Gene 1794 (Tetrahymena)
1794
Group:
Other
Family:
Ciliate-D1
Sequence
Protein domains of 1794.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 1794.AA | SLK | 610-681 | 26 | 8e-07 | 18.92 | In-house | 52-123 (259) | Show / Hide |
Range on Protein: 610-681 Range on HMM: 52-123/259 Sequence Identity: 26% (19 aa) KLKHPNLVEYMDHYRINNQLTAFKEYCPQGGLIKYLERNKKELNADILFDLIEDVCNALKFLYDRAVVDFEL ..||||.|. .. | ..|.|. . |.|. | . . .. | | . . . .|.||..|... |. .| ECKHPNIVKLYEAYYYDNKLWMMIEFCDGGAVDNIMVELEHPLTEDQIQYVCKHMCEALNWLHSNKVIHRDL |
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| Kinase | 1794.AA | ULK | 610-695 | 23 | 2.5e-05 | 14.95 | In-house | 66-179 (324) | Show / Hide |
Range on Protein: 610-695
Range on HMM: 66-179/324
Sequence Identity: 23% (27 aa)
KLK---HPN--LVEYMDHYRIN--NQLTAFKEYCPQGGLIKYLERNKKE--------LNADILFDLIEDVCNALKFLYDRAVVDFELSLEMIYVSNNI--
||| ||| |.. | .. | . . |||..| | .|...|||. |. .. . . ||..|.|... .. . .. | ..|..
KLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPK
-----------IKI
.||
TDSKKVHPNGVLKI
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| Kinase | 1794.AA | Jak | 634-677 | 26 | 3e-05 | 14.64 | In-house | 91-140 (299) | Show / Hide |
Range on Protein: 634-677 Range on HMM: 91-140/299 Sequence Identity: 26% (13 aa) EYCPQGGLIKYLE----RNKKELNA--DILFDLIEDVCNALKFLYDRAVV || . | | .|| |.|. .|. | .... ..|.....|.|. . EYWCYGPLDDYLHKVKERHKWCVNHTEDWKMQFAKQICWGMHYLEDKRYI |
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| Kinase | 1794.AA | ULK | 610-695 | 22 | 0.000102 | 12.5 | In-house | 66-183 (329) | Show / Hide |
Range on Protein: 610-695 Range on HMM: 66-183/329 Sequence Identity: 22% (26 aa) KLK--------HPNLVEYMDHYRIN--NQLTAFKEYCPQGGLIKYLERNKKE---------LNADILFDLIEDVCNALKFLYDRAVVDFELSLEMIYVSN ||| ||| |.. | .. | . . |||..| | .|...|||. |. .. . . .|..|.|... .. . .. | ..| KLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHN NI-------------IKI .. .|| GQPKTDSKKVHPNGVLKI |
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| Kinase | 1794.AA | TKL-Unique | 601-671 | 28 | 0.000103 | 12.76 | In-house | 42-126 (290) | Show / Hide |
Range on Protein: 601-671 Range on HMM: 42-126/290 Sequence Identity: 28% (24 aa) HEKQVRFFEKLK-HPNLVEYM----DHYRINNQLTAFKEYCPQGGLIKYLE---------RNKKELNADILFDLIEDVCNALKFL .|..|. .||. |||.| || || .... . |||| | | ..| .|...|| ....|. .. .| FENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYL |
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| Kinase | 1794.AA | NEK4 | 602-652 | 32 | 0.000192 | 12.08 | In-house | 46-98 (257) | Show / Hide |
Range on Protein: 602-652 Range on HMM: 46-98/257 Sequence Identity: 32% (17 aa) EKQVRFFEKLKHPNLVEYMDHYRINNQ--LTAFKEYCPQGGLIKYLERNKKEL |. .. .||||| ||| . . | | | .| | | . | . | .. EHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKLKQQKNQF |
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| Kinase | 1794.AA | Pkinase | 605-677 | 16 | 0.003997 | 12.13 | Pfam | 51-130 (293) | Show / Hide |
Range on Protein: 605-677 Range on HMM: 51-130/293 Sequence Identity: 16% (13 aa) VRFFEKLKHPNLVEYMDHYRINNQLTAFKEYCPQG----GLIKYLE-RNKKEL--NADILFDLIEDVCNALKFLYDRAVV .. .|.||| |.. | .. .. . |||. | | |.. .... . . . . . .. .|...... .. IQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGII |
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| Kinase | 1794.AA | SAK | 603-695 | 19 | 0.070921 | 1.86 | In-house | 48-141 (254) | Show / Hide |
Range on Protein: 603-695 Range on HMM: 48-141/254 Sequence Identity: 19% (18 aa) KQVRFFEKLKHPNLVEYMDHYRINNQLTAFKEYCPQGGLIKYLERNKKELNADILFDLIEDVCNALKFLYDRAVVDFELSLEMIYVSNNI-IKI . |. .|||| ..| .. || | | | . .|... . . ...... . .| .. .|.| | .. .. .|| NEVEIHCQLKHPSILELYNYFEDNNYVYLVLEMCHNGEMHRYMKHRMRPFTEEEARHFMHQIVIGMLYLHSHGIMHRDLTLSNILLTRDMHCKI |
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| Kinase | 1794.AA | C8 | 1114-1229 | 23 | 5.1e-09 | 27.57 | In-house | 111-226 (226) | Show / Hide |
Range on Protein: 1114-1229 Range on HMM: 111-226/226 Sequence Identity: 23% (29 aa) LYSQNLQQYLINSSKLDIACQLIEFLHQFLSGLHELHVKDIIHRQLSFESICIQSPSSSAQNKTIAKISNLELAIQLKSQN--YISSD---IPLNSYSSP .. .| ||.. . |. || |.|. |. .|.| |.||.. .. . .. . .. . |.. . .| |... ..| . . |. | DERRNKQQQFSKEMKEIIAIQMID-------GVNYIHCKNIMHRDIKPHNFLVC---LDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAP EMREK-----QAYGIASDVFSAGVII |. .| . | | ||.|| |.. EIEKKQDNQYKQYRIQSDLFSVGLVL |
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| Kinase | 1794.AA | S_TKc | 1053-1399 | 14 | 3e-08 | -55.85 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 1053-1399
Range on HMM: 1-231/231
Sequence Identity: 14% (55 aa)
FRIENVI-----------KSQP--RALCLKISKSKSYNPFLEKEFTILKQFGTPYIIKSYSQVHIKGLNGIVVDLYSQ---NLQQYLINSSK------LD
..| ..| . | .|| | ...| |||. . |.|.| | . . .| .. .. .| .|. . . ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP
IACQLIEFLHQFLSGLHELHVKDIIHRQLSFESICIQSPSSSAQNKTIAKISNLELAIQLKSQNYISSDIPLNSYSSPEMREKQAYGI-ASDVFSAGVII
. ...| ...| .| . |||| | | | . . ||. || || . .. | .||. || ..|. | |.|.
E--HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---------HIKICDFGLARQL-----TTFCGTPW-YMAPEVL---GYGKCKCDWWSCGCIL
LSALCNVSPKKIQSIACPDLLPQGKQNLYVSHIVDQKVDLQQSHYQRVFSKIQKKQPKDEQRKIGTSETKGTTESNIFKSHSILVDSSPSQSKNQSKNEI
|| | .. |. .
YEMLCGYPPFP-------QMQMMFKKIG------------------------------------------------------------------------
ELQQSAMNSQRVQTSRQNINQKGLREVLGEKCPQLIIDTFEKMISKYPQIRGNCSDYLSDLQRLKNQPEV
.. .| .|. | |. | . . | | . |. | .
--------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | 1794.AA | Ciliate-E2 | 1079-1229 | 17 | 3.6e-07 | 20.65 | In-house | 79-286 (365) | Show / Hide |
Range on Protein: 1079-1229
Range on HMM: 79-286/365
Sequence Identity: 17% (39 aa)
FLEKEFTILKQFGTPYIIKSYSQVH--IKGLNGIVVDLYSQ-NLQQYLINSSKLDIAC----------QLIEFLHQFLS---------------GLHELH
.. .| ||.| |.||| | . .| ..... .|..|..|..| . . ... | |. .|..||
KI-NEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLH
VKD-IIHRQLSFESICIQSPSSSAQNKTIAKISNLELAIQLKSQNYISSDIPLNS--------------------------------YSSPEMREKQA--
| |||| . | | . ||. . |. ... .|. .. ... | .||. ...
SKNNIIHRDIKPENILF------------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYD
-------YGIASDVFSAGVII
|. ..|..|.|||.
NQQKQKGYDYKCDIWSLGVIL
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| Kinase | 1794.AA | SAK | 1137-1229 | 32 | 1.8e-05 | 14.31 | In-house | 104-190 (254) | Show / Hide |
Range on Protein: 1137-1229 Range on HMM: 104-190/254 Sequence Identity: 32% (31 aa) EFLHQFLSGLHELHVKDIIHRQLSFESICIQSPSSSAQNKTIAKISNLELAIQLKS---QNYISSDIPLNSYSSPEMREKQAYGIASDVFSAGVII .|.|| . |. || .|.|| |. | . . . . || || ||| . | | | |||. . | |. |||.| | .. HFMHQIVIGMLYLHSHGIMHRDLTLSNILL------TRDMHC-KIADFGLATQLKMPHEKHYTMCGTP--NYISPEIATRTAHGLQSDVWSLGCML |
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| Kinase | 1794.AA | TyrKc | 1043-1390 | 11 | 0.00011 | -146.89 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 1043-1390
Range on HMM: 1-280/280
Sequence Identity: 11% (46 aa)
LINKSEYGLGF-------RIENVIKSQPRALCL-KISKSKSYNPFLEKEFTILKQF--GTPYIIKSYSQVHIK-------GLNGIVVDLYSQ-NLQQYLI
. . . | |. . . | |. . . .| |.... | |.. | . . . ||. . . .|..||
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR
NSSK-LDIACQLIEFLHQFLSGLHELHVKDIIHR-------QLSFESICIQSPSSSAQNKTIAKISNLELAIQLKSQ-------NYIS------SD--IP
.. . | . .|..| .| .| || | .||| .. . ..||| |. ... |.. .. .|
KHRPKLCMK-DLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--------------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLP
LNSYSSPEMREKQAYGIASDVFSAGVII--LSALCNVSPKKIQS--IACPDLLPQGKQNLYVSHIVD----QKVDLQQSHYQRVFSKIQKKQPKDEQRKI
. .|| . . ..|||.| || . . .. . . . ... . || . .
IR-WMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS----------------------------
GTSETKGTTESNIFKSHSILVDSSPSQSKNQSKNEIELQQSAMNSQRVQTSRQNINQKGLREVLGEKCPQLIIDTFEKMISKYPQIRGNCSDYLSDL
||. . . .. | | . |. ...
---------------------------------------------------------------F-VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
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| Kinase | 1794.AA | Ciliate-E3 | 1205-1234 | 33 | 0.000115 | 10.8 | In-house | 174-202 (202) | Show / Hide |
Range on Protein: 1205-1234 Range on HMM: 174-202/202 Sequence Identity: 33% (10 aa) YSSPEMREKQAYGIASDVFSAGVIILSALC |..|| ..|. || | |.... || YAAPEQNDQQQISKESDYYSVGAVFC-QLC |
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| Kinase | 1794.AA | ULK | 1134-1157 | 50 | 0.000162 | 11.78 | In-house | 131-154 (329) | Show / Hide |
Range on Protein: 1134-1157 Range on HMM: 131-154/329 Sequence Identity: 50% (12 aa) QLIEFLHQFLSGLHELHVKDIIHR . |.|..|.|.|. ||| . |||| EAIQFFKQILNGFKELHKHNIIHR |
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| Kinase | 1794.AA | ULK | 1134-1157 | 45 | 0.000181 | 11.84 | In-house | 127-150 (324) | Show / Hide |
Range on Protein: 1134-1157 Range on HMM: 127-150/324 Sequence Identity: 45% (11 aa) QLIEFLHQFLSGLHELHVKDIIHR . |.|..|...|. ||| . |||| EAIQFFKQICNGFKELHKHNIIHR |
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| Kinase | 1794.AA | ULK | 1205-1229 | 23 | 0.053997 | 2.94 | In-house | 213-242 (324) | Show / Hide |
Range on Protein: 1205-1229 Range on HMM: 213-242/324 Sequence Identity: 23% (7 aa) YSSPEMRE----KQAYG-IASDVFSAGVII | .|. . .. |. . .|..| |.|. YMAPQILQGQGEQKPYYDYKCDIWSLGCIF |
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| Kinase | 1794.AA | ULK | 1205-1229 | 23 | 0.06093 | 2.67 | In-house | 217-246 (329) | Show / Hide |
Range on Protein: 1205-1229 Range on HMM: 217-246/329 Sequence Identity: 23% (7 aa) YSSPEMRE----KQAYG-IASDVFSAGVII | .|. . .. |. .|..| |.|. YMAPQILQGQGEQKPYYDYKCDIWSLGCIF |
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| Kinase | 1794.AA | Ciliate-E3 | 1038-1054 | 17 | 0.071024 | 1.98 | In-house | 1-17 (202) | Show / Hide |
Range on Protein: 1038-1054 Range on HMM: 1-17/202 Sequence Identity: 17% (3 aa) YYVASLINKSEYGLGFR | | .......|. .. YTVQQILGCGQFGRVYK |
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| Kinase | 1794.AA | TKL-Unique | 1144-1228 | 21 | 0.136841 | 1.6 | In-house | 121-217 (290) | Show / Hide |
Range on Protein: 1144-1228 Range on HMM: 121-217/290 Sequence Identity: 21% (21 aa) SGLHELHVKD--IIHRQLSFESICIQSPSSSAQNKTIAKISNLELAIQLK--SQNYIS--------SDIPLNSYSSPEMREK--QAYGIASDVFSAGVI .|.. || .. |||| | .. . . | .|... .||. .|.. .. ... .. . . ...||. . | . |||.| |.. QGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWN--IKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIV |
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| Kinase | 1794.AA | Pkinase | 1205-1238 | 40 | 0.155315 | 6.51 | Pfam | 177-211 (293) | Show / Hide |
Range on Protein: 1205-1238 Range on HMM: 177-211/293 Sequence Identity: 40% (14 aa) YSSPEM-REKQAYGIASDVFSAGVIILSALCNVSP | .|| |. | || ..|..|.|.|. || | YMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPP |
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| Kinase | 1794.AA | NEK4 | 1145-1226 | 27 | 0.266811 | 0.65 | In-house | 114-189 (257) | Show / Hide |
Range on Protein: 1145-1226 Range on HMM: 114-189/257 Sequence Identity: 27% (23 aa) GLHELHVKDIIHRQLSFESICIQSPSSSAQNKTIAKISNLELAIQLK-SQNYISSDIPLNSYSSPEMREKQAYGIASDVFSAG .| .| | |.|| | | . | | || . .. | . .. . | | |||. ..| ||. | | ALQYMHEKHILHRDLKTQNIFL-------TKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLG |
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