15732

Species: Tetrahymena
Alias: PreTt15732, 15732, 581, TTHERM_00297210, 27.m00392, 3692.m01165
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: TKL
Family: TKL-ciliate4

Sequence

Name Sequence Type Origin Length Description Download
15732.AA Protein None 259 None Fasta, JSON
15732.NA RNA None 783 None Fasta, JSON
15732.kin_dom Protein Kinase Domain None 222 None Fasta, JSON

Protein domain

Protein domains of 15732.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 15732.AA TKL 32-255 22 1.4e-65 224.23 In-house 1-364 (364) Show / Hide
Range on Protein: 32-255
Range on HMM: 1-364/364
Sequence Identity: 22% (85 aa)

IIKGGFSIVHKGKYKG----------CDVAIKKIFNPN-------------------------ITQDVLDEINNEVNMLATLRHPNIILLMGIVSQPQN-
| .|||..|.|||..|           |||.||.   |                          ..   .....|..|.  ||||||...||.. .|.. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------MCIVTDLVEGGDLFTYLHKQRKDLSGVQKAFIVKQIINAFYYLHSHQ--------IVHRDLKSYNILLDVGFK--------------I
            .|||.....||.|. |||         |.  ....|  . .||||..        |.|||||| |||.|  ..              .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

KLCDFGLARKYSDLN------------------------QG-------------------------------YDEKVDVFAFGTLLWEIYAQEVPFDGLE
|.|||||.|  |  .                        |.                               |.||.||..|| .||||.. ..|.... 
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYP

P----------NDIMVRVTNDEQLPQK------------QTINSSIYKLIVKCRALNPNLRPSFEKIYQEF
.           ..|... . ...| .             ..  |. ||. .| . .|. ||||..| ...
YMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL

Kinase 15732.AA TK 27-255 15 4.9e-45 148.44 In-house 1-486 (486) Show / Hide
Range on Protein: 27-255
Range on HMM: 1-486/486
Sequence Identity: 15% (75 aa)

IHFLLIIKGG-FS---IVHKGKYKG---------------------------CDVAIKKIF--NPNITQDVLD-EIN---------NEVNMLATLR----
|...  .  | |     |.||...|                           ..||.| .   ...  .. .| |..         .|..... ..    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNIILLMGIVSQPQN------------MCIVTDLVEGGD----LFTYLHKQRKD--------------------------------------------
 ||||. | |...|...            ..||. ....||    | .||.| |..                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LSGVQKAFIVKQIINAFYYLHSH------QIVHRDLKSYNILLDVGFK-----------IKLCDFG---
                               |.  |.  .  || ..  ||||.      ..|||||   |.|.. . .           .|..|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LARKYSD---------------------------------------------LNQG----------YDEKVDVFAFGTLLWEIYAQE-VPFDGLE
     |||.  .                                             || .          . .| ||..|| |.|||.    .|. |  
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

PN----------DIMVRVTND--------------EQLPQKQTIN--------------SSIYKLIVKCRALNPNLRPSFEKIYQEF
.|          ..| ....                ..|| .                   .| |. .| ...|. ||.|. .....
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL

Kinase 15732.AA S_TKc 27-259 28 6.2e-44 153.2 SMART 1-231 (231) Show / Hide
Range on Protein: 27-259
Range on HMM: 1-231/231
Sequence Identity: 28% (74 aa)

IHFLLII-KGGFSIVHKGKYKG--CDVAIKKIFNPNITQDVLDEINNEVNMLATLRHPNIILLMGIVSQPQNMCIVTDLVEG--GDLFTYLHKQRKD---
 ..| .| ||.|. |.|.. |.    ||||.|          . | .|...|   .||||. | ..    .....|.....|  ||||.|..|...    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--LSGVQKAFIVKQIINAFYYLHSHQIVHRDLKSYNILLDVGFKIKLCDFGLARKYSD-------------LNQGYDE-KVDVFAFGTLLWEIYAQEVPF
  ..  . .|...||..|  |.|||.|.|||||  |||||    ||.|||||||.. .             |  ||.  |.|. ..| .|.| .. . ||
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCILYEMLCGYPPF

DGLEPNDIMVRVTNDEQLPQKQTINSSIYKLIVKCRALNPNLRPSFEKIYQEF-----NQLA
.  ... .. ..             ..   .| ||   .|. ||.  .. |.       .  
P--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase 15732.AA TyrKc 27-255 24 4.8e-40 140.28 SMART 1-280 (280) Show / Hide
Range on Protein: 27-255
Range on HMM: 1-280/280
Sequence Identity: 24% (70 aa)

IHFLLII-KGGFSIVHKGKYKGCDVAIKKIFNPNITQDVLDEINNEVNMLATL--RHPNIILLMGIVSQP-------QNMCIVTDLVEGGDLFTYLHKQR
|... ..  | | .|.||..|  .||.|.. .       . .. .| ...  |  .||||. | |...|.       . ..||. ....|||  ||.| |
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

KDLSGVQKAFIVKQIINAFYYLHSHQIVHRDLKSYNILLDVGFKIKLCDFGLARKY--------------------SD------------LNQG-YDEKV
..|.  ..  .  || .   ||||....||||   |.|.. .. .| .||||.|.                     ..            .| | . .| 
PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKS

DVFAFGTLLWEIYAQ-EVPFDG-----LEPNDIMVRVTNDEQLPQKQT--------INSSIYKLIVKCRALNPNLRPSFEKIYQEF
||..|| ..|||.   . |  |     ... ... .| . . .|| .           . .|... .| . .|. ||.|. |...|
DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF

Kinase 15732.AA TKL-Unique 28-170 36 4.8e-38 131.8 In-house 1-165 (290) Show / Hide
Range on Protein: 28-170
Range on HMM: 1-165/290
Sequence Identity: 36% (60 aa)

HFLLIIKGGFSIVHKGKYKGCDVAIKKIF-NPNITQDVLDEINNEVNMLATLR-HPNIILLMGIVS----QPQNMCIVTDLVEGGDLFTYLH--------
 . .|  ||.. | |||..| .||||... |  .  ....| .|||| . .|. |||| ..||.      .| |||||.. ..|| |  .||        
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

-KQRKDLSGVQKAFIVKQIINAFYYLHSHQ--IVHRDLKSYNILLDVG-----FKIKLCDFGLAR
 .. ..|.  |.  ....|  . ||||. .  | |||||| |.|.| .     ..||.|||||..
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSK

Kinase 15732.AA Pkinase 34-173 32 1.8e-37 133.61 Pfam 9-163 (293) Show / Hide
Range on Protein: 34-173
Range on HMM: 9-163/293
Sequence Identity: 32% (50 aa)

KGGFSIVHKGKYKGCD--VAIKKIFNPNITQDVLDEINN--EVNMLATLRHPNIILLMGIVSQPQNMCIVTDLVEGG----DLFTYLH-KQRKDL--SGV
.|.|. | |.. ||    ||.|.|  ...  ... .  .  |. ... |.||||. | ...  ......|....|||    |||.|.. .... .  |  
SGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEW

QKAFIVKQIINAFYYLHSHQIVHRDLKSYNILLD-VGFK---IKLCDFGLARKYS
.  |...||. . .|.||. |.|||||. |||.|  |     .|.||||||....
ECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD

Kinase 15732.AA LISK 31-171 38 3.3e-37 118.32 In-house 1-154 (296) Show / Hide
Range on Protein: 31-171
Range on HMM: 1-154/296
Sequence Identity: 38% (59 aa)

LIIKGGFSIVHKGKYK--GCDVAIKKIF---NPNITQDVLDEINNEVNMLATLRHPNIILLMGIVSQ-PQNMCIVTDLVEGGDLFTYLHKQRK---DLSG
 | ||.|. | || ..  | ..|||.|    |  .  . .  .. || |.  ||||||.  ||.  .      ||| ...||||. ||..  |   .|. 
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPW

VQKAFIVKQIINAFYYLHSHQIVHRDLKSYNILLD----VGFKIKLCDFGLARK
 |.  | . |  .. |||| .|.|||||| |.|..     ...||.||||.||.
PQRVKIALDIACGMSYLHSMNIIHRDLKSKNCLVRENDNNQWRIKVCDFGFARM

Kinase 15732.AA Dicty4 27-170 35 6.2e-34 110.69 In-house 1-162 (277) Show / Hide
Range on Protein: 27-170
Range on HMM: 1-162/277
Sequence Identity: 35% (57 aa)

IHFLLII-KGGFSIVHKGKYKGCDVAIKKIFNPNIT--QDVLDEINNEVNMLATLRHPNIILLMGIVS----QPQNMCIVTDLVEGGDLFTYLHK-----
| .  .| ||.|. |.||. .| .||.|| .| |..  .. | |  .||. .. .|||||.|.||       .|  ||||| ..  |.|.. ||.     
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ

-QRKDLS--GVQK-AFIVKQIINAFYYLHS--HQIVHRDLKSYNILLDVGFKIKLCDFGLAR
 |.. |.   . .   . . .     .||.    |.|||||| |.| |  ...| |||||..
QQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQ

Kinase 15732.AA LISK-DD1 31-171 35 1.9e-32 114.13 In-house 1-176 (290) Show / Hide
Range on Protein: 31-171
Range on HMM: 1-176/290
Sequence Identity: 35% (62 aa)

LIIKGGFSIVHKGKYKGCDVAIKKIFN---PNITQDVLDEINNEVNMLAT---LRHPNIILLMGIVSQ-------------PQNMCIVTDLVEGGDLFTY
 | ||.| .| || | | .|||||| .     .  | .  .. |. ||     .|||||.   ||                     ||| ..|||||. |
EIGKGSFGKVYKGCYFGTPVAIKKIHKQPNDPNDPDYWKFMQREIKMLKNLLNIRHPNIVQFIGICEHPLASPSLVNRLLNESSLYIVTEFIEGGDLHWY

LHK------------QRKDLSGVQKAFIVKQIINAFYYLHSHQIVHRDLKSYNILLDVG----FKIKLCDFGLARK
| .            . ....   .. | . |  |. |||| .|.|||||| |||.|       .||.||||.||.
LKNTPFDDTPEQYIHHKIPIPWKLRVKIALDIACAMAYLHSKNIIHRDLKSKNILVDENGDSQWRIKVCDFGFARM

Kinase 15732.AA Pkinase_Tyr 37-170 30 3.7e-32 109.52 Pfam 12-159 (270) Show / Hide
Range on Protein: 37-170
Range on HMM: 12-159/270
Sequence Identity: 30% (45 aa)

FSIVHKGKYK------GCDVAIKKIFNPNITQDV--LDEINNEVNMLATL-RHPNIILLMGIVS-QPQN--MCIVTDLVEGGDLFTYLHKQ---RKDLSG
|  |.||..|      ...||.|.. ... ...   ...  .|.... .| .||||. |.|... | .   ..||. ....||| .||.|.   .. |. 
FGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTM

VQKAFIVKQIINAFYYLHSHQIVHRDLKSYNILLDVGFKIKLCDFGLAR
 ..  .  || ..  ||.|....||||   |.|.. ....| |||||||
KDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR

Kinase 15732.AA MLK 27-170 30 2.5e-30 102.48 In-house 1-181 (291) Show / Hide
Range on Protein: 27-170
Range on HMM: 1-181/291
Sequence Identity: 30% (56 aa)

IHFLLII-KGGFSIVHKGKYKGCD-----VAIKKIF----NPNITQDVLDEINNEVNMLATLRHPN----IILLMGIVSQPQN-MCIVTDLVEGGDLFTY
| |. .| .|.|  |.||.... |     ||.|...       .|    .... |.. |. |.|||    || ..|. .||..  |||.  .||| |...
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LHKQRK-------------DLSGVQKAFIVKQIINAFYYLHSHQ---IVHRDLKSYNILLDV------GFKIKLCDFGLAR
|| .|.               .  ... . .|. ..  ||||..   |.|||||| |||.|       . . | ||||..|
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSR

Kinase 15732.AA RAF 27-169 35 8.9e-30 99.09 In-house 1-147 (275) Show / Hide
Range on Protein: 27-169
Range on HMM: 1-147/275
Sequence Identity: 35% (52 aa)

IHFL-LIIKGGFSIVHKGKYKGCDVAIKKIFNPNITQ-DVLDEINNEVNMLATLRHPNIILLMGIVSQP--QNMCIVTDLVEGGDLFTYLHKQRK-DLSG
.  .  | .| |  |..|.. | |||.| .    .|. . |..  ||| |.   || ||.| || .. |   .  ||| . .|  |....| |.  ..  
VQIGERIGQGRFGTVYRGHWHG-DVAVKTLNMKYPTPEHQLQAFKNEVMMYKKTRHENIVLFMGYCMKPDNPHYAIVTQWCKGSTLYHHIHVQKTEKFDM

VQKAFIVKQIINAFYYLHSHQIVHRDLKSYNILLDVGFKIKLCDFGLA
 ..  | .||. .  |||.  |.|||||| ||.|. | .... ||||.
NWTIQIAQQICQGMDYLHAKNIIHRDLKSKNIFLHNGKVVVITDFGLF

Kinase 15732.AA LRRK 26-172 25 8.3e-27 91.86 In-house 1-230 (351) Show / Hide
Range on Protein: 26-172
Range on HMM: 1-230/351
Sequence Identity: 25% (60 aa)

LIHFLLIIKGGFS-IVHKGKYKG---------------------------C-DVAIKKIFNP---------NITQ-----------------------DV
|..  .| .|||  .|...|..|                           | .|||||.  .         | .                         .
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

LDEINNEVNMLATLRHPNIILLMGIVSQPQNMCIVTDLVEGGDLFTYLHKQRKD--------LSGVQKAFIVKQIINAFYYLHSHQ--IVHRDLKSYNIL
. |  .|| .. .|.||||. |.|.  .|  .|.|....  ||| ..||. ..|        .|   |  |. ||  .  |||||   |.|||||| |||
FREFRHEVWIMSHLNHPNIVSLKGFCIHP--LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNIL

L---D---------VGFKIKLCDFGLAR--KY
|   .            ..|..|||. |  ..
LWSSPQNHSPNYPNAHVCAKIADFGISRMFQC

Kinase 15732.AA Dicty5 40-170 36 2.7e-24 80.5 In-house 15-152 (260) Show / Hide
Range on Protein: 40-170
Range on HMM: 15-152/260
Sequence Identity: 36% (51 aa)

VHKGKYKGCDVAIKKIFNPN-ITQDVLDEINNEVNMLATLR--HPNIILLMGIVSQPQNM-CIVTDLVEGGDLFTYLHKQRK----DLSGVQKAFIVKQI
| .| ||| |||||     | .  | ..|   || ..      |||.|   |   . ..   .|| ..  | || ||  |||     ..  |.  .   |
VYNGIYKGMDVAIKVYSQENCMCFD-WNEFYREVTIMSIFQSDHPNFIRCYGAHQYNDKYPFHVTEYCHNGSLFNYLNDQRKTTGQPIAYFQQLHMAIDI

INAFYYLHSHQIVHRDLKSYNILLDVGFKIKLCDFGLAR
 ..  .|||  |.|||||| |.|.   .|||. |||  |
AQSMRHLHSMNIIHRDLKSMNFLITENWKIKIIDFGTSR

Kinase 15732.AA TKL-Unique 176-255 26 9.7e-19 62.85 In-house 202-290 (290) Show / Hide
Range on Protein: 176-255
Range on HMM: 202-290/290
Sequence Identity: 26% (24 aa)

NQGYDEKVDVFAFGTLLWEIYAQEV------PFDGLEPNDIM--VRVTNDEQLPQK-QTINSSIYKLIVKCRALNPNLRPSFEKIYQEF
.  |.||.||..||. ||||.  ..      |..|.... .   |... ... |   . .. .. .|| .|.. .|  ||||. |. . 
FCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL

Kinase 15732.AA MLK 176-255 32 2.8e-18 60.09 In-house 210-291 (291) Show / Hide
Range on Protein: 176-255
Range on HMM: 210-291/291
Sequence Identity: 32% (27 aa)

NQGYDEKVDVFAFGTLLWEIYAQEVPFD-GLEPNDIMVRVTNDE-QLPQKQTINSSIYKLIVKCRALNPNLRPSFEKIYQEF
.. |.||.||. .| .|||. . |||.. ...|  |   |.. .  .|  .|.. .. ||. .|   .|. ||||  | |..
CEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL

Kinase 15732.AA Dicty5 177-259 34 2.5e-16 52.69 In-house 178-260 (260) Show / Hide
Range on Protein: 177-259
Range on HMM: 178-260/260
Sequence Identity: 34% (29 aa)

QGYDEKVDVFAFGTLLWEIYAQEVPFDGLEPNDIMVRVTNDE--QLPQKQTINSSIYKLIVKCRALNPNLRPSFEKIYQEFNQLA
|.|..|.||..||  |||. ..  |.| .   .| | |   |   .|   .. ..| .|| ||    | .|||| .| . |... 
QPYHQKCDVYSFGIVLWEMFTRKEPYDNINNWNIPVMVMKGERPTIP--KDCPTEISNLIKKCWQQKPHNRPSFKEICKYFESII

Kinase 15732.AA Pkinase_Tyr 179-255 26 3e-14 48.88 Pfam 191-270 (270) Show / Hide
Range on Protein: 179-255
Range on HMM: 191-270/270
Sequence Identity: 26% (21 aa)

YDEKVDVFAFGTLLWEIYAQE-VP-FDGLEPNDIMVRV-TNDEQLPQKQTINSSIYKLIVKCRALNPNLRPSFEKIYQEF
. .| || .|| |.|||.     | . |. ..... ..  . ...|. .     ||.|. .| . .|. ||.|. |....
FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL

Kinase 15732.AA LRRK 179-257 25 8.2e-12 38.06 In-house 259-351 (351) Show / Hide
Range on Protein: 179-257
Range on HMM: 259-351/351
Sequence Identity: 25% (24 aa)

YDEKVDVFAFGTLLWEIYAQE-VPFDGLE-------PNDIMVRVTNDEQLPQKQT-INS-----SIYKLIVKCRALNPNLRPSFEKIYQEFNQ
|.||||...|| .|||..  .  |||...        . |  ....    . .|.  .      .  .||..| . .|. ||.|..| .   |
YTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ

Kinase 15732.AA Dicty4 176-257 32 8.8e-11 32.36 In-house 191-277 (277) Show / Hide
Range on Protein: 176-257
Range on HMM: 191-277/277
Sequence Identity: 32% (28 aa)

NQGYDEKVDVFAFGTLLWEIYAQEVPFD--GLEPNDIMVRVTN-DEQLPQKQTINSSIYKLIVKCRALNPNLRPSFEKIYQE--FNQ
.|.|.||.||. || .||||   . |.   . ..  .   | |  . .|  .    |. .||..|   .|. ||||| | |.   . 
HQPYNEKADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH

Kinase 15732.AA Pkinase 176-255 20 2.2e-10 37.77 Pfam 186-293 (293) Show / Hide
Range on Protein: 176-255
Range on HMM: 186-293/293
Sequence Identity: 20% (22 aa)

NQGYDEKVDVFAFGTLLWEIYAQEVPFDGL----EPNDIMVRVTNDEQ----LPQKQTIN-------------------SSIYKLIVKCRALNPNLRPSF
.|.|. |||....| .|.| .  . ||.|     . .| |... .. .     .  ....                   ..  ..| .| ...|. ||..
GQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTA

EKIYQE--F
| | |   |
EQILQHPWF

Kinase 15732.AA RAF 184-255 25 5.1e-10 30.51 In-house 199-275 (275) Show / Hide
Range on Protein: 184-255
Range on HMM: 199-275/275
Sequence Identity: 25% (20 aa)

DVFAFGTLLWEIYAQEVPFDGLEP-NDIMVRVTNDEQLPQ----KQTINSSIYKLIVKCRALNPNLRPSFEKIYQEF
||.|||| . |. |.| |. .  .   |   |   .  ..     ... ... .|.. | . .|. |||| .|  . 
DVYAFGTVWYELMAGEWPYQHIQWHEQIIWMVCRGYLRMDRSKARVQCPKEMKELLMECWSYQPEERPSFQQIMKMI

Kinase 15732.AA LISK 231-255 36 7e-06 14.9 In-house 272-296 (296) Show / Hide
Range on Protein: 231-255
Range on HMM: 272-296/296
Sequence Identity: 36% (9 aa)

YKLIVKCRALNPNLRPSFEKIYQEF
..| ..|  ..|. ||||..| | .
LDLCFDCCKYDPKNRPSFKEIVQWL

Kinase 15732.AA LISK 179-195 64 4.4e-05 12.25 In-house 216-232 (296) Show / Hide
Range on Protein: 179-195
Range on HMM: 216-232/296
Sequence Identity: 64% (11 aa)

YDEKVDVFAFGTLLWEI
|||..||| || .| ||
YDESCDVFSFGIVLCEI

Kinase 15732.AA LISK-DD1 231-255 40 0.005374 6.96 In-house 266-290 (290) Show / Hide
Range on Protein: 231-255
Range on HMM: 266-290/290
Sequence Identity: 40% (10 aa)

YKLIVKCRALNPNLRPSFEKIYQEF
..| ..|   .|| |||| .| |  
MDLCMWCCKYDPNNRPSFKEIVQTL

Kinase 15732.AA LISK-DD1 175-195 47 0.009712 6.02 In-house 204-224 (290) Show / Hide
Range on Protein: 175-195
Range on HMM: 204-224/290
Sequence Identity: 47% (10 aa)

LNQGYDEKVDVFAFGTLLWEI
| . ||. .||| || .| |.
LGMSYDWSCDVFSFGMVLLEL