKNCIHRDLAARNCLVTENNVVKICDF